TreeWAS – Variant ID: rs2516408

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	1.000	0.000	0.000
E05.9 Thyrotoxicosis, unspecified	1.000	0.000	0.000
E05.0 Thyrotoxicosis with diffuse goitre	1.000	0.000	0.000
E10.9 Without complications	1.000	0.000	0.000
E10.3 With ophthalmic complications	1.000	0.000	0.000
K90.0 Coeliac disease	1.000	0.000	0.000
E05 Thyrotoxicosis [hyperthyroidism]	1.000	0.000	0.000
E14 Unspecified diabetes mellitus	1.000	0.000	0.000
E11 Non-insulin-dependent diabetes mellitus	1.000	0.000	0.000
E10 Insulin-dependent diabetes mellitus	1.000	0.000	0.000
E10-E14 Diabetes mellitus	1.000	0.000	0.000
E00-E07 Disorders of thyroid gland	1.000	0.000	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	1.000	0.000	0.000
E10.1 With ketoacidosis	1.000	0.000	0.000
H36.0 Diabetic retinopathy	1.000	0.000	0.000
D64.9 Anaemia, unspecified	1.000	0.000	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	1.000	0.000	0.000
E11.9 Without complications	1.000	0.000	0.000
E14.3 With ophthalmic complications	1.000	0.000	0.000
D60-D64 Aplastic and other anaemias	1.000	0.000	0.000
M35.0 Sicca syndrome [Sjogren]	1.000	0.000	0.000
D64 Other anaemias	1.000	0.000	0.000
E03 Other hypothyroidism	1.000	0.000	0.000
K90 Intestinal malabsorption	1.000	0.000	0.000
E10.4 With neurological complications	1.000	0.000	0.000
M35 Other systemic involvement of connective tissue	0.999	0.001	0.000
M20-M25 Other joint disorders	0.998	0.002	0.000
K90.9 Intestinal malabsorption, unspecified	0.998	0.002	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.996	0.004	0.000
E10.2 With renal complications	0.996	0.004	0.000
# Top node	0.994	0.006	0.000
D80-D89 Certain disorders involving the immune mechanism	0.994	0.006	0.000
E06 Thyroiditis	0.990	0.010	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.989	0.011	0.000
M60-M63 Disorders of muscles	0.986	0.014	0.000
M34 Systemic sclerosis	0.986	0.014	0.000
E16 Other disorders of pancreatic internal secretion	0.982	0.018	0.000
Chapter VIII Diseases of the ear and mastoid process	0.982	0.018	0.000
E11.3 With ophthalmic complications	0.981	0.019	0.000
E16.2 Hypoglycaemia, unspecified	0.973	0.027	0.000
M65-M68 Disorders of synovium and tendon	0.967	0.033	0.000
E14.9 Without complications	0.965	0.035	0.000
D61 Other aplastic anaemias	0.964	0.036	0.000
E10.5 With peripheral circulatory complications	0.962	0.038	0.000
M62 Other disorders of muscle	0.960	0.040	0.000
H60-H62 Diseases of external ear	0.960	0.040	0.000
E06.3 Autoimmune thyroiditis	0.959	0.041	0.000
D50-D53 Nutritional anaemias	0.958	0.042	0.000
D86 Sarcoidosis	0.957	0.043	0.000
K75 Other inflammatory liver diseases	0.940	0.060	0.000
K75.4 Autoimmune hepatitis	0.938	0.062	0.000
K90-K93 Other diseases of the digestive system	0.937	0.063	0.000
Chapter XI Diseases of the digestive system	0.933	0.067	0.000
K70-K77 Diseases of liver	0.932	0.068	0.000
E11.5 With peripheral circulatory complications	0.932	0.068	0.000
M35.1 Other overlap syndromes	0.931	0.069	0.000
H90-H95 Other disorders of ear	0.929	0.071	0.000
M62.8 Other specified disorders of muscle	0.924	0.076	0.000
E06.9 Thyroiditis, unspecified	0.921	0.079	0.000
D86.9 Sarcoidosis, unspecified	0.921	0.079	0.000
D61.9 Aplastic anaemia, unspecified	0.919	0.081	0.000
M34.1 CR(E)ST syndrome	0.912	0.088	0.000
E50-E64 Other nutritional deficiencies	0.910	0.090	0.000
M60 Myositis	0.910	0.090	0.000
M67 Other disorders of synovium and tendon	0.908	0.092	0.000
M32 Systemic lupus erythematosus	0.905	0.095	0.000
D51 Vitamin B12 deficiency anaemia	0.904	0.096	0.000
H90 Conductive and sensorineural hearing loss	0.901	0.099	0.000
H61 Other disorders of external ear	0.899	0.101	0.000
M66 Spontaneous rupture of synovium and tendon	0.898	0.102	0.000
M67.1 Other contracture of tendon (sheath)	0.896	0.104	0.000
D80 Immunodeficiency with predominantly antibody defects	0.890	0.110	0.000
H36 Retinal disorders in diseases classified elsewhere	0.888	0.112	0.000
M34.8 Other forms of systemic sclerosis	0.886	0.114	0.000
E10.8 With unspecified complications	0.884	0.116	0.000
E16.0 Drug-induced hypoglycaemia without coma	0.882	0.118	0.000
E10.0 With coma	0.881	0.119	0.000
E14.6 With other specified complications	0.878	0.122	0.000
H90.3 Sensorineural hearing loss, bilateral	0.875	0.125	0.000
M62.81 Other specified disorders of muscle (Shoulder region)	0.872	0.128	0.000
K74 Fibrosis and cirrhosis of liver	0.863	0.137	0.000
H60 Otitis externa	0.861	0.139	0.000
M60.9 Myositis, unspecified	0.858	0.142	0.000
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.854	0.146	0.000
H61.2 Impacted cerumen	0.847	0.153	0.000
M34.9 Systemic sclerosis, unspecified	0.844	0.156	0.000
E10.7 With multiple complications	0.841	0.159	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.839	0.161	0.000
E14.8 With unspecified complications	0.839	0.161	0.000
E70-E90 Metabolic disorders	0.839	0.161	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.838	0.162	0.000
E14.2 Withrenal complications	0.837	0.163	0.000
D83 Common variable immunodeficiency	0.837	0.163	0.000
E89.0 Postprocedural hypothyroidism	0.835	0.165	0.000
K75.9 Inflammatory liver disease, unspecified	0.834	0.166	0.000
E14.1 With ketoacidosis	0.831	0.169	0.000
E11.1 With ketoacidosis	0.829	0.171	0.000
M32.1 Systemic lupus erythematosus with organ or system involvement	0.826	0.174	0.000
E61 Deficiency of other nutrient elements	0.822	0.178	0.000
K75.8 Other specified inflammatory liver diseases	0.820	0.180	0.000
M25 Other joint disorders, not elsewhere classified	0.813	0.187	0.000
E14.5 With peripheral circulatory complications	0.807	0.193	0.000
H30-H36 Disorders of choroid and retina	0.807	0.193	0.000
D53 Other nutritional anaemias	0.806	0.194	0.000
M86-M90 Other osteopathies	0.804	0.196	0.000
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.803	0.197	0.000
K74.5 Biliary cirrhosis, unspecified	0.803	0.197	0.000
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.800	0.200	0.000
M34.0 Progressive systemic sclerosis	0.798	0.202	0.000
M05-M14 Inflammatory polyarthropathies	0.797	0.203	0.000
E10.6 With other specified complications	0.796	0.204	0.000
E20-E35 Disorders of other endocrine glands	0.796	0.204	0.000
H92 Otalgia and effusion of ear	0.795	0.205	0.000
D69 Purpura and other haemorrhagic conditions	0.794	0.206	0.000
D86.8 Sarcoidosis of other and combined sites	0.793	0.206	0.000
D55-D59 Haemolytic anaemias	0.792	0.208	0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.791	0.209	0.000
H60.1 Cellulitis of external ear	0.788	0.212	0.000
M62.86 Other specified disorders of muscle (Lower leg)	0.787	0.213	0.000
D61.1 Drug-induced aplastic anaemia	0.787	0.213	0.000
M60.99 Myositis, unspecified (Site unspecified)	0.786	0.214	0.000
E11.7 With multiple complications	0.786	0.214	0.000
M45.X9 Ankylosing spondylitis (Site unspecified)	0.000	0.216	0.783
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.778	0.222	0.000
D50 Iron deficiency anaemia	0.777	0.223	0.000
M66.0 Rupture of popliteal cyst	0.775	0.225	0.000
E11.0 With coma	0.775	0.225	0.000
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified	0.774	0.226	0.000
K74.3 Primary biliary cirrhosis	0.773	0.227	0.000
M35.2 Behcet's disease	0.768	0.232	0.000
D64.3 Other sideroblastic anaemias	0.768	0.232	0.000
H61.0 Perichondritis of external ear	0.768	0.232	0.000
H90.8 Mixed conductive and sensorineural hearing loss, unspecified	0.765	0.235	0.000
K73 Chronic hepatitis, not elsewhere classified	0.764	0.236	0.000
K75.0 Abscess of liver	0.763	0.237	0.000
M35.7 Hypermobility syndrome	0.761	0.239	0.000
H62 Disorders of external ear in diseases classified elsewhere	0.761	0.239	0.000
H65-H75 Diseases of middle ear and mastoid	0.760	0.240	0.000
K90.8 Other intestinal malabsorption	0.759	0.241	0.000
E51 Thiamine deficiency	0.759	0.241	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.757	0.243	0.000
M66.3 Spontaneous rupture of flexor tendons	0.756	0.244	0.000
Chapter VII Diseases of the eye and adnexa	0.753	0.247	0.000
D82 Immunodeficiency associated with other major defects	0.753	0.247	0.000
D80.1 Nonfamilial hypogammaglobulinaemia	0.752	0.248	0.000
E53 Deficiency of other B group vitamins	0.750	0.250	0.000
E27 Other disorders of adrenal gland	0.748	0.252	0.000
E61.1 Iron deficiency	0.748	0.252	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.747	0.253	0.000
D86.1 Sarcoidosis of lymph nodes	0.747	0.253	0.000
H90.2 Conductive hearing loss, unspecified	0.746	0.254	0.000
M67.4 Ganglion	0.744	0.256	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.742	0.258	0.000
M25.9 Joint disorder, unspecified	0.736	0.264	0.000
M62.82 Other specified disorders of muscle (Upper arm)	0.735	0.265	0.000
E11.6 With other specified complications	0.734	0.266	0.000
M62.85 Other specified disorders of muscle (Pelvic region and thigh)	0.733	0.267	0.000
M66.5 Spontaneous rupture of unspecified tendon	0.730	0.270	0.000
H92.1 Otorrhoea	0.730	0.270	0.000
D84 Other immunodeficiencies	0.729	0.271	0.000
D61.0 Constitutional aplastic anaemia	0.729	0.271	0.000
E06.5 Other chronic thyroiditis	0.726	0.274	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.725	0.275	0.000
M10 Gout	0.725	0.275	0.000
D83.9 Common variable immunodeficiency, unspecified	0.724	0.276	0.000
M62.6 Muscle strain	0.724	0.276	0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.723	0.277	0.000
E27.1 Primary adrenocortical insufficiency	0.723	0.277	0.000
H30 Chorioretinal inflammation	0.722	0.278	0.000
D69.4 Other primary thrombocytopenia	0.720	0.280	0.000
E05.5 Thyroid crisis or storm	0.717	0.283	0.000
E05.4 Thyrotoxicosis factitia	0.717	0.283	0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.717	0.283	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.717	0.283	0.000
E14.7 With multiple complications	0.717	0.283	0.000
E14.0 With coma	0.717	0.283	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.717	0.283	0.000
E00 Congenital iodine-deficiency syndrome	0.717	0.283	0.000
E12 Malnutrition-related diabetes mellitus	0.717	0.283	0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.717	0.283	0.000
D64.4 Congenital dyserythropoietic anaemia	0.717	0.283	0.000
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.717	0.283	0.000
D64.1 Secondary sideroblastic anaemia due to disease	0.717	0.283	0.000
D64.0 Hereditary sideroblastic anaemia	0.717	0.283	0.000
E03.5 Myxoedema coma	0.717	0.283	0.000
E03.4 Atrophy of thyroid (acquired)	0.717	0.283	0.000
E03.3 Postinfectious hypothyroidism	0.717	0.283	0.000
E03.1 Congenital hypothyroidism without goitre	0.717	0.283	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.717	0.283	0.000
K90.3 Pancreatic steatorrhoea	0.717	0.283	0.000
K90.2 Blind loop syndrome, not elsewhere classified	0.717	0.283	0.000
K90.1 Tropical sprue	0.717	0.283	0.000
M35.9 Systemic involvement of connective tissue, unspecified	0.717	0.283	0.000
M35.6 Relapsing panniculitis [Weber-Christian]	0.717	0.283	0.000
M35.5 Multifocal fibrosclerosis	0.717	0.283	0.000
M35.4 Diffuse (eosinophilic) fasciitis	0.717	0.283	0.000
H60.3 Other infective otitis externa	0.716	0.284	0.000
M62.1 Other rupture of muscle (nontraumatic)	0.716	0.284	0.000
M40-M43 Deforming dorsopathies	0.714	0.286	0.000
M25.0 Haemarthrosis	0.713	0.287	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.713	0.287	0.000
D81 Combined immunodeficiencies	0.713	0.287	0.000
E89.3 Postprocedural hypopituitarism	0.711	0.289	0.000
M06 Other rheumatoid arthritis	0.710	0.290	0.000
E06.4 Drug-induced thyroiditis	0.710	0.290	0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.710	0.290	0.000
E06.1 Subacute thyroiditis	0.710	0.290	0.000
E06.0 Acute thyroiditis	0.710	0.290	0.000
E15 Nondiabetic hypoglycaemic coma	0.709	0.291	0.000
I83.9 Varicose veins of lower extremities without ulcer or inflammation	0.000	0.292	0.708
M63 Disorders of muscle in diseases classified elsewhere	0.707	0.293	0.000
M61 Calcification and ossification of muscle	0.707	0.293	0.000
H90.6 Mixed conductive and sensorineural hearing loss, bilateral	0.707	0.293	0.000
M34.2 Systemic sclerosis induced by drugs and chemicals	0.707	0.293	0.000
H61.3 Acquired stenosis of external ear canal	0.707	0.293	0.000
E78.2 Mixed hyperlipidaemia	0.706	0.294	0.000
D64.8 Other specified anaemias	0.706	0.294	0.000
D70 Agranulocytosis	0.706	0.294	0.000
E16.9 Disorder of pancreatic internal secretion, unspecified	0.704	0.296	0.000
E16.8 Other specified disorders of pancreatic internal secretion	0.704	0.296	0.000
E16.4 Abnormal secretion of gastrin	0.704	0.296	0.000
E16.3 Increased secretion of glucagon	0.704	0.296	0.000
M31 Other necrotising vasculopathies	0.703	0.297	0.000
M24 Other specific joint derangements	0.700	0.300	0.000
H60.5 Acute otitis externa, non-infective	0.698	0.302	0.000
D53.9 Nutritional anaemia, unspecified	0.698	0.302	0.000
M86 Osteomyelitis	0.697	0.303	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.695	0.305	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.693	0.307	0.000
D61.8 Other specified aplastic anaemias	0.691	0.308	0.000
D61.3 Idiopathic aplastic anaemia	0.691	0.308	0.000
D61.2 Aplastic anaemia due to other external agents	0.691	0.308	0.000
M06.9 Rheumatoid arthritis, unspecified	0.689	0.311	0.000
M35.8 Other specified systemic involvement of connective tissue	0.689	0.311	0.000
M62.9 Disorder of muscle, unspecified	0.689	0.311	0.000
M62.4 Contracture of muscle	0.689	0.311	0.000
M62.3 Immobility syndrome (paraplegic)	0.689	0.311	0.000
M62.2 Ischaemic infarction of muscle	0.689	0.311	0.000
M60.98 Myositis, unspecified (Other)	0.688	0.312	0.000
D89.9 Disorder involving the immune mechanism, unspecified	0.688	0.312	0.000
M66.06 Rupture of popliteal cyst-Lower leg	0.687	0.313	0.000
I83.0 Varicose veins of lower extremities with ulcer	0.000	0.313	0.687
M32.0 Drug-induced systemic lupus erythematosus	0.687	0.313	0.000
I83 Varicose veins of lower extremities	0.000	0.314	0.686
H60.4 Cholesteatoma of external ear	0.685	0.315	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.683	0.317	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.683	0.317	0.000
K73.2 Chronic active hepatitis, not elsewhere classified	0.682	0.318	0.000
M62.83 Other specified disorders of muscle (Forearm)	0.682	0.318	0.000
E89.1 Postprocedural hypoinsulinaemia	0.681	0.319	0.000
M62.0 Diastasis of muscle	0.680	0.320	0.000
D51.8 Other vitamin B12 deficiency anaemias	0.679	0.321	0.000
E14.4 With neurological complications	0.678	0.322	0.000
M60.95 Myositis, unspecified (Pelvic region and thigh)	0.677	0.323	0.000
M60.8 Other myositis	0.675	0.325	0.000
M35.3 Polymyalgia rheumatica	0.675	0.325	0.000
K75.2 Nonspecific reactive hepatitis	0.674	0.326	0.000
K75.1 Phlebitis of portal vein	0.674	0.326	0.000
E13 Other specified diabetes mellitus	0.673	0.326	0.000
M33 Dermatopolymyositis	0.673	0.327	0.000
K93 Disorders of other digestive organs in diseases classified elsewhere	0.672	0.328	0.000
H90.0 Conductive hearing loss, bilateral	0.672	0.328	0.000
E20 Hypoparathyroidism	0.671	0.329	0.000
D51.3 Other dietary vitamin B12 deficiency anaemia	0.671	0.329	0.000
M62.89 Other specified disorders of muscle (Site unspecified)	0.670	0.329	0.000
M88 Paget's disease of bone [osteitis deformans]	0.669	0.331	0.000
M60.2 Foreign body granuloma of soft tissue, not elsewhere classified	0.669	0.331	0.000
K77 Liver disorders in diseases classified elsewhere	0.669	0.331	0.000
E07 Other disorders of thyroid	0.668	0.332	0.000
E11.2 With renal complications	0.668	0.332	0.000
E79 Disorders of purine and pyrimidine metabolism	0.667	0.333	0.000
H94 Other disorders of ear in diseases classified elsewhere	0.666	0.334	0.000
H73 Other disorders of tympanic membrane	0.665	0.335	0.000
E53.8 Deficiency of other specified B group vitamins	0.663	0.337	0.000
M62.87 Other specified disorders of muscle (Ankle and foot)	0.662	0.338	0.000
D86.0 Sarcoidosis of lung	0.662	0.338	0.000
H35 Other retinal disorders	0.662	0.338	0.000
M00-M03 Infectious arthropathies	0.660	0.339	0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.661	0.339	0.000
M10.9 Gout, unspecified	0.660	0.340	0.000
D50.1 Sideropenic dysphagia	0.659	0.341	0.000
D56 Thalassaemia	0.658	0.342	0.000
K75.3 Granulomatous hepatitis, not elsewhere classified	0.658	0.342	0.000
E27.3 Drug-induced adrenocortical insufficiency	0.656	0.344	0.000
D50.8 Other iron deficiency anaemias	0.656	0.344	0.000
E40-E46 Malnutrition	0.654	0.346	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.653	0.347	0.000
E63 Other nutritional deficiencies	0.653	0.347	0.000
E50 Vitamin A deficiency	0.653	0.347	0.000
E60 Dietary zinc deficiency	0.653	0.347	0.000
E59 Dietary selenium deficiency	0.653	0.347	0.000
E54 Ascorbic acid deficiency	0.653	0.347	0.000
E52 Niacin deficiency [pellagra]	0.653	0.347	0.000
M60.1 Interstitial myositis	0.652	0.348	0.000
H61.8 Other specified disorders of external ear	0.651	0.349	0.000
M67.9 Disorder of synovium and tendon, unspecified	0.651	0.349	0.000
M67.3 Transient synovitis	0.651	0.349	0.000
E51.2 Wernicke's encephalopathy	0.650	0.350	0.000
M32.9 Systemic lupus erythematosus, unspecified	0.648	0.351	0.000
M32.8 Other forms of systemic lupus erythematosus	0.648	0.351	0.000
D51.2 Transcobalamin II deficiency	0.648	0.352	0.000
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.648	0.352	0.000
H30.9 Chorioretinal inflammation, unspecified	0.648	0.352	0.000
M62.55 Muscle wasting and atrophy, not elsewhere classified (Pelvic region and thigh)	0.646	0.353	0.000
M62.84 Other specified disorders of muscle (Hand)	0.644	0.356	0.000
M66.1 Rupture of synovium	0.643	0.356	0.000
D86.3 Sarcoidosis of skin	0.643	0.357	0.000
E24 Cushing's syndrome	0.642	0.358	0.000
M25.06 Haemarthrosis (Lower leg)	0.642	0.358	0.000
M24.1 Other articular cartilage disorders	0.641	0.359	0.000
D80.8 Other immunodeficiencies with predominantly antibody defects	0.638	0.361	0.000
D80.7 Transient hypogammaglobulinaemia of infancy	0.638	0.361	0.000
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.638	0.361	0.000
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.638	0.361	0.000
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.638	0.361	0.000
D80.0 Hereditary hypogammaglobulinaemia	0.638	0.361	0.000
E05.8 Other thyrotoxicosis	0.637	0.362	0.000
H36.8 Other retinal disorders in diseases classified elsewhere	0.636	0.363	0.000
M66.2 Spontaneous rupture of extensor tendons	0.635	0.365	0.000
M62.51 Muscle wasting and atrophy, not elsewhere classified (Shoulder region)	0.635	0.365	0.000
E70 Disorders of aromatic amino-acid metabolism	0.634	0.365	0.000
D69.2 Other nonthrombocytopenic purpura	0.633	0.367	0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.631	0.369	0.000
H70 Mastoiditis and related conditions	0.631	0.369	0.000
M30 Polyarteritis nodosa and related conditions	0.630	0.370	0.000
M67.0 Short Achilles tendon (acquired)	0.630	0.370	0.000
M62.80 Other specified disorders of muscle (Multiple sites)	0.629	0.371	0.000
D69.5 Secondary thrombocytopenia	0.629	0.371	0.000
M66.4 Spontaneous rupture of other tendons	0.628	0.372	0.000
E56 Other vitamin deficiencies	0.627	0.373	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.627	0.373	0.000
E11.8 With unspecified complications	0.626	0.374	0.000
D89.1 Cryoglobulinaemia	0.625	0.375	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.623	0.376	0.000
E61.2 Magnesium deficiency	0.623	0.377	0.000
M25.96 Joint disorder, unspecified (Lower leg)	0.622	0.378	0.000
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.622	0.378	0.000
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.619	0.381	0.000
K74.4 Secondary biliary cirrhosis	0.619	0.381	0.000
K74.2 Hepatic fibrosis with hepatic sclerosis	0.619	0.381	0.000
K74.1 Hepatic sclerosis	0.619	0.381	0.000
H62.0 Otitis externa in bacterial diseases classified elsewhere	0.618	0.382	0.000
M12 Other specific arthropathies	0.617	0.383	0.000
H95.8 Other postprocedural disorders of ear and mastoid process	0.616	0.384	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.615	0.385	0.000
M60.97 Myositis, unspecified (Ankle and foot)	0.615	0.385	0.000
M60.96 Myositis, unspecified (Lower leg)	0.615	0.385	0.000
M60.94 Myositis, unspecified (Hand)	0.615	0.385	0.000
M60.93 Myositis, unspecified (Forearm)	0.615	0.385	0.000
M60.92 Myositis, unspecified (Upper arm)	0.615	0.385	0.000
M60.91 Myositis, unspecified (Shoulder region)	0.615	0.385	0.000
M60.90 Myositis, unspecified (Multiple sites)	0.615	0.385	0.000
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.614	0.386	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.613	0.387	0.000
M66.31 Spontaneous rupture of flexor tendons (Shoulder region)	0.613	0.387	0.000
D89.0 Polyclonal hypergammaglobulinaemia	0.612	0.388	0.000
H35.8 Other specified retinal disorders	0.611	0.389	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.610	0.390	0.000
M66.57 Spontaneous rupture of unspecified tendon (Ankle and foot)	0.610	0.390	0.000
M25.3 Other instability of joint	0.610	0.390	0.000
H35.4 Peripheral retinal degeneration	0.610	0.390	0.000
M10.97 Gout, unspecified (Ankle and foot)	0.609	0.391	0.000
E74 Other disorders of carbohydrate metabolism	0.608	0.392	0.000
H31 Other disorders of choroid	0.608	0.392	0.000
M67.43 Ganglion, wrist	0.608	0.392	0.000
H90.7 Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.607	0.392	0.000
H43-H45 Disorders of vitreous body and globe	0.606	0.394	0.000
H73.8 Other specified disorders of tympanic membrane	0.605	0.395	0.000
M66.34 Spontaneous rupture of flexor tendons (Hand)	0.604	0.396	0.000
M08 Juvenile arthritis	0.604	0.396	0.000
D69.9 Haemorrhagic condition, unspecified	0.603	0.397	0.000
M62.56 Muscle wasting and atrophy, not elsewhere classified (Lower leg)	0.603	0.397	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.602	0.398	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.602	0.398	0.000
E89.5 Postprocedural testicular hypofunction	0.602	0.398	0.000
E77 Disorders of glycoprotein metabolism	0.601	0.399	0.000
E76 Disorders of glycosaminoglycan metabolism	0.601	0.399	0.000
E72 Other disorders of amino-acid metabolism	0.601	0.399	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.601	0.399	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.601	0.399	0.000
M43 Other deforming dorsopathies	0.601	0.399	0.000
M90 Osteopathies in diseases classified elsewhere	0.600	0.400	0.000
D83.8 Other common variable immunodeficiencies	0.600	0.400	0.000
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.600	0.400	0.000
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.600	0.400	0.000
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.600	0.400	0.000
H60.2 Malignant otitis externa	0.599	0.401	0.000
D67 Hereditary factor IX deficiency	0.599	0.401	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.599	0.401	0.000
E31 Polyglandular dysfunction	0.598	0.402	0.000
H95.1 Other disorders following mastoidectomy	0.598	0.402	0.000
K71 Toxic liver disease	0.597	0.403	0.000
M06.8 Other specified rheumatoid arthritis	0.597	0.403	0.000
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.596	0.404	0.000
H66 Suppurative and unspecified otitis media	0.595	0.405	0.000
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.594	0.406	0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.593	0.407	0.000
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side	0.591	0.409	0.000
E61.9 Deficiency of nutrient element, unspecified	0.589	0.411	0.000
E61.8 Deficiency of other specified nutrient elements	0.589	0.411	0.000
E61.7 Deficiency of multiple nutrient elements	0.589	0.411	0.000
E61.6 Vanadium deficiency	0.589	0.411	0.000
E61.5 Molybdenum deficiency	0.589	0.411	0.000
E61.4 Chromium deficiency	0.589	0.411	0.000
E61.3 Manganese deficiency	0.589	0.411	0.000
E61.0 Copper deficiency	0.589	0.411	0.000
M60.0 Infective myositis	0.588	0.411	0.000
M62.68 Muscle strain (Other)	0.587	0.413	0.000
M25.99 Joint disorder, unspecified (Site unspecified)	0.587	0.413	0.000
H60.0 Abscess of external ear	0.586	0.414	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.585	0.415	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.585	0.415	0.000
E78.4 Other hyperlipidaemia	0.584	0.416	0.000
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.583	0.416	0.000
D57 Sickle-cell disorders	0.583	0.417	0.000
M25.2 Flail joint	0.583	0.417	0.000
M25.1 Fistula of joint	0.583	0.417	0.000
E20.9 Hypoparathyroidism, unspecified	0.582	0.418	0.000
H95.0 Recurrent cholesteatoma of postmastoidectomy cavity	0.581	0.418	0.000
H35.2 Other proliferative retinopathy	0.580	0.420	0.000
D82.1 Di George's syndrome	0.580	0.420	0.000
E58 Dietary calcium deficiency	0.579	0.420	0.000
K72 Hepatic failure, not elsewhere classified	0.579	0.421	0.000
H32 Chorioretinal disorders in diseases classified elsewhere	0.579	0.421	0.000
D53.8 Other specified nutritional anaemias	0.578	0.422	0.000
D53.2 Scorbutic anaemia	0.578	0.422	0.000
D53.1 Other megaloblastic anaemias, not elsewhere classified	0.578	0.422	0.000
D53.0 Protein deficiency anaemia	0.578	0.422	0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.577	0.423	0.000
D69.0 Allergic purpura	0.576	0.424	0.000
H74 Other disorders of middle ear and mastoid	0.575	0.425	0.000
D89.3 Immune reconstitution syndrome	0.573	0.427	0.000
M65 Synovitis and tenosynovitis	0.573	0.427	0.000
M25.93 Joint disorder, unspecified (Forearm)	0.573	0.427	0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)	0.572	0.428	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.572	0.428	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.571	0.429	0.000
E32 Diseases of thymus	0.571	0.429	0.000
E30 Disorders of puberty, not elsewhere classified	0.571	0.429	0.000
M43.0 Spondylolysis	0.570	0.430	0.000
H92.2 Otorrhagia	0.569	0.431	0.000
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.569	0.431	0.000
D69.8 Other specified haemorrhagic conditions	0.569	0.431	0.000
D69.1 Qualitative platelet defects	0.569	0.431	0.000
E21.4 Other specified disorders of parathyroid gland	0.569	0.431	0.000
D55 Anaemia due to enzyme disorders	0.568	0.432	0.000
M62.59 Muscle wasting and atrophy, not elsewhere classified (Site unspecified)	0.567	0.433	0.000
M62.58 Muscle wasting and atrophy, not elsewhere classified (Other)	0.567	0.433	0.000
M62.57 Muscle wasting and atrophy, not elsewhere classified (Ankle and foot)	0.567	0.433	0.000
M62.53 Muscle wasting and atrophy, not elsewhere classified (Forearm)	0.567	0.433	0.000
M62.52 Muscle wasting and atrophy, not elsewhere classified (Upper arm)	0.567	0.433	0.000
D84.9 Immunodeficiency, unspecified	0.565	0.435	0.000
M67.47 Ganglion, ankle and foot	0.564	0.436	0.000
Q38-Q45 Other congenital malformations of the digestive system	0.564	0.436	0.000
M31.3 Wegener's granulomatosis	0.563	0.437	0.000
E84 Cystic fibrosis	0.562	0.437	0.000
M10.0 Idiopathic gout	0.562	0.438	0.000
E89.4 Postprocedural ovarian failure	0.560	0.440	0.000
E73 Lactose intolerance	0.559	0.441	0.000
M25.95 Joint disorder, unspecified (Pelvic region and thigh)	0.557	0.443	0.000
M25.97 Joint disorder, unspecified (Ankle and foot)	0.557	0.443	0.000
M24.2 Disorder of ligament	0.556	0.444	0.000
M66.09 Rupture of popliteal cyst-Site unspec	0.556	0.444	0.000
M66.08 Rupture of popliteal cyst-Other	0.556	0.444	0.000
M66.07 Rupture of popliteal cyst-Ankle/foot	0.556	0.444	0.000
M66.05 Rupture of popliteal cyst-Pelvic/thigh	0.556	0.444	0.000
M66.04 Rupture of popliteal cyst-Hand	0.556	0.444	0.000
M66.03 Rupture of popliteal cyst-Forearm	0.556	0.444	0.000
M66.02 Rupture of popliteal cyst-Upper arm	0.556	0.444	0.000
M66.01 Rupture of popliteal cyst-Shldr region	0.556	0.444	0.000
M66.00 Rupture of popliteal cyst-Mult sites	0.556	0.444	0.000
M14 Arthropathies in other diseases classified elsewhere	0.555	0.445	0.000
H30.2 Posterior cyclitis	0.555	0.445	0.000
H43 Disorders of vitreous body	0.555	0.445	0.000
H95.9 Postprocedural disorder of ear and mastoid process, unspecified	0.555	0.445	0.000
H61.1 Non-infective disorders of pinna	0.553	0.447	0.000
M88.9 Paget's disease of bone, unspecified	0.553	0.447	0.000
D58 Other hereditary haemolytic anaemias	0.552	0.447	0.000
M86.8 Other osteomyelitis	0.552	0.448	0.000
I83.2 Varicose veins of lower extremities with both ulcer and inflammation	0.000	0.449	0.551
D52 Folate deficiency anaemia	0.551	0.449	0.000
H69 Other disorders of Eustachian tube	0.550	0.449	0.000
M86.1 Other acute osteomyelitis	0.549	0.451	0.000
M24.11 Other articular cartilage disorders (Shoulder region)	0.549	0.451	0.000
D84.8 Other specified immunodeficiencies	0.548	0.452	0.000
K73.1 Chronic lobular hepatitis, not elsewhere classified	0.548	0.452	0.000
K73.0 Chronic persistent hepatitis, not elsewhere classified	0.548	0.452	0.000
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.547	0.453	0.000
D56.3 Thalassaemia trait	0.547	0.453	0.000
M21 Other acquired deformities of limbs	0.547	0.453	0.000
E55 Vitamin D deficiency	0.547	0.453	0.000
H62.8 Other disorders of external ear in diseases classified elsewhere	0.545	0.455	0.000
H62.4 Otitis externa in other diseases classified elsewhere	0.545	0.455	0.000
H62.3 Otitis externa in other infectious and parasitic diseases classified elsewhere	0.545	0.455	0.000
H62.2 Otitis externa in mycoses	0.545	0.455	0.000
H62.1 Otitis externa in viral diseases classified elsewhere	0.545	0.455	0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.545	0.455	0.000
H68 Eustachian salpingitis and obstruction	0.545	0.455	0.000
H67 Otitis media in diseases classified elsewhere	0.545	0.455	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.544	0.455	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations