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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2523897
log Bayes Factor = 16.9149
Chromosome 6   position 30,993,958  (GRCh37) Explore rs2523897 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
K90.0 Coeliac disease
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
E10.9 Without complications
0.000 0.001 0.999
E10-E14 Diabetes mellitus
0.000 0.001 0.999
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.011 0.989
E00-E07 Disorders of thyroid gland
0.000 0.012 0.988
E03 Other hypothyroidism
0.000 0.013 0.987
E03.9 Hypothyroidism, unspecified
0.000 0.015 0.985
G35 Multiple sclerosis
0.983 0.017 0.000
E14 Unspecified diabetes mellitus
0.000 0.030 0.970
E10.3 With ophthalmic complications
0.000 0.043 0.957
E07 Other disorders of thyroid
0.000 0.049 0.951
E14.9 Without complications
0.000 0.060 0.940
E07.9 Disorder of thyroid, unspecified
0.000 0.073 0.927
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.075 0.925
E10.4 With neurological complications
0.000 0.085 0.915
E16 Other disorders of pancreatic internal secretion
0.000 0.121 0.879
E10.8 With unspecified complications
0.000 0.156 0.843
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.168 0.832
E20-E35 Disorders of other endocrine glands
0.000 0.174 0.826
E83 Disorders of mineral metabolism
0.819 0.177 0.003
E10.0 With coma
0.000 0.177 0.823
E16.2 Hypoglycaemia, unspecified
0.000 0.181 0.819
E10.1 With ketoacidosis
0.000 0.181 0.819
E14.3 With ophthalmic complications
0.000 0.188 0.812
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.195 0.804
E11 Non-insulin-dependent diabetes mellitus
0.000 0.205 0.795
E14.4 With neurological complications
0.000 0.246 0.754
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.258 0.742
E05.9 Thyrotoxicosis, unspecified
0.000 0.273 0.727
E83.5 Disorders of calcium metabolism
0.718 0.282 0.000
E10.7 With multiple complications
0.000 0.283 0.717
E10.6 With other specified complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.284 0.716
E10.2 With renal complications
0.000 0.285 0.715
E83.3 Disorders of phosphorus metabolism
0.708 0.291 0.001
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.291 0.708
E00 Congenital iodine-deficiency syndrome
0.000 0.291 0.708
E03.5 Myxoedema coma
0.000 0.293 0.707
E03.4 Atrophy of thyroid (acquired)
0.000 0.293 0.707
E03.3 Postinfectious hypothyroidism
0.000 0.293 0.707
E03.1 Congenital hypothyroidism without goitre
0.000 0.293 0.707
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.293 0.707
G35-G37 Demyelinating diseases of the central nervous system
0.704 0.296 0.000
E14.8 With unspecified complications
0.000 0.304 0.696
E14.7 With multiple complications
0.000 0.304 0.696
E14.6 With other specified complications
0.000 0.304 0.696
E14.2 Withrenal complications
0.000 0.304 0.696
E14.0 With coma
0.000 0.304 0.696
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.314 0.686
E07.1 Dyshormogenetic goitre
0.000 0.318 0.682
E07.0 Hypersecretion of calcitonin
0.000 0.318 0.682
E28 Ovarian dysfunction
0.000 0.318 0.682
E14.1 With ketoacidosis
0.000 0.323 0.677
E22 Hyperfunction of pituitary gland
0.000 0.325 0.675
E24 Cushing's syndrome
0.000 0.327 0.673
E11.1 With ketoacidosis
0.000 0.331 0.669
E29 Testicular dysfunction
0.000 0.334 0.666
E13 Other specified diabetes mellitus
0.000 0.336 0.664
E15 Nondiabetic hypoglycaemic coma
0.000 0.337 0.663
E07.8 Other specified disorders of thyroid
0.000 0.340 0.660
E05.8 Other thyrotoxicosis
0.000 0.342 0.658
E11.9 Without complications
0.000 0.355 0.645
E11.6 With other specified complications
0.000 0.357 0.643
E06 Thyroiditis
0.000 0.357 0.642
E11.5 With peripheral circulatory complications
0.000 0.359 0.641
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.370 0.630
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.370 0.630
E16.4 Abnormal secretion of gastrin
0.000 0.370 0.630
E16.3 Increased secretion of glucagon
0.000 0.370 0.630
E16.1 Other hypoglycaemia
0.000 0.370 0.630
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.370 0.630
G37 Other demyelinating diseases of central nervous system
0.630 0.370 0.000
E03.8 Other specified hypothyroidism
0.000 0.374 0.626
E11.0 With coma
0.000 0.378 0.622
E28.2 Polycystic ovarian syndrome
0.000 0.380 0.620
E21.3 Hyperparathyroidism, unspecified
0.000 0.388 0.612
E20 Hypoparathyroidism
0.000 0.399 0.601
E05.5 Thyroid crisis or storm
0.000 0.403 0.597
E05.4 Thyrotoxicosis factitia
0.000 0.403 0.597
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.403 0.597
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.403 0.597
E40-E46 Malnutrition
0.000 0.404 0.596
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.408 0.592
E32 Diseases of thymus
0.000 0.408 0.592
E31 Polyglandular dysfunction
0.000 0.408 0.592
E30 Disorders of puberty, not elsewhere classified
0.000 0.408 0.592
E25 Adrenogenital disorders
0.000 0.408 0.592
E14.5 With peripheral circulatory complications
0.000 0.408 0.591
E83.9 Disorder of mineral metabolism, unspecified
0.588 0.410 0.003
E83.8 Other disorders of mineral metabolism
0.588 0.410 0.003
E83.2 Disorders of zinc metabolism
0.588 0.410 0.003
E83.0 Disorders of copper metabolism
0.588 0.410 0.003
E22.0 Acromegaly and pituitary gigantism
0.000 0.428 0.572
E11.7 With multiple complications
0.000 0.430 0.570
E83.4 Disorders of magnesium metabolism
0.567 0.431 0.001
E24.9 Cushing's syndrome, unspecified
0.000 0.436 0.564
E23 Hypofunction and other disorders of pituitary gland
0.000 0.445 0.555
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.447 0.552
E29.1 Testicular hypofunction
0.000 0.448 0.552
E10.5 With peripheral circulatory complications
0.000 0.455 0.545
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.455 0.545
E11.3 With ophthalmic complications
0.000 0.459 0.541
G37.9 Demyelinating disease of central nervous system, unspecified
0.534 0.466 0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.467 0.533
E26 Hyperaldosteronism
0.000 0.473 0.527
G37.8 Other specified demyelinating diseases of central nervous system
0.527 0.473 0.000
E12.9 Without complications
0.000 0.486 0.513
E12.8 With unspecified complications
0.000 0.486 0.513
E12.7 With multiple complications
0.000 0.486 0.513
E12.6 With other specified complications
0.000 0.486 0.513
E12.5 With peripheral circulatory complications
0.000 0.486 0.513
E12.4 With neurological complications
0.000 0.486 0.513
E12.3 With ophthalmic complications
0.000 0.486 0.513
E12.2 With renal complications
0.000 0.486 0.513
E12.1 With ketoacidosis
0.000 0.486 0.513
E12.0 With coma
0.000 0.486 0.513
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.492 0.508
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.492 0.508
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.492 0.508
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.492 0.508
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.492 0.508
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.492 0.508
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.492 0.508
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.492 0.508
G36 Other acute disseminated demyelination
0.505 0.495 0.000
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.508 0.492
E21.4 Other specified disorders of parathyroid gland
0.000 0.508 0.492
E21.2 Other hyperparathyroidism
0.000 0.508 0.492
E28.9 Ovarian dysfunction, unspecified
0.000 0.511 0.489
E28.8 Other ovarian dysfunction
0.000 0.511 0.489
E28.1 Androgen excess
0.000 0.511 0.489
E28.0 Oestrogen excess
0.000 0.511 0.489
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.516 0.484
E22.8 Other hyperfunction of pituitary gland
0.000 0.516 0.484
E24.8 Other Cushing's syndrome
0.000 0.517 0.483
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.517 0.483
E24.3 Ectopic ACTH syndrome
0.000 0.517 0.483
E24.2 Drug-induced Cushing's syndrome
0.000 0.517 0.483
E24.1 Nelson's syndrome
0.000 0.517 0.483
E24.0 Pituitary-dependent Cushing's disease
0.000 0.517 0.483
E29.9 Testicular dysfunction, unspecified
0.000 0.522 0.478
E29.8 Other testicular dysfunction
0.000 0.522 0.478
E29.0 Testicular hyperfunction
0.000 0.522 0.478
E13.8 With unspecified complications
0.000 0.524 0.476
E13.7 With multiple complications
0.000 0.524 0.476
E13.6 With other specified complications
0.000 0.524 0.476
E13.5 With peripheral circulatory complications
0.000 0.524 0.476
E13.4 With neurological complications
0.000 0.524 0.476
E13.3 With ophthalmic complications
0.000 0.524 0.476
E13.2 With renal complications
0.000 0.524 0.476
E13.1 With ketoacidosis
0.000 0.524 0.476
E13.0 With coma
0.000 0.524 0.476
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.524 0.476
K90 Intestinal malabsorption
0.000 0.524 0.476
E06.3 Autoimmune thyroiditis
0.000 0.539 0.461
E06.5 Other chronic thyroiditis
0.000 0.539 0.461
E06.4 Drug-induced thyroiditis
0.000 0.539 0.461
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.539 0.461
E06.1 Subacute thyroiditis
0.000 0.539 0.461
E06.0 Acute thyroiditis
0.000 0.539 0.461
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.459 0.541 0.000
E50-E64 Other nutritional deficiencies
0.000 0.544 0.456
E11.2 With renal complications
0.000 0.544 0.456
G37.5 Concentric sclerosis [Balo]
0.452 0.548 0.000
G37.4 Subacute necrotising myelitis
0.452 0.548 0.000
G37.2 Central pontine myelinolysis
0.452 0.548 0.000
G37.1 Central demyelination of corpus callosum
0.452 0.548 0.000
G37.0 Diffuse sclerosis
0.452 0.548 0.000
K51 Ulcerative colitis
0.451 0.549 0.000
E34 Other endocrine disorders
0.000 0.550 0.449
E21.0 Primary hyperparathyroidism
0.000 0.557 0.443
K51.9 Ulcerative colitis, unspecified
0.442 0.558 0.000
E11.8 With unspecified complications
0.000 0.559 0.441
E20.9 Hypoparathyroidism, unspecified
0.000 0.561 0.439
K51.3 Ulcerative (chronic) rectosigmoiditis
0.439 0.561 0.000
K51.5 Mucosal proctocolitis
0.432 0.568 0.000
E20.8 Other hypoparathyroidism
0.000 0.569 0.431
E20.1 Pseudohypoparathyroidism
0.000 0.569 0.431
E20.0 Idiopathic hypoparathyroidism
0.000 0.569 0.431
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.572 0.427
E45 Retarded development following protein-energy malnutrition
0.000 0.572 0.427
E43 Unspecified severe protein-energy malnutrition
0.000 0.572 0.427
E42 Marasmic kwashiorkor
0.000 0.572 0.427
E41 Nutritional marasmus
0.000 0.572 0.427
E40 Kwashiorkor
0.000 0.572 0.427
E25.9 Adrenogenital disorder, unspecified
0.000 0.575 0.425
E25.8 Other adrenogenital disorders
0.000 0.575 0.425
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.575 0.425
E30.9 Disorder of puberty, unspecified
0.000 0.575 0.425
E30.8 Other disorders of puberty
0.000 0.575 0.425
E30.1 Precocious puberty
0.000 0.575 0.425
E30.0 Delayed puberty
0.000 0.575 0.425
E31.9 Polyglandular dysfunction, unspecified
0.000 0.575 0.425
E31.8 Other polyglandular dysfunction
0.000 0.575 0.425
E31.1 Polyglandular hyperfunction
0.000 0.575 0.425
E31.0 Autoimmune polyglandular failure
0.000 0.575 0.425
E32.9 Disease of thymus, unspecified
0.000 0.575 0.425
E32.8 Other diseases of thymus
0.000 0.575 0.425
E32.1 Abscess of thymus
0.000 0.575 0.425
E32.0 Persistent hyperplasia of thymus
0.000 0.575 0.425
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.575 0.425
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.575 0.425
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.575 0.425
E13.9 Without complications
0.000 0.575 0.425
E23.0 Hypopituitarism
0.000 0.583 0.417
K51.4 Pseudopolyposis of colon
0.413 0.587 0.000
E22.1 Hyperprolactinaemia
0.000 0.593 0.407
E23.2 Diabetes insipidus
0.000 0.593 0.407
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.602 0.398
E23.1 Drug-induced hypopituitarism
0.000 0.602 0.398
E06.9 Thyroiditis, unspecified
0.000 0.606 0.394
E11.4 With neurological complications
0.000 0.609 0.391
K51.8 Other ulcerative colitis
0.381 0.619 0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.621 0.379
E26.9 Hyperaldosteronism, unspecified
0.000 0.622 0.378
E26.8 Other hyperaldosteronism
0.000 0.622 0.378
E26.1 Secondary hyperaldosteronism
0.000 0.622 0.378
K51.2 Ulcerative (chronic) proctitis
0.377 0.623 0.000
E65-E68 Obesity and other hyperalimentation
0.000 0.625 0.375
E70-E90 Metabolic disorders
0.073 0.628 0.299
E23.6 Other disorders of pituitary gland
0.000 0.634 0.366
G36.9 Acute disseminated demyelination, unspecified
0.362 0.638 0.000
G36.8 Other specified acute disseminated demyelination
0.362 0.638 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.362 0.638 0.000
G36.0 Neuromyelitis optica [Devic]
0.362 0.638 0.000
E23.7 Disorder of pituitary gland, unspecified
0.000 0.639 0.360
E28.3 Primary ovarian failure
0.000 0.644 0.356
K90.9 Intestinal malabsorption, unspecified
0.000 0.646 0.354
E61 Deficiency of other nutrient elements
0.000 0.646 0.354
E27 Other disorders of adrenal gland
0.000 0.650 0.349
K90.3 Pancreatic steatorrhoea
0.000 0.659 0.341
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.659 0.341
K90.1 Tropical sprue
0.000 0.659 0.341
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.673 0.327
E63 Other nutritional deficiencies
0.000 0.673 0.327
E56 Other vitamin deficiencies
0.000 0.673 0.327
E51 Thiamine deficiency
0.000 0.673 0.327
E50 Vitamin A deficiency
0.000 0.673 0.327
E60 Dietary zinc deficiency
0.000 0.673 0.327
E59 Dietary selenium deficiency
0.000 0.673 0.327
E58 Dietary calcium deficiency
0.000 0.673 0.327
E54 Ascorbic acid deficiency
0.000 0.673 0.327
E52 Niacin deficiency [pellagra]
0.000 0.673 0.327
E34.5 Androgen resistance syndrome
0.000 0.677 0.322
E34.4 Constitutional tall stature
0.000 0.677 0.322
E34.3 Short stature, not elsewhere classified
0.000 0.677 0.322
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.677 0.322
E34.1 Other hypersecretion of intestinal hormones
0.000 0.677 0.322
E46 Unspecified protein-energy malnutrition
0.000 0.685 0.315
E26.0 Primary hyperaldosteronism
0.000 0.686 0.313
E34.9 Endocrine disorder, unspecified
0.000 0.693 0.307
E44.1 Mild protein-energy malnutrition
0.000 0.693 0.306
E44.0 Moderate protein-energy malnutrition
0.000 0.693 0.306
K51.1 Ulcerative (chronic) ileocolitis
0.306 0.694 0.000
K90.8 Other intestinal malabsorption
0.000 0.699 0.301
E27.9 Disorder of adrenal gland, unspecified
0.000 0.700 0.300
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.001 0.701 0.298
E78.0 Pure hypercholesterolaemia
0.000 0.706 0.294
E34.0 Carcinoid syndrome
0.000 0.722 0.278
E74 Other disorders of carbohydrate metabolism
0.047 0.728 0.225
E34.8 Other specified endocrine disorders
0.000 0.728 0.271
E61.1 Iron deficiency
0.000 0.730 0.270
E67 Other hyperalimentation
0.000 0.731 0.269
E68 Sequelae of hyperalimentation
0.000 0.731 0.269
E77 Disorders of glycoprotein metabolism
0.053 0.733 0.214
E76 Disorders of glycosaminoglycan metabolism
0.053 0.733 0.214
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.053 0.733 0.214
E72 Other disorders of amino-acid metabolism
0.053 0.733 0.214
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.053 0.733 0.214
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.053 0.733 0.214
E61.2 Magnesium deficiency
0.000 0.734 0.266
K51.0 Ulcerative (chronic) enterocolitis
0.266 0.734 0.000
E84 Cystic fibrosis
0.053 0.739 0.207
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.743 0.256
E79 Disorders of purine and pyrimidine metabolism
0.055 0.744 0.201
E70 Disorders of aromatic amino-acid metabolism
0.056 0.745 0.198
E61.9 Deficiency of nutrient element, unspecified
0.000 0.746 0.254
E61.8 Deficiency of other specified nutrient elements
0.000 0.746 0.254
E61.7 Deficiency of multiple nutrient elements
0.000 0.746 0.254
E61.6 Vanadium deficiency
0.000 0.746 0.254
E61.5 Molybdenum deficiency
0.000 0.746 0.254
E61.4 Chromium deficiency
0.000 0.746 0.254
E61.3 Manganese deficiency
0.000 0.746 0.254
E61.0 Copper deficiency
0.000 0.746 0.254
E27.5 Adrenomedullary hyperfunction
0.000 0.749 0.250
E27.0 Other adrenocortical overactivity
0.000 0.749 0.250
E78.2 Mixed hyperlipidaemia
0.000 0.750 0.250
E78.8 Other disorders of lipoprotein metabolism
0.000 0.750 0.250
E78.1 Pure hyperglyceridaemia
0.001 0.754 0.246
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.024 0.756 0.220
E27.8 Other specified disorders of adrenal gland
0.000 0.757 0.243
E80 Disorders of porphyrin and bilirubin metabolism
0.044 0.757 0.199
E50.9 Vitamin A deficiency, unspecified
0.000 0.765 0.235
E50.8 Other manifestations of vitamin A deficiency
0.000 0.765 0.235
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.765 0.235
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.765 0.235
E50.5 Vitamin A deficiency with night blindness
0.000 0.765 0.235
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.765 0.235
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.765 0.235
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.765 0.235
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.765 0.235
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.765 0.235
E51.9 Thiamine deficiency, unspecified
0.000 0.765 0.235
E51.8 Other manifestations of thiamine deficiency
0.000 0.765 0.235
E51.2 Wernicke's encephalopathy
0.000 0.765 0.235
E51.1 Beriberi
0.000 0.765 0.235
E56.9 Vitamin deficiency, unspecified
0.000 0.765 0.235
E56.8 Deficiency of other vitamins
0.000 0.765 0.235
E56.1 Deficiency of vitamin K
0.000 0.765 0.235
E56.0 Deficiency of vitamin E
0.000 0.765 0.235
E63.9 Nutritional deficiency, unspecified
0.000 0.765 0.235
E63.8 Other specified nutritional deficiencies
0.000 0.765 0.235
E63.1 Imbalance of constituents of food intake
0.000 0.765 0.235
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.765 0.235
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.765 0.235
E64.8 Sequelae of other nutritional deficiencies
0.000 0.765 0.235
E64.3 Sequelae of rickets
0.000 0.765 0.235
E64.2 Sequelae of vitamin C deficiency
0.000 0.765 0.235
E64.1 Sequelae of vitamin A deficiency
0.000 0.765 0.235
E64.0 Sequelae of protein-energy malnutrition
0.000 0.765 0.235
E85 Amyloidosis
0.055 0.768 0.177
E73 Lactose intolerance
0.061 0.770 0.169
E55 Vitamin D deficiency
0.001 0.779 0.220
E78.6 Lipoprotein deficiency
0.001 0.786 0.213
E78.3 Hyperchylomicronaemia
0.001 0.786 0.213
E78.4 Other hyperlipidaemia
0.001 0.789 0.210
E89.3 Postprocedural hypopituitarism
0.010 0.799 0.190
E74.3 Other disorders of intestinal carbohydrate absorption
0.028 0.800 0.171
E65 Localised adiposity
0.000 0.801 0.199
E78.9 Disorder of lipoprotein metabolism, unspecified
0.001 0.802 0.197
E74.9 Disorder of carbohydrate metabolism, unspecified
0.034 0.805 0.161
E74.8 Other specified disorders of carbohydrate metabolism
0.034 0.805 0.161
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.034 0.805 0.161
E74.2 Disorders of galactose metabolism
0.034 0.805 0.161
E74.1 Disorders of fructose metabolism
0.034 0.805 0.161
E74.0 Glycogen storage disease
0.034 0.805 0.161
E53 Deficiency of other B group vitamins
0.000 0.806 0.194
E67.8 Other specified hyperalimentation
0.000 0.807 0.193
E67.3 Hypervitaminosis D
0.000 0.807 0.193
E67.2 Megavitamin-B6 syndrome
0.000 0.807 0.193
E67.1 Hypercarotenaemia
0.000 0.807 0.193
E67.0 Hypervitaminosis A
0.000 0.807 0.193
E71.3 Disorders of fatty-acid metabolism
0.038 0.808 0.154
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.038 0.808 0.154
E71.1 Other disorders of branched-chain amino-acid metabolism
0.038 0.808 0.154
E71.0 Maple-syrup-urine disease
0.038 0.808 0.154
E72.9 Disorder of amino-acid metabolism, unspecified
0.038 0.808 0.154
E72.8 Other specified disorders of amino-acid metabolism
0.038 0.808 0.154
E72.5 Disorders of glycine metabolism
0.038 0.808 0.154
E72.4 Disorders of ornithine metabolism
0.038 0.808 0.154
E72.3 Disorders of lysine and hydroxylysine metabolism
0.038 0.808 0.154
E72.2 Disorders of urea cycle metabolism
0.038 0.808 0.154
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.038 0.808 0.154
E72.0 Disorders of amino-acid transport
0.038 0.808 0.154
E75.6 Lipid storage disorder, unspecified
0.038 0.808 0.154
E75.5 Other lipid storage disorders
0.038 0.808 0.154
E75.4 Neuronal ceroid lipofuscinosis
0.038 0.808 0.154
E75.3 Sphingolipidosis, unspecified
0.038 0.808 0.154
E75.2 Other sphingolipidosis
0.038 0.808 0.154
E75.1 Other gangliosidosis
0.038 0.808 0.154
E75.0 GM2 gangliosidosis
0.038 0.808 0.154
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.038 0.808 0.154
E76.8 Other disorders of glucosaminoglycan metabolism
0.038 0.808 0.154
E76.3 Mucopolysaccharidosis, unspecified
0.038 0.808 0.154
E76.2 Other mucopolysaccharidoses
0.038 0.808 0.154
E76.1 Mucopolysaccharidosis, type II
0.038 0.808 0.154
E76.0 Mucopolysaccharidosis, type I
0.038 0.808 0.154
E77.9 Disorder of glycoprotein metabolism, unspecified
0.038 0.808 0.154
E77.8 Other disorders of glycoprotein metabolism
0.038 0.808 0.154
E77.1 Defects in glycoprotein degradation
0.038 0.808 0.154
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.038 0.808 0.154
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.809 0.191
E84.8 Cystic fibrosis with other manifestations
0.038 0.813 0.149
E84.1 Cystic fibrosis with intestinal manifestations
0.038 0.813 0.149
E84.0 Cystic fibrosis with pulmonary manifestations
0.038 0.813 0.149
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.040 0.816 0.144
E79.8 Other disorders of purine and pyrimidine metabolism
0.040 0.816 0.144
E79.1 Lesch-Nyhan syndrome
0.040 0.816 0.144
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.040 0.817 0.142
E70.8 Other disorders of aromatic amino-acid metabolism
0.040 0.817 0.142
E70.2 Disorders of tyrosine metabolism
0.040 0.817 0.142
E70.1 Other hyperphenylalaninaemias
0.040 0.817 0.142
E70.0 Classical phenylketonuria
0.040 0.817 0.142
E88 Other metabolic disorders
0.061 0.818 0.121
E84.9 Cystic fibrosis, unspecified
0.039 0.819 0.142
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.017 0.825 0.158
E89.8 Other postprocedural endocrine and metabolic disorders
0.017 0.825 0.158
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.017 0.825 0.158
E89.5 Postprocedural testicular hypofunction
0.017 0.825 0.158
E89.4 Postprocedural ovarian failure
0.017 0.825 0.158
E89.1 Postprocedural hypoinsulinaemia
0.017 0.825 0.158
E80.7 Disorder of bilirubin metabolism, unspecified
0.032 0.826 0.142
E80.6 Other disorders of bilirubin metabolism
0.032 0.826 0.142
E80.5 Crigler-Najjar syndrome
0.032 0.826 0.142
E80.3 Defects of catalase and peroxydase
0.032 0.826 0.142
E80.2 Other porphyria
0.032 0.826 0.142
E80.0 Hereditary erythropoietic porphyria
0.032 0.826 0.142
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.042 0.828 0.130
M06.9 Rheumatoid arthritis, unspecified
0.000 0.829 0.171
E70.3 Albinism
0.044 0.830 0.126
Chapter VI Diseases of the nervous system
0.170 0.830 0.000
G20-G26 Extrapyramidal and movement disorders
0.169 0.831 0.000
G20 Parkinson's disease
0.167 0.833 0.000
E85.8 Other amyloidosis
0.039 0.834 0.127
E85.2 Heredofamilial amyloidosis, unspecified
0.039 0.834 0.127
E85.1 Neuropathic heredofamilial amyloidosis
0.039 0.834 0.127
E85.0 Nonneuropathic heredofamilial amyloidosis
0.039 0.834 0.127
E85.4 Organ-limited amyloidosis
0.033 0.834 0.134
E73.8 Other lactose intolerance
0.044 0.835 0.122
E73.1 Secondary lactase deficiency
0.044 0.835 0.122
E73.0 Congenital lactase deficiency
0.044 0.835 0.122
E80.4 Gilbert's syndrome
0.015 0.838 0.147
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.838 0.162
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.840 0.160
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.840 0.160
E55.0 Rickets, active
0.001 0.842 0.158
G30-G32 Other degenerative diseases of the nervous system
0.157 0.843 0.000
E27.2 Addisonian crisis
0.001 0.844 0.156
E80.1 Porphyria cutanea tarda
0.036 0.844 0.120
G31 Other degenerative diseases of nervous system, not elsewhere classified
0.153 0.847 0.000
E89.0 Postprocedural hypothyroidism
0.003 0.849 0.149
G31.9 Degenerative disease of nervous system, unspecified
0.151 0.849 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.850 0.150
E85.9 Amyloidosis, unspecified
0.041 0.850 0.109
E85.3 Secondary systemic amyloidosis
0.044 0.852 0.103
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.860 0.140
E53.1 Pyridoxine deficiency
0.000 0.861 0.139
E53.0 Riboflavin deficiency
0.000 0.861 0.139
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.862 0.138
E89.2 Postprocedural hypoparathyroidism
0.019 0.862 0.119
G23 Other degenerative diseases of basal ganglia
0.134 0.866 0.000
E27.1 Primary adrenocortical insufficiency
0.001 0.866 0.133
G21 Secondary Parkinsonism
0.133 0.867 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.867 0.133
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.869 0.131
E88.9 Metabolic disorder, unspecified
0.044 0.869 0.087
E88.8 Other specified metabolic disorders
0.044 0.869 0.087
E88.1 Lipodystrophy, not elsewhere classified
0.044 0.869 0.087
E53.9 Vitamin B deficiency, unspecified
0.000 0.870 0.130
E73.9 Lactose intolerance, unspecified
0.052 0.872 0.077
G31.2 Degeneration of nervous system due to alcohol
0.128 0.872 0.000
E88.2 Lipomatosis, not elsewhere classified
0.044 0.875 0.081
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.121 0.879 0.000
G22 Parkinsonism in diseases classified elsewhere
0.121 0.879 0.000
E88.3 Tumour lysis syndrome
0.050 0.879 0.071
G25 Other extrapyramidal and movement disorders
0.120 0.880 0.000
G31.0 Circumscribed brain atrophy
0.120 0.880 0.000
M06 Other rheumatoid arthritis
0.000 0.882 0.118
G24 Dystonia
0.118 0.882 0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.882 0.118
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.883 0.117
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.117 0.883 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.116 0.884 0.000
G32 Other degenerative disorders of nervous system in diseases classified elsewhere
0.113 0.887 0.000
G31.1 Senile degeneration of brain, not elsewhere classified
0.110 0.890 0.000
E66 Obesity
0.000 0.891 0.109
G23.8 Other specified degenerative diseases of basal ganglia
0.108 0.891 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.108 0.892 0.000
G21.1 Other drug-induced secondary Parkinsonism
0.107 0.893 0.000
G80 Infantile cerebral palsy
0.100 0.900 0.000
M06.3 Rheumatoid nodule
0.000 0.900 0.099
E78.5 Hyperlipidaemia, unspecified
0.000 0.902 0.098
G25.1 Drug-induced tremor
0.097 0.903 0.000
G70-G73 Diseases of myoneural junction and muscle
0.097 0.903 0.000
G23.9 Degenerative disease of basal ganglia, unspecified
0.096 0.904 0.000
G23.3 Multiple system atrophy, cerebellar type
0.096 0.904 0.000
G23.2 Striatonigral degeneration
0.096 0.904 0.000
G23.1 Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
0.096 0.904 0.000
G23.0 Hallervorden-Spatz disease
0.096 0.904 0.000
G21.9 Secondary Parkinsonism, unspecified
0.095 0.905 0.000
G21.8 Other secondary Parkinsonism
0.095 0.905 0.000
G21.4 Vascular parkinsonism
0.095 0.905 0.000
G21.3 Postencephalitic Parkinsonism
0.095 0.905 0.000
G21.2 Secondary Parkinsonism due to other external agents
0.095 0.905 0.000
G21.0 Malignant neuroleptic syndrome
0.095 0.905 0.000
J45.9 Asthma, unspecified
0.000 0.906 0.094
G24.9 Dystonia, unspecified
0.094 0.906 0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.048 0.907 0.045
G25.8 Other specified extrapyramidal and movement disorders
0.093 0.907 0.000
M06.4 Inflammatory polyarthropathy
0.000 0.912 0.088
G05 Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
0.088 0.912 0.000
G09 Sequelae of inflammatory diseases of central nervous system
0.088 0.912 0.000
G25.9 Extrapyramidal and movement disorder, unspecified
0.087 0.913 0.000
M06.34 Rheumatoid nodule (Hand)
0.000 0.913 0.087
G80.9 Infantile cerebral palsy, unspecified
0.087 0.913 0.000
G10 Huntington's disease
0.086 0.913 0.000
G25.6 Drug-induced tics and other tics of organic origin
0.086 0.914 0.000
G25.5 Other chorea
0.086 0.914 0.000
G25.4 Drug-induced chorea
0.086 0.914 0.000
G25.2 Other specified forms of tremor
0.086 0.914 0.000
G24.8 Other dystonia
0.086 0.914 0.000
M06.8 Other specified rheumatoid arthritis
0.000 0.915 0.085
M06.2 Rheumatoid bursitis
0.000 0.915 0.085
M06.1 Adult-onset Still's disease
0.000 0.915 0.085
E66.0 Obesity due to excess calories
0.000 0.915 0.085
G24.4 Idiopathic orofacial dystonia
0.085 0.915 0.000
G24.3 Spasmodic torticollis
0.085 0.915 0.000
G24.2 Idiopathic nonfamilial dystonia
0.085 0.915 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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