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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2228638
log Bayes Factor = 5.52783
Chromosome 10   position 33,475,282  (GRCh37) Explore rs2228638 on Ensembl!
Variant rs2228638 is listed in the   GWAS Catalog   ⇪
Variant rs2228638 is part of Cluster X0007

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter VIII Diseases of the ear and mastoid process
0.999 0.001 0.000
Chapter XIV Diseases of the genitourinary system
0.999 0.001 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.999 0.001 0.000
N17-N19 Renal failure
0.999 0.001 0.000
Chapter V Mental and behavioural disorders
0.999 0.001 0.000
N18 Chronic renal failure
0.998 0.002 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.998 0.002 0.000
N60-N64 Disorders of breast
0.997 0.003 0.000
N18.9 Chronic renal failure, unspecified
0.992 0.008 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.990 0.010 0.000
T42.4 Benzodiazepines
0.989 0.011 0.000
H90-H95 Other disorders of ear
0.978 0.022 0.000
N60 Benign mammary dysplasia
0.975 0.025 0.000
Chapter XX External causes of morbidity and mortality
0.973 0.027 0.000
N17 Acute renal failure
0.970 0.030 0.000
H60-H62 Diseases of external ear
0.965 0.035 0.000
F30-F39 Mood [affective] disorders
0.963 0.037 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.955 0.045 0.000
N63 Unspecified lump in breast
0.951 0.049 0.000
N17.9 Acute renal failure, unspecified
0.951 0.049 0.000
N18.8 Other chronic renal failure
0.951 0.049 0.000
F31 Bipolar affective disorder
0.948 0.052 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.948 0.052 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.947 0.053 0.000
H91 Other hearing loss
0.942 0.058 0.000
H61 Other disorders of external ear
0.936 0.064 0.000
R21 Rash and other nonspecific skin eruption
0.924 0.076 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.919 0.081 0.000
H91.9 Hearing loss, unspecified
0.919 0.081 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.917 0.083 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.914 0.086 0.000
H80-H83 Diseases of inner ear
0.912 0.088 0.000
F60-F69 Disorders of adult personality and behaviour
0.911 0.089 0.000
F00-F09 Organic, including symptomatic, mental disorders
0.907 0.093 0.000
N60.4 Mammary duct ectasia
0.898 0.102 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.898 0.102 0.000
F40-F48 Neurotic, stress-related and somatoform disorders
0.897 0.103 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.895 0.105 0.000
Chapter IX Diseases of the circulatory system
0.893 0.107 0.000
H61.0 Perichondritis of external ear
0.888 0.112 0.000
N64 Other disorders of breast
0.887 0.113 0.000
H65-H75 Diseases of middle ear and mastoid
0.887 0.113 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.886 0.114 0.000
N18.0 End-stage renal disease
0.884 0.116 0.000
F31.9 Bipolar affective disorder, unspecified
0.883 0.117 0.000
H90 Conductive and sensorineural hearing loss
0.879 0.121 0.000
R41.0 Disorientation, unspecified
0.877 0.123 0.000
F41 Other anxiety disorders
0.875 0.125 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.874 0.126 0.000
X50-X57 Overexertion, travel and privation
0.871 0.129 0.000
T39.1 4-Aminophenol derivatives
0.865 0.135 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.864 0.136 0.000
N18.5 Chronic kidney disease, stage 5
0.859 0.141 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.856 0.144 0.000
F01 Vascular dementia
0.853 0.147 0.000
H80 Otosclerosis
0.853 0.147 0.000
Y00-Y09 Assault
0.849 0.151 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.846 0.154 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.846 0.154 0.000
V10-V19 Pedal cyclist injured in transport accident
0.846 0.154 0.000
H61.3 Acquired stenosis of external ear canal
0.845 0.155 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.842 0.158 0.000
F41.2 Mixed anxiety and depressive disorder
0.831 0.169 0.000
N60.8 Other benign mammary dysplasias
0.830 0.170 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.828 0.172 0.000
N25-N29 Other disorders of kidney and ureter
0.825 0.175 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.825 0.175 0.000
T51 Toxic effect of alcohol
0.824 0.176 0.000
N60.1 Diffuse cystic mastopathy
0.822 0.178 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.822 0.178 0.000
I60-I69 Cerebrovascular diseases
0.821 0.179 0.000
F33 Recurrent depressive disorder
0.818 0.182 0.000
R42 Dizziness and giddiness
0.817 0.183 0.000
I71 Aortic aneurysm and dissection
0.815 0.185 0.000
F01.9 Vascular dementia, unspecified
0.814 0.186 0.000
I77 Other disorders of arteries and arterioles
0.813 0.187 0.000
T42.1 Iminostilbenes
0.812 0.188 0.000
F31.3 Bipolar affective disorder, current episode mild or moderate depression
0.812 0.188 0.000
F99-F99 Unspecified mental disorder
0.811 0.189 0.000
H80.9 Otosclerosis, unspecified
0.810 0.190 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.802 0.198 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.802 0.198 0.000
I60 Subarachnoid haemorrhage
0.800 0.200 0.000
V40-V49 Car occupant injured in transport accident
0.800 0.200 0.000
H74 Other disorders of middle ear and mastoid
0.797 0.203 0.000
F31.7 Bipolar affective disorder, currently in remission
0.792 0.208 0.000
I70 Atherosclerosis
0.791 0.209 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.789 0.211 0.000
F60 Specific personality disorders
0.788 0.212 0.000
Chapter XXII Codes for special purposes
0.785 0.215 0.000
H73 Other disorders of tympanic membrane
0.785 0.215 0.000
N17.1 Acute renal failure with acute cortical necrosis
0.782 0.217 0.000
N64.1 Fat necrosis of breast
0.782 0.218 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.781 0.219 0.000
N60.2 Fibroadenosis of breast
0.781 0.219 0.000
X51 Travel and motion
0.779 0.221 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.779 0.221 0.000
E20-E35 Disorders of other endocrine glands
0.778 0.222 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.777 0.223 0.000
I77.1 Stricture of artery
0.775 0.225 0.000
N60.3 Fibrosclerosis of breast
0.774 0.226 0.000
N10-N16 Renal tubulo-interstitial diseases
0.773 0.227 0.000
I60.9 Subarachnoid haemorrhage, unspecified
0.772 0.228 0.000
N60.9 Benign mammary dysplasia, unspecified
0.770 0.230 0.000
F41.8 Other specified anxiety disorders
0.767 0.233 0.000
T39.0 Salicylates
0.767 0.233 0.000
T50.9 Other and unspecified drugs, medicaments and biological substances
0.766 0.234 0.000
T36 Poisoning by systemic antibiotics
0.765 0.235 0.000
Y04 Assault by bodily force
0.761 0.239 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.758 0.242 0.000
Y60 Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care
0.756 0.244 0.000
N99-N99 Other disorders of the genitourinary system
0.756 0.244 0.000
T46.4 Angiotensin-converting-enzyme inhibitors
0.753 0.247 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.753 0.247 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.753 0.247 0.000
X20-X29 Contact with venomous animals and plants
0.751 0.249 0.000
F31.1 Bipolar affective disorder, current episode manic without psychotic symptoms
0.751 0.249 0.000
H70 Mastoiditis and related conditions
0.751 0.249 0.000
H61.9 Disorder of external ear, unspecified
0.750 0.250 0.000
F05 Delirium, not induced by alcohol and other psychoactive substances
0.748 0.252 0.000
F64 Gender identity disorders
0.746 0.254 0.000
F31.2 Bipolar affective disorder, current episode manic with psychotic symptoms
0.741 0.259 0.000
N28 Other disorders of kidney and ureter, not elsewhere classified
0.738 0.262 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.736 0.264 0.000
I70.2 Atherosclerosis of arteries of the extremities
0.735 0.265 0.000
T51.0 Ethanol
0.735 0.265 0.000
I69 Sequelae of cerebrovascular disease
0.734 0.266 0.000
X10-X19 Contact with heat and hot substances
0.733 0.267 0.000
T00-T07 Injuries involving multiple body regions
0.733 0.267 0.000
R43 Disturbances of smell and taste
0.733 0.267 0.000
H60 Otitis externa
0.733 0.267 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.732 0.268 0.000
T43.6 Psychostimulants with abuse potential
0.731 0.269 0.000
V01-V09 Pedestrian injured in transport accident
0.730 0.270 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.730 0.270 0.000
F80-F89 Disorders of psychological development
0.728 0.272 0.000
N64.4 Mastodynia
0.727 0.272 0.000
T66-T78 Other and unspecified effects of external causes
0.727 0.273 0.000
V70-V79 Bus occupant injured in transport accident
0.726 0.274 0.000
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.726 0.274 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.724 0.275 0.000
F33.1 Recurrent depressive disorder, current episode moderate
0.723 0.277 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.719 0.280 0.000
R46 Symptoms and signs involving appearance and behaviour
0.719 0.281 0.000
F31.6 Bipolar affective disorder, current episode mixed
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.716 0.283 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.716 0.283 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.716 0.283 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.716 0.283 0.000
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence
0.716 0.284 0.000
N18.1 Chronic kidney disease, stage 1
0.716 0.284 0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants
0.715 0.285 0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified
0.715 0.285 0.000
T42.5 Mixed antiepileptics, not elsewhere classified
0.715 0.285 0.000
T42.3 Barbiturates
0.715 0.285 0.000
T42.2 Succinimides and oxazolidinediones
0.715 0.285 0.000
T42.0 Hydantoin derivatives
0.715 0.285 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.715 0.285 0.000
I77.9 Disorder of arteries and arterioles, unspecified
0.714 0.286 0.000
H92 Otalgia and effusion of ear
0.712 0.288 0.000
H73.8 Other specified disorders of tympanic membrane
0.712 0.288 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.710 0.290 0.000
T33-T35 Frostbite
0.710 0.290 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.710 0.290 0.000
N00-N08 Glomerular diseases
0.709 0.291 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.706 0.294 0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic
0.705 0.295 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.705 0.295 0.000
H90.5 Sensorineural hearing loss, unspecified
0.704 0.296 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.704 0.296 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.703 0.296 0.000
F42 Obsessive-compulsive disorder
0.703 0.297 0.000
Chapter VI Diseases of the nervous system
0.703 0.297 0.000
F69 Unspecified disorder of adult personality and behaviour
0.702 0.298 0.000
X41 Accidental poisoning by and exposure to antiepileptic, sedative-hypnotic, anti-Parkinsonism and psychotropic drugs, not elsewhere classified
0.702 0.298 0.000
V98-V99 Other and unspecified transport accidents
0.702 0.298 0.000
F70-F79 Mental retardation
0.701 0.299 0.000
H94 Other disorders of ear in diseases classified elsewhere
0.701 0.299 0.000
V20-V29 Motorcycle rider injured in transport accident
0.699 0.301 0.000
Y35-Y36 Legal intervention and operations of war
0.698 0.302 0.000
Y10-Y34 Event of undetermined intent
0.698 0.302 0.000
X85-X99 Assault
0.698 0.302 0.000
X30-X39 Exposure to forces of nature
0.698 0.302 0.000
X00-X09 Exposure to smoke, fire and flames
0.698 0.302 0.000
W75-W84 Other accidental threats to breathing
0.698 0.302 0.000
W65-W74 Accidental drowning and submersion
0.698 0.302 0.000
V95-V97 Air and space transport accidents
0.698 0.302 0.000
V90-V94 Water transport accidents
0.698 0.302 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.698 0.302 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.698 0.302 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.698 0.302 0.000
N18.4 Chronic kidney disease, stage 4
0.696 0.304 0.000
N17.8 Other acute renal failure
0.696 0.304 0.000
N17.2 Acute renal failure with medullary necrosis
0.696 0.304 0.000
R41.1 Anterograde amnesia
0.696 0.304 0.000
N64.5 Other signs and symptoms in breast
0.695 0.305 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.693 0.307 0.000
T63 Toxic effect of contact with venomous animals
0.692 0.307 0.000
R44.3 Hallucinations, unspecified
0.692 0.307 0.000
I00-I02 Acute rheumatic fever
0.692 0.308 0.000
T59 Toxic effect of other gases, fumes and vapours
0.692 0.308 0.000
H62 Disorders of external ear in diseases classified elsewhere
0.692 0.308 0.000
X51.9 Unspecified place
0.691 0.309 0.000
X60-X84 Intentional self-harm
0.691 0.309 0.000
F38 Other mood [affective] disorders
0.691 0.309 0.000
F39 Unspecified mood [affective] disorder
0.691 0.309 0.000
V19 Pedal cyclist injured in other and unspecified transport accidents
0.690 0.310 0.000
R45 Symptoms and signs involving emotional state
0.690 0.310 0.000
F20 Schizophrenia
0.689 0.311 0.000
T51.9 Alcohol, unspecified
0.688 0.312 0.000
W50-W64 Exposure to animate mechanical forces
0.688 0.312 0.000
N64.9 Disorder of breast, unspecified
0.688 0.312 0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified
0.687 0.313 0.000
Y60.0 During surgical operation
0.687 0.313 0.000
F07 Personality and behavioural disorders due to brain disease, damage and dysfunction
0.686 0.314 0.000
T43.2 Other and unspecified antidepressants
0.685 0.315 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.684 0.315 0.000
T39.4 Antirheumatics, not elsewhere classified
0.684 0.315 0.000
T39.2 Pyrazolone derivatives
0.684 0.315 0.000
H83 Other diseases of inner ear
0.684 0.316 0.000
R86 Abnormal findings in specimens from male genital organs
0.684 0.316 0.000
H74.4 Polyp of middle ear
0.683 0.317 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.682 0.318 0.000
T46.1 Calcium-channel blockers
0.682 0.318 0.000
I70.20 Atherosclerosis of arteries of extremities (without gangrene)
0.681 0.319 0.000
H90.2 Conductive hearing loss, unspecified
0.680 0.320 0.000
F31.8 Other bipolar affective disorders
0.680 0.320 0.000
F31.4 Bipolar affective disorder, current episode severe depression without psychotic symptoms
0.680 0.320 0.000
T43.9 Psychotropic drug, unspecified
0.679 0.321 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.679 0.321 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.679 0.321 0.000
N61 Inflammatory disorders of breast
0.679 0.321 0.000
E34 Other endocrine disorders
0.679 0.321 0.000
T46.5 Other antihypertensive drugs, not elsewhere classified
0.677 0.323 0.000
S10-S19 Injuries to the neck
0.677 0.323 0.000
F99 Mental disorder, not otherwise specified
0.676 0.324 0.000
T56 Toxic effect of metals
0.676 0.324 0.000
V49 Car occupant injured in other and unspecified transport accidents
0.676 0.324 0.000
H91.3 Deaf mutism, not elsewhere classified
0.676 0.324 0.000
H91.2 Sudden idiopathic hearing loss
0.676 0.324 0.000
H91.1 Presbycusis
0.676 0.324 0.000
H91.0 Ototoxic hearing loss
0.676 0.324 0.000
I74 Arterial embolism and thrombosis
0.675 0.325 0.000
F48 Other neurotic disorders
0.675 0.325 0.000
F41.0 Panic disorder [episodic paroxysmal anxiety]
0.674 0.326 0.000
Chapter I Certain infectious and parasitic diseases
0.674 0.326 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.673 0.327 0.000
F31.5 Bipolar affective disorder, current episode severe depression with psychotic symptoms
0.673 0.327 0.000
X50 Overexertion and strenuous or repetitive movements
0.673 0.327 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.673 0.327 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.671 0.329 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.671 0.329 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.671 0.329 0.000
F33.9 Recurrent depressive disorder, unspecified
0.670 0.330 0.000
T45.5 Anticoagulants
0.670 0.330 0.000
F06 Other mental disorders due to brain damage and dysfunction and to physical disease
0.669 0.331 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.669 0.331 0.000
X42 Accidental poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.668 0.331 0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral
0.666 0.334 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.665 0.335 0.000
R41.8 Other and unspecified symptoms and signs involving cognitive functions and awareness
0.664 0.336 0.000
E10-E14 Diabetes mellitus
0.664 0.336 0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery
0.662 0.338 0.000
I60.6 Subarachnoid haemorrhage from other intracranial arteries
0.662 0.338 0.000
E20 Hypoparathyroidism
0.660 0.340 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.660 0.340 0.000
F60.3 Emotionally unstable personality disorder
0.660 0.340 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.659 0.341 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.659 0.341 0.000
Y04.8 Other specified place
0.659 0.341 0.000
T47.4 Other laxatives
0.658 0.342 0.000
E50-E64 Other nutritional deficiencies
0.658 0.342 0.000
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors
0.658 0.342 0.000
F05.8 Other delirium
0.657 0.343 0.000
A30-A49 Other bacterial diseases
0.656 0.344 0.000
H61.1 Non-infective disorders of pinna
0.655 0.344 0.000
E24 Cushing's syndrome
0.655 0.345 0.000
H72 Perforation of tympanic membrane
0.655 0.345 0.000
F31.0 Bipolar affective disorder, current episode hypomanic
0.655 0.345 0.000
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
0.655 0.345 0.000
H70.9 Mastoiditis, unspecified
0.654 0.346 0.000
H82 Vertiginous syndromes in diseases classified elsewhere
0.654 0.346 0.000
F68 Other disorders of adult personality and behaviour
0.653 0.347 0.000
F66 Psychological and behavioural disorders associated with sexual development and orientation
0.653 0.347 0.000
F65 Disorders of sexual preference
0.653 0.347 0.000
F63 Habit and impulse disorders
0.653 0.347 0.000
F62 Enduring personality changes, not attributable to brain damage and disease
0.653 0.347 0.000
F61 Mixed and other personality disorders
0.653 0.347 0.000
H90.0 Conductive hearing loss, bilateral
0.652 0.347 0.000
F09 Unspecified organic or symptomatic mental disorder
0.651 0.349 0.000
F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances
0.651 0.349 0.000
H91.8 Other specified hearing loss
0.650 0.350 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.648 0.352 0.000
I61 Intracerebral haemorrhage
0.648 0.352 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.648 0.352 0.000
I05-I09 Chronic rheumatic heart diseases
0.648 0.352 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.648 0.352 0.000
N62 Hypertrophy of breast
0.647 0.353 0.000
H93 Other disorders of ear, not elsewhere classified
0.646 0.354 0.000
H66 Suppurative and unspecified otitis media
0.645 0.355 0.000
X45 Accidental poisoning by and exposure to alcohol
0.644 0.356 0.000
T65 Toxic effect of other and unspecified substances
0.644 0.356 0.000
T62 Toxic effect of other noxious substances eaten as food
0.644 0.356 0.000
T61 Toxic effect of noxious substances eaten as seafood
0.644 0.356 0.000
T60 Toxic effect of pesticides
0.644 0.356 0.000
T57 Toxic effect of other inorganic substances
0.644 0.356 0.000
T54 Toxic effect of corrosive substances
0.644 0.356 0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone
0.644 0.356 0.000
T52 Toxic effect of organic solvents
0.644 0.356 0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants
0.644 0.356 0.000
T55 Toxic effect of soaps and detergents
0.644 0.356 0.000
F30 Manic episode
0.643 0.357 0.000
F44 Dissociative [conversion] disorders
0.643 0.357 0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.642 0.358 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.642 0.358 0.000
T46.7 Peripheral vasodilators
0.642 0.358 0.000
T46.3 Coronary vasodilators, not elsewhere classified
0.642 0.358 0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.642 0.358 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.642 0.358 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.642 0.358 0.000
F41.9 Anxiety disorder, unspecified
0.640 0.360 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.639 0.360 0.000
T45.0 Antiallergic and antiemetic drugs
0.640 0.360 0.000
I69.0 Sequelae of subarachnoid haemorrhage
0.639 0.361 0.000
F22 Persistent delusional disorders
0.639 0.361 0.000
F29 Unspecified nonorganic psychosis
0.638 0.362 0.000
F34 Persistent mood [affective] disorders
0.637 0.362 0.000
W87 Exposure to unspecified electric current
0.637 0.363 0.000
F60.9 Personality disorder, unspecified
0.636 0.364 0.000
N64.3 Galactorrhoea not associated with childbirth
0.636 0.364 0.000
N64.2 Atrophy of breast
0.636 0.364 0.000
N64.0 Fissure and fistula of nipple
0.636 0.364 0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere
0.636 0.364 0.000
H68 Eustachian salpingitis and obstruction
0.636 0.364 0.000
H67 Otitis media in diseases classified elsewhere
0.636 0.364 0.000
H61.2 Impacted cerumen
0.633 0.367 0.000
T31 Burns classified according to extent of body surface involved
0.632 0.368 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.631 0.369 0.000
T82.1 Mechanical complication of cardiac electronic device
0.631 0.369 0.000
S37 Injury of urinary and pelvic organs
0.630 0.369 0.000
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
0.630 0.370 0.000
S36 Injury of intra-abdominal organs
0.630 0.370 0.000
F64.0 Transsexualism
0.628 0.371 0.000
H74.9 Disorder of middle ear and mastoid, unspecified
0.628 0.372 0.000
F41.3 Other mixed anxiety disorders
0.627 0.373 0.000
F20.9 Schizophrenia, unspecified
0.627 0.373 0.000
Y04.5 Trade and service area
0.626 0.374 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.626 0.374 0.000
F25 Schizoaffective disorders
0.626 0.374 0.000
X57 Unspecified privation
0.624 0.376 0.000
X54 Lack of water
0.624 0.376 0.000
X53 Lack of food
0.624 0.376 0.000
X52 Prolonged stay in weightless environment
0.624 0.376 0.000
I95 Hypotension
0.624 0.376 0.000
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities
0.624 0.376 0.000
E27 Other disorders of adrenal gland
0.623 0.377 0.000
I80 Phlebitis and thrombophlebitis
0.623 0.377 0.000
N28.0 Ischaemia and infarction of kidney
0.622 0.378 0.000
H90.3 Sensorineural hearing loss, bilateral
0.622 0.378 0.000
E11 Non-insulin-dependent diabetes mellitus
0.620 0.380 0.000
Y77 Ophthalmic devices associated with adverse incidents
0.620 0.380 0.000
T50.8 Diagnostic agents
0.619 0.381 0.000
T50.7 Analeptics and opioid receptor antagonists
0.619 0.381 0.000
T50.6 Antidotes and chelating agents, not elsewhere classified
0.619 0.381 0.000
T50.5 Appetite depressants
0.619 0.381 0.000
T50.4 Drugs affecting uric acid metabolism
0.619 0.381 0.000
T50.3 Electrolytic, caloric and water-balance agents
0.619 0.381 0.000
T50.2 Carbonic-anhydrase inhibitors, benzothiadiazides and other diuretics
0.619 0.381 0.000
T50.1 Loop [high-ceiling] diuretics
0.619 0.381 0.000
T50.0 Mineralocorticoids and their antagonists
0.619 0.381 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.617 0.383 0.000
X51.8 Other specified place
0.616 0.384 0.000
I77.0 Arteriovenous fistula, acquired
0.614 0.386 0.000
E23 Hypofunction and other disorders of pituitary gland
0.614 0.386 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.614 0.386 0.000
T45.8 Other primarily systemic and haematological agents
0.614 0.386 0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.614 0.386 0.000
T45.6 Fibrinolysis-affecting drugs
0.614 0.386 0.000
T45.4 Iron and its compounds
0.614 0.386 0.000
T45.3 Enzymes, not elsewhere classified
0.614 0.386 0.000
T45.2 Vitamins, not elsewhere classified
0.614 0.386 0.000
S39.9 Unspecified injury of abdomen, lower back and pelvis
0.613 0.387 0.000
R85 Abnormal findings in specimens from digestive organs and abdominal cavity
0.613 0.387 0.000
F01.8 Other vascular dementia
0.612 0.388 0.000
F01.3 Mixed cortical and subcortical vascular dementia
0.612 0.388 0.000
F01.2 Subcortical vascular dementia
0.612 0.388 0.000
F01.1 Multi-infarct dementia
0.612 0.388 0.000
F01.0 Vascular dementia of acute onset
0.612 0.388 0.000
N28.1 Cyst of kidney, acquired
0.612 0.388 0.000
X41.9 Unspecified place
0.611 0.389 0.000
H80.8 Other otosclerosis
0.611 0.389 0.000
H80.2 Cochlear otosclerosis
0.611 0.389 0.000
H80.1 Otosclerosis involving oval window, obliterative
0.611 0.389 0.000
H80.0 Otosclerosis involving oval window, nonobliterative
0.611 0.389 0.000
U82-U85 Resistance to antimicrobial and antineoplastic drugs
0.611 0.389 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.609 0.390 0.000
Y09 Assault by unspecified means
0.609 0.391 0.000
Y08 Assault by other specified means
0.609 0.391 0.000
Y07 Other maltreatment syndromes
0.609 0.391 0.000
Y06 Neglect and abandonment
0.609 0.391 0.000
Y05 Sexual assault by bodily force
0.609 0.391 0.000
Y03 Assault by crashing of motor vehicle
0.609 0.391 0.000
Y02 Assault by pushing or placing victim before moving object
0.609 0.391 0.000
Y01 Assault by pushing from high place
0.609 0.391 0.000
Y00 Assault by blunt object
0.609 0.391 0.000
F00 Dementia in Alzheimer's disease
0.608 0.392 0.000
Y64 Contaminated medical or biological substances
0.607 0.393 0.000
Y63 Failure in dosage during surgical and medical care
0.607 0.393 0.000
Y62 Failure of sterile precautions during surgical and medical care
0.607 0.393 0.000
Y61 Foreign object accidentally left in body during surgical and medical care
0.607 0.393 0.000
Y69 Unspecified misadventure during surgical and medical care
0.607 0.393 0.000
Y66 Nonadministration of surgical and medical care
0.607 0.393 0.000
F28 Other nonorganic psychotic disorders
0.606 0.393 0.000
F24 Induced delusional disorder
0.606 0.393 0.000
F21 Schizotypal disorder
0.606 0.393 0.000
V17 Pedal cyclist injured in collision with fixed or stationary object
0.606 0.394 0.000
V16 Pedal cyclist injured in collision with other nonmotor vehicle
0.606 0.394 0.000
V15 Pedal cyclist injured in collision with railway train or railway vehicle
0.606 0.394 0.000
V14 Pedal cyclist injured in collision with heavy transport vehicle or bus
0.606 0.394 0.000
V13 Pedal cyclist injured in collision with car, pick-up truck or van
0.606 0.394 0.000
V12 Pedal cyclist injured in collision with two- or three-wheeled motor vehicle
0.606 0.394 0.000
V11 Pedal cyclist injured in collision with other pedal cycle
0.606 0.394 0.000
V10 Pedal cyclist injured in collision with pedestrian or animal
0.606 0.394 0.000
V80-V89 Other land transport accidents
0.606 0.394 0.000
Y65 Other misadventures during surgical and medical care
0.605 0.395 0.000
Y60.5 During heart catheterisation
0.605 0.395 0.000
F23 Acute and transient psychotic disorders
0.604 0.396 0.000
F41.1 Generalised anxiety disorder
0.604 0.396 0.000
H81 Disorders of vestibular function
0.603 0.397 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.603 0.397 0.000
N14 Drug- and heavy-metal-induced tubulo-interstitial and tubular conditions
0.603 0.397 0.000
Q80-Q89 Other congenital malformations
0.603 0.397 0.000
R43.8 Other and unspecified disturbances of smell and taste
0.603 0.397 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.603 0.397 0.000
G90-G99 Other disorders of the nervous system
0.603 0.397 0.000
R44.0 Auditory hallucinations
0.602 0.398 0.000
H90.8 Mixed conductive and sensorineural hearing loss, unspecified
0.600 0.400 0.000
S31 Open wound of abdomen, lower back and pelvis
0.599 0.401 0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft
0.599 0.401 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.599 0.401 0.000
N08 Glomerular disorders in diseases classified elsewhere
0.598 0.402 0.000
T36.0 Penicillins
0.598 0.402 0.000
R86.7 Abnormal histological findings
0.597 0.403 0.000
F05.1 Delirium superimposed on dementia
0.596 0.404 0.000
B15-B19 Viral hepatitis
0.596 0.404 0.000
H74.8 Other specified disorders of middle ear and mastoid
0.595 0.404 0.000
V18.2 Unspecified pedal cyclist injured in nontraffic accident
0.594 0.406 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.594 0.406 0.000
X48 Accidental poisoning by and exposure to pesticides
0.594 0.406 0.000
X47 Accidental poisoning by and exposure to other gases and vapours
0.594 0.406 0.000
X46 Accidental poisoning by and exposure to organic solvents and halogenated hydrocarbons and their vapours
0.594 0.406 0.000
X44 Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
0.594 0.406 0.000
X43 Accidental poisoning by and exposure to other drugs acting on the autonomic nervous system
0.594 0.406 0.000
X40 Accidental poisoning by and exposure to nonopioid analgesics, antipyretics and antirheumatics
0.594 0.406 0.000
T92 Sequelae of injuries of upper limb
0.594 0.406 0.000
A41 Other septicaemia
0.593 0.407 0.000
E29 Testicular dysfunction
0.593 0.407 0.000
X23 Contact with hornets, wasps and bees
0.592 0.407 0.000
N29 Other disorders of kidney and ureter in diseases classified elsewhere
0.592 0.408 0.000
N27 Small kidney of unknown cause
0.592 0.408 0.000
T51.8 Other alcohols
0.591 0.409 0.000
T51.3 Fusel oil
0.591 0.409 0.000
T51.2 2-Propanol
0.591 0.409 0.000
T51.1 Methanol
0.591 0.409 0.000
A40 Streptococcal septicaemia
0.590 0.410 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.589 0.411 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.589 0.411 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.589 0.411 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.589 0.411 0.000
I95.9 Hypotension, unspecified
0.589 0.411 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.589 0.411 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.589 0.411 0.000
N15 Other renal tubulo-interstitial diseases
0.589 0.411 0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use
0.588 0.411 0.000
H74.0 Tympanosclerosis
0.588 0.412 0.000
R40 Somnolence, stupor and coma
0.587 0.412 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.587 0.413 0.000
G62 Other polyneuropathies
0.587 0.413 0.000
F33.8 Other recurrent depressive disorders
0.586 0.413 0.000
F33.4 Recurrent depressive disorder, currently in remission
0.586 0.413 0.000
R41.2 Retrograde amnesia
0.586 0.414 0.000
H74.2 Discontinuity and dislocation of ear ossicles
0.585 0.415 0.000
F02 Dementia in other diseases classified elsewhere
0.584 0.416 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.584 0.416 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.584 0.416 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.584 0.416 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.584 0.416 0.000
T40.6 Other and unspecified narcotics
0.584 0.416 0.000
I60.2 Subarachnoid haemorrhage from anterior communicating artery
0.584 0.416 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.584 0.416 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.583 0.417 0.000
I77.5 Necrosis of artery
0.583 0.417 0.000
I77.4 Coeliac artery compression syndrome
0.583 0.417 0.000
I77.3 Arterial fibromuscular dysplasia
0.583 0.417 0.000
I77.2 Rupture of artery
0.583 0.417 0.000
N18.2 Chronic kidney disease, stage 2
0.582 0.418 0.000
N99 Postprocedural disorders of genito-urinary system, not elsewhere classified
0.581 0.419 0.000
T47.1 Other antacids and anti-gastric-secretion drugs
0.580 0.420 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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