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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs386628
log Bayes Factor = 51.3209
Chromosome 6   position 28,784,396  (GRCh37) Explore rs386628 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E83.1 Disorders of iron metabolism
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.001 0.999
E05.9 Thyrotoxicosis, unspecified
0.000 0.002 0.998
E10.9 Without complications
0.000 0.003 0.997
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.006 0.994
E10-E14 Diabetes mellitus
0.000 0.010 0.990
E10.3 With ophthalmic complications
0.000 0.010 0.990
E16.2 Hypoglycaemia, unspecified
0.000 0.012 0.988
E16 Other disorders of pancreatic internal secretion
0.000 0.012 0.988
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.013 0.987
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.013 0.987
E00-E07 Disorders of thyroid gland
0.000 0.016 0.984
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.058 0.942
E10.2 With renal complications
0.000 0.065 0.935
E10.1 With ketoacidosis
0.000 0.107 0.893
E10.4 With neurological complications
0.000 0.144 0.856
E13 Other specified diabetes mellitus
0.000 0.176 0.824
E05.8 Other thyrotoxicosis
0.000 0.188 0.812
E16.1 Other hypoglycaemia
0.000 0.226 0.774
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.240 0.760
E10.7 With multiple complications
0.000 0.251 0.749
I83.9 Varicose veins of lower extremities without ulcer or inflammation
0.746 0.254 0.000
E10.0 With coma
0.000 0.277 0.723
E05.5 Thyroid crisis or storm
0.000 0.287 0.713
E05.4 Thyrotoxicosis factitia
0.000 0.287 0.713
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.287 0.713
E12 Malnutrition-related diabetes mellitus
0.000 0.290 0.710
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.292 0.708
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.292 0.708
E16.4 Abnormal secretion of gastrin
0.000 0.292 0.708
E16.3 Increased secretion of glucagon
0.000 0.292 0.708
E15 Nondiabetic hypoglycaemic coma
0.000 0.292 0.708
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.294 0.706
E00 Congenital iodine-deficiency syndrome
0.000 0.294 0.706
E13.9 Without complications
0.000 0.298 0.702
E40-E46 Malnutrition
0.000 0.328 0.672
E10.6 With other specified complications
0.000 0.360 0.640
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.365 0.634
E14 Unspecified diabetes mellitus
0.000 0.372 0.628
E13.3 With ophthalmic complications
0.000 0.404 0.595
E07 Other disorders of thyroid
0.000 0.407 0.593
E13.8 With unspecified complications
0.000 0.409 0.590
E13.7 With multiple complications
0.000 0.409 0.590
E13.6 With other specified complications
0.000 0.409 0.590
E13.5 With peripheral circulatory complications
0.000 0.409 0.590
E13.4 With neurological complications
0.000 0.409 0.590
E13.2 With renal complications
0.000 0.409 0.590
E13.1 With ketoacidosis
0.000 0.409 0.590
E13.0 With coma
0.000 0.409 0.590
E06 Thyroiditis
0.000 0.418 0.582
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.430 0.569
E10.5 With peripheral circulatory complications
0.000 0.434 0.566
E14.3 With ophthalmic complications
0.000 0.483 0.517
E10.8 With unspecified complications
0.000 0.490 0.510
E12.9 Without complications
0.000 0.491 0.509
E12.8 With unspecified complications
0.000 0.491 0.509
E12.7 With multiple complications
0.000 0.491 0.509
E12.6 With other specified complications
0.000 0.491 0.509
E12.5 With peripheral circulatory complications
0.000 0.491 0.509
E12.4 With neurological complications
0.000 0.491 0.509
E12.3 With ophthalmic complications
0.000 0.491 0.509
E12.2 With renal complications
0.000 0.491 0.509
E12.1 With ketoacidosis
0.000 0.491 0.509
E12.0 With coma
0.000 0.491 0.509
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.000 0.494 0.506
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.000 0.494 0.506
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.000 0.494 0.506
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.000 0.494 0.506
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.494 0.506
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.000 0.494 0.506
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.000 0.494 0.506
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.000 0.494 0.506
E14.1 With ketoacidosis
0.000 0.508 0.492
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.518 0.482
E45 Retarded development following protein-energy malnutrition
0.000 0.518 0.482
E43 Unspecified severe protein-energy malnutrition
0.000 0.518 0.482
E42 Marasmic kwashiorkor
0.000 0.518 0.482
E41 Nutritional marasmus
0.000 0.518 0.482
E40 Kwashiorkor
0.000 0.518 0.482
E14.6 With other specified complications
0.000 0.522 0.478
E06.9 Thyroiditis, unspecified
0.000 0.528 0.472
E14.4 With neurological complications
0.000 0.532 0.468
E14.8 With unspecified complications
0.000 0.544 0.456
E07.8 Other specified disorders of thyroid
0.000 0.544 0.456
E14.7 With multiple complications
0.000 0.550 0.450
E46 Unspecified protein-energy malnutrition
0.000 0.554 0.446
E06.1 Subacute thyroiditis
0.000 0.562 0.437
E14.2 Withrenal complications
0.000 0.569 0.430
E14.5 With peripheral circulatory complications
0.000 0.574 0.426
E07.1 Dyshormogenetic goitre
0.000 0.575 0.425
E07.0 Hypersecretion of calcitonin
0.000 0.575 0.425
E14.0 With coma
0.000 0.578 0.422
E06.4 Drug-induced thyroiditis
0.000 0.583 0.417
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.583 0.417
E06.0 Acute thyroiditis
0.000 0.583 0.417
K90 Intestinal malabsorption
0.000 0.583 0.417
E06.5 Other chronic thyroiditis
0.000 0.599 0.401
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.001 0.612 0.388
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.644 0.356
E44.1 Mild protein-energy malnutrition
0.000 0.654 0.345
E44.0 Moderate protein-energy malnutrition
0.000 0.654 0.345
E03 Other hypothyroidism
0.000 0.656 0.344
E65-E68 Obesity and other hyperalimentation
0.000 0.679 0.321
C19 Malignant neoplasm of rectosigmoid junction
0.000 0.679 0.321
K90.3 Pancreatic steatorrhoea
0.000 0.701 0.299
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.701 0.299
K90.1 Tropical sprue
0.000 0.701 0.299
K90.8 Other intestinal malabsorption
0.000 0.714 0.286
E50-E64 Other nutritional deficiencies
0.000 0.723 0.277
E11 Non-insulin-dependent diabetes mellitus
0.000 0.730 0.270
E11.6 With other specified complications
0.000 0.750 0.250
E07.9 Disorder of thyroid, unspecified
0.000 0.750 0.249
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.752 0.248
E03.5 Myxoedema coma
0.000 0.753 0.247
E03.4 Atrophy of thyroid (acquired)
0.000 0.753 0.247
E03.3 Postinfectious hypothyroidism
0.000 0.753 0.247
E03.1 Congenital hypothyroidism without goitre
0.000 0.762 0.238
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.762 0.238
E67 Other hyperalimentation
0.000 0.769 0.230
E68 Sequelae of hyperalimentation
0.000 0.769 0.230
C15-C26 Malignant neoplasms of digestive organs
0.000 0.774 0.226
E11.0 With coma
0.000 0.775 0.225
E11.1 With ketoacidosis
0.000 0.778 0.222
C20 Malignant neoplasm of rectum
0.000 0.778 0.222
C15 Malignant neoplasm of oesophagus
0.000 0.780 0.220
M45.X9 Ankylosing spondylitis (Site unspecified)
0.205 0.795 0.000
E54 Ascorbic acid deficiency
0.000 0.798 0.202
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.801 0.199
E63 Other nutritional deficiencies
0.000 0.801 0.199
E50 Vitamin A deficiency
0.000 0.801 0.199
E60 Dietary zinc deficiency
0.000 0.801 0.199
E59 Dietary selenium deficiency
0.000 0.801 0.199
E52 Niacin deficiency [pellagra]
0.000 0.801 0.199
E11.2 With renal complications
0.000 0.802 0.198
K90.9 Intestinal malabsorption, unspecified
0.000 0.802 0.198
E51 Thiamine deficiency
0.000 0.802 0.198
C25 Malignant neoplasm of pancreas
0.000 0.806 0.194
E11.7 With multiple complications
0.000 0.806 0.194
C15.5 Lower third of oesophagus
0.000 0.807 0.193
E03.8 Other specified hypothyroidism
0.000 0.809 0.191
C15.4 Middle third of oesophagus
0.000 0.810 0.190
C15.9 Oesophagus, unspecified
0.000 0.810 0.190
E56 Other vitamin deficiencies
0.000 0.812 0.188
E65 Localised adiposity
0.000 0.826 0.174
E58 Dietary calcium deficiency
0.000 0.827 0.173
E83 Disorders of mineral metabolism
0.163 0.827 0.009
C15.0 Cervical part of oesophagus
0.000 0.830 0.170
E55 Vitamin D deficiency
0.000 0.832 0.168
C17 Malignant neoplasm of small intestine
0.000 0.833 0.167
E67.8 Other specified hyperalimentation
0.000 0.834 0.165
E67.3 Hypervitaminosis D
0.000 0.834 0.165
E67.2 Megavitamin-B6 syndrome
0.000 0.834 0.165
E67.1 Hypercarotenaemia
0.000 0.834 0.165
E67.0 Hypervitaminosis A
0.000 0.834 0.165
C25.2 Tail of pancreas
0.000 0.836 0.164
C25.3 Pancreatic duct
0.000 0.839 0.161
C15.1 Thoracic part of oesophagus
0.000 0.840 0.160
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.000 0.840 0.160
C25.1 Body of pancreas
0.000 0.842 0.158
C15.8 Overlapping lesion of oesophagus
0.000 0.842 0.158
C15.2 Abdominal part of oesophagus
0.000 0.842 0.158
C17.0 Duodenum
0.000 0.842 0.158
C25.4 Endocrine pancreas
0.000 0.844 0.156
C15.3 Upper third of oesophagus
0.000 0.846 0.154
C21 Malignant neoplasm of anus and anal canal
0.000 0.847 0.153
I83 Varicose veins of lower extremities
0.151 0.849 0.000
E20-E35 Disorders of other endocrine glands
0.000 0.855 0.145
E11.8 With unspecified complications
0.000 0.855 0.144
C25.9 Pancreas, unspecified
0.000 0.856 0.144
E61 Deficiency of other nutrient elements
0.000 0.857 0.143
E50.9 Vitamin A deficiency, unspecified
0.000 0.857 0.143
E50.8 Other manifestations of vitamin A deficiency
0.000 0.857 0.143
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.857 0.143
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.857 0.143
E50.5 Vitamin A deficiency with night blindness
0.000 0.857 0.143
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.857 0.143
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.857 0.143
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.857 0.143
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.857 0.143
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.857 0.143
E63.9 Nutritional deficiency, unspecified
0.000 0.857 0.143
E63.8 Other specified nutritional deficiencies
0.000 0.857 0.143
E63.1 Imbalance of constituents of food intake
0.000 0.857 0.143
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.857 0.143
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.857 0.143
E64.8 Sequelae of other nutritional deficiencies
0.000 0.857 0.143
E64.3 Sequelae of rickets
0.000 0.857 0.143
E64.2 Sequelae of vitamin C deficiency
0.000 0.857 0.143
E64.1 Sequelae of vitamin A deficiency
0.000 0.857 0.143
E64.0 Sequelae of protein-energy malnutrition
0.000 0.857 0.143
E51.9 Thiamine deficiency, unspecified
0.000 0.858 0.142
E51.8 Other manifestations of thiamine deficiency
0.000 0.858 0.142
E51.1 Beriberi
0.000 0.858 0.142
E83.3 Disorders of phosphorus metabolism
0.139 0.858 0.002
E51.2 Wernicke's encephalopathy
0.000 0.859 0.141
C24.0 Extrahepatic bile duct
0.000 0.860 0.140
C25.8 Overlapping lesion of pancreas
0.000 0.860 0.140
E56.9 Vitamin deficiency, unspecified
0.000 0.865 0.135
E56.8 Deficiency of other vitamins
0.000 0.865 0.135
E56.0 Deficiency of vitamin E
0.000 0.865 0.135
E06.3 Autoimmune thyroiditis
0.001 0.865 0.134
E11.5 With peripheral circulatory complications
0.000 0.867 0.133
E53 Deficiency of other B group vitamins
0.000 0.868 0.132
C25.7 Other parts of pancreas
0.000 0.873 0.127
E24 Cushing's syndrome
0.000 0.873 0.127
E83.8 Other disorders of mineral metabolism
0.117 0.876 0.007
E83.2 Disorders of zinc metabolism
0.117 0.876 0.007
E83.0 Disorders of copper metabolism
0.117 0.876 0.007
E56.1 Deficiency of vitamin K
0.000 0.876 0.124
E83.9 Disorder of mineral metabolism, unspecified
0.117 0.877 0.006
C21.8 Overlapping lesion of rectum, anus and anal canal
0.000 0.877 0.122
E14.9 Without complications
0.000 0.878 0.122
E55.0 Rickets, active
0.000 0.879 0.121
C17.8 Overlapping lesion of small intestine
0.000 0.880 0.120
C17.3 Meckel's diverticulum
0.000 0.880 0.120
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.882 0.118
C24.8 Overlapping lesion of biliary tract
0.000 0.885 0.114
I83.0 Varicose veins of lower extremities with ulcer
0.112 0.888 0.000
E21.3 Hyperparathyroidism, unspecified
0.000 0.888 0.112
C21.2 Cloacogenic zone
0.000 0.890 0.110
E20 Hypoparathyroidism
0.000 0.891 0.109
C24.9 Biliary tract, unspecified
0.000 0.892 0.108
C17.1 Jejunum
0.000 0.893 0.107
M45 Ankylosing spondylitis
0.106 0.894 0.000
E28 Ovarian dysfunction
0.000 0.894 0.106
C23 Malignant neoplasm of gallbladder
0.000 0.894 0.105
E24.0 Pituitary-dependent Cushing's disease
0.000 0.894 0.106
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.896 0.104
E32 Diseases of thymus
0.000 0.896 0.104
E30 Disorders of puberty, not elsewhere classified
0.000 0.896 0.104
E25 Adrenogenital disorders
0.000 0.896 0.104
E61.9 Deficiency of nutrient element, unspecified
0.000 0.897 0.102
E61.8 Deficiency of other specified nutrient elements
0.000 0.897 0.102
E61.7 Deficiency of multiple nutrient elements
0.000 0.897 0.102
E61.6 Vanadium deficiency
0.000 0.897 0.102
E61.5 Molybdenum deficiency
0.000 0.897 0.102
E61.4 Chromium deficiency
0.000 0.897 0.102
E61.3 Manganese deficiency
0.000 0.897 0.102
E61.0 Copper deficiency
0.000 0.897 0.102
E31 Polyglandular dysfunction
0.000 0.898 0.102
C26 Malignant neoplasm of other and ill-defined digestive organs
0.000 0.898 0.102
E24.9 Cushing's syndrome, unspecified
0.000 0.899 0.101
C21.1 Anal canal
0.000 0.901 0.099
E03.9 Hypothyroidism, unspecified
0.000 0.903 0.097
E24.2 Drug-induced Cushing's syndrome
0.000 0.904 0.096
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.000 0.904 0.096
C21.0 Anus, unspecified
0.000 0.904 0.096
E53.1 Pyridoxine deficiency
0.000 0.905 0.095
E53.0 Riboflavin deficiency
0.000 0.905 0.095
E53.9 Vitamin B deficiency, unspecified
0.000 0.906 0.094
E24.8 Other Cushing's syndrome
0.000 0.908 0.092
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.909 0.091
E24.3 Ectopic ACTH syndrome
0.000 0.909 0.091
E24.1 Nelson's syndrome
0.000 0.909 0.091
E61.2 Magnesium deficiency
0.000 0.909 0.090
E29 Testicular dysfunction
0.000 0.909 0.090
E55.9 Vitamin D deficiency, unspecified
0.000 0.910 0.090
E21.2 Other hyperparathyroidism
0.000 0.915 0.085
E21.4 Other specified disorders of parathyroid gland
0.000 0.915 0.085
I83.2 Varicose veins of lower extremities with both ulcer and inflammation
0.084 0.916 0.000
M45.X2 Ankylosing spondylitis (Cervical region)
0.084 0.916 0.000
E20.9 Hypoparathyroidism, unspecified
0.000 0.917 0.083
E34 Other endocrine disorders
0.000 0.918 0.082
M45.X6 Ankylosing spondylitis (Lumbar region)
0.082 0.918 0.000
E28.2 Polycystic ovarian syndrome
0.000 0.919 0.081
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.920 0.080
C17.9 Small intestine, unspecified
0.000 0.921 0.079
C17.2 Ileum
0.000 0.921 0.078
E20.8 Other hypoparathyroidism
0.000 0.922 0.078
E20.1 Pseudohypoparathyroidism
0.000 0.922 0.078
E20.0 Idiopathic hypoparathyroidism
0.000 0.922 0.078
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)
0.076 0.923 0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)
0.076 0.923 0.000
M45.X5 Ankylosing spondylitis (Thoracolumbar region)
0.076 0.923 0.000
M45.X4 Ankylosing spondylitis (Thoracic region)
0.076 0.923 0.000
M45.X3 Ankylosing spondylitis (Cervicothoracic region)
0.076 0.923 0.000
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)
0.076 0.923 0.000
E28.9 Ovarian dysfunction, unspecified
0.000 0.924 0.076
E28.8 Other ovarian dysfunction
0.000 0.924 0.076
E28.1 Androgen excess
0.000 0.924 0.076
E28.0 Oestrogen excess
0.000 0.924 0.076
E30.9 Disorder of puberty, unspecified
0.000 0.925 0.075
E30.8 Other disorders of puberty
0.000 0.925 0.075
E30.1 Precocious puberty
0.000 0.925 0.075
E30.0 Delayed puberty
0.000 0.925 0.075
E32.9 Disease of thymus, unspecified
0.000 0.925 0.075
E32.8 Other diseases of thymus
0.000 0.925 0.075
E32.1 Abscess of thymus
0.000 0.925 0.075
E32.0 Persistent hyperplasia of thymus
0.000 0.925 0.075
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.925 0.075
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.925 0.075
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.925 0.075
E25.9 Adrenogenital disorder, unspecified
0.000 0.925 0.074
E25.8 Other adrenogenital disorders
0.000 0.925 0.074
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.926 0.074
E31.9 Polyglandular dysfunction, unspecified
0.000 0.926 0.073
E31.8 Other polyglandular dysfunction
0.000 0.926 0.073
E31.1 Polyglandular hyperfunction
0.000 0.926 0.073
C26.8 Overlapping lesion of digestive system
0.000 0.927 0.073
C26.1 Spleen
0.000 0.927 0.073
E28.3 Primary ovarian failure
0.000 0.928 0.072
E31.0 Autoimmune polyglandular failure
0.000 0.928 0.072
E11.3 With ophthalmic complications
0.000 0.930 0.070
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.931 0.069
C22.7 Other specified carcinomas of liver
0.000 0.931 0.069
C22.4 Other sarcomas of liver
0.000 0.931 0.069
C22.3 Angiosarcoma of liver
0.000 0.931 0.069
C22.2 Hepatoblastoma
0.000 0.931 0.069
E61.1 Iron deficiency
0.000 0.931 0.069
E26 Hyperaldosteronism
0.000 0.931 0.068
C22.1 Intrahepatic bile duct carcinoma
0.000 0.933 0.067
E29.9 Testicular dysfunction, unspecified
0.000 0.934 0.066
E83.4 Disorders of magnesium metabolism
0.062 0.934 0.004
E29.8 Other testicular dysfunction
0.000 0.935 0.065
E29.0 Testicular hyperfunction
0.000 0.935 0.065
C22.9 Liver, unspecified
0.000 0.936 0.064
C25.0 Head of pancreas
0.000 0.936 0.064
C24.1 Ampulla of Vater
0.001 0.937 0.062
M45.X0 Ankylosing spondylitis (Multiple sites in spine)
0.062 0.937 0.000
E21.0 Primary hyperparathyroidism
0.000 0.938 0.062
R31 Unspecified haematuria
0.061 0.939 0.000
E34.3 Short stature, not elsewhere classified
0.000 0.940 0.060
E34.5 Androgen resistance syndrome
0.000 0.941 0.059
E34.4 Constitutional tall stature
0.000 0.941 0.059
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.941 0.059
E34.1 Other hypersecretion of intestinal hormones
0.000 0.941 0.059
E11.4 With neurological complications
0.000 0.943 0.056
E22 Hyperfunction of pituitary gland
0.000 0.944 0.056
E34.8 Other specified endocrine disorders
0.000 0.945 0.055
E23 Hypofunction and other disorders of pituitary gland
0.000 0.946 0.054
E34.9 Endocrine disorder, unspecified
0.000 0.946 0.054
C16 Malignant neoplasm of stomach
0.000 0.946 0.054
C26.9 Ill-defined sites within the digestive system
0.001 0.948 0.052
E70-E90 Metabolic disorders
0.001 0.948 0.051
C18 Malignant neoplasm of colon
0.000 0.948 0.052
I83.1 Varicose veins of lower extremities with inflammation
0.052 0.948 0.000
C26.0 Intestinal tract, part unspecified
0.000 0.950 0.050
C18.1 Appendix
0.000 0.950 0.050
E04 Other non-toxic goitre
0.002 0.950 0.048
E29.1 Testicular hypofunction
0.000 0.950 0.050
E26.8 Other hyperaldosteronism
0.000 0.951 0.049
E26.1 Secondary hyperaldosteronism
0.000 0.951 0.049
E34.0 Carcinoid syndrome
0.000 0.951 0.049
C18.9 Colon, unspecified
0.000 0.951 0.049
E23.7 Disorder of pituitary gland, unspecified
0.000 0.954 0.046
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.000 0.955 0.045
E78.2 Mixed hyperlipidaemia
0.000 0.956 0.044
E26.9 Hyperaldosteronism, unspecified
0.001 0.957 0.043
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.001 0.959 0.040
E88 Other metabolic disorders
0.000 0.959 0.040
E22.8 Other hyperfunction of pituitary gland
0.000 0.960 0.040
E74 Other disorders of carbohydrate metabolism
0.001 0.960 0.039
E78.1 Pure hyperglyceridaemia
0.000 0.960 0.040
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.961 0.039
E23.1 Drug-induced hypopituitarism
0.000 0.961 0.039
C16.2 Body of stomach
0.000 0.961 0.039
C16.0 Cardia
0.000 0.962 0.038
E22.1 Hyperprolactinaemia
0.000 0.962 0.038
E84 Cystic fibrosis
0.001 0.962 0.037
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.962 0.037
E77 Disorders of glycoprotein metabolism
0.001 0.962 0.037
E76 Disorders of glycosaminoglycan metabolism
0.001 0.962 0.037
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.001 0.962 0.037
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.001 0.962 0.037
E85 Amyloidosis
0.001 0.962 0.037
C18.8 Overlapping lesion of colon
0.000 0.963 0.037
E73 Lactose intolerance
0.001 0.963 0.036
E78.6 Lipoprotein deficiency
0.000 0.963 0.037
C16.5 Lesser curvature of stomach, unspecified
0.000 0.964 0.036
C16.6 Greater curvature of stomach, unspecified
0.000 0.964 0.036
E04.8 Other specified non-toxic goitre
0.001 0.964 0.035
E70 Disorders of aromatic amino-acid metabolism
0.001 0.964 0.035
E88.9 Metabolic disorder, unspecified
0.000 0.965 0.035
E79 Disorders of purine and pyrimidine metabolism
0.001 0.965 0.034
E78.3 Hyperchylomicronaemia
0.000 0.966 0.034
C16.8 Overlapping lesion of stomach
0.000 0.966 0.034
E72 Other disorders of amino-acid metabolism
0.001 0.966 0.033
C16.4 Pylorus
0.000 0.966 0.034
E78.5 Hyperlipidaemia, unspecified
0.000 0.967 0.033
E75.5 Other lipid storage disorders
0.001 0.967 0.032
C18.6 Descending colon
0.000 0.968 0.032
E78.9 Disorder of lipoprotein metabolism, unspecified
0.000 0.968 0.032
C16.9 Stomach, unspecified
0.000 0.968 0.032
E88.2 Lipomatosis, not elsewhere classified
0.000 0.968 0.032
C16.1 Fundus of stomach
0.000 0.968 0.032
E74.3 Other disorders of intestinal carbohydrate absorption
0.001 0.968 0.031
C18.4 Transverse colon
0.000 0.968 0.032
E53.8 Deficiency of other specified B group vitamins
0.000 0.969 0.031
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.969 0.031
E85.4 Organ-limited amyloidosis
0.000 0.969 0.031
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.970 0.030
E75.2 Other sphingolipidosis
0.001 0.970 0.029
C16.3 Pyloric antrum
0.000 0.970 0.030
E23.6 Other disorders of pituitary gland
0.000 0.970 0.029
E75.6 Lipid storage disorder, unspecified
0.001 0.970 0.029
E75.4 Neuronal ceroid lipofuscinosis
0.001 0.970 0.029
E75.3 Sphingolipidosis, unspecified
0.001 0.970 0.029
E75.1 Other gangliosidosis
0.001 0.970 0.029
E75.0 GM2 gangliosidosis
0.001 0.970 0.029
E78.4 Other hyperlipidaemia
0.000 0.971 0.029
E74.9 Disorder of carbohydrate metabolism, unspecified
0.001 0.971 0.028
E74.8 Other specified disorders of carbohydrate metabolism
0.001 0.971 0.028
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.001 0.971 0.028
E74.2 Disorders of galactose metabolism
0.001 0.971 0.028
E74.1 Disorders of fructose metabolism
0.001 0.971 0.028
E85.3 Secondary systemic amyloidosis
0.001 0.972 0.028
E74.0 Glycogen storage disease
0.001 0.972 0.027
E84.0 Cystic fibrosis with pulmonary manifestations
0.001 0.972 0.027
C18.3 Hepatic flexure
0.000 0.972 0.028
E88.8 Other specified metabolic disorders
0.000 0.972 0.027
E84.8 Cystic fibrosis with other manifestations
0.001 0.972 0.027
E84.1 Cystic fibrosis with intestinal manifestations
0.001 0.972 0.027
E85.8 Other amyloidosis
0.001 0.973 0.027
E23.2 Diabetes insipidus
0.000 0.973 0.027
E71.3 Disorders of fatty-acid metabolism
0.001 0.973 0.026
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.001 0.973 0.026
E71.1 Other disorders of branched-chain amino-acid metabolism
0.001 0.973 0.026
E71.0 Maple-syrup-urine disease
0.001 0.973 0.026
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.001 0.973 0.026
E76.8 Other disorders of glucosaminoglycan metabolism
0.001 0.973 0.026
E76.3 Mucopolysaccharidosis, unspecified
0.001 0.973 0.026
E76.2 Other mucopolysaccharidoses
0.001 0.973 0.026
E76.1 Mucopolysaccharidosis, type II
0.001 0.973 0.026
E76.0 Mucopolysaccharidosis, type I
0.001 0.973 0.026
E77.9 Disorder of glycoprotein metabolism, unspecified
0.001 0.973 0.026
E77.8 Other disorders of glycoprotein metabolism
0.001 0.973 0.026
E77.1 Defects in glycoprotein degradation
0.001 0.973 0.026
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.001 0.973 0.026
E85.2 Heredofamilial amyloidosis, unspecified
0.001 0.973 0.027
E85.1 Neuropathic heredofamilial amyloidosis
0.001 0.973 0.027
E85.0 Nonneuropathic heredofamilial amyloidosis
0.001 0.973 0.027
E84.9 Cystic fibrosis, unspecified
0.001 0.973 0.026
E04.0 Non-toxic diffuse goitre
0.002 0.973 0.026
E73.8 Other lactose intolerance
0.001 0.973 0.026
E73.1 Secondary lactase deficiency
0.001 0.973 0.026
E73.0 Congenital lactase deficiency
0.001 0.973 0.026
E26.0 Primary hyperaldosteronism
0.001 0.973 0.026
E73.9 Lactose intolerance, unspecified
0.001 0.973 0.026
M45-M49 Spondylopathies
0.027 0.973 0.000
E66 Obesity
0.000 0.973 0.026
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.001 0.974 0.025
E70.8 Other disorders of aromatic amino-acid metabolism
0.001 0.974 0.025
E70.2 Disorders of tyrosine metabolism
0.001 0.974 0.025
E70.1 Other hyperphenylalaninaemias
0.001 0.974 0.025
E70.0 Classical phenylketonuria
0.001 0.974 0.025
E22.0 Acromegaly and pituitary gigantism
0.000 0.974 0.026
K90-K93 Other diseases of the digestive system
0.000 0.974 0.026
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.001 0.974 0.025
E79.8 Other disorders of purine and pyrimidine metabolism
0.001 0.974 0.025
E79.1 Lesch-Nyhan syndrome
0.001 0.974 0.025
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.975 0.025
E72.9 Disorder of amino-acid metabolism, unspecified
0.001 0.975 0.024
E72.8 Other specified disorders of amino-acid metabolism
0.001 0.975 0.024
E72.5 Disorders of glycine metabolism
0.001 0.975 0.024
E72.4 Disorders of ornithine metabolism
0.001 0.975 0.024
E72.3 Disorders of lysine and hydroxylysine metabolism
0.001 0.975 0.024
E72.2 Disorders of urea cycle metabolism
0.001 0.975 0.024
E88.3 Tumour lysis syndrome
0.001 0.976 0.024
E72.0 Disorders of amino-acid transport
0.001 0.976 0.023
E70.3 Albinism
0.001 0.976 0.023
E27 Other disorders of adrenal gland
0.000 0.977 0.023
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.001 0.977 0.022
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.001 0.977 0.021
C22.0 Liver cell carcinoma
0.001 0.978 0.021
C18.7 Sigmoid colon
0.000 0.979 0.021
M49 Spondylopathies in diseases classified elsewhere
0.020 0.979 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.001 0.980 0.019
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.020 0.980 0.000
E78.8 Other disorders of lipoprotein metabolism
0.000 0.980 0.020
M46 Other inflammatory spondylopathies
0.020 0.980 0.000
E66.1 Drug-induced obesity
0.000 0.981 0.019
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.981 0.019
E85.9 Amyloidosis, unspecified
0.001 0.981 0.018
I89 Other non-infective disorders of lymphatic vessels and lymph nodes
0.018 0.982 0.000
S02.40 Fracture of malar and maxillary bones (closed)
0.000 0.982 0.018
M46.9 Inflammatory spondylopathy, unspecified
0.018 0.982 0.000
I86 Varicose veins of other sites
0.018 0.982 0.000
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)
0.018 0.982 0.000
M47.12 Other spondylosis with myelopathy (Cervical region)
0.017 0.983 0.000
E27.5 Adrenomedullary hyperfunction
0.000 0.983 0.017
E27.0 Other adrenocortical overactivity
0.000 0.983 0.017
I89.9 Non-infective disorder of lymphatic vessels and lymph nodes, unspecified
0.017 0.983 0.000
I86.8 Varicose veins of other specified sites
0.017 0.983 0.000
I89.0 Lymphoedema, not elsewhere classified
0.017 0.983 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.984 0.016
M47.1 Other spondylosis with myelopathy
0.016 0.984 0.000
I81 Portal vein thrombosis
0.016 0.984 0.000
M49.5 Collapsed vertebra in diseases classified elsewhere
0.016 0.984 0.000
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.984 0.016
E80.2 Other porphyria
0.001 0.984 0.015
E27.2 Addisonian crisis
0.000 0.985 0.015
M47 Spondylosis
0.015 0.985 0.000
M49.8 Spondylopathy in other diseases classified elsewhere
0.015 0.985 0.000
M49.4 Neuropathic spondylopathy
0.015 0.985 0.000
M49.3 Spondylopathy in other infectious and parasitic diseases classified elsewhere
0.015 0.985 0.000
M49.2 Enterobacterial spondylitis
0.015 0.985 0.000
M49.1 Brucella spondylitis
0.015 0.985 0.000
M49.0 Tuberculosis of spine
0.015 0.985 0.000
E80.7 Disorder of bilirubin metabolism, unspecified
0.001 0.985 0.014

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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