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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2535298
log Bayes Factor = 56.6006
Chromosome 6   position 31,059,462  (GRCh37) Explore rs2535298 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
E78.0 Pure hypercholesterolaemia
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.000 1.000
E11.9 Without complications
0.000 0.001 0.999
M06.9 Rheumatoid arthritis, unspecified
0.000 0.001 0.999
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.001 0.999
E11 Non-insulin-dependent diabetes mellitus
0.000 0.001 0.999
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.003 0.997
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.010 0.990
E70-E90 Metabolic disorders
0.000 0.011 0.989
E05.9 Thyrotoxicosis, unspecified
0.000 0.012 0.988
E78.5 Hyperlipidaemia, unspecified
0.000 0.017 0.983
L40 Psoriasis
0.000 0.047 0.953
E07 Other disorders of thyroid
0.000 0.077 0.923
G35-G37 Demyelinating diseases of the central nervous system
0.917 0.083 0.000
L40.5 Arthropathic psoriasis
0.000 0.085 0.915
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.093 0.907
E78.8 Other disorders of lipoprotein metabolism
0.000 0.099 0.901
G37 Other demyelinating diseases of central nervous system
0.898 0.102 0.000
I25 Chronic ischaemic heart disease
0.000 0.110 0.890
E10.3 With ophthalmic complications
0.000 0.117 0.883
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.118 0.882
I25.1 Atherosclerotic heart disease
0.000 0.118 0.882
E07.9 Disorder of thyroid, unspecified
0.000 0.125 0.875
G37.9 Demyelinating disease of central nervous system, unspecified
0.872 0.128 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.146 0.854
E11.1 With ketoacidosis
0.000 0.148 0.852
I25.5 Ischaemic cardiomyopathy
0.000 0.148 0.852
I20-I25 Ischaemic heart diseases
0.000 0.154 0.846
E78.4 Other hyperlipidaemia
0.000 0.163 0.837
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.165 0.835
E11.0 With coma
0.000 0.166 0.834
E14 Unspecified diabetes mellitus
0.000 0.167 0.833
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.168 0.832
E78.2 Mixed hyperlipidaemia
0.000 0.185 0.815
L40.8 Other psoriasis
0.000 0.188 0.812
E10.8 With unspecified complications
0.000 0.191 0.809
I22 Subsequent myocardial infarction
0.000 0.203 0.797
I24 Other acute ischaemic heart diseases
0.000 0.205 0.795
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.208 0.792
E13 Other specified diabetes mellitus
0.000 0.211 0.789
E03.8 Other specified hypothyroidism
0.000 0.212 0.788
I25.2 Old myocardial infarction
0.000 0.219 0.781
E10.1 With ketoacidosis
0.000 0.224 0.776
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.224 0.776
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.231 0.769
E74 Other disorders of carbohydrate metabolism
0.000 0.234 0.766
E78.1 Pure hyperglyceridaemia
0.000 0.235 0.765
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.243 0.757
E78.6 Lipoprotein deficiency
0.000 0.247 0.753
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.249 0.751
L40.0 Psoriasis vulgaris
0.000 0.254 0.746
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.257 0.743
G37.8 Other specified demyelinating diseases of central nervous system
0.734 0.266 0.000
E10.6 With other specified complications
0.000 0.274 0.726
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E03.1 Congenital hypothyroidism without goitre
0.000 0.283 0.717
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.283 0.717
E10.7 With multiple complications
0.000 0.283 0.717
E78.3 Hyperchylomicronaemia
0.000 0.283 0.717
E11.7 With multiple complications
0.000 0.284 0.716
E05.5 Thyroid crisis or storm
0.000 0.290 0.710
E05.4 Thyrotoxicosis factitia
0.000 0.290 0.710
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.290 0.710
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.290 0.710
E79 Disorders of purine and pyrimidine metabolism
0.000 0.291 0.709
E77 Disorders of glycoprotein metabolism
0.000 0.291 0.709
E76 Disorders of glycosaminoglycan metabolism
0.000 0.291 0.709
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.291 0.709
E72 Other disorders of amino-acid metabolism
0.000 0.291 0.709
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.291 0.709
E70 Disorders of aromatic amino-acid metabolism
0.000 0.291 0.709
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.291 0.709
E14.3 With ophthalmic complications
0.000 0.294 0.706
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.296 0.704
I23 Certain current complications following acute myocardial infarction
0.000 0.299 0.701
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.701 0.299 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.304 0.696
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.305 0.694
L40.4 Guttate psoriasis
0.000 0.317 0.683
L40.2 Acrodermatitis continua
0.000 0.317 0.683
L40.1 Generalised pustular psoriasis
0.000 0.317 0.683
G36 Other acute disseminated demyelination
0.681 0.319 0.000
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.324 0.676
E10.2 With renal complications
0.000 0.325 0.675
E40-E46 Malnutrition
0.000 0.327 0.673
E10.0 With coma
0.000 0.330 0.670
I24.8 Other forms of acute ischaemic heart disease
0.000 0.332 0.668
E10.5 With peripheral circulatory complications
0.000 0.332 0.668
E84 Cystic fibrosis
0.000 0.334 0.665
E07.1 Dyshormogenetic goitre
0.000 0.338 0.662
E07.0 Hypersecretion of calcitonin
0.000 0.338 0.662
E13.9 Without complications
0.000 0.340 0.660
I25.3 Aneurysm of heart
0.000 0.349 0.651
E11.2 With renal complications
0.000 0.355 0.645
G37.5 Concentric sclerosis [Balo]
0.644 0.356 0.000
G37.4 Subacute necrotising myelitis
0.644 0.356 0.000
G37.2 Central pontine myelinolysis
0.644 0.356 0.000
G37.1 Central demyelination of corpus callosum
0.644 0.356 0.000
G37.0 Diffuse sclerosis
0.644 0.356 0.000
I25.6 Silent myocardial ischaemia
0.000 0.361 0.638
E14.1 With ketoacidosis
0.000 0.364 0.635
E85 Amyloidosis
0.000 0.367 0.633
E14.9 Without complications
0.000 0.368 0.632
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.372 0.628
E07.8 Other specified disorders of thyroid
0.000 0.379 0.621
E14.4 With neurological complications
0.000 0.383 0.617
E14.5 With peripheral circulatory complications
0.000 0.390 0.610
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.391 0.609
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.393 0.606
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.394 0.606
E14.7 With multiple complications
0.000 0.402 0.597
E14.0 With coma
0.000 0.402 0.597
I23.8 Other current complications following acute myocardial infarction
0.000 0.402 0.597
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.408 0.592
I25.4 Coronary artery aneurysm
0.000 0.419 0.581
E11.6 With other specified complications
0.000 0.422 0.578
E05.8 Other thyrotoxicosis
0.000 0.424 0.575
E11.8 With unspecified complications
0.000 0.424 0.575
E73 Lactose intolerance
0.000 0.426 0.574
L40-L45 Papulosquamous disorders
0.000 0.426 0.574
E14.6 With other specified complications
0.000 0.429 0.571
E14.8 With unspecified complications
0.000 0.429 0.571
E13.8 With unspecified complications
0.000 0.434 0.566
E13.7 With multiple complications
0.000 0.434 0.566
E13.6 With other specified complications
0.000 0.434 0.566
E13.5 With peripheral circulatory complications
0.000 0.434 0.566
E13.4 With neurological complications
0.000 0.434 0.566
E13.2 With renal complications
0.000 0.434 0.566
E13.1 With ketoacidosis
0.000 0.434 0.566
E13.0 With coma
0.000 0.434 0.566
K90 Intestinal malabsorption
0.000 0.437 0.563
I22.8 Subsequent myocardial infarction of other sites
0.000 0.449 0.551
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.450 0.549
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.450 0.549
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.450 0.549
E74.2 Disorders of galactose metabolism
0.000 0.450 0.549
E74.1 Disorders of fructose metabolism
0.000 0.450 0.549
E74.0 Glycogen storage disease
0.000 0.450 0.549
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.452 0.548
I20 Angina pectoris
0.000 0.454 0.546
E14.2 Withrenal complications
0.000 0.455 0.545
L40.3 Pustulosis palmaris et plantaris
0.000 0.459 0.540
I21 Acute myocardial infarction
0.000 0.462 0.538
E50-E64 Other nutritional deficiencies
0.000 0.465 0.535
E10.4 With neurological complications
0.000 0.470 0.530
E13.3 With ophthalmic complications
0.000 0.472 0.527
E11.5 With peripheral circulatory complications
0.000 0.473 0.527
I20.9 Angina pectoris, unspecified
0.000 0.474 0.526
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.476 0.524
E80.6 Other disorders of bilirubin metabolism
0.000 0.483 0.517
E16 Other disorders of pancreatic internal secretion
0.000 0.485 0.515
E15 Nondiabetic hypoglycaemic coma
0.000 0.485 0.514
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
G36.0 Neuromyelitis optica [Devic]
0.511 0.488 0.000
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.489 0.511
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.491 0.508
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.491 0.508
E70.3 Albinism
0.000 0.491 0.508
E70.2 Disorders of tyrosine metabolism
0.000 0.491 0.508
E70.1 Other hyperphenylalaninaemias
0.000 0.491 0.508
E70.0 Classical phenylketonuria
0.000 0.491 0.508
E71.3 Disorders of fatty-acid metabolism
0.000 0.491 0.508
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.491 0.508
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.491 0.508
E71.0 Maple-syrup-urine disease
0.000 0.491 0.508
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.491 0.508
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.491 0.508
E72.5 Disorders of glycine metabolism
0.000 0.491 0.508
E72.4 Disorders of ornithine metabolism
0.000 0.491 0.508
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.491 0.508
E72.2 Disorders of urea cycle metabolism
0.000 0.491 0.508
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.491 0.508
E72.0 Disorders of amino-acid transport
0.000 0.491 0.508
E75.6 Lipid storage disorder, unspecified
0.000 0.491 0.508
E75.5 Other lipid storage disorders
0.000 0.491 0.508
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.491 0.508
E75.3 Sphingolipidosis, unspecified
0.000 0.491 0.508
E75.2 Other sphingolipidosis
0.000 0.491 0.508
E75.1 Other gangliosidosis
0.000 0.491 0.508
E75.0 GM2 gangliosidosis
0.000 0.491 0.508
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.491 0.508
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.491 0.508
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.491 0.508
E76.2 Other mucopolysaccharidoses
0.000 0.491 0.508
E76.1 Mucopolysaccharidosis, type II
0.000 0.491 0.508
E76.0 Mucopolysaccharidosis, type I
0.000 0.491 0.508
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.491 0.508
E77.8 Other disorders of glycoprotein metabolism
0.000 0.491 0.508
E77.1 Defects in glycoprotein degradation
0.000 0.491 0.508
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.491 0.508
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.491 0.508
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.491 0.508
E79.1 Lesch-Nyhan syndrome
0.000 0.491 0.508
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.491 0.508
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.497 0.503
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.497 0.503
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.497 0.503
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.497 0.503
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.497 0.503
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.497 0.503
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.497 0.503
E83 Disorders of mineral metabolism
0.392 0.500 0.108
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.502 0.498
E80.5 Crigler-Najjar syndrome
0.000 0.502 0.498
E80.3 Defects of catalase and peroxydase
0.000 0.502 0.498
E80.2 Other porphyria
0.000 0.502 0.498
E80.1 Porphyria cutanea tarda
0.000 0.502 0.498
E80.0 Hereditary erythropoietic porphyria
0.000 0.502 0.498
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.505 0.495
G36.9 Acute disseminated demyelination, unspecified
0.488 0.512 0.000
G36.8 Other specified acute disseminated demyelination
0.488 0.512 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.488 0.512 0.000
L43 Lichen planus
0.000 0.512 0.488
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.517 0.483
E45 Retarded development following protein-energy malnutrition
0.000 0.517 0.483
E43 Unspecified severe protein-energy malnutrition
0.000 0.517 0.483
E42 Marasmic kwashiorkor
0.000 0.517 0.483
E41 Nutritional marasmus
0.000 0.517 0.483
E40 Kwashiorkor
0.000 0.517 0.483
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.521 0.479
E84.8 Cystic fibrosis with other manifestations
0.000 0.523 0.477
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.523 0.477
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.523 0.477
I21.4 Acute subendocardial myocardial infarction
0.000 0.523 0.477
E06 Thyroiditis
0.000 0.525 0.475
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.531 0.469
E20-E35 Disorders of other endocrine glands
0.000 0.535 0.465
E80.4 Gilbert's syndrome
0.000 0.540 0.460
E85.4 Organ-limited amyloidosis
0.000 0.545 0.455
E85.8 Other amyloidosis
0.000 0.546 0.454
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.546 0.454
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.546 0.454
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.546 0.454
E89.3 Postprocedural hypopituitarism
0.000 0.547 0.453
I24.1 Dressler's syndrome
0.000 0.550 0.450
L43.9 Lichen planus, unspecified
0.000 0.558 0.442
E46 Unspecified protein-energy malnutrition
0.000 0.561 0.439
E61 Deficiency of other nutrient elements
0.000 0.563 0.436
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.566 0.434
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.566 0.434
E89.5 Postprocedural testicular hypofunction
0.000 0.566 0.434
E89.1 Postprocedural hypoinsulinaemia
0.000 0.566 0.434
E84.9 Cystic fibrosis, unspecified
0.000 0.566 0.433
E88 Other metabolic disorders
0.000 0.571 0.428
L42 Pityriasis rosea
0.000 0.572 0.428
E89.4 Postprocedural ovarian failure
0.000 0.575 0.425
E85.3 Secondary systemic amyloidosis
0.000 0.578 0.422
M06 Other rheumatoid arthritis
0.000 0.583 0.417
E85.9 Amyloidosis, unspecified
0.000 0.585 0.415
E16.1 Other hypoglycaemia
0.000 0.585 0.415
E73.8 Other lactose intolerance
0.000 0.588 0.412
E73.1 Secondary lactase deficiency
0.000 0.588 0.412
E73.0 Congenital lactase deficiency
0.000 0.588 0.412
L44 Other papulosquamous disorders
0.000 0.589 0.411
L41 Parapsoriasis
0.000 0.589 0.411
L45 Papulosquamous disorders in diseases classified elsewhere
0.000 0.589 0.411
E89.2 Postprocedural hypoparathyroidism
0.000 0.592 0.408
K90.3 Pancreatic steatorrhoea
0.000 0.596 0.404
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.596 0.404
K90.1 Tropical sprue
0.000 0.596 0.404
K90.9 Intestinal malabsorption, unspecified
0.000 0.603 0.397
E29 Testicular dysfunction
0.000 0.612 0.388
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.614 0.386
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.616 0.384
E63 Other nutritional deficiencies
0.000 0.616 0.384
E56 Other vitamin deficiencies
0.000 0.616 0.384
E51 Thiamine deficiency
0.000 0.616 0.384
E50 Vitamin A deficiency
0.000 0.616 0.384
E60 Dietary zinc deficiency
0.000 0.616 0.384
E59 Dietary selenium deficiency
0.000 0.616 0.384
E58 Dietary calcium deficiency
0.000 0.616 0.384
E54 Ascorbic acid deficiency
0.000 0.616 0.384
E52 Niacin deficiency [pellagra]
0.000 0.616 0.384
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.617 0.383
E28 Ovarian dysfunction
0.000 0.618 0.382
E61.1 Iron deficiency
0.000 0.626 0.374
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.629 0.371
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.631 0.369
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.631 0.369
E16.4 Abnormal secretion of gastrin
0.000 0.631 0.369
E16.3 Increased secretion of glucagon
0.000 0.631 0.369
I21.9 Acute myocardial infarction, unspecified
0.000 0.639 0.361
E83.9 Disorder of mineral metabolism, unspecified
0.281 0.641 0.077
E83.8 Other disorders of mineral metabolism
0.281 0.641 0.077
E83.2 Disorders of zinc metabolism
0.281 0.641 0.077
E83.0 Disorders of copper metabolism
0.281 0.641 0.077
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.642 0.357
M06.3 Rheumatoid nodule
0.000 0.648 0.352
L43.3 Subacute (active) lichen planus
0.000 0.650 0.350
L43.2 Lichenoid drug reaction
0.000 0.650 0.350
L43.1 Bullous lichen planus
0.000 0.650 0.350
L43.0 Hypertrophic lichen planus
0.000 0.650 0.350
E23 Hypofunction and other disorders of pituitary gland
0.000 0.650 0.350
K90.8 Other intestinal malabsorption
0.000 0.650 0.350
E44.1 Mild protein-energy malnutrition
0.000 0.654 0.346
E44.0 Moderate protein-energy malnutrition
0.000 0.654 0.346
E83.3 Disorders of phosphorus metabolism
0.296 0.657 0.047
E11.4 With neurological complications
0.000 0.657 0.343
M45 Ankylosing spondylitis
0.000 0.658 0.341
E26 Hyperaldosteronism
0.000 0.659 0.341
E06.5 Other chronic thyroiditis
0.000 0.659 0.341
E06.4 Drug-induced thyroiditis
0.000 0.659 0.341
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.659 0.341
E06.1 Subacute thyroiditis
0.000 0.659 0.341
E06.0 Acute thyroiditis
0.000 0.659 0.341
I20.1 Angina pectoris with documented spasm
0.000 0.661 0.339
E65-E68 Obesity and other hyperalimentation
0.000 0.665 0.335
E28.2 Polycystic ovarian syndrome
0.000 0.665 0.335
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.666 0.333
E32 Diseases of thymus
0.000 0.666 0.333
E31 Polyglandular dysfunction
0.000 0.666 0.333
E30 Disorders of puberty, not elsewhere classified
0.000 0.666 0.333
E25 Adrenogenital disorders
0.000 0.666 0.333
E29.1 Testicular hypofunction
0.000 0.667 0.333
E24 Cushing's syndrome
0.000 0.676 0.324
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.677 0.323
E22 Hyperfunction of pituitary gland
0.000 0.686 0.314
E61.9 Deficiency of nutrient element, unspecified
0.000 0.687 0.313
E61.8 Deficiency of other specified nutrient elements
0.000 0.687 0.313
E61.7 Deficiency of multiple nutrient elements
0.000 0.687 0.313
E61.6 Vanadium deficiency
0.000 0.687 0.313
E61.5 Molybdenum deficiency
0.000 0.687 0.313
E61.4 Chromium deficiency
0.000 0.687 0.313
E61.3 Manganese deficiency
0.000 0.687 0.313
E61.0 Copper deficiency
0.000 0.687 0.313
M06.4 Inflammatory polyarthropathy
0.000 0.691 0.308
E88.9 Metabolic disorder, unspecified
0.000 0.692 0.307
E88.8 Other specified metabolic disorders
0.000 0.692 0.307
L43.8 Other lichen planus
0.000 0.695 0.305
E16.2 Hypoglycaemia, unspecified
0.000 0.699 0.301
E55 Vitamin D deficiency
0.000 0.699 0.301
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.700 0.300
M06.2 Rheumatoid bursitis
0.000 0.701 0.299
M06.1 Adult-onset Still's disease
0.000 0.701 0.299
E61.2 Magnesium deficiency
0.000 0.703 0.297
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.704 0.296
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.704 0.296
L41.9 Parapsoriasis, unspecified
0.000 0.705 0.295
L41.8 Other parapsoriasis
0.000 0.705 0.295
L41.5 Retiform parapsoriasis
0.000 0.705 0.295
L41.4 Large plaque parapsoriasis
0.000 0.705 0.295
L41.3 Small plaque parapsoriasis
0.000 0.705 0.295
L41.2 Lymphomatoid papulosis
0.000 0.705 0.295
L41.1 Pityriasis lichenoides chronica
0.000 0.705 0.295
L41.0 Pityriasis lichenoides et varioliformis acuta
0.000 0.705 0.295
L44.9 Papulosquamous disorder, unspecified
0.000 0.705 0.295
L44.8 Other specified papulosquamous disorders
0.000 0.705 0.295
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.000 0.705 0.295
L44.3 Lichen ruber moniliformis
0.000 0.705 0.295
L44.2 Lichen striatus
0.000 0.705 0.295
L44.1 Lichen nitidus
0.000 0.705 0.295
L44.0 Pityriasis rubra pilaris
0.000 0.705 0.295
E88.3 Tumour lysis syndrome
0.000 0.708 0.292
E88.2 Lipomatosis, not elsewhere classified
0.000 0.710 0.290
M06.32 Rheumatoid nodule (Upper arm)
0.000 0.712 0.288
M06.34 Rheumatoid nodule (Hand)
0.000 0.714 0.286
M06.8 Other specified rheumatoid arthritis
0.000 0.718 0.282
E23.2 Diabetes insipidus
0.000 0.719 0.281
E23.7 Disorder of pituitary gland, unspecified
0.000 0.720 0.280
E29.9 Testicular dysfunction, unspecified
0.000 0.721 0.278
E29.8 Other testicular dysfunction
0.000 0.721 0.278
E29.0 Testicular hyperfunction
0.000 0.721 0.278
E73.9 Lactose intolerance, unspecified
0.001 0.723 0.276
E50.9 Vitamin A deficiency, unspecified
0.000 0.725 0.275
E50.8 Other manifestations of vitamin A deficiency
0.000 0.725 0.275
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.725 0.275
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.725 0.275
E50.5 Vitamin A deficiency with night blindness
0.000 0.725 0.275
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.725 0.275
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.725 0.275
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.725 0.275
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.725 0.275
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.725 0.275
E51.9 Thiamine deficiency, unspecified
0.000 0.725 0.275
E51.8 Other manifestations of thiamine deficiency
0.000 0.725 0.275
E51.2 Wernicke's encephalopathy
0.000 0.725 0.275
E51.1 Beriberi
0.000 0.725 0.275
E56.9 Vitamin deficiency, unspecified
0.000 0.725 0.275
E56.8 Deficiency of other vitamins
0.000 0.725 0.275
E56.1 Deficiency of vitamin K
0.000 0.725 0.275
E56.0 Deficiency of vitamin E
0.000 0.725 0.275
E63.9 Nutritional deficiency, unspecified
0.000 0.725 0.275
E63.8 Other specified nutritional deficiencies
0.000 0.725 0.275
E63.1 Imbalance of constituents of food intake
0.000 0.725 0.275
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.725 0.275
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.725 0.275
E64.8 Sequelae of other nutritional deficiencies
0.000 0.725 0.275
E64.3 Sequelae of rickets
0.000 0.725 0.275
E64.2 Sequelae of vitamin C deficiency
0.000 0.725 0.275
E64.1 Sequelae of vitamin A deficiency
0.000 0.725 0.275
E64.0 Sequelae of protein-energy malnutrition
0.000 0.725 0.275
E28.9 Ovarian dysfunction, unspecified
0.000 0.726 0.274
E28.8 Other ovarian dysfunction
0.000 0.726 0.274
E28.1 Androgen excess
0.000 0.726 0.274
E28.0 Oestrogen excess
0.000 0.726 0.274
E20 Hypoparathyroidism
0.000 0.726 0.273
E88.1 Lipodystrophy, not elsewhere classified
0.001 0.728 0.271
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.728 0.272
M06.37 Rheumatoid nodule (Ankle and foot)
0.000 0.729 0.271
E06.9 Thyroiditis, unspecified
0.000 0.729 0.271
E89.0 Postprocedural hypothyroidism
0.000 0.737 0.263
E83.4 Disorders of magnesium metabolism
0.210 0.744 0.046
E11.3 With ophthalmic complications
0.000 0.745 0.255
E26.0 Primary hyperaldosteronism
0.000 0.747 0.253
M06.39 Rheumatoid nodule (Site unspecified)
0.000 0.747 0.253
M06.38 Rheumatoid nodule (Other)
0.000 0.747 0.253
M06.36 Rheumatoid nodule (Lower leg)
0.000 0.747 0.253
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.000 0.747 0.253
M06.33 Rheumatoid nodule (Forearm)
0.000 0.747 0.253
M06.31 Rheumatoid nodule (Shoulder region)
0.000 0.747 0.253
E34 Other endocrine disorders
0.000 0.747 0.252
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.749 0.251
E23.1 Drug-induced hypopituitarism
0.000 0.749 0.251
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.754 0.246
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.755 0.245
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.755 0.245
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.755 0.245
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.755 0.245
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.755 0.245
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.755 0.245
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.755 0.245
E26.9 Hyperaldosteronism, unspecified
0.000 0.755 0.245
E26.8 Other hyperaldosteronism
0.000 0.755 0.245
E26.1 Secondary hyperaldosteronism
0.000 0.755 0.245
E28.3 Primary ovarian failure
0.000 0.757 0.243
E67 Other hyperalimentation
0.000 0.759 0.240
E68 Sequelae of hyperalimentation
0.000 0.759 0.240
E25.9 Adrenogenital disorder, unspecified
0.000 0.761 0.239
E25.8 Other adrenogenital disorders
0.000 0.761 0.239
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.761 0.239
E30.9 Disorder of puberty, unspecified
0.000 0.761 0.239
E30.8 Other disorders of puberty
0.000 0.761 0.239
E30.1 Precocious puberty
0.000 0.761 0.239
E30.0 Delayed puberty
0.000 0.761 0.239
E31.9 Polyglandular dysfunction, unspecified
0.000 0.761 0.239
E31.8 Other polyglandular dysfunction
0.000 0.761 0.239
E31.1 Polyglandular hyperfunction
0.000 0.761 0.239
E31.0 Autoimmune polyglandular failure
0.000 0.761 0.239
E32.9 Disease of thymus, unspecified
0.000 0.761 0.239
E32.8 Other diseases of thymus
0.000 0.761 0.239
E32.1 Abscess of thymus
0.000 0.761 0.239
E32.0 Persistent hyperplasia of thymus
0.000 0.761 0.239
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.761 0.239
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.761 0.239
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.761 0.239
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.764 0.236
E24.8 Other Cushing's syndrome
0.000 0.767 0.232
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.767 0.232
E24.3 Ectopic ACTH syndrome
0.000 0.767 0.232
E24.2 Drug-induced Cushing's syndrome
0.000 0.767 0.232
E24.1 Nelson's syndrome
0.000 0.767 0.232
E24.0 Pituitary-dependent Cushing's disease
0.000 0.767 0.232
E06.3 Autoimmune thyroiditis
0.000 0.772 0.227
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.774 0.225
E22.8 Other hyperfunction of pituitary gland
0.000 0.774 0.225
E23.6 Other disorders of pituitary gland
0.000 0.775 0.225
E24.9 Cushing's syndrome, unspecified
0.000 0.777 0.223
E22.1 Hyperprolactinaemia
0.000 0.777 0.222
M06.30 Rheumatoid nodule (Multiple sites)
0.000 0.778 0.222
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.779 0.221
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.779 0.221
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.779 0.221
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.779 0.221
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.779 0.221
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.779 0.221
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.779 0.221

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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