TreeWAS – Variant ID: rs3093059

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
Z42.1 Follow-up care involving plastic surgery of breast	0.453	0.547	0.000
Z42 Follow-up care involving plastic surgery	0.115	0.885	0.000
Z42.4 Follow-up care involving plastic surgery of lower extremity	0.086	0.914	0.000
Z42.9 Follow-up care involving plastic surgery, unspecified	0.083	0.917	0.000
Z42.8 Follow-up care involving plastic surgery of other body part	0.083	0.917	0.000
Z42.3 Follow-up care involving plastic surgery of upper extremity	0.075	0.924	0.000
Z42.2 Follow-up care involving plastic surgery of other parts of trunk	0.071	0.929	0.000
Z42.0 Follow-up care involving plastic surgery of head and neck	0.071	0.929	0.000
K92.1 Melaena	0.050	0.950	0.000
K92 Other diseases of digestive system	0.045	0.955	0.000
K92.0 Haematemesis	0.044	0.956	0.000
K90 Intestinal malabsorption	0.037	0.963	0.000
K90-K93 Other diseases of the digestive system	0.037	0.963	0.000
K90.0 Coeliac disease	0.036	0.964	0.000
K90.9 Intestinal malabsorption, unspecified	0.033	0.967	0.000
K92.8 Other specified diseases of digestive system	0.032	0.967	0.000
K92.9 Disease of digestive system, unspecified	0.032	0.968	0.000
K90.8 Other intestinal malabsorption	0.027	0.973	0.000
K90.3 Pancreatic steatorrhoea	0.027	0.973	0.000
K90.2 Blind loop syndrome, not elsewhere classified	0.027	0.973	0.000
K90.1 Tropical sprue	0.027	0.973	0.000
K93 Disorders of other digestive organs in diseases classified elsewhere	0.027	0.973	0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.026	0.974	0.000
K91 Postprocedural disorders of digestive system, not elsewhere classified	0.024	0.976	0.000
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere	0.019	0.980	0.000
K93.1 Megacolon in Chagas' disease	0.019	0.980	0.000
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands	0.019	0.980	0.000
K91.0 Vomiting following gastro-intestinal surgery	0.018	0.982	0.000
K91.3 Postoperative intestinal obstruction	0.018	0.982	0.000
K91.9 Postprocedural disorder of digestive system, unspecified	0.017	0.983	0.000
K91.5 Postcholecystectomy syndrome	0.017	0.983	0.000
K91.2 Postsurgical malabsorption, not elsewhere classified	0.017	0.983	0.000
K91.1 Postgastric surgery syndromes	0.017	0.983	0.000
K91.4 Colostomy and enterostomy malfunction	0.016	0.984	0.000
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified	0.015	0.985	0.000
K74.6 Other and unspecified cirrhosis of liver	0.014	0.986	0.000
K92.2 Gastro-intestinal haemorrhage, unspecified	0.010	0.990	0.000
M46.92 Inflammatory spondylopathy, unspecified (Cervical region)	0.009	0.991	0.000
M46.9 Inflammatory spondylopathy, unspecified	0.009	0.991	0.000
M46.96 Inflammatory spondylopathy, unspecified (Lumbar region)	0.008	0.991	0.000
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)	0.008	0.992	0.000
M46 Other inflammatory spondylopathies	0.007	0.993	0.000
M46.98 Inflammatory spondylopathy, unspecified (Sacral and sacrococcygeal region)	0.007	0.993	0.000
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)	0.007	0.993	0.000
M46.95 Inflammatory spondylopathy, unspecified (Thoracolumbar region)	0.007	0.993	0.000
M46.94 Inflammatory spondylopathy, unspecified (Thoracic region)	0.007	0.993	0.000
M46.93 Inflammatory spondylopathy, unspecified (Cervicothoracic region)	0.007	0.993	0.000
M46.91 Inflammatory spondylopathy, unspecified (Occipito-atlanto-axial region)	0.007	0.993	0.000
M46.90 Inflammatory spondylopathy, unspecified (Multiple sites in spine)	0.007	0.993	0.000
M46.4 Discitis, unspecified	0.006	0.994	0.000
K74 Fibrosis and cirrhosis of liver	0.005	0.995	0.000
M46.46 Discitis, unspecified (Lumbar region)	0.005	0.995	0.000
M46.8 Other specified inflammatory spondylopathies	0.005	0.995	0.000
M46.5 Other infective spondylopathies	0.005	0.995	0.000
M46.3 Infection of intervertebral disk (pyogenic)	0.005	0.995	0.000
M46.2 Osteomyelitis of vertebra	0.005	0.995	0.000
M46.1 Sacro-iliitis, not elsewhere classified	0.005	0.995	0.000
M46.0 Spinal enthesopathy	0.005	0.995	0.000
D45 Polycythaemia vera	0.005	0.995	0.000
Z45.8 Adjustment and management of other implanted devices	0.000	0.995	0.005
K74.5 Biliary cirrhosis, unspecified	0.005	0.995	0.000
M46.49 Discitis, unspecified (Site unspecified)	0.004	0.995	0.000
M46.48 Discitis, unspecified (Sacral and sacrococcygeal region)	0.004	0.995	0.000
M46.47 Discitis, unspecified (Lumbosacral region)	0.004	0.995	0.000
M46.45 Discitis, unspecified (Thoracolumbar region)	0.004	0.995	0.000
M46.44 Discitis, unspecified (Thoracic region)	0.004	0.995	0.000
M46.43 Discitis, unspecified (Cervicothoracic region)	0.004	0.995	0.000
M46.42 Discitis, unspecified (Cervical region)	0.004	0.995	0.000
M46.41 Discitis, unspecified (Occipito-atlanto-axial region)	0.004	0.995	0.000
M46.40 Discitis, unspecified (Multiple sites in spine)	0.004	0.995	0.000
Z12.1 Special screening examination for neoplasm of intestinal tract	0.000	0.995	0.005
M45-M49 Spondylopathies	0.004	0.996	0.000
M81.98 Osteoporosis, unspecified (Other)	0.004	0.996	0.000
K74.4 Secondary biliary cirrhosis	0.004	0.996	0.000
K74.2 Hepatic fibrosis with hepatic sclerosis	0.004	0.996	0.000
K74.1 Hepatic sclerosis	0.004	0.996	0.000
R03.1 Nonspecific low blood-pressure reading	0.000	0.996	0.004
M85.85 Other specified disorders of bone density and structure (Pelvic region and thigh)	0.004	0.996	0.000
M46.09 Spinal enthesopathy (Site unspecified)	0.004	0.996	0.000
M46.08 Spinal enthesopathy (Sacral and sacrococcygeal region)	0.004	0.996	0.000
M46.07 Spinal enthesopathy (Lumbosacral region)	0.004	0.996	0.000
M46.06 Spinal enthesopathy (Lumbar region)	0.004	0.996	0.000
M46.05 Spinal enthesopathy (Thoracolumbar region)	0.004	0.996	0.000
M46.04 Spinal enthesopathy (Thoracic region)	0.004	0.996	0.000
M46.03 Spinal enthesopathy (Cervicothoracic region)	0.004	0.996	0.000
M46.02 Spinal enthesopathy (Cervical region)	0.004	0.996	0.000
M46.01 Spinal enthesopathy (Occipito-atlanto-axial region)	0.004	0.996	0.000
M46.00 Spinal enthesopathy (Multiple sites in spine)	0.004	0.996	0.000
M46.19 Sacroiliitis, not elsewhere classified-Site unspe	0.004	0.996	0.000
M46.18 Sacroiliitis, not elsewhere classified-Sacral/sacrococ	0.004	0.996	0.000
M46.17 Sacroiliitis, not elsewhere classified-Lumbosacral	0.004	0.996	0.000
M46.16 Sacroiliitis, not elsewhere classified-Lumbar	0.004	0.996	0.000
M46.15 Sacroiliitis, not elsewhere classified-Thoracolumbar	0.004	0.996	0.000
M46.14 Sacroiliitis, not elsewhere classified-Thoracic	0.004	0.996	0.000
M46.13 Sacroiliitis, not elsewhere classified-Cervicothoracic	0.004	0.996	0.000
M46.12 Sacroiliitis, not elsewhere classified-Cervical	0.004	0.996	0.000
M46.11 Sacroiliitis, not elsewhere classified-Occipit-atl-axl	0.004	0.996	0.000
M46.10 Sacroiliitis, not elsewhere classified-Mult site	0.004	0.996	0.000
M46.29 Osteomyelitis of vertebra (Site unspecified)	0.004	0.996	0.000
M46.28 Osteomyelitis of vertebra (Sacral and sacrococcygeal region)	0.004	0.996	0.000
M46.27 Osteomyelitis of vertebra (Lumbosacral region)	0.004	0.996	0.000
M46.26 Osteomyelitis of vertebra (Lumbar region)	0.004	0.996	0.000
M46.25 Osteomyelitis of vertebra (Thoracolumbar region)	0.004	0.996	0.000
M46.24 Osteomyelitis of vertebra (Thoracic region)	0.004	0.996	0.000
M46.23 Osteomyelitis of vertebra (Cervicothoracic region)	0.004	0.996	0.000
M46.22 Osteomyelitis of vertebra (Cervical region)	0.004	0.996	0.000
M46.21 Osteomyelitis of vertebra (Occipito-atlanto-axial region)	0.004	0.996	0.000
M46.20 Osteomyelitis of vertebra (Multiple sites in spine)	0.004	0.996	0.000
M46.39 Infection of intervertebral disc (pyogenic) (Site unspecified)	0.004	0.996	0.000
M46.38 Infection of intervertebral disc (pyogenic) (Sacral and sacrococcygeal region)	0.004	0.996	0.000
M46.37 Infection of intervertebral disc (pyogenic) (Lumbosacral region)	0.004	0.996	0.000
M46.36 Infection of intervertebral disc (pyogenic) (Lumbar region)	0.004	0.996	0.000
M46.35 Infection of intervertebral disc (pyogenic) (Thoracolumbar region)	0.004	0.996	0.000
M46.34 Infection of intervertebral disc (pyogenic) (Thoracic region)	0.004	0.996	0.000
M46.33 Infection of intervertebral disc (pyogenic) (Cervicothoracic region)	0.004	0.996	0.000
M46.32 Infection of intervertebral disc (pyogenic) (Cervical region)	0.004	0.996	0.000
M46.31 Infection of intervertebral disc (pyogenic) (Occipito-atlanto-axial region)	0.004	0.996	0.000
M46.30 Infection of intervertebral disc (pyogenic) (Multiple sites in spine)	0.004	0.996	0.000
M46.59 Other infective spondylopathies (Site unspecified)	0.004	0.996	0.000
M46.58 Other infective spondylopathies (Sacral and sacrococcygeal region)	0.004	0.996	0.000
M46.57 Other infective spondylopathies (Lumbosacral region)	0.004	0.996	0.000
M46.56 Other infective spondylopathies (Lumbar region)	0.004	0.996	0.000
M46.55 Other infective spondylopathies (Thoracolumbar region)	0.004	0.996	0.000
M46.54 Other infective spondylopathies (Thoracic region)	0.004	0.996	0.000
M46.53 Other infective spondylopathies (Cervicothoracic region)	0.004	0.996	0.000
M46.52 Other infective spondylopathies (Cervical region)	0.004	0.996	0.000
M46.51 Other infective spondylopathies (Occipito-atlanto-axial region)	0.004	0.996	0.000
M46.50 Other infective spondylopathies (Multiple sites in spine)	0.004	0.996	0.000
M46.89 Other specified inflammatory spondylopathies (Site unspecified)	0.004	0.996	0.000
M46.88 Other specified inflammatory spondylopathies (Sacral and sacrococcygeal region)	0.004	0.996	0.000
M46.87 Other specified inflammatory spondylopathies (Lumbosacral region)	0.004	0.996	0.000
M46.86 Other specified inflammatory spondylopathies (Lumbar region)	0.004	0.996	0.000
M46.85 Other specified inflammatory spondylopathies (Thoracolumbar region)	0.004	0.996	0.000
M46.84 Other specified inflammatory spondylopathies (Thoracic region)	0.004	0.996	0.000
M46.83 Other specified inflammatory spondylopathies (Cervicothoracic region)	0.004	0.996	0.000
M46.82 Other specified inflammatory spondylopathies (Cervical region)	0.004	0.996	0.000
M46.81 Other specified inflammatory spondylopathies (Occipito-atlanto-axial region)	0.004	0.996	0.000
M46.80 Other specified inflammatory spondylopathies (Multiple sites in spine)	0.004	0.996	0.000
M25.7 Osteophyte	0.004	0.996	0.000
B07 Viral warts	0.004	0.996	0.000
M25.76 Osteophyte (Lower leg)	0.004	0.996	0.000
M25 Other joint disorders, not elsewhere classified	0.004	0.996	0.000
M35 Other systemic involvement of connective tissue	0.004	0.996	0.000
M20-M25 Other joint disorders	0.004	0.996	0.000
M80-M85 Disorders of bone density and structure	0.004	0.996	0.000
M85 Other disorders of bone density and structure	0.004	0.996	0.000
Z45.0 Adjustment and management of cardiac pacemaker	0.000	0.996	0.004
L40.5 Arthropathic psoriasis	0.000	0.996	0.004
M25.4 Effusion of joint	0.004	0.996	0.000
M85.8 Other specified disorders of bone density and structure	0.004	0.996	0.000
M81 Osteoporosis without pathological fracture	0.004	0.996	0.000
D05.9 Carcinoma in situ of breast, unspecified	0.004	0.996	0.000
M34.9 Systemic sclerosis, unspecified	0.004	0.996	0.000
M35.1 Other overlap syndromes	0.004	0.996	0.000
M86-M90 Other osteopathies	0.004	0.996	0.000
M34 Systemic sclerosis	0.004	0.996	0.000
M35.0 Sicca syndrome [Sjogren]	0.004	0.996	0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs	0.004	0.996	0.000
M89 Other disorders of bone	0.003	0.996	0.000
M25.47 Effusion of joint (Ankle and foot)	0.003	0.996	0.000
Z45 Adjustment and management of implanted device	0.000	0.997	0.003
D37.9 Digestive organ, unspecified	0.003	0.997	0.000
M81.9 Osteoporosis, unspecified	0.003	0.997	0.000
M49 Spondylopathies in diseases classified elsewhere	0.003	0.997	0.000
J34.8 Other specified disorders of nose and nasal sinuses	0.003	0.997	0.000
K74.3 Primary biliary cirrhosis	0.003	0.997	0.000
M25.3 Other instability of joint	0.003	0.997	0.000
M31 Other necrotising vasculopathies	0.003	0.997	0.000
D37.5 Rectum	0.003	0.997	0.000
M25.72 Osteophyte (Upper arm)	0.003	0.997	0.000
M89.9 Disorder of bone, unspecified	0.003	0.997	0.000
M30 Polyarteritis nodosa and related conditions	0.003	0.997	0.000
K74.0 Hepatic fibrosis	0.003	0.997	0.000
M35.7 Hypermobility syndrome	0.003	0.997	0.000
D50.9 Iron deficiency anaemia, unspecified	0.003	0.997	0.000
O75.6 Delayed delivery after spontaneous or unspecified rupture of membranes	0.003	0.997	0.000
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium	0.003	0.997	0.000
M47 Spondylosis	0.003	0.997	0.000
Z45.1 Adjustment and management of infusion pump	0.000	0.997	0.003
M33 Dermatopolymyositis	0.003	0.997	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.003	0.997	0.000
M25.45 Effusion of joint (Pelvic region and thigh)	0.003	0.997	0.000
M89.96 Disorder of bone, unspecified (Lower leg)	0.003	0.997	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.003	0.997	0.000
D37.4 Colon	0.003	0.997	0.000
M86 Osteomyelitis	0.003	0.997	0.000
M47.90 Spondylosis, unspecified (Multiple sites in spine)	0.003	0.997	0.000
M81.4 Drug-induced osteoporosis	0.003	0.997	0.000
M24 Other specific joint derangements	0.003	0.997	0.000
M21 Other acquired deformities of limbs	0.003	0.997	0.000
M25.77 Osteophyte (Ankle and foot)	0.003	0.997	0.000
M85.6 Other cyst of bone	0.003	0.997	0.000
M25.75 Osteophyte (Pelvic region and thigh)	0.003	0.997	0.000
D50.8 Other iron deficiency anaemias	0.003	0.997	0.000
D37.6 Liver, gallbladder and bile ducts	0.003	0.997	0.000
M25.79 Osteophyte (Site unspecified)	0.003	0.997	0.000
M25.73 Osteophyte (Forearm)	0.003	0.997	0.000
M25.70 Osteophyte (Multiple sites)	0.003	0.997	0.000
M82 Osteoporosis in diseases classified elsewhere	0.003	0.997	0.000
M80 Osteoporosis with pathological fracture	0.003	0.997	0.000
M87 Osteonecrosis	0.003	0.997	0.000
D37-D48 Neoplasms of uncertain or unknown behaviour	0.003	0.997	0.000
M25.74 Osteophyte (Hand)	0.003	0.997	0.000
M25.2 Flail joint	0.003	0.997	0.000
M25.1 Fistula of joint	0.003	0.997	0.000
M35.9 Systemic involvement of connective tissue, unspecified	0.003	0.997	0.000
M35.8 Other specified systemic involvement of connective tissue	0.003	0.997	0.000
M35.6 Relapsing panniculitis [Weber-Christian]	0.003	0.997	0.000
M35.5 Multifocal fibrosclerosis	0.003	0.997	0.000
M35.4 Diffuse (eosinophilic) fasciitis	0.003	0.997	0.000
M35.2 Behcet's disease	0.003	0.997	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.003	0.997	0.000
M32 Systemic lupus erythematosus	0.003	0.997	0.000
I61.9 Intracerebral haemorrhage, unspecified	0.003	0.997	0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.003	0.997	0.000
M47.8 Other spondylosis	0.003	0.997	0.000
M85.0 Fibrous dysplasia (monostotic)	0.003	0.997	0.000
M83 Adult osteomalacia	0.003	0.997	0.000
M85.9 Disorder of bone density and structure, unspecified	0.003	0.997	0.000
M85.5 Aneurysmal bone cyst	0.003	0.997	0.000
M85.4 Solitary bone cyst	0.003	0.997	0.000
M85.3 Osteitis condensans	0.003	0.997	0.000
M85.2 Hyperostosis of skull	0.003	0.997	0.000
M85.1 Skeletal fluorosis	0.003	0.997	0.000
M89.0 Algoneurodystrophy	0.003	0.997	0.000
M88 Paget's disease of bone [osteitis deformans]	0.003	0.997	0.000
M25.0 Haemarthrosis	0.003	0.997	0.000
M31.6 Other giant cell arteritis	0.003	0.997	0.000
M60-M63 Disorders of muscles	0.003	0.997	0.000
M25.49 Effusion of joint (Site unspecified)	0.003	0.997	0.000
M25.48 Effusion of joint (Other)	0.003	0.997	0.000
M25.44 Effusion of joint (Hand)	0.003	0.997	0.000
M25.43 Effusion of joint (Forearm)	0.003	0.997	0.000
M25.42 Effusion of joint (Upper arm)	0.003	0.997	0.000
M25.41 Effusion of joint (Shoulder region)	0.003	0.997	0.000
M25.40 Effusion of joint (Multiple sites)	0.003	0.997	0.000
M47.97 Spondylosis, unspecified (Lumbosacral region)	0.003	0.997	0.000
M85.88 Other specified disorders of bone density and structure (Other)	0.003	0.997	0.000
M85.87 Other specified disorders of bone density and structure (Ankle and foot)	0.003	0.997	0.000
M85.86 Other specified disorders of bone density and structure (Lower leg)	0.003	0.997	0.000
M85.84 Other specified disorders of bone density and structure (Hand)	0.003	0.997	0.000
M85.83 Other specified disorders of bone density and structure (Forearm)	0.003	0.997	0.000
M85.82 Other specified disorders of bone density and structure (Upper arm)	0.003	0.997	0.000
M85.81 Other specified disorders of bone density and structure (Shoulder region)	0.003	0.997	0.000
M85.80 Other specified disorders of bone density and structure (Multiple sites)	0.003	0.997	0.000
M30.0 Polyarteritis nodosa	0.003	0.997	0.000
M25.37 Other instability of joint (Ankle and foot)	0.003	0.997	0.000
M25.31 Other instability of joint (Shoulder region)	0.003	0.997	0.000
M25.78 Osteophyte (Other)	0.003	0.997	0.000
M47.89 Other spondylosis (Site unspecified)	0.003	0.997	0.000
M81.97 Osteoporosis, unspecified (Ankle and foot)	0.003	0.997	0.000
M25.9 Joint disorder, unspecified	0.003	0.997	0.000
M86.9 Osteomyelitis, unspecified	0.003	0.997	0.000
M81.8 Other osteoporosis	0.003	0.997	0.000
M81.6 Localised osteoporosis [Lequesne]	0.003	0.997	0.000
M81.5 Idiopathic osteoporosis	0.003	0.997	0.000
M81.3 Postsurgical malabsorption osteoporosis	0.003	0.997	0.000
M81.2 Osteoporosis of disuse	0.003	0.997	0.000
M81.1 Postoophorectomy osteoporosis	0.003	0.997	0.000
M81.0 Postmenopausal osteoporosis	0.003	0.997	0.000
M45 Ankylosing spondylitis	0.003	0.997	0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium	0.003	0.997	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.003	0.997	0.000
M89.8 Other specified disorders of bone	0.003	0.997	0.000
M84 Disorders of continuity of bone	0.003	0.997	0.000
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.003	0.997	0.000
M34.8 Other forms of systemic sclerosis	0.003	0.997	0.000
M34.2 Systemic sclerosis induced by drugs and chemicals	0.003	0.997	0.000
M34.0 Progressive systemic sclerosis	0.003	0.997	0.000
M90 Osteopathies in diseases classified elsewhere	0.003	0.997	0.000
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.003	0.997	0.000
M21.0 Valgus deformity, not elsewhere classified	0.003	0.997	0.000
M33.1 Other dermatomyositis	0.003	0.997	0.000
M25.8 Other specified joint disorders	0.003	0.997	0.000
M49.5 Collapsed vertebra in diseases classified elsewhere	0.003	0.997	0.000
M25.71 Osteophyte (Shoulder region)	0.003	0.997	0.000
M81.40 Drug-induced osteoporosis (Multiple sites)	0.003	0.997	0.000
D37.3 Appendix	0.003	0.997	0.000
D37.2 Small intestine	0.003	0.997	0.000
D37.1 Stomach	0.003	0.997	0.000
M89.6 Osteopathy after poliomyelitis	0.003	0.997	0.000
M89.5 Osteolysis	0.003	0.997	0.000
M89.4 Other hypertrophic osteo-arthropathy	0.003	0.997	0.000
M89.3 Hypertrophy of bone	0.003	0.997	0.000
M89.2 Other disorders of bone development and growth	0.003	0.997	0.000
M89.1 Epiphyseal arrest	0.003	0.997	0.000
E83.5 Disorders of calcium metabolism	0.000	0.997	0.003
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.003	0.997	0.000
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)	0.003	0.997	0.000
M89.94 Disorder of bone, unspecified (Hand)	0.003	0.997	0.000
Z45.9 Adjustment and management of unspecified implanted device	0.000	0.997	0.003
Z45.3 Adjustment and management of implanted hearing device	0.000	0.997	0.003
M25.46 Effusion of joint (Lower leg)	0.003	0.997	0.000
M81.96 Osteoporosis, unspecified (Lower leg)	0.003	0.997	0.000
M81.94 Osteoporosis, unspecified (Hand)	0.003	0.997	0.000
M81.93 Osteoporosis, unspecified (Forearm)	0.003	0.997	0.000
M81.92 Osteoporosis, unspecified (Upper arm)	0.003	0.997	0.000
M81.91 Osteoporosis, unspecified (Shoulder region)	0.003	0.997	0.000
M47.9 Spondylosis, unspecified	0.003	0.997	0.000
M49.8 Spondylopathy in other diseases classified elsewhere	0.003	0.997	0.000
M49.4 Neuropathic spondylopathy	0.003	0.997	0.000
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere	0.003	0.997	0.000
M49.2 Enterobacterial spondylitis	0.003	0.997	0.000
M49.1 Brucella spondylitis	0.003	0.997	0.000
M49.0 Tuberculosis of spine	0.003	0.997	0.000
M87.9 Osteonecrosis, unspecified	0.003	0.997	0.000
D50 Iron deficiency anaemia	0.003	0.997	0.000
M89.97 Disorder of bone, unspecified (Ankle and foot)	0.003	0.997	0.000
E83.4 Disorders of magnesium metabolism	0.000	0.997	0.003
M31.9 Necrotising vasculopathy, unspecified	0.003	0.997	0.000
M31.8 Other specified necrotising vasculopathies	0.003	0.997	0.000
M31.7 Microscopic polyangiitis	0.003	0.997	0.000
M31.4 Aortic arch syndrome [Takayasu]	0.003	0.997	0.000
M31.2 Lethal midline granuloma	0.003	0.997	0.000
M31.1 Thrombotic microangiopathy	0.003	0.997	0.000
M31.0 Hypersensitivity angiitis	0.003	0.997	0.000
M24.82 Other specific joint derangements, not elsewhere classified (Upper arm)	0.003	0.997	0.000
M25.39 Other instability of joint (Site unspecified)	0.003	0.997	0.000
M25.38 Other instability of joint (Other)	0.003	0.997	0.000
M25.36 Other instability of joint (Lower leg)	0.003	0.997	0.000
M25.35 Other instability of joint (Pelvic region and thigh)	0.003	0.997	0.000
M25.34 Other instability of joint (Hand)	0.003	0.997	0.000
M25.33 Other instability of joint (Forearm)	0.003	0.997	0.000
M25.32 Other instability of joint (Upper arm)	0.003	0.997	0.000
M25.30 Other instability of joint (Multiple sites)	0.003	0.997	0.000
M21.4 Flat foot [pes planus] (acquired)	0.003	0.997	0.000
M62 Other disorders of muscle	0.003	0.997	0.000
M00-M03 Infectious arthropathies	0.003	0.997	0.000
M86.99 Osteomyelitis, unspecified (Site unspecified)	0.003	0.997	0.000
M24.5 Contracture of joint	0.003	0.997	0.000
M30.8 Other conditions related to polyarteritis nodosa	0.003	0.997	0.000
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.003	0.997	0.000
M30.2 Juvenile polyarteritis	0.003	0.997	0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.003	0.997	0.000
M47.80 Other spondylosis (Multiple sites in spine)	0.003	0.997	0.000
M85.65 Other cyst of bone (Pelvic region and thigh)	0.003	0.997	0.000
M89.99 Disorder of bone, unspecified (Site unspecified)	0.003	0.997	0.000
M89.98 Disorder of bone, unspecified (Other)	0.003	0.997	0.000
M89.95 Disorder of bone, unspecified (Pelvic region and thigh)	0.003	0.997	0.000
M89.93 Disorder of bone, unspecified (Forearm)	0.003	0.997	0.000
M89.92 Disorder of bone, unspecified (Upper arm)	0.003	0.997	0.000
M89.91 Disorder of bone, unspecified (Shoulder region)	0.003	0.997	0.000
M89.90 Disorder of bone, unspecified (Multiple sites)	0.003	0.997	0.000
M48 Other spondylopathies	0.003	0.997	0.000
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.003	0.997	0.000
M24.0 Loose body in joint	0.003	0.997	0.000
M34.1 CR(E)ST syndrome	0.002	0.997	0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium	0.003	0.997	0.000
S64.4 Injury of digital nerve of other finger	0.000	0.997	0.003
M21.2 Flexion deformity	0.002	0.997	0.000
M31.3 Wegener's granulomatosis	0.003	0.997	0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs	0.003	0.997	0.000
M81.90 Osteoporosis, unspecified (Multiple sites)	0.003	0.997	0.000
D37.0 Lip, oral cavity and pharynx	0.002	0.997	0.000
M47.0 Anterior spinal and vertebral artery compression syndromes	0.002	0.997	0.000
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)	0.002	0.997	0.000
S92.50 Fracture of other toe (closed)	0.003	0.997	0.000
E21.0 Primary hyperparathyroidism	0.003	0.997	0.000
M91-M94 Chondropathies	0.003	0.997	0.000
M40-M43 Deforming dorsopathies	0.003	0.997	0.000
K62.8 Other specified diseases of anus and rectum	0.000	0.997	0.003
M33.9 Dermatopolymyositis, unspecified	0.002	0.997	0.000
M33.2 Polymyositis	0.002	0.997	0.000
M33.0 Juvenile dermatomyositis	0.002	0.997	0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs	0.002	0.997	0.000
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.002	0.997	0.000
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.002	0.997	0.000
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.002	0.997	0.000
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.002	0.997	0.000
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.002	0.997	0.000
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.002	0.997	0.000
M62.85 Other specified disorders of muscle (Pelvic region and thigh)	0.002	0.997	0.000
M89.04 Algoneurodystrophy (Hand)	0.002	0.997	0.000
M62.8 Other specified disorders of muscle	0.002	0.997	0.000
M24.2 Disorder of ligament	0.002	0.997	0.000
M86.8 Other osteomyelitis	0.002	0.997	0.000
M86.6 Other chronic osteomyelitis	0.002	0.997	0.000
M86.5 Other chronic haematogenous osteomyelitis	0.002	0.997	0.000
M86.4 Chronic osteomyelitis with draining sinus	0.002	0.997	0.000
M86.3 Chronic multifocal osteomyelitis	0.002	0.997	0.000
M86.2 Subacute osteomyelitis	0.002	0.997	0.000
M86.1 Other acute osteomyelitis	0.002	0.997	0.000
M86.0 Acute haematogenous osteomyelitis	0.002	0.997	0.000
M81.49 Drug-induced osteoporosis (Site unspecified)	0.002	0.997	0.000
M81.48 Drug-induced osteoporosis (Other)	0.002	0.997	0.000
M81.47 Drug-induced osteoporosis (Ankle and foot)	0.002	0.997	0.000
M81.46 Drug-induced osteoporosis (Lower leg)	0.002	0.997	0.000
M81.45 Drug-induced osteoporosis (Pelvic region and thigh)	0.002	0.997	0.000
M81.44 Drug-induced osteoporosis (Hand)	0.002	0.997	0.000
M81.43 Drug-induced osteoporosis (Forearm)	0.002	0.997	0.000
M81.42 Drug-induced osteoporosis (Upper arm)	0.002	0.997	0.000
M81.41 Drug-induced osteoporosis (Shoulder region)	0.002	0.997	0.000
M82.1 Osteoporosis in endocrine disorders	0.002	0.997	0.000
M85.69 Other cyst of bone (Site unspecified)	0.002	0.997	0.000
M85.68 Other cyst of bone (Other)	0.002	0.997	0.000
M85.67 Other cyst of bone (Ankle and foot)	0.002	0.997	0.000
M85.66 Other cyst of bone (Lower leg)	0.002	0.997	0.000
M85.64 Other cyst of bone (Hand)	0.002	0.997	0.000
M85.63 Other cyst of bone (Forearm)	0.002	0.997	0.000
M85.62 Other cyst of bone (Upper arm)	0.002	0.997	0.000
M85.61 Other cyst of bone (Shoulder region)	0.002	0.997	0.000
M85.60 Other cyst of bone (Multiple sites)	0.002	0.997	0.000
M21.9 Acquired deformity of limb, unspecified	0.002	0.997	0.000
M21.8 Other specified acquired deformities of limbs	0.002	0.997	0.000
M21.7 Unequal limb length (acquired)	0.002	0.997	0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.002	0.997	0.000
M24.9 Joint derangement, unspecified	0.002	0.997	0.000
M24.7 Protrusio acetabuli	0.002	0.997	0.000
M24.6 Ankylosis of joint	0.002	0.997	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.002	0.997	0.000
M88.9 Paget's disease of bone, unspecified	0.002	0.997	0.000
M65-M68 Disorders of synovium and tendon	0.003	0.997	0.000
M24.4 Recurrent dislocation and subluxation of joint	0.002	0.997	0.000
M21.06 Valgus deformity, not elsewhere classified (Lower leg)	0.002	0.997	0.000
O99.5 Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium	0.002	0.997	0.000
M82.8 Osteoporosis in other diseases classified elsewhere	0.002	0.998	0.000
M82.0 Osteoporosis in multiple myelomatosis	0.002	0.998	0.000
M82.3 Osteoporosis in diseases classified elsewhere, Forearm	0.002	0.998	0.000
M87.8 Other osteonecrosis	0.002	0.998	0.000
M87.3 Other secondary osteonecrosis	0.002	0.998	0.000
M87.1 Osteonecrosis due to drugs	0.002	0.998	0.000
M87.0 Idiopathic aseptic necrosis of bone	0.002	0.998	0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands	0.002	0.998	0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges	0.002	0.998	0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs	0.002	0.998	0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.002	0.998	0.000
I84.5 External haemorrhoids without complication	0.002	0.998	0.000
M80.8 Other osteoporosis with pathological fracture	0.002	0.998	0.000
M80.5 Idiopathic osteoporosis with pathological fracture	0.002	0.998	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.002	0.998	0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.002	0.998	0.000
M80.2 Osteoporosis of disuse with pathological fracture	0.002	0.998	0.000
M60 Myositis	0.002	0.998	0.000
M25.19 Fistula of joint (Site unspecified)	0.002	0.998	0.000
M25.18 Fistula of joint (Other)	0.002	0.998	0.000
M25.17 Fistula of joint (Ankle and foot)	0.002	0.998	0.000
M25.16 Fistula of joint (Lower leg)	0.002	0.998	0.000
M25.15 Fistula of joint (Pelvic region and thigh)	0.002	0.998	0.000
M25.14 Fistula of joint (Hand)	0.002	0.998	0.000
M25.13 Fistula of joint (Forearm)	0.002	0.998	0.000
M25.12 Fistula of joint (Upper arm)	0.002	0.998	0.000
M25.11 Fistula of joint (Shoulder region)	0.002	0.998	0.000
M25.10 Fistula of joint (Multiple sites)	0.002	0.998	0.000
M25.29 Flail joint (Site unspecified)	0.002	0.998	0.000
M25.28 Flail joint (Other)	0.002	0.998	0.000
M25.27 Flail joint (Ankle and foot)	0.002	0.998	0.000
M25.26 Flail joint (Lower leg)	0.002	0.998	0.000
M25.25 Flail joint (Pelvic region and thigh)	0.002	0.998	0.000
M25.24 Flail joint (Hand)	0.002	0.998	0.000
M25.23 Flail joint (Forearm)	0.002	0.998	0.000
M25.22 Flail joint (Upper arm)	0.002	0.998	0.000
M25.21 Flail joint (Shoulder region)	0.002	0.998	0.000
M25.20 Flail joint (Multiple sites)	0.002	0.998	0.000
M35.99 Systemic involvement of connective tissue, unspecified, Site unspecified	0.002	0.998	0.000
M85.00 Fibrous dysplasia (monostotic) (Multiple sites)	0.002	0.998	0.000
D05 Carcinoma in situ of breast	0.002	0.998	0.000
O75 Other complications of labour and delivery, not elsewhere classified	0.002	0.998	0.000
M24.56 Contracture of joint (Lower leg)	0.002	0.998	0.000
M87.97 Osteonecrosis, unspecified (Ankle and foot)	0.002	0.998	0.000
M32.9 Systemic lupus erythematosus, unspecified	0.002	0.998	0.000
M32.8 Other forms of systemic lupus erythematosus	0.002	0.998	0.000
M32.1 Systemic lupus erythematosus with organ or system involvement	0.002	0.998	0.000
M32.0 Drug-induced systemic lupus erythematosus	0.002	0.998	0.000
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.002	0.998	0.000
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.002	0.998	0.000
M36.3 Arthropathy in other blood disorders	0.002	0.998	0.000
M36.2 Haemophilic arthropathy	0.002	0.998	0.000
M36.1 Arthropathy in neoplastic disease	0.002	0.998	0.000
M36.0 Dermato(poly)myositis in neoplastic disease	0.002	0.998	0.000
O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium	0.002	0.998	0.000
M24.01 Loose body in joint (Shoulder region)	0.002	0.998	0.000
M47.88 Other spondylosis (Sacral and sacrococcygeal region)	0.002	0.998	0.000
M47.85 Other spondylosis (Thoracolumbar region)	0.002	0.998	0.000
M47.84 Other spondylosis (Thoracic region)	0.002	0.998	0.000
M47.83 Other spondylosis (Cervicothoracic region)	0.002	0.998	0.000
M47.81 Other spondylosis (Occipito-atlanto-axial region)	0.002	0.998	0.000
M85.09 Fibrous dysplasia (monostotic) (Site unspecified)	0.002	0.998	0.000
M85.08 Fibrous dysplasia (monostotic) (Other)	0.002	0.998	0.000
M85.07 Fibrous dysplasia (monostotic) (Ankle and foot)	0.002	0.998	0.000
M85.06 Fibrous dysplasia (monostotic) (Lower leg)	0.002	0.998	0.000
M85.05 Fibrous dysplasia (monostotic) (Pelvic region and thigh)	0.002	0.998	0.000
M85.04 Fibrous dysplasia (monostotic) (Hand)	0.002	0.998	0.000
M85.03 Fibrous dysplasia (monostotic) (Forearm)	0.002	0.998	0.000
M85.02 Fibrous dysplasia (monostotic) (Upper arm)	0.002	0.998	0.000
M85.01 Fibrous dysplasia (monostotic) (Shoulder region)	0.002	0.998	0.000
M89.86 Other specified disorders of bone (Lower leg)	0.002	0.998	0.000
M83.9 Adult osteomalacia, unspecified	0.002	0.998	0.000
M83.8 Other adult osteomalacia	0.002	0.998	0.000
M83.5 Other drug-induced osteomalacia in adults	0.002	0.998	0.000
M83.4 Aluminum bone disease	0.002	0.998	0.000
M83.3 Adult osteomalacia due to malnutrition	0.002	0.998	0.000
M83.2 Adult osteomalacia due to malabsorption	0.002	0.998	0.000
M83.1 Senile osteomalacia	0.002	0.998	0.000
M83.0 Puerperal osteomalacia	0.002	0.998	0.000
M88.8 Paget's disease of other bones	0.002	0.998	0.000
M88.0 Paget's disease of skull	0.002	0.998	0.000
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot	0.002	0.998	0.000
M85.19 Skeletal fluorosis (Site unspecified)	0.002	0.998	0.000
M85.18 Skeletal fluorosis (Other)	0.002	0.998	0.000
M85.17 Skeletal fluorosis (Ankle and foot)	0.002	0.998	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations