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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2516399
log Bayes Factor = 7.15187
Chromosome 6   position 31,481,299  (GRCh37) Explore rs2516399 on Ensembl!
Variant rs2516399 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.002 0.998
E03 Other hypothyroidism
0.000 0.002 0.998
E10 Insulin-dependent diabetes mellitus
0.000 0.003 0.997
E00-E07 Disorders of thyroid gland
0.000 0.004 0.996
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.013 0.987
E10-E14 Diabetes mellitus
0.000 0.013 0.987
E10.3 With ophthalmic complications
0.000 0.024 0.976
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.057 0.943
E06 Thyroiditis
0.000 0.058 0.942
E06.3 Autoimmune thyroiditis
0.000 0.092 0.908
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.101 0.899
E10.1 With ketoacidosis
0.000 0.132 0.868
E05.9 Thyrotoxicosis, unspecified
0.000 0.200 0.800
E70-E90 Metabolic disorders
0.000 0.232 0.768
E03.8 Other specified hypothyroidism
0.000 0.237 0.763
E40-E46 Malnutrition
0.000 0.238 0.762
E65-E68 Obesity and other hyperalimentation
0.000 0.270 0.730
E86 Volume depletion
0.000 0.275 0.725
E03.5 Myxoedema coma
0.000 0.285 0.715
E03.4 Atrophy of thyroid (acquired)
0.000 0.285 0.715
E03.3 Postinfectious hypothyroidism
0.000 0.285 0.715
E03.1 Congenital hypothyroidism without goitre
0.000 0.285 0.715
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.285 0.715
E10.7 With multiple complications
0.000 0.285 0.715
E10.0 With coma
0.000 0.285 0.715
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.286 0.714
E00 Congenital iodine-deficiency syndrome
0.000 0.286 0.714
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.286 0.714
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.289 0.711
E10.5 With peripheral circulatory complications
0.000 0.291 0.709
E12 Malnutrition-related diabetes mellitus
0.000 0.293 0.707
E10.2 With renal complications
0.000 0.313 0.687
E10.8 With unspecified complications
0.000 0.318 0.682
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.322 0.678
E05.5 Thyroid crisis or storm
0.000 0.324 0.676
E05.4 Thyrotoxicosis factitia
0.000 0.324 0.676
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.324 0.676
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.324 0.676
E06.5 Other chronic thyroiditis
0.000 0.325 0.675
E06.4 Drug-induced thyroiditis
0.000 0.325 0.675
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.325 0.675
E06.1 Subacute thyroiditis
0.000 0.325 0.675
E06.0 Acute thyroiditis
0.000 0.325 0.675
E80.4 Gilbert's syndrome
0.000 0.329 0.671
E10.6 With other specified complications
0.000 0.352 0.648
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.354 0.646
E20-E35 Disorders of other endocrine glands
0.000 0.360 0.640
E73 Lactose intolerance
0.000 0.362 0.637
E06.9 Thyroiditis, unspecified
0.000 0.367 0.633
E10.4 With neurological complications
0.000 0.371 0.628
E65 Localised adiposity
0.000 0.397 0.603
E46 Unspecified protein-energy malnutrition
0.000 0.399 0.601
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.418 0.582
E27 Other disorders of adrenal gland
0.000 0.434 0.566
E88 Other metabolic disorders
0.000 0.439 0.561
E05.8 Other thyrotoxicosis
0.000 0.445 0.554
E84 Cystic fibrosis
0.000 0.449 0.551
E79 Disorders of purine and pyrimidine metabolism
0.000 0.449 0.551
E77 Disorders of glycoprotein metabolism
0.000 0.449 0.551
E76 Disorders of glycosaminoglycan metabolism
0.000 0.449 0.551
E72 Other disorders of amino-acid metabolism
0.000 0.449 0.551
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.449 0.551
E70 Disorders of aromatic amino-acid metabolism
0.000 0.449 0.551
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.449 0.551
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.453 0.546
E45 Retarded development following protein-energy malnutrition
0.000 0.453 0.546
E43 Unspecified severe protein-energy malnutrition
0.000 0.453 0.546
E42 Marasmic kwashiorkor
0.000 0.453 0.546
E41 Nutritional marasmus
0.000 0.453 0.546
E40 Kwashiorkor
0.000 0.453 0.546
E73.9 Lactose intolerance, unspecified
0.000 0.456 0.544
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.464 0.536
E28 Ovarian dysfunction
0.000 0.464 0.536
E27.1 Primary adrenocortical insufficiency
0.000 0.472 0.528
E67 Other hyperalimentation
0.000 0.476 0.524
E68 Sequelae of hyperalimentation
0.000 0.476 0.524
E50-E64 Other nutritional deficiencies
0.000 0.482 0.518
E13 Other specified diabetes mellitus
0.001 0.483 0.517
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.488 0.512
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.488 0.512
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.488 0.512
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.488 0.512
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.488 0.512
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.488 0.512
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.488 0.512
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.488 0.512
E74 Other disorders of carbohydrate metabolism
0.000 0.489 0.511
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.490 0.510
E80.6 Other disorders of bilirubin metabolism
0.000 0.490 0.510
E80.5 Crigler-Najjar syndrome
0.000 0.490 0.510
E80.3 Defects of catalase and peroxydase
0.000 0.490 0.510
E80.2 Other porphyria
0.000 0.490 0.510
E80.1 Porphyria cutanea tarda
0.000 0.490 0.510
E80.0 Hereditary erythropoietic porphyria
0.000 0.490 0.510
E12.9 Without complications
0.000 0.493 0.507
E12.8 With unspecified complications
0.000 0.493 0.507
E12.7 With multiple complications
0.000 0.493 0.507
E12.6 With other specified complications
0.000 0.493 0.507
E12.5 With peripheral circulatory complications
0.000 0.493 0.507
E12.4 With neurological complications
0.000 0.493 0.507
E12.3 With ophthalmic complications
0.000 0.493 0.507
E12.2 With renal complications
0.000 0.493 0.507
E12.1 With ketoacidosis
0.000 0.493 0.507
E12.0 With coma
0.000 0.493 0.507
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.495 0.505
E07 Other disorders of thyroid
0.000 0.514 0.486
E89.0 Postprocedural hypothyroidism
0.000 0.521 0.479
E20 Hypoparathyroidism
0.000 0.528 0.472
E14 Unspecified diabetes mellitus
0.000 0.534 0.466
E28.2 Polycystic ovarian syndrome
0.000 0.537 0.463
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.541 0.459
E32 Diseases of thymus
0.000 0.541 0.459
E31 Polyglandular dysfunction
0.000 0.541 0.459
E30 Disorders of puberty, not elsewhere classified
0.000 0.541 0.459
E25 Adrenogenital disorders
0.000 0.541 0.459
E73.8 Other lactose intolerance
0.000 0.543 0.457
E73.1 Secondary lactase deficiency
0.000 0.543 0.457
E73.0 Congenital lactase deficiency
0.000 0.543 0.457
E24 Cushing's syndrome
0.000 0.543 0.457
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.554 0.446
E26 Hyperaldosteronism
0.000 0.555 0.445
E66 Obesity
0.000 0.569 0.431
E27.8 Other specified disorders of adrenal gland
0.000 0.574 0.426
E27.9 Disorder of adrenal gland, unspecified
0.000 0.580 0.419
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.581 0.419
E15 Nondiabetic hypoglycaemic coma
0.000 0.583 0.417
E27.5 Adrenomedullary hyperfunction
0.000 0.594 0.406
E27.2 Addisonian crisis
0.000 0.594 0.406
E27.0 Other adrenocortical overactivity
0.000 0.594 0.406
E88.9 Metabolic disorder, unspecified
0.000 0.597 0.403
E88.8 Other specified metabolic disorders
0.000 0.597 0.403
E88.3 Tumour lysis syndrome
0.000 0.597 0.403
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.597 0.403
E66.8 Other obesity
0.000 0.598 0.402
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.605 0.395
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.605 0.395
E70.3 Albinism
0.000 0.605 0.395
E70.2 Disorders of tyrosine metabolism
0.000 0.605 0.395
E70.1 Other hyperphenylalaninaemias
0.000 0.605 0.395
E70.0 Classical phenylketonuria
0.000 0.605 0.395
E71.3 Disorders of fatty-acid metabolism
0.000 0.605 0.395
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.605 0.395
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.605 0.395
E71.0 Maple-syrup-urine disease
0.000 0.605 0.395
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.605 0.395
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.605 0.395
E72.5 Disorders of glycine metabolism
0.000 0.605 0.395
E72.4 Disorders of ornithine metabolism
0.000 0.605 0.395
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.605 0.395
E72.2 Disorders of urea cycle metabolism
0.000 0.605 0.395
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.605 0.395
E72.0 Disorders of amino-acid transport
0.000 0.605 0.395
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.605 0.395
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.605 0.395
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.605 0.395
E76.2 Other mucopolysaccharidoses
0.000 0.605 0.395
E76.1 Mucopolysaccharidosis, type II
0.000 0.605 0.395
E76.0 Mucopolysaccharidosis, type I
0.000 0.605 0.395
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.605 0.395
E77.8 Other disorders of glycoprotein metabolism
0.000 0.605 0.395
E77.1 Defects in glycoprotein degradation
0.000 0.605 0.395
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.605 0.395
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.605 0.395
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.605 0.395
E79.1 Lesch-Nyhan syndrome
0.000 0.605 0.395
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.605 0.395
E84.9 Cystic fibrosis, unspecified
0.000 0.605 0.395
E84.8 Cystic fibrosis with other manifestations
0.000 0.605 0.395
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.605 0.395
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.605 0.395
E44.1 Mild protein-energy malnutrition
0.000 0.608 0.392
E44.0 Moderate protein-energy malnutrition
0.000 0.608 0.392
E85 Amyloidosis
0.000 0.611 0.388
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.615 0.384
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.615 0.384
E89.5 Postprocedural testicular hypofunction
0.000 0.615 0.384
E89.4 Postprocedural ovarian failure
0.000 0.615 0.384
E89.1 Postprocedural hypoinsulinaemia
0.000 0.615 0.384
E28.9 Ovarian dysfunction, unspecified
0.000 0.615 0.384
E28.8 Other ovarian dysfunction
0.000 0.615 0.384
E28.1 Androgen excess
0.000 0.615 0.384
E28.0 Oestrogen excess
0.000 0.615 0.384
E22 Hyperfunction of pituitary gland
0.000 0.616 0.383
E28.3 Primary ovarian failure
0.000 0.617 0.382
E29 Testicular dysfunction
0.000 0.617 0.382
E83 Disorders of mineral metabolism
0.000 0.622 0.378
E89.3 Postprocedural hypopituitarism
0.000 0.623 0.376
E67.8 Other specified hyperalimentation
0.000 0.624 0.375
E67.3 Hypervitaminosis D
0.000 0.624 0.375
E67.2 Megavitamin-B6 syndrome
0.000 0.624 0.375
E67.1 Hypercarotenaemia
0.000 0.624 0.375
E67.0 Hypervitaminosis A
0.000 0.624 0.375
E34 Other endocrine disorders
0.000 0.625 0.374
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.628 0.371
E63 Other nutritional deficiencies
0.000 0.628 0.371
E56 Other vitamin deficiencies
0.000 0.628 0.371
E51 Thiamine deficiency
0.000 0.628 0.371
E50 Vitamin A deficiency
0.000 0.628 0.371
E60 Dietary zinc deficiency
0.000 0.628 0.371
E59 Dietary selenium deficiency
0.000 0.628 0.371
E58 Dietary calcium deficiency
0.000 0.628 0.371
E54 Ascorbic acid deficiency
0.000 0.628 0.371
E52 Niacin deficiency [pellagra]
0.000 0.628 0.371
E53 Deficiency of other B group vitamins
0.000 0.629 0.371
E13.8 With unspecified complications
0.001 0.629 0.370
E13.7 With multiple complications
0.001 0.629 0.370
E13.6 With other specified complications
0.001 0.629 0.370
E13.5 With peripheral circulatory complications
0.001 0.629 0.370
E13.4 With neurological complications
0.001 0.629 0.370
E13.3 With ophthalmic complications
0.001 0.629 0.370
E13.2 With renal complications
0.001 0.629 0.370
E13.1 With ketoacidosis
0.001 0.629 0.370
E13.0 With coma
0.001 0.629 0.370
E04 Other non-toxic goitre
0.000 0.631 0.369
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.632 0.368
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.634 0.366
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.634 0.366
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.634 0.366
E74.2 Disorders of galactose metabolism
0.000 0.634 0.366
E74.1 Disorders of fructose metabolism
0.000 0.634 0.366
E74.0 Glycogen storage disease
0.000 0.634 0.366
E21.3 Hyperparathyroidism, unspecified
0.000 0.635 0.365
E87 Other disorders of fluid, electrolyte and acid-base balance
0.000 0.636 0.364
E75.6 Lipid storage disorder, unspecified
0.000 0.638 0.362
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.638 0.362
E75.3 Sphingolipidosis, unspecified
0.000 0.638 0.362
E75.2 Other sphingolipidosis
0.000 0.638 0.362
E75.1 Other gangliosidosis
0.000 0.638 0.362
E75.0 GM2 gangliosidosis
0.000 0.638 0.362
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.641 0.359
E88.2 Lipomatosis, not elsewhere classified
0.000 0.642 0.358
E20.9 Hypoparathyroidism, unspecified
0.000 0.648 0.352
E07.1 Dyshormogenetic goitre
0.000 0.651 0.348
E07.0 Hypersecretion of calcitonin
0.000 0.651 0.348
E23 Hypofunction and other disorders of pituitary gland
0.000 0.655 0.345
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.656 0.343
E07.8 Other specified disorders of thyroid
0.000 0.658 0.342
E20.8 Other hypoparathyroidism
0.000 0.661 0.338
E20.1 Pseudohypoparathyroidism
0.000 0.661 0.338
E20.0 Idiopathic hypoparathyroidism
0.000 0.661 0.338
E14.8 With unspecified complications
0.000 0.666 0.334
E14.7 With multiple complications
0.000 0.666 0.334
E14.6 With other specified complications
0.000 0.666 0.334
E14.5 With peripheral circulatory complications
0.000 0.666 0.334
E14.4 With neurological complications
0.000 0.666 0.334
E14.1 With ketoacidosis
0.000 0.666 0.334
E14.0 With coma
0.000 0.666 0.334
E83.3 Disorders of phosphorus metabolism
0.000 0.666 0.333
E25.9 Adrenogenital disorder, unspecified
0.000 0.671 0.329
E25.8 Other adrenogenital disorders
0.000 0.671 0.329
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.671 0.329
E30.9 Disorder of puberty, unspecified
0.000 0.671 0.329
E30.8 Other disorders of puberty
0.000 0.671 0.329
E30.1 Precocious puberty
0.000 0.671 0.329
E30.0 Delayed puberty
0.000 0.671 0.329
E31.9 Polyglandular dysfunction, unspecified
0.000 0.671 0.329
E31.8 Other polyglandular dysfunction
0.000 0.671 0.329
E31.1 Polyglandular hyperfunction
0.000 0.671 0.329
E31.0 Autoimmune polyglandular failure
0.000 0.671 0.329
E32.9 Disease of thymus, unspecified
0.000 0.671 0.329
E32.8 Other diseases of thymus
0.000 0.671 0.329
E32.1 Abscess of thymus
0.000 0.671 0.329
E32.0 Persistent hyperplasia of thymus
0.000 0.671 0.329
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.671 0.329
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.671 0.329
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.671 0.329
E24.8 Other Cushing's syndrome
0.000 0.672 0.328
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.672 0.328
E24.3 Ectopic ACTH syndrome
0.000 0.672 0.328
E24.2 Drug-induced Cushing's syndrome
0.000 0.672 0.328
E24.1 Nelson's syndrome
0.000 0.672 0.328
E24.0 Pituitary-dependent Cushing's disease
0.000 0.672 0.328
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.674 0.326
E24.9 Cushing's syndrome, unspecified
0.000 0.674 0.326
E61 Deficiency of other nutrient elements
0.000 0.675 0.325
E26.9 Hyperaldosteronism, unspecified
0.000 0.681 0.319
E26.8 Other hyperaldosteronism
0.000 0.681 0.319
E26.1 Secondary hyperaldosteronism
0.000 0.681 0.319
E75.5 Other lipid storage disorders
0.000 0.684 0.316
E14.3 With ophthalmic complications
0.000 0.687 0.313
E22.0 Acromegaly and pituitary gigantism
0.000 0.690 0.310
E04.0 Non-toxic diffuse goitre
0.000 0.691 0.309
E66.1 Drug-induced obesity
0.000 0.691 0.309
E87.7 Fluid overload
0.000 0.693 0.307
E26.0 Primary hyperaldosteronism
0.000 0.694 0.305
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.700 0.300
E21.4 Other specified disorders of parathyroid gland
0.000 0.700 0.300
E21.2 Other hyperparathyroidism
0.000 0.700 0.300
E14.2 Withrenal complications
0.000 0.706 0.294
E85.4 Organ-limited amyloidosis
0.000 0.709 0.291
E16 Other disorders of pancreatic internal secretion
0.000 0.709 0.291
E66.0 Obesity due to excess calories
0.000 0.713 0.287
E87.2 Acidosis
0.000 0.713 0.287
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.721 0.279
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.721 0.279
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.721 0.279
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.725 0.275
E22.8 Other hyperfunction of pituitary gland
0.000 0.725 0.275
E29.9 Testicular dysfunction, unspecified
0.000 0.726 0.274
E29.8 Other testicular dysfunction
0.000 0.726 0.274
E29.0 Testicular hyperfunction
0.000 0.726 0.274
E53.8 Deficiency of other specified B group vitamins
0.000 0.726 0.274
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.729 0.271
E83.8 Other disorders of mineral metabolism
0.000 0.729 0.271
E83.2 Disorders of zinc metabolism
0.000 0.729 0.271
E83.0 Disorders of copper metabolism
0.000 0.729 0.271
E34.5 Androgen resistance syndrome
0.000 0.731 0.269
E34.4 Constitutional tall stature
0.000 0.731 0.269
E34.3 Short stature, not elsewhere classified
0.000 0.731 0.269
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.731 0.269
E34.1 Other hypersecretion of intestinal hormones
0.000 0.731 0.269
E87.0 Hyperosmolality and hypernatraemia
0.000 0.732 0.268
E50.9 Vitamin A deficiency, unspecified
0.000 0.733 0.266
E50.8 Other manifestations of vitamin A deficiency
0.000 0.733 0.266
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.733 0.266
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.733 0.266
E50.5 Vitamin A deficiency with night blindness
0.000 0.733 0.266
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.733 0.266
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.733 0.266
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.733 0.266
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.733 0.266
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.733 0.266
E51.9 Thiamine deficiency, unspecified
0.000 0.733 0.266
E51.8 Other manifestations of thiamine deficiency
0.000 0.733 0.266
E51.2 Wernicke's encephalopathy
0.000 0.733 0.266
E51.1 Beriberi
0.000 0.733 0.266
E56.9 Vitamin deficiency, unspecified
0.000 0.733 0.266
E56.8 Deficiency of other vitamins
0.000 0.733 0.266
E56.1 Deficiency of vitamin K
0.000 0.733 0.266
E56.0 Deficiency of vitamin E
0.000 0.733 0.266
E63.9 Nutritional deficiency, unspecified
0.000 0.733 0.266
E63.8 Other specified nutritional deficiencies
0.000 0.733 0.266
E63.1 Imbalance of constituents of food intake
0.000 0.733 0.266
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.733 0.266
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.733 0.266
E64.8 Sequelae of other nutritional deficiencies
0.000 0.733 0.266
E64.3 Sequelae of rickets
0.000 0.733 0.266
E64.2 Sequelae of vitamin C deficiency
0.000 0.733 0.266
E64.1 Sequelae of vitamin A deficiency
0.000 0.733 0.266
E64.0 Sequelae of protein-energy malnutrition
0.000 0.733 0.266
E53.1 Pyridoxine deficiency
0.000 0.734 0.266
E53.0 Riboflavin deficiency
0.000 0.734 0.266
E04.8 Other specified non-toxic goitre
0.000 0.735 0.264
E55 Vitamin D deficiency
0.000 0.736 0.264
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
0.000 0.738 0.262
E87.4 Mixed disorder of acid-base balance
0.000 0.739 0.261
E53.9 Vitamin B deficiency, unspecified
0.000 0.743 0.257
E34.8 Other specified endocrine disorders
0.000 0.745 0.255
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.746 0.254
E34.0 Carcinoid syndrome
0.000 0.750 0.250
E23.7 Disorder of pituitary gland, unspecified
0.000 0.753 0.247
E23.6 Other disorders of pituitary gland
0.000 0.753 0.247
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.753 0.247
E23.1 Drug-induced hypopituitarism
0.000 0.753 0.247
E87.3 Alkalosis
0.000 0.753 0.247
E83.4 Disorders of magnesium metabolism
0.000 0.753 0.247
E85.9 Amyloidosis, unspecified
0.001 0.756 0.243
E61.9 Deficiency of nutrient element, unspecified
0.000 0.767 0.233
E61.8 Deficiency of other specified nutrient elements
0.000 0.767 0.233
E61.7 Deficiency of multiple nutrient elements
0.000 0.767 0.233
E61.6 Vanadium deficiency
0.000 0.767 0.233
E61.5 Molybdenum deficiency
0.000 0.767 0.233
E61.4 Chromium deficiency
0.000 0.767 0.233
E61.3 Manganese deficiency
0.000 0.767 0.233
E61.0 Copper deficiency
0.000 0.767 0.233
E22.1 Hyperprolactinaemia
0.000 0.768 0.232
E34.9 Endocrine disorder, unspecified
0.000 0.768 0.232
E61.1 Iron deficiency
0.000 0.769 0.231
E85.8 Other amyloidosis
0.001 0.769 0.231
E85.3 Secondary systemic amyloidosis
0.001 0.773 0.226
E23.2 Diabetes insipidus
0.000 0.776 0.224
E14.9 Without complications
0.000 0.780 0.220
E66.2 Extreme obesity with alveolar hypoventilation
0.001 0.785 0.214
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.791 0.209
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.791 0.209
E16.4 Abnormal secretion of gastrin
0.000 0.791 0.209
E16.3 Increased secretion of glucagon
0.000 0.791 0.209
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.791 0.209
E87.6 Hypokalaemia
0.000 0.795 0.205
E04.1 Non-toxic single thyroid nodule
0.000 0.800 0.200
E29.1 Testicular hypofunction
0.000 0.802 0.198
E55.0 Rickets, active
0.000 0.810 0.189
E61.2 Magnesium deficiency
0.001 0.811 0.189
E83.1 Disorders of iron metabolism
0.000 0.811 0.189
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.811 0.189
E13.9 Without complications
0.001 0.819 0.180
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.819 0.181
E87.1 Hypo-osmolality and hyponatraemia
0.000 0.819 0.181
E04.2 Non-toxic multinodular goitre
0.000 0.823 0.177
E89.2 Postprocedural hypoparathyroidism
0.002 0.826 0.173
E23.0 Hypopituitarism
0.000 0.826 0.174
E16.1 Other hypoglycaemia
0.000 0.828 0.171
E21.0 Primary hyperparathyroidism
0.000 0.833 0.167
M06.9 Rheumatoid arthritis, unspecified
0.000 0.835 0.165
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.835 0.165
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.839 0.161
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.843 0.157
E16.2 Hypoglycaemia, unspecified
0.000 0.852 0.148
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.853 0.147
E78.1 Pure hyperglyceridaemia
0.000 0.859 0.141
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.860 0.140
E07.9 Disorder of thyroid, unspecified
0.001 0.862 0.137
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.865 0.135
E78.3 Hyperchylomicronaemia
0.000 0.870 0.130
E78.4 Other hyperlipidaemia
0.000 0.871 0.129
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.875 0.125
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.875 0.125
E78.6 Lipoprotein deficiency
0.000 0.878 0.122
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.880 0.120
M06 Other rheumatoid arthritis
0.000 0.880 0.120
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.881 0.118
E87.5 Hyperkalaemia
0.000 0.883 0.117
M06.0 Seronegative rheumatoid arthritis
0.000 0.886 0.114
G35 Multiple sclerosis
0.000 0.888 0.112
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.888 0.112
E78.2 Mixed hyperlipidaemia
0.000 0.892 0.108
M06.09 Seronegative rheumatoid arthritis (Site unspecified)
0.000 0.893 0.107
E04.9 Non-toxic goitre, unspecified
0.000 0.894 0.105
E11 Non-insulin-dependent diabetes mellitus
0.000 0.896 0.104
M06.00 Seronegative rheumatoid arthritis (Multiple sites)
0.000 0.903 0.097
E78.8 Other disorders of lipoprotein metabolism
0.000 0.904 0.096
Z88.0 Personal history of allergy to penicillin
0.087 0.913 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.914 0.086
M06.2 Rheumatoid bursitis
0.000 0.914 0.086
M06.1 Adult-onset Still's disease
0.000 0.914 0.086
E11.8 With unspecified complications
0.000 0.917 0.083
M06.08 Seronegative rheumatoid arthritis (Other)
0.000 0.918 0.082
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)
0.000 0.918 0.082
M06.06 Seronegative rheumatoid arthritis (Lower leg)
0.000 0.918 0.082
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)
0.000 0.918 0.082
M06.04 Seronegative rheumatoid arthritis (Hand)
0.000 0.918 0.082
M06.03 Seronegative rheumatoid arthritis (Forearm)
0.000 0.918 0.082
M06.02 Seronegative rheumatoid arthritis (Upper arm)
0.000 0.918 0.082
M06.01 Seronegative rheumatoid arthritis (Shoulder region)
0.000 0.918 0.082
E55.9 Vitamin D deficiency, unspecified
0.001 0.918 0.081
M06.3 Rheumatoid nodule
0.000 0.918 0.082
E11.1 With ketoacidosis
0.000 0.918 0.081
E11.3 With ophthalmic complications
0.000 0.920 0.080
E11.0 With coma
0.000 0.925 0.075
E11.7 With multiple complications
0.000 0.925 0.074
E11.2 With renal complications
0.000 0.927 0.073
E83.5 Disorders of calcium metabolism
0.000 0.928 0.071
M06.4 Inflammatory polyarthropathy
0.001 0.935 0.065
M06.19 Adult-onset Still's disease (Site unspecified)
0.000 0.938 0.062
M06.18 Adult-onset Still's disease (Other)
0.000 0.938 0.062
M06.17 Adult-onset Still's disease (Ankle and foot)
0.000 0.938 0.062
M06.16 Adult-onset Still's disease (Lower leg)
0.000 0.938 0.062
M06.15 Adult-onset Still's disease (Pelvic region and thigh)
0.000 0.938 0.062
M06.14 Adult-onset Still's disease (Hand)
0.000 0.938 0.062
M06.13 Adult-onset Still's disease (Forearm)
0.000 0.938 0.062
M06.12 Adult-onset Still's disease (Upper arm)
0.000 0.938 0.062
M06.11 Adult-onset Still's disease (Shoulder region)
0.000 0.938 0.062
M06.10 Adult-onset Still's disease (Multiple sites)
0.000 0.938 0.062
M06.29 Rheumatoid bursitis (Site unspecified)
0.000 0.938 0.062
M06.28 Rheumatoid bursitis (Other)
0.000 0.938 0.062
M06.27 Rheumatoid bursitis (Ankle and foot)
0.000 0.938 0.062
M06.26 Rheumatoid bursitis (Lower leg)
0.000 0.938 0.062
M06.25 Rheumatoid bursitis (Pelvic region and thigh)
0.000 0.938 0.062
M06.24 Rheumatoid bursitis (Hand)
0.000 0.938 0.062
M06.23 Rheumatoid bursitis (Forearm)
0.000 0.938 0.062
M06.22 Rheumatoid bursitis (Upper arm)
0.000 0.938 0.062
M06.21 Rheumatoid bursitis (Shoulder region)
0.000 0.938 0.062
M06.20 Rheumatoid bursitis (Multiple sites)
0.000 0.938 0.062
M06.89 Other specified rheumatoid arthritis (Site unspecified)
0.000 0.938 0.062
M06.88 Other specified rheumatoid arthritis (Other)
0.000 0.938 0.062
M06.87 Other specified rheumatoid arthritis (Ankle and foot)
0.000 0.938 0.062
M06.86 Other specified rheumatoid arthritis (Lower leg)
0.000 0.938 0.062
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)
0.000 0.938 0.062
M06.84 Other specified rheumatoid arthritis (Hand)
0.000 0.938 0.062
M06.83 Other specified rheumatoid arthritis (Forearm)
0.000 0.938 0.062
M06.82 Other specified rheumatoid arthritis (Upper arm)
0.000 0.938 0.062
M06.81 Other specified rheumatoid arthritis (Shoulder region)
0.000 0.938 0.062
M06.80 Other specified rheumatoid arthritis (Multiple sites)
0.000 0.938 0.062
M06.34 Rheumatoid nodule (Hand)
0.000 0.940 0.060
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.941 0.059
M06.38 Rheumatoid nodule (Other)
0.000 0.941 0.059
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.941 0.059
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.941 0.059
M06.33 Rheumatoid nodule (Forearm)
0.000 0.941 0.059
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.941 0.059
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.941 0.059
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.941 0.059
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.947 0.053
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.953 0.047
M06.48 Inflammatory polyarthropathy (Other)
0.001 0.953 0.047
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.001 0.953 0.047
M06.46 Inflammatory polyarthropathy (Lower leg)
0.001 0.953 0.047
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.001 0.953 0.047
M06.44 Inflammatory polyarthropathy (Hand)
0.001 0.953 0.047
M06.43 Inflammatory polyarthropathy (Forearm)
0.001 0.953 0.047
M06.42 Inflammatory polyarthropathy (Upper arm)
0.001 0.953 0.047
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.001 0.953 0.047
E11.6 With other specified complications
0.001 0.954 0.046
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.957 0.043
E11.5 With peripheral circulatory complications
0.000 0.961 0.039
H40.9 Glaucoma, unspecified
0.000 0.961 0.039
H40 Glaucoma
0.000 0.963 0.037
H40.0 Glaucoma suspect
0.000 0.964 0.036
H40.2 Primary angle-closure glaucoma
0.000 0.966 0.034

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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