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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs3093999
log Bayes Factor = 74.4813
Chromosome 6   position 31,484,550  (GRCh37) Explore rs3093999 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
E10.9 Without complications
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
L40.9 Psoriasis, unspecified
1.000 0.000 0.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
G35 Multiple sclerosis
1.000 0.000 0.000
E10-E14 Diabetes mellitus
0.000 0.000 1.000
E10.3 With ophthalmic complications
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
J45.9 Asthma, unspecified
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
E14 Unspecified diabetes mellitus
0.000 0.001 0.999
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.001 0.999
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.003 0.997
E10.4 With neurological complications
0.000 0.003 0.997
E05.9 Thyrotoxicosis, unspecified
0.000 0.006 0.994
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.012 0.988
E14.3 With ophthalmic complications
0.000 0.016 0.984
E10.1 With ketoacidosis
0.000 0.018 0.982
E14.9 Without complications
0.000 0.022 0.978
M45.X9 Ankylosing spondylitis (Site unspecified)
0.000 0.050 0.950
L40 Psoriasis
0.943 0.057 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.064 0.936
G35-G37 Demyelinating diseases of the central nervous system
0.932 0.068 0.000
G37 Other demyelinating diseases of central nervous system
0.920 0.080 0.000
E10.2 With renal complications
0.000 0.085 0.915
I20.9 Angina pectoris, unspecified
0.000 0.088 0.912
I20-I25 Ischaemic heart diseases
0.000 0.096 0.904
I20 Angina pectoris
0.000 0.097 0.903
I22 Subsequent myocardial infarction
0.000 0.100 0.900
G37.9 Demyelinating disease of central nervous system, unspecified
0.897 0.103 0.000
E16 Other disorders of pancreatic internal secretion
0.000 0.108 0.892
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.114 0.886
L40.0 Psoriasis vulgaris
0.885 0.115 0.000
I25 Chronic ischaemic heart disease
0.000 0.125 0.875
L40.5 Arthropathic psoriasis
0.867 0.133 0.000
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.141 0.859
E10.5 With peripheral circulatory complications
0.000 0.157 0.843
E10.0 With coma
0.000 0.166 0.834
E13 Other specified diabetes mellitus
0.000 0.168 0.832
I25.5 Ischaemic cardiomyopathy
0.000 0.177 0.823
E14.8 With unspecified complications
0.000 0.182 0.818
M45 Ankylosing spondylitis
0.000 0.187 0.813
I25.1 Atherosclerotic heart disease
0.000 0.194 0.806
I24 Other acute ischaemic heart diseases
0.000 0.195 0.805
E07 Other disorders of thyroid
0.000 0.198 0.802
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.202 0.798
E11 Non-insulin-dependent diabetes mellitus
0.000 0.210 0.790
E16.2 Hypoglycaemia, unspecified
0.000 0.219 0.781
E14.6 With other specified complications
0.000 0.226 0.774
G37.8 Other specified demyelinating diseases of central nervous system
0.772 0.228 0.000
E11.9 Without complications
0.000 0.240 0.760
L40.1 Generalised pustular psoriasis
0.757 0.243 0.000
E10.8 With unspecified complications
0.000 0.254 0.746
I24.9 Acute ischaemic heart disease, unspecified
0.000 0.255 0.745
E14.1 With ketoacidosis
0.000 0.255 0.745
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system
0.742 0.258 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.000 0.266 0.734
I23 Certain current complications following acute myocardial infarction
0.000 0.266 0.734
I25.3 Aneurysm of heart
0.000 0.268 0.732
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.268 0.732
E10.6 With other specified complications
0.000 0.268 0.732
E14.5 With peripheral circulatory complications
0.000 0.271 0.729
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.000 0.271 0.729
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E05.5 Thyroid crisis or storm
0.000 0.283 0.716
E05.4 Thyrotoxicosis factitia
0.000 0.283 0.716
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.283 0.716
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.283 0.716
E14.7 With multiple complications
0.000 0.283 0.716
E14.2 Withrenal complications
0.000 0.283 0.716
E14.0 With coma
0.000 0.283 0.716
E13.9 Without complications
0.000 0.284 0.716
E11.0 With coma
0.000 0.286 0.714
E07.9 Disorder of thyroid, unspecified
0.000 0.294 0.706
E16.1 Other hypoglycaemia
0.000 0.299 0.701
K90 Intestinal malabsorption
0.000 0.300 0.700
I20.1 Angina pectoris with documented spasm
0.000 0.301 0.699
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.302 0.698
I25.2 Old myocardial infarction
0.000 0.309 0.691
E03.1 Congenital hypothyroidism without goitre
0.000 0.311 0.688
E14.4 With neurological complications
0.000 0.314 0.686
E05.8 Other thyrotoxicosis
0.000 0.323 0.676
L40.4 Guttate psoriasis
0.676 0.324 0.000
L40.2 Acrodermatitis continua
0.676 0.324 0.000
E15 Nondiabetic hypoglycaemic coma
0.000 0.329 0.671
E06 Thyroiditis
0.000 0.337 0.663
L40.3 Pustulosis palmaris et plantaris
0.661 0.338 0.000
G37.5 Concentric sclerosis [Balo]
0.660 0.340 0.000
G37.4 Subacute necrotising myelitis
0.660 0.340 0.000
G37.2 Central pontine myelinolysis
0.660 0.340 0.000
G37.1 Central demyelination of corpus callosum
0.660 0.340 0.000
G37.0 Diffuse sclerosis
0.660 0.340 0.000
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.342 0.658
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.357 0.643
G36 Other acute disseminated demyelination
0.642 0.358 0.000
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.360 0.640
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.360 0.640
E16.4 Abnormal secretion of gastrin
0.000 0.360 0.640
E16.3 Increased secretion of glucagon
0.000 0.360 0.640
E11.6 With other specified complications
0.000 0.364 0.636
K90.9 Intestinal malabsorption, unspecified
0.000 0.366 0.634
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.367 0.633
I25.6 Silent myocardial ischaemia
0.000 0.373 0.627
I24.0 Coronary thrombosis not resulting in myocardial infarction
0.000 0.374 0.626
E83.1 Disorders of iron metabolism
0.616 0.384 0.000
I23.8 Other current complications following acute myocardial infarction
0.000 0.389 0.611
L40.8 Other psoriasis
0.607 0.392 0.000
E40-E46 Malnutrition
0.000 0.394 0.605
E13.8 With unspecified complications
0.000 0.403 0.597
E13.7 With multiple complications
0.000 0.403 0.597
E13.6 With other specified complications
0.000 0.403 0.597
E13.5 With peripheral circulatory complications
0.000 0.403 0.597
E13.4 With neurological complications
0.000 0.403 0.597
E13.2 With renal complications
0.000 0.403 0.597
E13.1 With ketoacidosis
0.000 0.403 0.597
E13.0 With coma
0.000 0.403 0.597
E13.3 With ophthalmic complications
0.000 0.412 0.588
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.000 0.417 0.583
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.000 0.417 0.583
M45.X6 Ankylosing spondylitis (Lumbar region)
0.000 0.417 0.583
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.000 0.417 0.583
M45.X4 Ankylosing spondylitis (Thoracic region)
0.000 0.417 0.583
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.000 0.417 0.583
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.000 0.417 0.583
E07.1 Dyshormogenetic goitre
0.000 0.425 0.575
E07.0 Hypersecretion of calcitonin
0.000 0.425 0.575
I24.1 Dressler's syndrome
0.000 0.429 0.571
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.431 0.569
E11.7 With multiple complications
0.000 0.433 0.567
K90.8 Other intestinal malabsorption
0.000 0.447 0.553
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.474 0.526
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.474 0.526
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.474 0.526
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.474 0.526
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.474 0.526
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.474 0.526
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.474 0.526
E65-E68 Obesity and other hyperalimentation
0.000 0.481 0.519
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.486 0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.486 0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.486 0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.486 0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.486 0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.486 0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.486 0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.486 0.514
E11.5 With peripheral circulatory complications
0.000 0.487 0.513
I25.4 Coronary artery aneurysm
0.000 0.491 0.509
E06.9 Thyroiditis, unspecified
0.000 0.494 0.506
K90.3 Pancreatic steatorrhoea
0.000 0.498 0.502
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.498 0.502
K90.1 Tropical sprue
0.000 0.498 0.502
I22.8 Subsequent myocardial infarction of other sites
0.000 0.502 0.497
E11.1 With ketoacidosis
0.000 0.503 0.497
E11.2 With renal complications
0.000 0.512 0.488
E06.5 Other chronic thyroiditis
0.000 0.524 0.476
E06.4 Drug-induced thyroiditis
0.000 0.524 0.476
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.524 0.476
E06.1 Subacute thyroiditis
0.000 0.524 0.476
E06.0 Acute thyroiditis
0.000 0.524 0.476
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.000 0.526 0.474
I20.0 Unstable angina
0.000 0.527 0.473
I24.8 Other forms of acute ischaemic heart disease
0.000 0.532 0.468
E07.8 Other specified disorders of thyroid
0.000 0.534 0.466
G36.9 Acute disseminated demyelination, unspecified
0.460 0.539 0.000
G36.8 Other specified acute disseminated demyelination
0.460 0.539 0.000
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]
0.460 0.539 0.000
E50-E64 Other nutritional deficiencies
0.000 0.541 0.459
E03.8 Other specified hypothyroidism
0.001 0.561 0.438
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.563 0.437
G36.0 Neuromyelitis optica [Devic]
0.434 0.566 0.000
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.566 0.434
E45 Retarded development following protein-energy malnutrition
0.000 0.566 0.434
E43 Unspecified severe protein-energy malnutrition
0.000 0.566 0.434
E42 Marasmic kwashiorkor
0.000 0.566 0.434
E41 Nutritional marasmus
0.000 0.566 0.434
E40 Kwashiorkor
0.000 0.566 0.434
E65 Localised adiposity
0.000 0.612 0.388
E06.3 Autoimmune thyroiditis
0.000 0.625 0.375
E67 Other hyperalimentation
0.000 0.627 0.372
E68 Sequelae of hyperalimentation
0.000 0.627 0.372
E11.8 With unspecified complications
0.001 0.632 0.367
I21 Acute myocardial infarction
0.000 0.649 0.351
E58 Dietary calcium deficiency
0.000 0.662 0.337
E61 Deficiency of other nutrient elements
0.000 0.664 0.336
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.670 0.329
E63 Other nutritional deficiencies
0.000 0.670 0.329
E56 Other vitamin deficiencies
0.000 0.670 0.329
E51 Thiamine deficiency
0.000 0.670 0.329
E50 Vitamin A deficiency
0.000 0.670 0.329
E60 Dietary zinc deficiency
0.000 0.670 0.329
E59 Dietary selenium deficiency
0.000 0.670 0.329
E54 Ascorbic acid deficiency
0.000 0.670 0.329
E52 Niacin deficiency [pellagra]
0.000 0.670 0.329
E11.3 With ophthalmic complications
0.000 0.673 0.327
E46 Unspecified protein-energy malnutrition
0.000 0.675 0.325
E44.1 Mild protein-energy malnutrition
0.000 0.688 0.311
E44.0 Moderate protein-energy malnutrition
0.000 0.688 0.311
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.694 0.306
E55 Vitamin D deficiency
0.000 0.730 0.270
E67.8 Other specified hyperalimentation
0.000 0.733 0.267
E67.3 Hypervitaminosis D
0.000 0.733 0.267
E67.2 Megavitamin-B6 syndrome
0.000 0.733 0.267
E67.1 Hypercarotenaemia
0.000 0.733 0.267
E67.0 Hypervitaminosis A
0.000 0.733 0.267
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.736 0.264
E11.4 With neurological complications
0.000 0.741 0.259
E61.2 Magnesium deficiency
0.000 0.741 0.259
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.748 0.252
E61.9 Deficiency of nutrient element, unspecified
0.000 0.759 0.241
E61.8 Deficiency of other specified nutrient elements
0.000 0.759 0.241
E61.7 Deficiency of multiple nutrient elements
0.000 0.759 0.241
E61.6 Vanadium deficiency
0.000 0.759 0.241
E61.5 Molybdenum deficiency
0.000 0.759 0.241
E61.4 Chromium deficiency
0.000 0.759 0.241
E61.3 Manganese deficiency
0.000 0.759 0.241
E61.0 Copper deficiency
0.000 0.759 0.241
E50.9 Vitamin A deficiency, unspecified
0.000 0.763 0.236
E50.8 Other manifestations of vitamin A deficiency
0.000 0.763 0.236
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.763 0.236
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.763 0.236
E50.5 Vitamin A deficiency with night blindness
0.000 0.763 0.236
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.763 0.236
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.763 0.236
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.763 0.236
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.763 0.236
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.763 0.236
E51.9 Thiamine deficiency, unspecified
0.000 0.763 0.236
E51.8 Other manifestations of thiamine deficiency
0.000 0.763 0.236
E51.2 Wernicke's encephalopathy
0.000 0.763 0.236
E51.1 Beriberi
0.000 0.763 0.236
E56.9 Vitamin deficiency, unspecified
0.000 0.763 0.236
E56.8 Deficiency of other vitamins
0.000 0.763 0.236
E56.1 Deficiency of vitamin K
0.000 0.763 0.236
E56.0 Deficiency of vitamin E
0.000 0.763 0.236
E63.9 Nutritional deficiency, unspecified
0.000 0.763 0.236
E63.8 Other specified nutritional deficiencies
0.000 0.763 0.236
E63.1 Imbalance of constituents of food intake
0.000 0.763 0.236
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.763 0.236
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.763 0.236
E64.8 Sequelae of other nutritional deficiencies
0.000 0.763 0.236
E64.3 Sequelae of rickets
0.000 0.763 0.236
E64.2 Sequelae of vitamin C deficiency
0.000 0.763 0.236
E64.1 Sequelae of vitamin A deficiency
0.000 0.763 0.236
E64.0 Sequelae of protein-energy malnutrition
0.000 0.763 0.236
I21.9 Acute myocardial infarction, unspecified
0.000 0.768 0.232
E61.1 Iron deficiency
0.000 0.773 0.227
L40-L45 Papulosquamous disorders
0.212 0.778 0.010
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.794 0.206
J45 Asthma
0.000 0.805 0.195
E55.0 Rickets, active
0.000 0.806 0.194
L44 Other papulosquamous disorders
0.159 0.834 0.007
E53 Deficiency of other B group vitamins
0.000 0.837 0.162
L41 Parapsoriasis
0.152 0.841 0.007
L45 Papulosquamous disorders in diseases classified elsewhere
0.152 0.841 0.007
E20-E35 Disorders of other endocrine glands
0.000 0.841 0.159
L42 Pityriasis rosea
0.145 0.848 0.007
J45.1 Nonallergic asthma
0.000 0.860 0.140
E22 Hyperfunction of pituitary gland
0.000 0.864 0.135
E66 Obesity
0.000 0.865 0.135
E55.9 Vitamin D deficiency, unspecified
0.000 0.866 0.134
J45.8 Mixed asthma
0.000 0.866 0.134
I20.8 Other forms of angina pectoris
0.000 0.867 0.133
L44.0 Pityriasis rubra pilaris
0.122 0.874 0.005
E29 Testicular dysfunction
0.000 0.875 0.124
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.876 0.124
E04 Other non-toxic goitre
0.000 0.880 0.120
L44.9 Papulosquamous disorder, unspecified
0.114 0.880 0.005
L44.8 Other specified papulosquamous disorders
0.114 0.880 0.005
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]
0.114 0.880 0.005
L44.3 Lichen ruber moniliformis
0.114 0.880 0.005
L44.2 Lichen striatus
0.114 0.880 0.005
L44.1 Lichen nitidus
0.114 0.880 0.005
E53.1 Pyridoxine deficiency
0.000 0.883 0.117
E53.0 Riboflavin deficiency
0.000 0.883 0.117
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.884 0.116
L41.9 Parapsoriasis, unspecified
0.109 0.885 0.005
L41.8 Other parapsoriasis
0.109 0.885 0.005
L41.5 Retiform parapsoriasis
0.109 0.885 0.005
L41.4 Large plaque parapsoriasis
0.109 0.885 0.005
L41.3 Small plaque parapsoriasis
0.109 0.885 0.005
L41.2 Lymphomatoid papulosis
0.109 0.885 0.005
L41.1 Pityriasis lichenoides chronica
0.109 0.885 0.005
L41.0 Pityriasis lichenoides et varioliformis acuta
0.109 0.885 0.005
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.886 0.114
E32 Diseases of thymus
0.000 0.886 0.114
E31 Polyglandular dysfunction
0.000 0.886 0.114
E30 Disorders of puberty, not elsewhere classified
0.000 0.886 0.114
E28 Ovarian dysfunction
0.000 0.886 0.114
E22.1 Hyperprolactinaemia
0.000 0.887 0.112
E83 Disorders of mineral metabolism
0.104 0.889 0.007
E23 Hypofunction and other disorders of pituitary gland
0.000 0.890 0.110
E66.0 Obesity due to excess calories
0.000 0.893 0.107
E24 Cushing's syndrome
0.000 0.894 0.106
E20 Hypoparathyroidism
0.000 0.896 0.104
I21.4 Acute subendocardial myocardial infarction
0.000 0.899 0.101
E29.1 Testicular hypofunction
0.000 0.900 0.100
E26 Hyperaldosteronism
0.000 0.900 0.099
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.902 0.098
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.902 0.097
E22.8 Other hyperfunction of pituitary gland
0.000 0.902 0.097
E66.1 Drug-induced obesity
0.000 0.903 0.097
E23.2 Diabetes insipidus
0.000 0.904 0.096
E25 Adrenogenital disorders
0.001 0.904 0.095
L43 Lichen planus
0.052 0.906 0.042
E53.9 Vitamin B deficiency, unspecified
0.000 0.907 0.092
E83.3 Disorders of phosphorus metabolism
0.090 0.908 0.002
E28.3 Primary ovarian failure
0.000 0.909 0.091
E29.9 Testicular dysfunction, unspecified
0.000 0.910 0.089
E29.8 Other testicular dysfunction
0.000 0.910 0.089
E29.0 Testicular hyperfunction
0.000 0.910 0.089
E04.8 Other specified non-toxic goitre
0.000 0.913 0.086
E23.6 Other disorders of pituitary gland
0.000 0.914 0.086
E22.0 Acromegaly and pituitary gigantism
0.000 0.918 0.082
E30.9 Disorder of puberty, unspecified
0.000 0.918 0.082
E30.8 Other disorders of puberty
0.000 0.918 0.082
E30.1 Precocious puberty
0.000 0.918 0.082
E30.0 Delayed puberty
0.000 0.918 0.082
E31.9 Polyglandular dysfunction, unspecified
0.000 0.918 0.082
E31.8 Other polyglandular dysfunction
0.000 0.918 0.082
E31.1 Polyglandular hyperfunction
0.000 0.918 0.082
E31.0 Autoimmune polyglandular failure
0.000 0.918 0.082
E32.9 Disease of thymus, unspecified
0.000 0.918 0.082
E32.8 Other diseases of thymus
0.000 0.918 0.082
E32.1 Abscess of thymus
0.000 0.918 0.082
E32.0 Persistent hyperplasia of thymus
0.000 0.918 0.082
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.918 0.082
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.918 0.082
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.918 0.082
E28.9 Ovarian dysfunction, unspecified
0.000 0.918 0.082
E28.8 Other ovarian dysfunction
0.000 0.918 0.082
E28.1 Androgen excess
0.000 0.918 0.082
E28.0 Oestrogen excess
0.000 0.918 0.082
E34 Other endocrine disorders
0.001 0.919 0.080
E83.9 Disorder of mineral metabolism, unspecified
0.075 0.920 0.005
E83.8 Other disorders of mineral metabolism
0.075 0.920 0.005
E83.2 Disorders of zinc metabolism
0.075 0.920 0.005
E83.0 Disorders of copper metabolism
0.075 0.920 0.005
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.921 0.079
E23.1 Drug-induced hypopituitarism
0.000 0.921 0.079
E24.8 Other Cushing's syndrome
0.000 0.924 0.076
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.924 0.076
E24.3 Ectopic ACTH syndrome
0.000 0.924 0.076
E24.2 Drug-induced Cushing's syndrome
0.000 0.924 0.076
E24.1 Nelson's syndrome
0.000 0.924 0.076
E24.0 Pituitary-dependent Cushing's disease
0.000 0.924 0.075
E20.8 Other hypoparathyroidism
0.000 0.925 0.074
E20.1 Pseudohypoparathyroidism
0.000 0.925 0.074
E20.0 Idiopathic hypoparathyroidism
0.000 0.925 0.074
E26.9 Hyperaldosteronism, unspecified
0.000 0.928 0.071
E26.8 Other hyperaldosteronism
0.000 0.928 0.071
E26.1 Secondary hyperaldosteronism
0.000 0.928 0.071
E28.2 Polycystic ovarian syndrome
0.000 0.930 0.070
E24.9 Cushing's syndrome, unspecified
0.000 0.931 0.069
E25.9 Adrenogenital disorder, unspecified
0.001 0.931 0.068
E25.8 Other adrenogenital disorders
0.001 0.931 0.068
L43.3 Subacute (active) lichen planus
0.037 0.933 0.030
L43.2 Lichenoid drug reaction
0.037 0.933 0.030
L43.1 Bullous lichen planus
0.037 0.933 0.030
L43.0 Hypertrophic lichen planus
0.037 0.933 0.030
E20.9 Hypoparathyroidism, unspecified
0.000 0.935 0.064
E23.7 Disorder of pituitary gland, unspecified
0.000 0.936 0.064
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.938 0.062
E34.8 Other specified endocrine disorders
0.001 0.940 0.060
E04.0 Non-toxic diffuse goitre
0.000 0.940 0.060
E04.9 Non-toxic goitre, unspecified
0.000 0.941 0.059
L43.8 Other lichen planus
0.020 0.941 0.038
E34.5 Androgen resistance syndrome
0.001 0.942 0.058
E34.4 Constitutional tall stature
0.001 0.942 0.058
E34.3 Short stature, not elsewhere classified
0.001 0.942 0.058
E34.2 Ectopic hormone secretion, not elsewhere classified
0.001 0.942 0.058
E34.1 Other hypersecretion of intestinal hormones
0.001 0.942 0.058
E26.0 Primary hyperaldosteronism
0.001 0.943 0.057
L43.9 Lichen planus, unspecified
0.002 0.945 0.053
E04.1 Non-toxic single thyroid nodule
0.000 0.945 0.055
E34.0 Carcinoid syndrome
0.001 0.947 0.053
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.001 0.950 0.049
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.951 0.049
K90-K93 Other diseases of the digestive system
0.000 0.953 0.047
J45.0 Predominantly allergic asthma
0.000 0.954 0.046
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.955 0.045
E21.4 Other specified disorders of parathyroid gland
0.000 0.955 0.045
E21.2 Other hyperparathyroidism
0.000 0.955 0.045
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.956 0.043
E23.0 Hypopituitarism
0.000 0.957 0.042
M45-M49 Spondylopathies
0.000 0.963 0.037
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.966 0.034
E70-E90 Metabolic disorders
0.002 0.967 0.031
H36.0 Diabetic retinopathy
0.000 0.968 0.032
E34.9 Endocrine disorder, unspecified
0.001 0.970 0.029
E21.3 Hyperparathyroidism, unspecified
0.000 0.972 0.028
E21.0 Primary hyperparathyroidism
0.000 0.973 0.027
M49 Spondylopathies in diseases classified elsewhere
0.000 0.973 0.027
E83.5 Disorders of calcium metabolism
0.025 0.973 0.002
E85 Amyloidosis
0.001 0.973 0.026
E27 Other disorders of adrenal gland
0.004 0.974 0.022
E83.4 Disorders of magnesium metabolism
0.019 0.975 0.006
M75.0 Adhesive capsulitis of shoulder
0.000 0.975 0.025
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.975 0.025
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.975 0.025
K93.1 Megacolon in Chagas' disease
0.000 0.975 0.025
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.975 0.025
E79 Disorders of purine and pyrimidine metabolism
0.001 0.976 0.023
E77 Disorders of glycoprotein metabolism
0.002 0.976 0.022
E76 Disorders of glycosaminoglycan metabolism
0.002 0.976 0.022
E72 Other disorders of amino-acid metabolism
0.002 0.976 0.022
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.002 0.976 0.022
E70 Disorders of aromatic amino-acid metabolism
0.002 0.976 0.022
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.002 0.976 0.022
E53.8 Deficiency of other specified B group vitamins
0.000 0.976 0.023
E74 Other disorders of carbohydrate metabolism
0.001 0.977 0.022
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.002 0.977 0.022
H36 Retinal disorders in diseases classified elsewhere
0.000 0.977 0.023
E85.9 Amyloidosis, unspecified
0.000 0.977 0.022
E73 Lactose intolerance
0.001 0.977 0.021
E89.3 Postprocedural hypopituitarism
0.000 0.978 0.022
E84 Cystic fibrosis
0.002 0.978 0.020
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.979 0.021
E27.3 Drug-induced adrenocortical insufficiency
0.002 0.979 0.018
M49.5 Collapsed vertebra in diseases classified elsewhere
0.000 0.980 0.020
M49.8 Spondylopathy in other diseases classified elsewhere
0.000 0.980 0.019
M49.4 Neuropathic spondylopathy
0.000 0.980 0.019
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.000 0.980 0.019
M49.2 Enterobacterial spondylitis
0.000 0.980 0.019
M49.1 Brucella spondylitis
0.000 0.980 0.019
M49.0 Tuberculosis of spine
0.000 0.980 0.019
E85.3 Secondary systemic amyloidosis
0.001 0.980 0.019
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.981 0.019
E85.8 Other amyloidosis
0.001 0.981 0.019
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.981 0.019
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.981 0.019
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.981 0.019
E85.4 Organ-limited amyloidosis
0.001 0.981 0.018
E27.5 Adrenomedullary hyperfunction
0.003 0.981 0.016
E27.0 Other adrenocortical overactivity
0.003 0.981 0.016
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.982 0.018
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.982 0.018
E89.5 Postprocedural testicular hypofunction
0.000 0.982 0.018
E89.1 Postprocedural hypoinsulinaemia
0.000 0.982 0.018
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.982 0.017
E27.9 Disorder of adrenal gland, unspecified
0.002 0.982 0.015
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.982 0.017
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.982 0.016
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.982 0.016
E79.1 Lesch-Nyhan syndrome
0.001 0.982 0.016
E04.2 Non-toxic multinodular goitre
0.000 0.983 0.017
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.983 0.016
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.983 0.016
E70.3 Albinism
0.001 0.983 0.016
E70.2 Disorders of tyrosine metabolism
0.001 0.983 0.016
E70.1 Other hyperphenylalaninaemias
0.001 0.983 0.016
E70.0 Classical phenylketonuria
0.001 0.983 0.016
E71.3 Disorders of fatty-acid metabolism
0.001 0.983 0.016
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.983 0.016
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.983 0.016
E71.0 Maple-syrup-urine disease
0.001 0.983 0.016
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.983 0.016
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.983 0.016
E72.5 Disorders of glycine metabolism
0.001 0.983 0.016
E72.4 Disorders of ornithine metabolism
0.001 0.983 0.016
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.983 0.016
E72.2 Disorders of urea cycle metabolism
0.001 0.983 0.016
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.983 0.016
E72.0 Disorders of amino-acid transport
0.001 0.983 0.016
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.983 0.016
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.983 0.016
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.983 0.016
E76.2 Other mucopolysaccharidoses
0.001 0.983 0.016
E76.1 Mucopolysaccharidosis, type II
0.001 0.983 0.016
E76.0 Mucopolysaccharidosis, type I
0.001 0.983 0.016
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.983 0.016
E77.8 Other disorders of glycoprotein metabolism
0.001 0.983 0.016
E77.1 Defects in glycoprotein degradation
0.001 0.983 0.016
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.983 0.016
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.983 0.016
E78.0 Pure hypercholesterolaemia
0.000 0.983 0.017
H35 Other retinal disorders
0.000 0.983 0.017
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.983 0.016
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.983 0.016
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.983 0.016
E74.2 Disorders of galactose metabolism
0.001 0.983 0.016
E74.1 Disorders of fructose metabolism
0.001 0.983 0.016
E66.9 Obesity, unspecified
0.000 0.983 0.017

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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