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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs35220816
log Bayes Factor = 7.31535
Chromosome 12   position 115,082,017  (GRCh37) Explore rs35220816 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
S00-S09 Injuries to the head
0.999 0.001 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.998 0.002 0.000
S50-S59 Injuries to the elbow and forearm
0.998 0.002 0.000
S52 Fracture of forearm
0.995 0.005 0.000
S02 Fracture of skull and facial bones
0.993 0.007 0.000
S52.6 Fracture of lower end of both ulna and radius
0.992 0.008 0.000
S52.60 Fracture of lower end of both ulna and radius (closed)
0.990 0.010 0.000
S06 Intracranial injury
0.988 0.012 0.000
S60-S69 Injuries to the wrist and hand
0.985 0.015 0.000
I30-I52 Other forms of heart disease
0.960 0.040 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.960 0.040 0.000
Chapter IX Diseases of the circulatory system
0.959 0.041 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.952 0.048 0.000
I34 Nonrheumatic mitral valve disorders
0.950 0.050 0.000
S61 Open wound of wrist and hand
0.939 0.061 0.000
I05-I09 Chronic rheumatic heart diseases
0.935 0.065 0.000
I71 Aortic aneurysm and dissection
0.931 0.069 0.000
I35 Nonrheumatic aortic valve disorders
0.927 0.073 0.000
S02.4 Fracture of malar and maxillary bones
0.923 0.077 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.922 0.078 0.000
I34.0 Mitral (valve) insufficiency
0.921 0.079 0.000
S06.5 Traumatic subdural haemorrhage
0.914 0.086 0.000
I60-I69 Cerebrovascular diseases
0.892 0.108 0.000
S02.1 Fracture of base of skull
0.891 0.109 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.889 0.111 0.000
S61.0 Open wound of finger(s) without damage to nail
0.887 0.113 0.000
I38 Endocarditis, valve unspecified
0.886 0.114 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.879 0.121 0.000
I35.1 Aortic (valve) insufficiency
0.879 0.121 0.000
I08 Multiple valve diseases
0.876 0.124 0.000
T39.0 Salicylates
0.874 0.126 0.000
I45 Other conduction disorders
0.873 0.127 0.000
S02.40 Fracture of malar and maxillary bones (closed)
0.873 0.127 0.000
I05 Rheumatic mitral valve diseases
0.873 0.127 0.000
S02.7 Multiple fractures involving skull and facial bones
0.871 0.129 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.869 0.131 0.000
S06.4 Epidural haemorrhage
0.867 0.133 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.861 0.139 0.000
S06.50 Traumatic subdural haemorrhage (without open intracranial wound)
0.861 0.139 0.000
S05 Injury of eye and orbit
0.860 0.140 0.000
S02.0 Fracture of vault of skull
0.857 0.143 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.857 0.143 0.000
S90-S99 Injuries to the ankle and foot
0.856 0.144 0.000
S64 Injury of nerves at wrist and hand level
0.854 0.146 0.000
I78 Diseases of capillaries
0.846 0.154 0.000
I60 Subarachnoid haemorrhage
0.845 0.155 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.845 0.155 0.000
S02.6 Fracture of mandible
0.842 0.158 0.000
S61.9 Open wound of wrist and hand, part unspecified
0.839 0.161 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.837 0.163 0.000
S56 Injury of muscle and tendon at forearm level
0.835 0.165 0.000
S10-S19 Injuries to the neck
0.835 0.165 0.000
T43.2 Other and unspecified antidepressants
0.834 0.166 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.830 0.170 0.000
I34.2 Nonrheumatic mitral (valve) stenosis
0.829 0.171 0.000
S06.2 Diffuse brain injury
0.829 0.171 0.000
S80-S89 Injuries to the knee and lower leg
0.827 0.173 0.000
I74 Arterial embolism and thrombosis
0.818 0.182 0.000
S02.10 Fracture of base of skull (closed)
0.817 0.183 0.000
I08.1 Disorders of both mitral and tricuspid valves
0.811 0.189 0.000
I31 Other diseases of pericardium
0.807 0.192 0.000
I33 Acute and subacute endocarditis
0.807 0.193 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.807 0.193 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.806 0.194 0.000
S06.6 Traumatic subarachnoid haemorrhage
0.806 0.194 0.000
T43.3 Phenothiazine antipsychotics and neuroleptics
0.805 0.195 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.800 0.200 0.000
I34.1 Mitral (valve) prolapse
0.800 0.200 0.000
S51 Open wound of forearm
0.800 0.200 0.000
S66 Injury of muscle and tendon at wrist and hand level
0.798 0.202 0.000
S60 Superficial injury of wrist and hand
0.797 0.203 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.795 0.205 0.000
S52.5 Fracture of lower end of radius
0.791 0.209 0.000
S67 Crushing injury of wrist and hand
0.788 0.212 0.000
S02.70 Multiple fractures involving skull and facial bones (closed)
0.784 0.216 0.000
S54 Injury of nerves at forearm level
0.782 0.218 0.000
S06.40 Epidural haemorrhage (without open intracranial wound)
0.780 0.220 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.775 0.225 0.000
T51 Toxic effect of alcohol
0.774 0.226 0.000
S64.2 Injury of radial nerve at wrist and hand level
0.770 0.230 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.766 0.234 0.000
T79-T79 Certain early complications of trauma
0.766 0.234 0.000
I42 Cardiomyopathy
0.765 0.235 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.765 0.235 0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified
0.763 0.237 0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis
0.762 0.238 0.000
# Top node
0.762 0.238 0.000
S02.00 Fracture of vault of skull (closed)
0.760 0.240 0.000
I05.2 Mitral stenosis with insufficiency
0.760 0.240 0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves
0.759 0.241 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.758 0.242 0.000
S06.3 Focal brain injury
0.756 0.244 0.000
I05.9 Mitral valve disease, unspecified
0.755 0.245 0.000
S06.0 Concussion
0.749 0.251 0.000
T46.1 Calcium-channel blockers
0.746 0.254 0.000
O99.8 Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
0.742 0.258 0.000
S61.7 Multiple open wounds of wrist and hand
0.741 0.259 0.000
T43.0 Tricyclic and tetracyclic antidepressants
0.741 0.259 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.740 0.260 0.000
S52.8 Fracture of other parts of forearm
0.739 0.261 0.000
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.738 0.262 0.000
I77 Other disorders of arteries and arterioles
0.737 0.263 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.736 0.264 0.000
S02.60 Fracture of mandible (closed)
0.734 0.266 0.000
S70-S79 Injuries to the hip and thigh
0.733 0.267 0.000
I51 Complications and ill-defined descriptions of heart disease
0.733 0.267 0.000
T40.2 Other opioids
0.733 0.267 0.000
S89 Other and unspecified injuries of lower leg
0.727 0.273 0.000
S52.7 Multiple fractures of forearm
0.727 0.273 0.000
I71.3 Abdominal aortic aneurysm, ruptured
0.726 0.274 0.000
I69 Sequelae of cerebrovascular disease
0.723 0.277 0.000
I35.0 Aortic (valve) stenosis
0.723 0.277 0.000
I35.8 Other aortic valve disorders
0.722 0.278 0.000
I60.8 Other subarachnoid haemorrhage
0.722 0.278 0.000
I31.9 Disease of pericardium, unspecified
0.721 0.279 0.000
T92 Sequelae of injuries of upper limb
0.721 0.279 0.000
I45.1 Other and unspecified right bundle-branch block
0.720 0.280 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.718 0.282 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
S08 Traumatic amputation of part of head
0.716 0.283 0.000
S07 Crushing injury of head
0.716 0.283 0.000
S04 Injury of cranial nerves
0.716 0.283 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.716 0.283 0.000
T40.4 Other synthetic narcotics
0.716 0.284 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.716 0.284 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.716 0.284 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.716 0.284 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.716 0.284 0.000
T36 Poisoning by systemic antibiotics
0.716 0.284 0.000
S59 Other and unspecified injuries of forearm
0.716 0.284 0.000
S58 Traumatic amputation of forearm
0.716 0.284 0.000
S57 Crushing injury of forearm
0.716 0.284 0.000
S55 Injury of blood vessels at forearm level
0.716 0.284 0.000
S53 Dislocation, sprain and strain of joints and ligaments of elbow
0.716 0.284 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.715 0.285 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.715 0.285 0.000
I60.1 Subarachnoid haemorrhage from middle cerebral artery
0.715 0.285 0.000
S06.20 Diffuse brain injury (without open intracranial wound)
0.715 0.285 0.000
S52.9 Fracture of forearm, part unspecified
0.713 0.287 0.000
S52.4 Fracture of shafts of both ulna and radius
0.713 0.287 0.000
S52.3 Fracture of shaft of radius
0.713 0.287 0.000
S52.2 Fracture of shaft of ulna
0.713 0.287 0.000
S02.8 Fractures of other skull and facial bones
0.712 0.287 0.000
S02.9 Fracture of skull and facial bones, part unspecified
0.712 0.288 0.000
I60.6 Subarachnoid haemorrhage from other intracranial arteries
0.712 0.288 0.000
S52.61 Fracture of lower end of both ulna and radius (open)
0.711 0.289 0.000
I78.0 Hereditary haemorrhagic telangiectasia
0.711 0.289 0.000
T39.1 4-Aminophenol derivatives
0.711 0.289 0.000
S02.5 Fracture of tooth
0.710 0.290 0.000
S05.0 Injury of conjunctiva and corneal abrasion without mention of foreign body
0.709 0.291 0.000
Chapter XX External causes of morbidity and mortality
0.709 0.291 0.000
I09 Other rheumatic heart diseases
0.708 0.292 0.000
S06.9 Intracranial injury, unspecified
0.708 0.292 0.000
S06.8 Other intracranial injuries
0.708 0.292 0.000
S06.7 Intracranial injury with prolonged coma
0.708 0.292 0.000
S06.1 Traumatic cerebral oedema
0.708 0.292 0.000
S30 Superficial injury of abdomen, lower back and pelvis
0.708 0.292 0.000
S65 Injury of blood vessels at wrist and hand level
0.706 0.294 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.705 0.295 0.000
T51.0 Ethanol
0.704 0.295 0.000
S99 Other and unspecified injuries of ankle and foot
0.704 0.296 0.000
I45.2 Bifascicular block
0.703 0.297 0.000
S52.0 Fracture of upper end of ulna
0.702 0.298 0.000
I33.0 Acute and subacute infective endocarditis
0.697 0.303 0.000
S20-S29 Injuries to the thorax
0.695 0.305 0.000
O60-O75 Complications of labour and delivery
0.694 0.306 0.000
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level
0.693 0.307 0.000
S50 Superficial injury of forearm
0.691 0.309 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.691 0.309 0.000
S05.8 Other injuries of eye and orbit
0.690 0.310 0.000
I71.9 Aortic aneurysm of unspecified site, without mention of rupture
0.689 0.311 0.000
I52 Other heart disorders in diseases classified elsewhere
0.688 0.312 0.000
I48 Atrial fibrillation and flutter
0.688 0.312 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.688 0.312 0.000
I41 Myocarditis in diseases classified elsewhere
0.688 0.312 0.000
I40 Acute myocarditis
0.688 0.312 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.688 0.312 0.000
I37 Pulmonary valve disorders
0.688 0.312 0.000
I36 Nonrheumatic tricuspid valve disorders
0.688 0.312 0.000
I32 Pericarditis in diseases classified elsewhere
0.688 0.312 0.000
T43.9 Psychotropic drug, unspecified
0.688 0.312 0.000
T43.8 Other psychotropic drugs, not elsewhere classified
0.688 0.312 0.000
T43.6 Psychostimulants with abuse potential
0.688 0.312 0.000
T43.4 Butyrophenone and thioxanthene neuroleptics
0.688 0.312 0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants
0.688 0.312 0.000
I00-I02 Acute rheumatic fever
0.688 0.312 0.000
I73 Other peripheral vascular diseases
0.688 0.312 0.000
S60.2 Contusion of other parts of wrist and hand
0.687 0.313 0.000
I27 Other pulmonary heart diseases
0.686 0.314 0.000
I45.5 Other specified heart block
0.685 0.315 0.000
S40-S49 Injuries to the shoulder and upper arm
0.684 0.316 0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.683 0.316 0.000
I78.1 Naevus, nonneoplastic
0.683 0.317 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.682 0.318 0.000
I34.8 Other nonrheumatic mitral valve disorders
0.681 0.319 0.000
S62 Fracture at wrist and hand level
0.680 0.320 0.000
T17 Foreign body in respiratory tract
0.680 0.320 0.000
S68 Traumatic amputation of wrist and hand
0.680 0.320 0.000
I60.9 Subarachnoid haemorrhage, unspecified
0.678 0.322 0.000
S86 Injury of muscle and tendon at lower leg level
0.676 0.323 0.000
S06.60 Traumatic subarachnoid haemorrhage (without open intracranial wound)
0.676 0.324 0.000
S56.1 Injury of flexor muscle and tendon of other finger(s) at forearm level
0.673 0.327 0.000
I45.9 Conduction disorder, unspecified
0.673 0.327 0.000
S12 Fracture of neck
0.671 0.329 0.000
S13 Dislocation, sprain and strain of joints and ligaments at neck level
0.671 0.329 0.000
I05.0 Mitral stenosis
0.671 0.329 0.000
I06 Rheumatic aortic valve diseases
0.671 0.329 0.000
T56 Toxic effect of metals
0.670 0.330 0.000
S51.0 Open wound of elbow
0.668 0.332 0.000
I71.8 Aortic aneurysm of unspecified site, ruptured
0.667 0.333 0.000
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture
0.667 0.333 0.000
I71.5 Thoracoabdominal aortic aneurysm, ruptured
0.667 0.333 0.000
I71.1 Thoracic aortic aneurysm, ruptured
0.667 0.333 0.000
S66.7 Injury of multiple extensor muscles and tendons at wrist and hand level
0.667 0.333 0.000
S02.3 Fracture of orbital floor
0.667 0.333 0.000
I62 Other nontraumatic intracranial haemorrhage
0.665 0.334 0.000
S56.8 Injury of other and unspecified muscles and tendons at forearm level
0.664 0.336 0.000
I34.9 Nonrheumatic mitral valve disorder, unspecified
0.663 0.337 0.000
I30 Acute pericarditis
0.662 0.338 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.662 0.338 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.662 0.338 0.000
S02.41 Fracture of malar and maxillary bones (open)
0.662 0.338 0.000
S92 Fracture of foot, except ankle
0.661 0.338 0.000
T18 Foreign body in alimentary tract
0.661 0.338 0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified
0.661 0.339 0.000
T39.4 Antirheumatics, not elsewhere classified
0.661 0.339 0.000
T39.2 Pyrazolone derivatives
0.661 0.339 0.000
I51.7 Cardiomegaly
0.660 0.340 0.000
I45.8 Other specified conduction disorders
0.660 0.340 0.000
I35.9 Aortic valve disorder, unspecified
0.660 0.340 0.000
T40.6 Other and unspecified narcotics
0.659 0.341 0.000
S11 Open wound of neck
0.657 0.343 0.000
S39.9 Unspecified injury of abdomen, lower back and pelvis
0.656 0.344 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.655 0.345 0.000
S06.51 Traumatic subdural haemorrhage (with open intracranial wound)
0.655 0.345 0.000
O99.0 Anaemia complicating pregnancy, childbirth and the puerperium
0.655 0.345 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.654 0.346 0.000
I71.0 Dissection of aorta [any part]
0.654 0.346 0.000
I08.2 Disorders of both aortic and tricuspid valves
0.650 0.350 0.000
I72 Other aneurysm
0.649 0.351 0.000
I69.4 Sequelae of stroke, not specified as haemorrhage or infarction
0.648 0.352 0.000
S67.0 Crushing injury of thumb and other finger(s)
0.647 0.353 0.000
S66.0 Injury of long flexor muscle and tendon of thumb at wrist and hand level
0.647 0.353 0.000
I78.8 Other diseases of capillaries
0.646 0.354 0.000
I67 Other cerebrovascular diseases
0.643 0.357 0.000
S69 Other and unspecified injuries of wrist and hand
0.642 0.358 0.000
W20-W49 Exposure to inanimate mechanical forces
0.641 0.359 0.000
I68 Cerebrovascular disorders in diseases classified elsewhere
0.640 0.360 0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction
0.640 0.360 0.000
I08.8 Other multiple valve diseases
0.639 0.361 0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified
0.639 0.361 0.000
S02.11 Fracture of base of skull (open)
0.638 0.361 0.000
S51.7 Multiple open wounds of forearm
0.638 0.362 0.000
T45.0 Antiallergic and antiemetic drugs
0.637 0.363 0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level
0.637 0.363 0.000
I45.6 Preexcitation syndrome
0.637 0.363 0.000
S52.50 Fracture of lower end of radius (closed)
0.635 0.365 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.634 0.366 0.000
O85-O92 Complications predominantly related to the puerperium
0.633 0.367 0.000
I61 Intracerebral haemorrhage
0.633 0.367 0.000
S02.2 Fracture of nasal bones
0.631 0.369 0.000
T40.9 Other and unspecified psychodysleptics [hallucinogens]
0.630 0.369 0.000
T40.8 Lysergide [LSD]
0.630 0.369 0.000
T40.7 Cannabis (derivatives)
0.630 0.369 0.000
T40.5 Cocaine
0.630 0.369 0.000
T40.3 Methadone
0.630 0.369 0.000
T40.1 Heroin
0.630 0.369 0.000
T40.0 Opium
0.630 0.369 0.000
S30.1 Contusion of abdominal wall
0.630 0.370 0.000
S05.1 Contusion of eyeball and orbital tissues
0.629 0.370 0.000
I08.9 Multiple valve disease, unspecified
0.628 0.372 0.000
S54.0 Injury of ulnar nerve at forearm level
0.626 0.374 0.000
I45.4 Nonspecific intraventricular block
0.626 0.374 0.000
I45.0 Right fascicular block
0.626 0.374 0.000
I05.8 Other mitral valve diseases
0.626 0.374 0.000
T21 Burn and corrosion of trunk
0.625 0.375 0.000
S64.4 Injury of digital nerve of other finger
0.625 0.375 0.000
S39.8 Other specified injuries of abdomen, lower back and pelvis
0.625 0.375 0.000
S02.71 Multiple fractures involving skull and facial bones (open)
0.625 0.375 0.000
T65 Toxic effect of other and unspecified substances
0.623 0.377 0.000
T62 Toxic effect of other noxious substances eaten as food
0.623 0.377 0.000
T61 Toxic effect of noxious substances eaten as seafood
0.623 0.377 0.000
T60 Toxic effect of pesticides
0.623 0.377 0.000
T57 Toxic effect of other inorganic substances
0.623 0.377 0.000
T54 Toxic effect of corrosive substances
0.623 0.377 0.000
T53 Toxic effect of halogen derivatives of aliphatic and aromatic hydrocarbone
0.623 0.377 0.000
T52 Toxic effect of organic solvents
0.623 0.377 0.000
T64 Toxic effect of aflatoxin and other mycotoxin food contaminants
0.623 0.377 0.000
T55 Toxic effect of soaps and detergents
0.623 0.377 0.000
I51.1 Rupture of chordae tendineae, not elsewhere classified
0.622 0.378 0.000
S91 Open wound of ankle and foot
0.622 0.378 0.000
S06.41 Epidural haemorrhage (with open intracranial wound)
0.622 0.378 0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria
0.621 0.379 0.000
I05.1 Rheumatic mitral insufficiency
0.621 0.379 0.000
T45.5 Anticoagulants
0.620 0.380 0.000
T58 Toxic effect of carbon monoxide
0.620 0.380 0.000
O16 Unspecified maternal hypertension
0.620 0.380 0.000
S90 Superficial injury of ankle and foot
0.619 0.380 0.000
I60.3 Subarachnoid haemorrhage from posterior communicating artery
0.618 0.382 0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system
0.618 0.382 0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified
0.618 0.382 0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified
0.618 0.382 0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified
0.618 0.382 0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified
0.618 0.382 0.000
T44.3 Other parasympatholytics [anticholinergics and antimuscarines] and spasmolytics, not elsewhere classified
0.618 0.382 0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified
0.618 0.382 0.000
T44.1 Other parasympathomimetics [cholinergics]
0.618 0.382 0.000
T44.0 Anticholinesterase agents
0.618 0.382 0.000
S05.9 Injury of eye and orbit, part unspecified
0.617 0.383 0.000
S05.7 Avulsion of eye
0.617 0.383 0.000
S05.6 Penetrating wound of eyeball without foreign body
0.617 0.383 0.000
S05.5 Penetrating wound of eyeball with foreign body
0.617 0.383 0.000
S05.4 Penetrating wound of orbit with or without foreign body
0.617 0.383 0.000
S05.3 Ocular laceration without prolapse or loss of intraocular tissue
0.617 0.383 0.000
S05.2 Ocular laceration and rupture with prolapse or loss of intraocular tissue
0.617 0.383 0.000
S89.9 Unspecified injury of lower leg
0.616 0.383 0.000
O68.1 Labour and delivery complicated by meconium in amniotic fluid
0.616 0.384 0.000
S02.01 Fracture of vault of skull (open)
0.615 0.385 0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis
0.614 0.386 0.000
S37 Injury of urinary and pelvic organs
0.614 0.386 0.000
S36 Injury of intra-abdominal organs
0.614 0.386 0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level
0.614 0.386 0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level
0.614 0.386 0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis
0.614 0.386 0.000
S31 Open wound of abdomen, lower back and pelvis
0.614 0.386 0.000
S66.6 Injury of multiple flexor muscles and tendons at wrist and hand level
0.614 0.386 0.000
S98 Traumatic amputation of ankle and foot
0.613 0.386 0.000
S97 Crushing injury of ankle and foot
0.613 0.386 0.000
S96 Injury of muscle and tendon at ankle and foot level
0.613 0.386 0.000
S95 Injury of blood vessels at ankle and foot level
0.613 0.386 0.000
S94 Injury of nerves at ankle and foot level
0.613 0.386 0.000
O63 Long labour
0.613 0.387 0.000
T24 Burn and corrosion of hip and lower limb, except ankle and foot
0.612 0.387 0.000
S64.9 Injury of unspecified nerve at wrist and hand level
0.612 0.387 0.000
S64.8 Injury of other nerves at wrist and hand level
0.612 0.387 0.000
S64.7 Injury of multiple nerves at wrist and hand level
0.612 0.387 0.000
S64.1 Injury of median nerve at wrist and hand level
0.612 0.387 0.000
S64.0 Injury of ulnar nerve at wrist and hand level
0.612 0.387 0.000
S52.1 Fracture of upper end of radius
0.612 0.388 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.611 0.389 0.000
T59 Toxic effect of other gases, fumes and vapours
0.609 0.391 0.000
T92.1 Sequelae of fracture of arm
0.608 0.392 0.000
S14 Injury of nerves and spinal cord at neck level
0.606 0.393 0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
0.606 0.394 0.000
I78.9 Disease of capillaries, unspecified
0.606 0.394 0.000
I60.7 Subarachnoid haemorrhage from intracranial artery, unspecified
0.606 0.394 0.000
I60.5 Subarachnoid haemorrhage from vertebral artery
0.606 0.394 0.000
I60.4 Subarachnoid haemorrhage from basilar artery
0.606 0.394 0.000
I60.0 Subarachnoid haemorrhage from carotid siphon and bifurcation
0.606 0.394 0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system
0.606 0.394 0.000
T46.8 Antivaricose drugs, including sclerosing agents
0.606 0.394 0.000
T46.7 Peripheral vasodilators
0.606 0.394 0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs
0.606 0.394 0.000
T46.5 Other antihypertensive drugs, not elsewhere classified
0.606 0.394 0.000
T46.3 Coronary vasodilators, not elsewhere classified
0.606 0.394 0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified
0.606 0.394 0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action
0.606 0.394 0.000
I42.9 Cardiomyopathy, unspecified
0.606 0.394 0.000
S02.61 Fracture of mandible (open)
0.604 0.396 0.000
I42.6 Alcoholic cardiomyopathy
0.602 0.398 0.000
I74.8 Embolism and thrombosis of other arteries
0.602 0.398 0.000
T23 Burn and corrosion of wrist and hand
0.602 0.398 0.000
T19 Foreign body in genito-urinary tract
0.600 0.400 0.000
T15 Foreign body on external eye
0.600 0.400 0.000
T16 Foreign body in ear
0.600 0.400 0.000
S56.2 Injury of other flexor muscle and tendon at forearm level
0.599 0.401 0.000
S56.7 Injury of multiple muscles and tendons at forearm level
0.599 0.401 0.000
S56.5 Injury of other extensor muscle and tendon at forearm level
0.599 0.401 0.000
S56.4 Injury of extensor muscle and tendon of other finger(s) at forearm level
0.599 0.401 0.000
S56.3 Injury of extensor or abductor muscles and tendons of thumb at forearm level
0.599 0.401 0.000
S56.0 Injury of flexor muscle and tendon of thumb at forearm level
0.599 0.401 0.000
T79 Certain early complications of trauma, not elsewhere classified
0.599 0.401 0.000
S17 Crushing injury of neck
0.598 0.401 0.000
S15 Injury of blood vessels at neck level
0.598 0.401 0.000
S18 Traumatic amputation at neck level
0.598 0.401 0.000
S16 Injury of muscle and tendon at neck level
0.598 0.401 0.000
Chapter I Certain infectious and parasitic diseases
0.597 0.403 0.000
S99.9 Unspecified injury of ankle and foot
0.596 0.404 0.000
S06.21 Diffuse brain injury (with open intracranial wound)
0.594 0.406 0.000
I77.8 Other specified disorders of arteries and arterioles
0.594 0.406 0.000
S89.8 Other specified injuries of lower leg
0.594 0.406 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.594 0.406 0.000
S88 Traumatic amputation of lower leg
0.593 0.407 0.000
S87 Crushing injury of lower leg
0.593 0.407 0.000
S85 Injury of blood vessels at lower leg level
0.593 0.407 0.000
S84 Injury of nerves at lower leg level
0.593 0.407 0.000
I73.0 Raynaud's syndrome
0.592 0.408 0.000
V20-V29 Motorcycle rider injured in transport accident
0.591 0.409 0.000
O99.6 Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
0.591 0.409 0.000
S06.30 Focal brain injury (without open intracranial wound)
0.590 0.410 0.000
T63 Toxic effect of contact with venomous animals
0.589 0.411 0.000
I67.1 Cerebral aneurysm, nonruptured
0.588 0.412 0.000
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.586 0.414 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.586 0.414 0.000
I74.0 Embolism and thrombosis of abdominal aorta
0.586 0.414 0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]
0.585 0.414 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.585 0.415 0.000
S70 Superficial injury of hip and thigh
0.585 0.415 0.000
I27.8 Other specified pulmonary heart diseases
0.584 0.416 0.000
I45.3 Trifascicular block
0.583 0.417 0.000
S52.51 Fracture of lower end of radius (open)
0.583 0.417 0.000
S40 Superficial injury of shoulder and upper arm
0.581 0.419 0.000
I47 Paroxysmal tachycardia
0.581 0.419 0.000
S09 Other and unspecified injuries of head
0.581 0.419 0.000
T92.0 Sequelae of open wound of upper limb
0.581 0.419 0.000
T46.4 Angiotensin-converting-enzyme inhibitors
0.580 0.420 0.000
I70 Atherosclerosis
0.580 0.420 0.000
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction
0.579 0.421 0.000
I31.8 Other specified diseases of pericardium
0.579 0.421 0.000
I31.2 Haemopericardium, not elsewhere classified
0.579 0.421 0.000
I31.1 Chronic constrictive pericarditis
0.579 0.421 0.000
I31.0 Chronic adhesive pericarditis
0.579 0.421 0.000
I33.9 Acute endocarditis, unspecified
0.579 0.421 0.000
T25 Burn and corrosion of ankle and foot
0.578 0.421 0.000
T22 Burn and corrosion of shoulder and upper limb, except wrist and hand
0.578 0.421 0.000
T20 Burn and corrosion of head and neck
0.578 0.421 0.000
T45.9 Primarily systemic and haematological agent, unspecified
0.578 0.422 0.000
T45.8 Other primarily systemic and haematological agents
0.578 0.422 0.000
T45.7 Anticoagulant antagonists, vitamin K and other coagulants
0.578 0.422 0.000
T45.6 Fibrinolysis-affecting drugs
0.578 0.422 0.000
T45.4 Iron and its compounds
0.578 0.422 0.000
T45.3 Enzymes, not elsewhere classified
0.578 0.422 0.000
T45.2 Vitamins, not elsewhere classified
0.578 0.422 0.000
T45.1 Antineoplastic and immunosuppressive drugs
0.578 0.422 0.000
S06.61 Traumatic subarachnoid haemorrhage (with open intracranial wound)
0.578 0.422 0.000
S06.00 Concussion (without open intracranial wound)
0.577 0.423 0.000
S83.2 Tear of meniscus, current
0.577 0.423 0.000
O80-O84 Delivery
0.577 0.423 0.000
O99.1 Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
0.577 0.423 0.000
I27.0 Primary pulmonary hypertension
0.576 0.424 0.000
T91 Sequelae of injuries of neck and trunk
0.574 0.426 0.000
I77.0 Arteriovenous fistula, acquired
0.574 0.426 0.000
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee
0.573 0.427 0.000
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level
0.573 0.427 0.000
S10 Superficial injury of neck
0.572 0.428 0.000
S66.9 Injury of unspecified muscle and tendon at wrist and hand level
0.572 0.428 0.000
S66.5 Injury of intrinsic muscle and tendon of other finger at wrist and hand level
0.572 0.428 0.000
S66.4 Injury of intrinsic muscle and tendon of thumb at wrist and hand level
0.572 0.428 0.000
S60.7 Multiple superficial injuries of wrist and hand
0.572 0.428 0.000
S60.1 Contusion of finger(s) with damage to nail
0.572 0.428 0.000
S60.0 Contusion of finger(s) without damage to nail
0.572 0.428 0.000
S64.3 Injury of digital nerve of thumb
0.571 0.429 0.000
T98 Sequelae of other and unspecified effects of external causes
0.570 0.430 0.000
T95 Sequelae of burns, corrosions and frostbite
0.570 0.430 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.570 0.430 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.570 0.430 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.570 0.430 0.000
I42.2 Other hypertrophic cardiomyopathy
0.568 0.432 0.000
T17.2 Foreign body in pharynx
0.567 0.433 0.000
S51.9 Open wound of forearm, part unspecified
0.567 0.433 0.000
I27.2 Other secondary pulmonary hypertension
0.565 0.435 0.000
S67.8 Crushing injury of other and unspecified parts of wrist and hand
0.565 0.435 0.000
V40-V49 Car occupant injured in transport accident
0.565 0.435 0.000
V01-V09 Pedestrian injured in transport accident
0.565 0.435 0.000
T92.8 Sequelae of other specified injuries of upper limb
0.563 0.437 0.000
T51.9 Alcohol, unspecified
0.562 0.438 0.000
T66-T78 Other and unspecified effects of external causes
0.561 0.439 0.000
S60.9 Superficial injury of wrist and hand, unspecified
0.561 0.439 0.000
S54.2 Injury of radial nerve at forearm level
0.560 0.439 0.000
S54.9 Injury of unspecified nerve at forearm level
0.560 0.439 0.000
S54.8 Injury of other nerves at forearm level
0.560 0.439 0.000
S54.7 Injury of multiple nerves at forearm level
0.560 0.439 0.000
S54.3 Injury of cutaneous sensory nerve at forearm level
0.560 0.439 0.000
S54.1 Injury of median nerve at forearm level
0.560 0.439 0.000
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.559 0.440 0.000
T13 Other injuries of lower limb, level unspecified
0.559 0.441 0.000
I97 Postprocedural disorders of circulatory system, not elsewhere classified
0.558 0.442 0.000
S66.8 Injury of other muscles and tendons at wrist and hand level
0.557 0.443 0.000
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level
0.556 0.444 0.000
S52.80 Fracture of other parts of forearm (closed)
0.556 0.444 0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.556 0.444 0.000
T51.8 Other alcohols
0.555 0.445 0.000
T51.3 Fusel oil
0.555 0.445 0.000
T51.2 2-Propanol
0.555 0.445 0.000
T51.1 Methanol
0.555 0.445 0.000
T47.1 Other antacids and anti-gastric-secretion drugs
0.555 0.445 0.000
I07 Rheumatic tricuspid valve diseases
0.555 0.445 0.000
T92.3 Sequelae of dislocation, sprain and strain of upper limb
0.554 0.446 0.000
S13.4 Sprain and strain of cervical spine
0.554 0.446 0.000
I77.1 Stricture of artery
0.554 0.446 0.000
I49 Other cardiac arrhythmias
0.554 0.446 0.000
S92.2 Fracture of other tarsal bone(s)
0.553 0.446 0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip
0.553 0.447 0.000
I42.0 Dilated cardiomyopathy
0.553 0.447 0.000
S61.8 Open wound of other parts of wrist and hand
0.552 0.448 0.000
S00 Superficial injury of head
0.551 0.449 0.000
I28 Other diseases of pulmonary vessels
0.549 0.450 0.000
I42.7 Cardiomyopathy due to drugs and other external agents
0.548 0.452 0.000
I42.5 Other restrictive cardiomyopathy
0.548 0.452 0.000
I42.4 Endocardial fibroelastosis
0.548 0.452 0.000
I42.3 Endomyocardial (eosinophilic) disease
0.548 0.452 0.000
O98 Maternal infectious and parasitic diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.548 0.452 0.000
O97 Death from sequelae of direct obstetric causes
0.548 0.452 0.000
O96 Death from any obstetric cause occurring more than 42 days but less than one year after delivery
0.548 0.452 0.000
O95 Obstetric death of unspecified cause
0.548 0.452 0.000
O94 Sequelae of complication of pregnancy, childbirth and the puerperium
0.548 0.452 0.000
O99.5 Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
0.547 0.453 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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