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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs2888406
log Bayes Factor = 18.0651
Chromosome 5   position 68,105,237  (GRCh37) Explore rs2888406 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter I Certain infectious and parasitic diseases
1.000 0.000 0.000
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
Chapter XIV Diseases of the genitourinary system
1.000 0.000 0.000
Chapter VII Diseases of the eye and adnexa
0.999 0.001 0.000
Chapter X Diseases of the respiratory system
0.991 0.009 0.000
B95-B98 Bacterial, viral and other infectious agents
0.990 0.010 0.000
N60-N64 Disorders of breast
0.988 0.012 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.986 0.014 0.000
Chapter XX External causes of morbidity and mortality
0.984 0.016 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.984 0.016 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.982 0.018 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.982 0.018 0.000
Chapter XXI Factors influencing health status and contact with health services
0.970 0.030 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.965 0.035 0.000
Chapter II Neoplasms
0.964 0.036 0.000
R70-R79 Abnormal findings on examination of blood, without diagnosis
0.963 0.037 0.000
I73 Other peripheral vascular diseases
0.962 0.038 0.000
I20-I25 Ischaemic heart diseases
0.961 0.039 0.000
R79 Other abnormal findings of blood chemistry
0.951 0.049 0.000
B96.8 Other specified bacterial agents as the cause of diseases classified to other chapters
0.951 0.049 0.000
I73.9 Peripheral vascular disease, unspecified
0.950 0.050 0.000
A00-A09 Intestinal infectious diseases
0.949 0.051 0.000
N17-N19 Renal failure
0.949 0.051 0.000
H02 Other disorders of eyelid
0.948 0.052 0.000
Chapter VIII Diseases of the ear and mastoid process
0.946 0.054 0.000
R79.8 Other specified abnormal findings of blood chemistry
0.942 0.058 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.936 0.064 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.934 0.066 0.000
H04 Disorders of lachrymal system
0.933 0.067 0.000
Z86 Personal history of certain other diseases
0.932 0.068 0.000
N80-N98 Noninflammatory disorders of female genital tract
0.932 0.068 0.000
N60 Benign mammary dysplasia
0.928 0.072 0.000
Z86.6 Personal history of diseases of the nervous system and sense organs
0.926 0.074 0.000
D10-D36 Benign neoplasms
0.924 0.076 0.000
M70-M79 Other soft tissue disorders
0.923 0.077 0.000
M20-M25 Other joint disorders
0.923 0.077 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.922 0.078 0.000
J20-J22 Other acute lower respiratory infections
0.918 0.082 0.000
D17 Benign lipomatous neoplasm
0.917 0.083 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.917 0.083 0.000
N18 Chronic renal failure
0.913 0.087 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.913 0.087 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.911 0.089 0.000
Z86.7 Personal history of diseases of the circulatory system
0.909 0.091 0.000
A30-A49 Other bacterial diseases
0.907 0.093 0.000
B96.2 Escherichia coli [E. coli] as the cause of diseases classified to other chapters
0.899 0.101 0.000
H65-H75 Diseases of middle ear and mastoid
0.897 0.103 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.895 0.105 0.000
N30-N39 Other diseases of urinary system
0.894 0.106 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.893 0.107 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.890 0.110 0.000
A09.9 Gastroenteritis and colitis of unspecified origin
0.890 0.110 0.000
H53-H54 Visual disturbances and blindness
0.890 0.110 0.000
I24 Other acute ischaemic heart diseases
0.883 0.117 0.000
R00 Abnormalities of heart beat
0.883 0.117 0.000
M25 Other joint disorders, not elsewhere classified
0.883 0.117 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.882 0.118 0.000
I60-I69 Cerebrovascular diseases
0.879 0.121 0.000
D17.2 Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs
0.879 0.121 0.000
Chapter VI Diseases of the nervous system
0.877 0.123 0.000
Z95.5 Presence of coronary angioplasty implant and graft
0.875 0.125 0.000
J40-J47 Chronic lower respiratory diseases
0.875 0.125 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.874 0.126 0.000
B25-B34 Other viral diseases
0.872 0.128 0.000
N81 Female genital prolapse
0.871 0.129 0.000
N18.3 Chronic kidney disease, stage 3
0.871 0.129 0.000
H02.3 Blepharochalasis
0.870 0.130 0.000
D50-D53 Nutritional anaemias
0.867 0.133 0.000
J22 Unspecified acute lower respiratory infection
0.865 0.135 0.000
D18 Haemangioma and lymphangioma, any site
0.864 0.136 0.000
Z97 Presence of other devices
0.863 0.137 0.000
H25-H28 Disorders of lens
0.862 0.138 0.000
J90-J94 Other diseases of pleura
0.861 0.139 0.000
J00-J06 Acute upper respiratory infections
0.860 0.140 0.000
M79.6 Pain in limb
0.860 0.140 0.000
N10-N16 Renal tubulo-interstitial diseases
0.858 0.142 0.000
R00.1 Bradycardia, unspecified
0.857 0.143 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.855 0.144 0.000
Chapter V Mental and behavioural disorders
0.855 0.145 0.000
C64-C68 Malignant neoplasms of urinary tract
0.849 0.151 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.848 0.152 0.000
N61 Inflammatory disorders of breast
0.847 0.153 0.000
B96.4 Proteus (mirabilis)(morganii) as the cause of diseases classified to other chapters
0.847 0.153 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.847 0.153 0.000
S40-S49 Injuries to the shoulder and upper arm
0.846 0.154 0.000
H04.2 Epiphora
0.841 0.159 0.000
Z93 Artificial opening status
0.838 0.162 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.831 0.169 0.000
D50 Iron deficiency anaemia
0.828 0.172 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.827 0.173 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.825 0.175 0.000
M20 Acquired deformities of fingers and toes
0.825 0.175 0.000
M79.66 Pain in limb (Lower leg)
0.825 0.175 0.000
Chapter XI Diseases of the digestive system
0.824 0.176 0.000
Z95.4 Presence of other heart-valve replacement
0.823 0.177 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.822 0.178 0.000
D18.0 Haemangioma, any site
0.822 0.178 0.000
W00-W19 Falls
0.820 0.180 0.000
L60-L75 Disorders of skin appendages
0.820 0.180 0.000
N39 Other disorders of urinary system
0.820 0.180 0.000
N81.2 Incomplete uterovaginal prolapse
0.820 0.180 0.000
H10-H13 Disorders of conjunctiva
0.819 0.181 0.000
N93 Other abnormal uterine and vaginal bleeding
0.819 0.181 0.000
H25 Senile cataract
0.818 0.182 0.000
N62 Hypertrophy of breast
0.817 0.183 0.000
N18.9 Chronic renal failure, unspecified
0.816 0.184 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.815 0.185 0.000
J47 Bronchiectasis
0.813 0.187 0.000
I20 Angina pectoris
0.813 0.187 0.000
A41 Other septicaemia
0.811 0.189 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.809 0.191 0.000
H54 Blindness and low vision
0.808 0.192 0.000
I24.9 Acute ischaemic heart disease, unspecified
0.805 0.195 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.805 0.195 0.000
J90 Pleural effusion, not elsewhere classified
0.802 0.198 0.000
I71 Aortic aneurysm and dissection
0.800 0.199 0.000
I25 Chronic ischaemic heart disease
0.800 0.200 0.000
N63 Unspecified lump in breast
0.800 0.200 0.000
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction
0.800 0.200 0.000
B02 Zoster [herpes zoster]
0.797 0.203 0.000
N64 Other disorders of breast
0.795 0.205 0.000
D17.3 Benign lipomatous neoplasm of skin and subcutaneous tissue of other and unspecified sites
0.793 0.207 0.000
G40-G47 Episodic and paroxysmal disorders
0.793 0.207 0.000
H66 Suppurative and unspecified otitis media
0.792 0.208 0.000
D50.9 Iron deficiency anaemia, unspecified
0.791 0.209 0.000
N60.1 Diffuse cystic mastopathy
0.791 0.209 0.000
D00-D09 In situ neoplasms
0.790 0.210 0.000
I65.2 Occlusion and stenosis of carotid artery
0.790 0.210 0.000
N97 Female infertility
0.789 0.211 0.000
B35-B49 Mycoses
0.788 0.212 0.000
F30-F39 Mood [affective] disorders
0.788 0.212 0.000
J09-J18 Influenza and pneumonia
0.787 0.213 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.787 0.213 0.000
R06 Abnormalities of breathing
0.786 0.214 0.000
H04.1 Other disorders of lachrymal gland
0.786 0.214 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.783 0.216 0.000
N60.4 Mammary duct ectasia
0.781 0.219 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.781 0.219 0.000
N31 Neuromuscular dysfunction of bladder, not elsewhere classified
0.780 0.220 0.000
H55-H59 Other disorders of eye and adnexa
0.778 0.222 0.000
Z97.8 Presence of other specified devices
0.778 0.222 0.000
H25.1 Senile nuclear cataract
0.778 0.222 0.000
I72 Other aneurysm
0.777 0.223 0.000
H02.8 Other specified disorders of eyelid
0.777 0.223 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.777 0.223 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.776 0.224 0.000
S42 Fracture of shoulder and upper arm
0.775 0.225 0.000
I80 Phlebitis and thrombophlebitis
0.774 0.226 0.000
S80-S89 Injuries to the knee and lower leg
0.774 0.226 0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters
0.774 0.226 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.772 0.228 0.000
N00-N08 Glomerular diseases
0.771 0.229 0.000
M25.7 Osteophyte
0.770 0.230 0.000
D17.9 Benign lipomatous neoplasm, unspecified
0.768 0.231 0.000
H02.4 Ptosis of eyelid
0.767 0.233 0.000
N39.0 Urinary tract infection, site not specified
0.765 0.235 0.000
V80-V89 Other land transport accidents
0.763 0.236 0.000
Y95 Nosocomial condition
0.763 0.237 0.000
Chapter XXII Codes for special purposes
0.762 0.237 0.000
G40 Epilepsy
0.762 0.238 0.000
M20.4 Other hammer toe(s) (acquired)
0.762 0.238 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.762 0.238 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.762 0.238 0.000
I77 Other disorders of arteries and arterioles
0.762 0.238 0.000
H72 Perforation of tympanic membrane
0.761 0.239 0.000
M20.5 Other deformities of toe(s) (acquired)
0.761 0.239 0.000
A09.0 Other and unspecified gastroenteritis and colitis of infectious origin
0.760 0.240 0.000
D17.1 Benign lipomatous neoplasm of skin and subcutaneous tissue of trunk
0.758 0.242 0.000
N81.8 Other female genital prolapse
0.757 0.243 0.000
H80-H83 Diseases of inner ear
0.757 0.243 0.000
N80 Endometriosis
0.754 0.246 0.000
N85 Other noninflammatory disorders of uterus, except cervix
0.752 0.248 0.000
B34 Viral infection of unspecified site
0.751 0.249 0.000
M21 Other acquired deformities of limbs
0.750 0.250 0.000
Z86.2 Personal history of diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.750 0.250 0.000
J43 Emphysema
0.750 0.250 0.000
N94 Pain and other conditions associated with female genital organs and menstrual cycle
0.749 0.251 0.000
I05-I09 Chronic rheumatic heart diseases
0.749 0.251 0.000
H02.1 Ectropion of eyelid
0.749 0.251 0.000
M25.4 Effusion of joint
0.747 0.253 0.000
Z95.8 Presence of other cardiac and vascular implants and grafts
0.747 0.253 0.000
K00-K14 Diseases of oral cavity, salivary glands and jaws
0.746 0.254 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.746 0.254 0.000
K70-K77 Diseases of liver
0.745 0.255 0.000
N60.8 Other benign mammary dysplasias
0.745 0.255 0.000
R50-R69 General symptoms and signs
0.745 0.255 0.000
M71 Other bursopathies
0.744 0.256 0.000
N99-N99 Other disorders of the genitourinary system
0.743 0.257 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.743 0.257 0.000
H04.5 Stenosis and insufficiency of lachrymal passages
0.742 0.258 0.000
I87 Other disorders of veins
0.741 0.259 0.000
H25.9 Senile cataract, unspecified
0.741 0.259 0.000
K90-K93 Other diseases of the digestive system
0.740 0.260 0.000
R00.0 Tachycardia, unspecified
0.740 0.260 0.000
L50-L54 Urticaria and erythema
0.739 0.261 0.000
I78 Diseases of capillaries
0.739 0.261 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.737 0.263 0.000
I95 Hypotension
0.737 0.263 0.000
B02.9 Zoster without complication
0.737 0.263 0.000
Z95.3 Presence of xenogenic heart valve
0.736 0.264 0.000
N20-N23 Urolithiasis
0.736 0.264 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.736 0.264 0.000
D10 Benign neoplasm of mouth and pharynx
0.736 0.264 0.000
M25.5 Pain in joint
0.735 0.265 0.000
J00 Acute nasopharyngitis [common cold]
0.735 0.265 0.000
R00.2 Palpitations
0.734 0.266 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.734 0.266 0.000
H65 Nonsuppurative otitis media
0.731 0.268 0.000
M65-M68 Disorders of synovium and tendon
0.731 0.269 0.000
N13 Obstructive and reflux uropathy
0.730 0.269 0.000
H40-H42 Glaucoma
0.730 0.270 0.000
A49 Bacterial infection of unspecified site
0.730 0.270 0.000
H54.4 Blindness, one eye
0.730 0.270 0.000
M80-M85 Disorders of bone density and structure
0.727 0.273 0.000
B97 Viral agents as the cause of diseases classified to other chapters
0.726 0.273 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.726 0.273 0.000
J42 Unspecified chronic bronchitis
0.726 0.274 0.000
N86 Erosion and ectropion of cervix uteri
0.725 0.274 0.000
G40.9 Epilepsy, unspecified
0.725 0.275 0.000
D21 Other benign neoplasms of connective and other soft tissue
0.724 0.276 0.000
V20-V29 Motorcycle rider injured in transport accident
0.721 0.279 0.000
C64 Malignant neoplasm of kidney, except renal pelvis
0.721 0.279 0.000
L72 Follicular cysts of skin and subcutaneous tissue
0.718 0.282 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.718 0.282 0.000
N60.3 Fibrosclerosis of breast
0.717 0.282 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.717 0.282 0.000
I30-I52 Other forms of heart disease
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
B99-B99 Other infectious diseases
0.717 0.283 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.717 0.283 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.717 0.283 0.000
B65-B83 Helminthiases
0.717 0.283 0.000
B50-B64 Protozoal diseases
0.717 0.283 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.717 0.283 0.000
B15-B19 Viral hepatitis
0.717 0.283 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.717 0.283 0.000
A80-A89 Viral infections of the central nervous system
0.717 0.283 0.000
A75-A79 Rickettsioses
0.717 0.283 0.000
A70-A74 Other diseases caused by chlamydiae
0.717 0.283 0.000
A65-A69 Other spirochaetal diseases
0.717 0.283 0.000
A20-A28 Certain zoonotic bacterial diseases
0.717 0.283 0.000
A15-A19 Tuberculosis
0.717 0.283 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
H46-H48 Disorders of optic nerve and visual pathways
0.716 0.284 0.000
D36 Benign neoplasm of other and unspecified sites
0.716 0.284 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.715 0.285 0.000
J95-J99 Other diseases of the respiratory system
0.715 0.285 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.712 0.288 0.000
Y84.8 Other medical procedures
0.712 0.288 0.000
H02.0 Entropion and trichiasis of eyelid
0.712 0.288 0.000
W20-W49 Exposure to inanimate mechanical forces
0.711 0.289 0.000
F32 Depressive episode
0.711 0.289 0.000
S20-S29 Injuries to the thorax
0.710 0.290 0.000
R74 Abnormal serum enzyme levels
0.710 0.290 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.709 0.291 0.000
N17 Acute renal failure
0.709 0.291 0.000
A08 Viral and other specified intestinal infections
0.709 0.291 0.000
V10-V19 Pedal cyclist injured in transport accident
0.708 0.292 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.707 0.293 0.000
Z89 Acquired absence of limb
0.706 0.294 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.706 0.294 0.000
Y35-Y36 Legal intervention and operations of war
0.706 0.294 0.000
Y10-Y34 Event of undetermined intent
0.706 0.294 0.000
Y00-Y09 Assault
0.706 0.294 0.000
X85-X99 Assault
0.706 0.294 0.000
X60-X84 Intentional self-harm
0.706 0.294 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.706 0.294 0.000
X50-X57 Overexertion, travel and privation
0.706 0.294 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.706 0.294 0.000
X30-X39 Exposure to forces of nature
0.706 0.294 0.000
X20-X29 Contact with venomous animals and plants
0.706 0.294 0.000
X10-X19 Contact with heat and hot substances
0.706 0.294 0.000
X00-X09 Exposure to smoke, fire and flames
0.706 0.294 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.706 0.294 0.000
W75-W84 Other accidental threats to breathing
0.706 0.294 0.000
W65-W74 Accidental drowning and submersion
0.706 0.294 0.000
W50-W64 Exposure to animate mechanical forces
0.706 0.294 0.000
V98-V99 Other and unspecified transport accidents
0.706 0.294 0.000
V95-V97 Air and space transport accidents
0.706 0.294 0.000
V90-V94 Water transport accidents
0.706 0.294 0.000
V70-V79 Bus occupant injured in transport accident
0.706 0.294 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.706 0.294 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.706 0.294 0.000
V40-V49 Car occupant injured in transport accident
0.706 0.294 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.706 0.294 0.000
V01-V09 Pedestrian injured in transport accident
0.706 0.294 0.000
H06 Disorders of lachrymal system and orbit in diseases classified elsewhere
0.706 0.294 0.000
H05 Disorders of orbit
0.706 0.294 0.000
H03 Disorders of eyelid in diseases classified elsewhere
0.706 0.294 0.000
A41.8 Other specified septicaemia
0.705 0.295 0.000
J60-J70 Lung diseases due to external agents
0.705 0.295 0.000
R06.0 Dyspnoea
0.705 0.295 0.000
B96.7 Clostridium perfringens [C. perfringens] as the cause of diseases classified to other chapters
0.704 0.296 0.000
B96.6 Bacillus fragilis [B. fragilis] as the cause of diseases classified to other chapters
0.704 0.296 0.000
B96.3 Haemophilus influenzae [H. influenzae] as the cause of diseases classified to other chapters
0.704 0.296 0.000
B96.0 Mycoplasma pneumoniae [M. pneumoniae] as the cause of diseases classified to other chapters
0.704 0.296 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.704 0.296 0.000
I25.2 Old myocardial infarction
0.704 0.296 0.000
I74 Arterial embolism and thrombosis
0.703 0.297 0.000
L60 Nail disorders
0.700 0.299 0.000
H30-H36 Disorders of choroid and retina
0.700 0.300 0.000
N81.1 Cystocele
0.700 0.300 0.000
H43-H45 Disorders of vitreous body and globe
0.699 0.301 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.699 0.301 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.699 0.301 0.000
M79.64 Pain in limb (Hand)
0.699 0.301 0.000
Z83 Family history of other specific disorders
0.698 0.302 0.000
Z93.6 Other artificial openings of urinary tract status
0.698 0.302 0.000
I67 Other cerebrovascular diseases
0.698 0.302 0.000
B96.5 Pseudomonas (aeruginosa)(mallei)(pseudomallei) as the cause of diseases classified to other chapters
0.697 0.303 0.000
C67 Malignant neoplasm of bladder
0.697 0.303 0.000
H52 Disorders of refraction and accommodation
0.696 0.304 0.000
N25-N29 Other disorders of kidney and ureter
0.696 0.304 0.000
H90-H95 Other disorders of ear
0.696 0.304 0.000
Y83.1 Surgical operation with implant of artificial internal device
0.696 0.304 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.695 0.304 0.000
D14 Benign neoplasm of middle ear and respiratory system
0.695 0.305 0.000
Z99.3 Dependence on wheelchair
0.694 0.306 0.000
R52 Pain, not elsewhere classified
0.694 0.306 0.000
C81 Hodgkin's disease
0.694 0.306 0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.693 0.307 0.000
M91-M94 Chondropathies
0.692 0.308 0.000
M60-M63 Disorders of muscles
0.692 0.308 0.000
M00-M03 Infectious arthropathies
0.692 0.308 0.000
Z13 Special screening examination for other diseases and disorders
0.691 0.309 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.691 0.309 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.691 0.309 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.691 0.309 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.691 0.309 0.000
R78 Findings of drugs and other substances, not normally found in blood
0.691 0.309 0.000
R77 Other abnormalities of plasma proteins
0.691 0.309 0.000
R76 Other abnormal immunological findings in serum
0.691 0.309 0.000
R70 Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity
0.691 0.309 0.000
R75 Laboratory evidence of human immunodeficiency virus [HIV]
0.691 0.309 0.000
R71 Abnormality of red blood cells
0.691 0.309 0.000
K02 Dental caries
0.691 0.309 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.690 0.310 0.000
H11 Other disorders of conjunctiva
0.690 0.310 0.000
M24 Other specific joint derangements
0.690 0.310 0.000
Y83.8 Other surgical procedures
0.690 0.310 0.000
R47-R49 Symptoms and signs involving speech and voice
0.690 0.310 0.000
I73.8 Other specified peripheral vascular diseases
0.690 0.310 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.690 0.310 0.000
Z93.3 Colostomy status
0.690 0.310 0.000
I23 Certain current complications following acute myocardial infarction
0.689 0.311 0.000
I22 Subsequent myocardial infarction
0.689 0.311 0.000
D35 Benign neoplasm of other and unspecified endocrine glands
0.688 0.312 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.688 0.312 0.000
S90-S99 Injuries to the ankle and foot
0.687 0.313 0.000
M25.8 Other specified joint disorders
0.687 0.313 0.000
I70 Atherosclerosis
0.685 0.315 0.000
Z97.5 Presence of (intra-uterine) contraceptive device
0.685 0.315 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.684 0.315 0.000
R73 Elevated blood glucose level
0.684 0.316 0.000
B25 Cytomegaloviral disease
0.684 0.316 0.000
K35-K38 Diseases of appendix
0.684 0.316 0.000
M86-M90 Other osteopathies
0.683 0.317 0.000
I83 Varicose veins of lower extremities
0.683 0.317 0.000
D17.0 Benign lipomatous neoplasm of skin and subcutaneous tissue of head, face and neck
0.682 0.317 0.000
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.682 0.318 0.000
R79.9 Abnormal finding of blood chemistry, unspecified
0.682 0.318 0.000
R79.0 Abnormal level of blood mineral
0.682 0.318 0.000
G35-G37 Demyelinating diseases of the central nervous system
0.681 0.319 0.000
N39.3 Stress incontinence
0.681 0.319 0.000
A07 Other protozoal intestinal diseases
0.681 0.319 0.000
A06 Amoebiasis
0.681 0.319 0.000
A05 Other bacterial foodborne intoxications
0.681 0.319 0.000
A03 Shigellosis
0.681 0.319 0.000
A02 Other Salmonella infections
0.681 0.319 0.000
A01 Typhoid and paratyphoid fevers
0.681 0.319 0.000
A00 Cholera
0.681 0.319 0.000
Z09 Follow-up examination after treatment for conditions other than malignant neoplasms
0.680 0.320 0.000
S70-S79 Injuries to the hip and thigh
0.680 0.320 0.000
H02.7 Other degenerative disorders of eyelid and periocular area
0.680 0.320 0.000
H02.6 Xanthelasma of eyelid
0.680 0.320 0.000
H02.5 Other disorders affecting eyelid function
0.680 0.320 0.000
H02.2 Lagophthalmos
0.680 0.320 0.000
W18 Other fall on same level
0.680 0.320 0.000
D17.5 Benign lipomatous neoplasm of intra-abdominal organs
0.679 0.321 0.000
Z93.5 Cystostomy status
0.679 0.321 0.000
D80-D89 Certain disorders involving the immune mechanism
0.678 0.321 0.000
H01 Other inflammation of eyelid
0.677 0.323 0.000
L90 Atrophic disorders of skin
0.677 0.323 0.000
M79.7 Fibromyalgia
0.676 0.324 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.675 0.325 0.000
M79.69 Pain in limb (Site unspecified)
0.675 0.325 0.000
N80.1 Endometriosis of ovary
0.675 0.325 0.000
D50.8 Other iron deficiency anaemias
0.674 0.326 0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.674 0.326 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.672 0.327 0.000
Z86.3 Personal history of endocrine, nutritional and metabolic diseases
0.672 0.328 0.000
B95.1 Streptococcus, group B, as the cause of diseases classified to other chapters
0.671 0.329 0.000
Z84 Family history of other conditions
0.671 0.329 0.000
Z81 Family history of mental and behavioural disorders
0.671 0.329 0.000
I24.8 Other forms of acute ischaemic heart disease
0.671 0.329 0.000
R25 Abnormal involuntary movements
0.671 0.329 0.000
A41.9 Septicaemia, unspecified
0.670 0.330 0.000
T79-T79 Certain early complications of trauma
0.670 0.330 0.000
T33-T35 Frostbite
0.670 0.330 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.670 0.330 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.670 0.330 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.670 0.330 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.670 0.330 0.000
T00-T07 Injuries involving multiple body regions
0.670 0.330 0.000
S10-S19 Injuries to the neck
0.670 0.330 0.000
C79 Secondary malignant neoplasm of other sites
0.670 0.330 0.000
Y83.5 Amputation of limb(s)
0.669 0.331 0.000
D17.6 Benign lipomatous neoplasm of spermatic cord
0.669 0.331 0.000
H04.9 Disorder of lachrymal system, unspecified
0.669 0.331 0.000
H04.8 Other disorders of lachrymal system
0.669 0.331 0.000
H04.6 Other changes in lachrymal passages
0.669 0.331 0.000
H04.4 Chronic inflammation of lachrymal passages
0.669 0.331 0.000
H04.3 Acute and unspecified inflammation of lachrymal passages
0.669 0.331 0.000
H04.0 Dacryoadenitis
0.669 0.331 0.000
G30-G32 Other degenerative diseases of the nervous system
0.668 0.331 0.000
H71 Cholesteatoma of middle ear
0.668 0.332 0.000
N98 Complications associated with artificial fertilisation
0.668 0.332 0.000
N91 Absent, scanty and rare menstruation
0.668 0.332 0.000
N82 Fistulae involving female genital tract
0.668 0.332 0.000
N96 Habitual aborter
0.668 0.332 0.000
N93.0 Postcoital and contact bleeding
0.667 0.333 0.000
B96.1 Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
0.667 0.333 0.000
H66.9 Otitis media, unspecified
0.667 0.333 0.000
N30 Cystitis
0.666 0.334 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.666 0.334 0.000
N31.9 Neuromuscular dysfunction of bladder, unspecified
0.666 0.334 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.665 0.335 0.000
N60.9 Benign mammary dysplasia, unspecified
0.665 0.335 0.000
N60.2 Fibroadenosis of breast
0.665 0.335 0.000
N60.0 Solitary cyst of breast
0.665 0.335 0.000
I85 Oesophageal varices
0.665 0.335 0.000
M45-M49 Spondylopathies
0.665 0.335 0.000
B34.9 Viral infection, unspecified
0.664 0.336 0.000
S42.2 Fracture of upper end of humerus
0.664 0.336 0.000
N12 Tubulo-interstitial nephritis, not specified as acute or chronic
0.663 0.336 0.000
M70 Soft tissue disorders related to use, overuse and pressure
0.663 0.337 0.000
D32 Benign neoplasm of meninges
0.662 0.338 0.000
D31 Benign neoplasm of eye and adnexa
0.662 0.338 0.000
D30 Benign neoplasm of urinary organs
0.662 0.338 0.000
D29 Benign neoplasm of male genital organs
0.662 0.338 0.000
D28 Benign neoplasm of other and unspecified female genital organs
0.662 0.338 0.000
D26 Other benign neoplasms of uterus
0.662 0.338 0.000
D20 Benign neoplasm of soft tissue of retroperitoneum and peritoneum
0.662 0.338 0.000
D19 Benign neoplasm of mesothelial tissue
0.662 0.338 0.000
D16 Benign neoplasm of bone and articular cartilage
0.662 0.338 0.000
D15 Benign neoplasm of other and unspecified intrathoracic organs
0.662 0.338 0.000
D34 Benign neoplasm of thyroid gland
0.662 0.338 0.000
N81.5 Vaginal enterocele
0.662 0.338 0.000
M77 Other enthesopathies
0.661 0.338 0.000
M76 Enthesopathies of lower limb, excluding foot
0.661 0.338 0.000
M73 Soft tissue disorders in diseases classified elsewhere
0.661 0.338 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.661 0.338 0.000
M34 Systemic sclerosis
0.661 0.338 0.000
M33 Dermatopolymyositis
0.661 0.338 0.000
M32 Systemic lupus erythematosus
0.661 0.338 0.000
M31 Other necrotising vasculopathies
0.661 0.338 0.000
M30 Polyarteritis nodosa and related conditions
0.661 0.338 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.661 0.338 0.000
N92 Excessive, frequent and irregular menstruation
0.661 0.339 0.000
M05-M14 Inflammatory polyarthropathies
0.661 0.339 0.000
I21 Acute myocardial infarction
0.660 0.340 0.000
Z86.1 Personal history of infectious and parasitic diseases
0.660 0.340 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.660 0.340 0.000
R72 Abnormality of white blood cells, not elsewhere classified
0.660 0.340 0.000
J43.9 Emphysema, unspecified
0.660 0.340 0.000
N94.1 Dyspareunia
0.660 0.340 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.660 0.340 0.000
M75 Shoulder lesions
0.659 0.341 0.000
J21 Acute bronchiolitis
0.658 0.342 0.000
J20 Acute bronchitis
0.658 0.342 0.000
D17.7 Benign lipomatous neoplasm of other sites
0.658 0.342 0.000
D17.4 Benign lipomatous neoplasm of intrathoracic organs
0.658 0.342 0.000
N93.9 Abnormal uterine and vaginal bleeding, unspecified
0.657 0.342 0.000
D55-D59 Haemolytic anaemias
0.657 0.343 0.000
Z11 Special screening examination for infectious and parasitic diseases
0.657 0.343 0.000
H66.3 Other chronic suppurative otitis media
0.657 0.343 0.000
N64.5 Other signs and symptoms in breast
0.656 0.343 0.000
M79.0 Rheumatism, unspecified
0.655 0.345 0.000
G90-G99 Other disorders of the nervous system
0.655 0.345 0.000
N18.8 Other chronic renal failure
0.654 0.345 0.000
N18.2 Chronic kidney disease, stage 2
0.654 0.345 0.000
N18.1 Chronic kidney disease, stage 1
0.654 0.345 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.655 0.345 0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.654 0.346 0.000
Z97.4 Presence of external hearing-aid
0.654 0.346 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.654 0.346 0.000
J03 Acute tonsillitis
0.654 0.346 0.000
L20-L30 Dermatitis and eczema
0.653 0.347 0.000
I20.9 Angina pectoris, unspecified
0.652 0.348 0.000
Y83.2 Surgical operation with anastomosis, bypass or graft
0.651 0.348 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.651 0.349 0.000
K02.9 Dental caries, unspecified
0.651 0.349 0.000
A48 Other bacterial diseases, not elsewhere classified
0.650 0.350 0.000
A44 Bartonellosis
0.650 0.350 0.000
A43 Nocardiosis
0.650 0.350 0.000
A42 Actinomycosis
0.650 0.350 0.000
A40 Streptococcal septicaemia
0.650 0.350 0.000
A39 Meningococcal infection
0.650 0.350 0.000
A37 Whooping cough
0.650 0.350 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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