TreeWAS – Variant ID: rs3902354

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E78.5 Hyperlipidaemia, unspecified	1.000	0.000	0.000
E78.0 Pure hypercholesterolaemia	1.000	0.000	0.000
I20.9 Angina pectoris, unspecified	1.000	0.000	0.000
I25.1 Atherosclerotic heart disease	1.000	0.000	0.000
Z95.1 Presence of aortocoronary bypass graft	1.000	0.000	0.000
I25 Chronic ischaemic heart disease	1.000	0.000	0.000
I20-I25 Ischaemic heart diseases	1.000	0.000	0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	1.000	0.000	0.000
I21.9 Acute myocardial infarction, unspecified	1.000	0.000	0.000
I25.2 Old myocardial infarction	1.000	0.000	0.000
I21 Acute myocardial infarction	1.000	0.000	0.000
I20 Angina pectoris	1.000	0.000	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.997	0.003	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.974	0.026	0.000
Z95 Presence of cardiac and vascular implants and grafts	0.966	0.034	0.000
Z95.5 Presence of coronary angioplasty implant and graft	0.961	0.039	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.958	0.042	0.000
Z95.0 Presence of cardiac pacemaker	0.945	0.055	0.000
I21.0 Acute transmural myocardial infarction of anterior wall	0.914	0.086	0.000
E78.8 Other disorders of lipoprotein metabolism	0.889	0.111	0.000
E78.4 Other hyperlipidaemia	0.885	0.115	0.000
I20.0 Unstable angina	0.881	0.119	0.000
Z95.8 Presence of other cardiac and vascular implants and grafts	0.869	0.131	0.000
I22 Subsequent myocardial infarction	0.832	0.168	0.000
E78.1 Pure hyperglyceridaemia	0.832	0.168	0.000
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system	0.821	0.179	0.000
I25.4 Coronary artery aneurysm	0.816	0.184	0.000
E78.6 Lipoprotein deficiency	0.804	0.196	0.000
E78.2 Mixed hyperlipidaemia	0.784	0.216	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.761	0.239	0.000
I21.1 Acute transmural myocardial infarction of inferior wall	0.736	0.264	0.000
I21.X Presumed acute myicardial infaction (unconfirmed)	0.717	0.283	0.000
I25.3 Aneurysm of heart	0.706	0.294	0.000
E78.3 Hyperchylomicronaemia	0.704	0.296	0.000
I25.6 Silent myocardial ischaemia	0.692	0.308	0.000
I25.5 Ischaemic cardiomyopathy	0.692	0.308	0.000
I21.2 Acute transmural myocardial infarction of other sites	0.676	0.324	0.000
E78.9 Disorder of lipoprotein metabolism, unspecified	0.653	0.347	0.000
I23 Certain current complications following acute myocardial infarction	0.630	0.370	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.625	0.375	0.000
I22.1 Subsequent myocardial infarction of inferior wall	0.571	0.429	0.000
I21.3 Acute transmural myocardial infarction of unspecified site	0.506	0.493	0.000
I21.4 Acute subendocardial myocardial infarction	0.480	0.520	0.000
I20.1 Angina pectoris with documented spasm	0.476	0.524	0.000
S00.8 Superficial injury of other parts of head	0.465	0.535	0.000
S00 Superficial injury of head	0.456	0.544	0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.452	0.548	0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.452	0.548	0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.452	0.548	0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.452	0.548	0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.452	0.548	0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.452	0.548	0.000
Z95.3 Presence of xenogenic heart valve	0.448	0.551	0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement	0.434	0.566	0.000
S00.9 Superficial injury of head, part unspecified	0.432	0.568	0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.427	0.572	0.000
I22.8 Subsequent myocardial infarction of other sites	0.426	0.574	0.000
S00.7 Multiple superficial injuries of head	0.416	0.584	0.000
I23.8 Other current complications following acute myocardial infarction	0.396	0.604	0.000
I24 Other acute ischaemic heart diseases	0.393	0.607	0.000
S00.1 Contusion of eyelid and periocular area	0.388	0.612	0.000
Z82.7 Family history of congenital malformations, deformations and chromosomal abnormalities	0.382	0.618	0.000
S00.0 Superficial injury of scalp	0.370	0.630	0.000
Z82.6 Family history of arthritis and other diseases of the musculoskeletal system and connective tissue	0.368	0.632	0.000
S00.5 Superficial injury of lip and oral cavity	0.368	0.632	0.000
Z82.2 Family history of deafness and hearing loss	0.357	0.643	0.000
S00.3 Superficial injury of nose	0.336	0.663	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.336	0.664	0.000
Z82.5 Family history of asthma and other chronic lower respiratory diseases	0.323	0.677	0.000
Z82.8 Family history of other disabilities and chronic diseases leading to disablement, not elsewhere classified	0.311	0.689	0.000
Z82.1 Family history of blindness and visual loss	0.306	0.694	0.000
S00.4 Superficial injury of ear	0.296	0.704	0.000
S00.2 Other superficial injuries of eyelid and periocular area	0.289	0.711	0.000
I20.8 Other forms of angina pectoris	0.262	0.738	0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified	0.260	0.739	0.001
I24.1 Dressler's syndrome	0.228	0.772	0.000
Z82.0 Family history of epilepsy and other diseases of the nervous system	0.200	0.800	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.188	0.812	0.000
Z95.2 Presence of prosthetic heart valve	0.178	0.822	0.000
S00-S09 Injuries to the head	0.135	0.865	0.000
Z82.3 Family history of stroke	0.129	0.871	0.000
S05 Injury of eye and orbit	0.123	0.877	0.000
S05.2 Ocular laceration and rupture with prolapse or loss of intraocular tissue	0.108	0.892	0.000
S01.9 Open wound of head, part unspecified	0.105	0.895	0.000
S05.6 Penetrating wound of eyeball without foreign body	0.103	0.897	0.000
S05.4 Penetrating wound of orbit with or without foreign body	0.099	0.901	0.000
S05.1 Contusion of eyeball and orbital tissues	0.098	0.902	0.000
S08 Traumatic amputation of part of head	0.097	0.903	0.000
S07 Crushing injury of head	0.097	0.903	0.000
S04 Injury of cranial nerves	0.097	0.903	0.000
S01 Open wound of head	0.095	0.905	0.000
S05.5 Penetrating wound of eyeball with foreign body	0.092	0.908	0.000
S05.9 Injury of eye and orbit, part unspecified	0.090	0.910	0.000
S05.7 Avulsion of eye	0.088	0.911	0.000
I24.8 Other forms of acute ischaemic heart disease	0.084	0.916	0.000
S05.0 Injury of conjunctiva and corneal abrasion without mention of foreign body	0.083	0.917	0.000
S06 Intracranial injury	0.082	0.918	0.000
S03 Dislocation, sprain and strain of joints and ligaments of head	0.081	0.918	0.000
S02 Fracture of skull and facial bones	0.080	0.920	0.000
S05.3 Ocular laceration without prolapse or loss of intraocular tissue	0.077	0.923	0.000
S05.8 Other injuries of eye and orbit	0.075	0.925	0.000
S02.0 Fracture of vault of skull	0.072	0.927	0.000
S01.7 Multiple open wounds of head	0.071	0.929	0.000
S08.1 Traumatic amputation of ear	0.070	0.930	0.000
S08.9 Traumatic amputation of unspecified part of head	0.070	0.930	0.000
S08.8 Traumatic amputation of other parts of head	0.070	0.930	0.000
S08.0 Avulsion of scalp	0.070	0.930	0.000
S04.9 Injury of unspecified cranial nerve	0.070	0.930	0.000
S04.8 Injury of other cranial nerves	0.070	0.930	0.000
S04.7 Injury of accessory nerve	0.070	0.930	0.000
S04.6 Injury of acoustic nerve	0.070	0.930	0.000
S04.5 Injury of facial nerve	0.070	0.930	0.000
S04.4 Injury of abducent nerve	0.070	0.930	0.000
S04.3 Injury of trigeminal nerve	0.070	0.930	0.000
S04.2 Injury of trochlear nerve	0.070	0.930	0.000
S04.1 Injury of oculomotor nerve	0.070	0.930	0.000
S04.0 Injury of optic nerve and pathways	0.070	0.930	0.000
S07.9 Crushing injury of head, part unspecified	0.070	0.930	0.000
S07.8 Crushing injury of other parts of head	0.070	0.930	0.000
S07.1 Crushing injury of skull	0.070	0.930	0.000
S07.0 Crushing injury of face	0.070	0.930	0.000
S09 Other and unspecified injuries of head	0.068	0.932	0.000
S02.00 Fracture of vault of skull (closed)	0.067	0.933	0.000
S02.2 Fracture of nasal bones	0.066	0.934	0.000
S01.1 Open wound of eyelid and periocular area	0.065	0.935	0.000
S06.1 Traumatic cerebral oedema	0.064	0.936	0.000
S06.3 Focal brain injury	0.062	0.938	0.000
S06.4 Epidural haemorrhage	0.061	0.939	0.000
S02.6 Fracture of mandible	0.060	0.940	0.000
S06.6 Traumatic subarachnoid haemorrhage	0.060	0.940	0.000
S06.2 Diffuse brain injury	0.059	0.941	0.000
S09.8 Other specified injuries of head	0.059	0.941	0.000
S06.7 Intracranial injury with prolonged coma	0.059	0.941	0.000
S03.2 Dislocation of tooth	0.059	0.941	0.000
S03.5 Sprain and strain of joints and ligaments of other and unspecified parts of head	0.059	0.941	0.000
S03.4 Sprain and strain of jaw	0.059	0.941	0.000
S03.3 Dislocation of other and unspecified parts of head	0.059	0.941	0.000
S06.9 Intracranial injury, unspecified	0.058	0.941	0.000
S06.5 Traumatic subdural haemorrhage	0.058	0.942	0.000
S01.3 Open wound of ear	0.058	0.942	0.000
E70-E90 Metabolic disorders	0.057	0.943	0.000
S02.20 Fracture of nasal bones (closed)	0.057	0.943	0.000
S02.7 Multiple fractures involving skull and facial bones	0.057	0.943	0.000
S01.4 Open wound of cheek and temporomandibular area	0.056	0.944	0.000
S02.9 Fracture of skull and facial bones, part unspecified	0.055	0.945	0.000
S02.8 Fractures of other skull and facial bones	0.054	0.946	0.000
S02.1 Fracture of base of skull	0.054	0.946	0.000
Z95.4 Presence of other heart-valve replacement	0.053	0.947	0.000
S03.0 Dislocation of jaw	0.053	0.947	0.000
S02.01 Fracture of vault of skull (open)	0.052	0.948	0.000
S06.10 Traumatic cerebral oedema (without open intracranial wound)	0.051	0.949	0.000
S03.1 Dislocation of septal cartilage of nose	0.050	0.949	0.000
S09.1 Injury of muscle and tendon of head	0.049	0.951	0.000
S06.30 Focal brain injury (without open intracranial wound)	0.048	0.952	0.000
S09.2 Traumatic rupture of ear drum	0.047	0.953	0.000
S01.5 Open wound of lip and oral cavity	0.047	0.953	0.000
S06.8 Other intracranial injuries	0.046	0.953	0.000
S06.11 Traumatic cerebral oedema (with open intracranial wound)	0.046	0.954	0.000
S09.7 Multiple injuries of head	0.046	0.954	0.000
S02.60 Fracture of mandible (closed)	0.046	0.954	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.046	0.954	0.000
S06.40 Epidural haemorrhage (without open intracranial wound)	0.045	0.954	0.000
S06.0 Concussion	0.045	0.955	0.000
S02.21 Fracture of nasal bones (open)	0.045	0.955	0.000
S06.31 Focal brain injury (with open intracranial wound)	0.045	0.955	0.000
E72 Other disorders of amino-acid metabolism	0.044	0.956	0.000
E84 Cystic fibrosis	0.044	0.956	0.000
S06.41 Epidural haemorrhage (with open intracranial wound)	0.044	0.956	0.000
S02.3 Fracture of orbital floor	0.044	0.956	0.000
S06.60 Traumatic subarachnoid haemorrhage (without open intracranial wound)	0.044	0.956	0.000
E87.7 Fluid overload	0.044	0.956	0.000
S02.61 Fracture of mandible (open)	0.043	0.957	0.000
S06.61 Traumatic subarachnoid haemorrhage (with open intracranial wound)	0.043	0.957	0.000
S06.21 Diffuse brain injury (with open intracranial wound)	0.043	0.957	0.000
S06.20 Diffuse brain injury (without open intracranial wound)	0.043	0.957	0.000
S06.71 Intracranial injury with prolonged coma (with open intracranial wound)	0.043	0.957	0.000
S06.70 Intracranial injury with prolonged coma (without open intracranial wound)	0.043	0.957	0.000
S06.91 Intracranial injury, unspecified (with open intracranial wound)	0.042	0.958	0.000
S06.51 Traumatic subdural haemorrhage (with open intracranial wound)	0.042	0.958	0.000
E77 Disorders of glycoprotein metabolism	0.042	0.958	0.000
S01.2 Open wound of nose	0.042	0.958	0.000
S06.90 Intracranial injury, unspecified (without open intracranial wound)	0.041	0.958	0.000
E76 Disorders of glycosaminoglycan metabolism	0.041	0.959	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.041	0.959	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.041	0.959	0.000
S06.50 Traumatic subdural haemorrhage (without open intracranial wound)	0.041	0.959	0.000
E88 Other metabolic disorders	0.041	0.959	0.000
S02.71 Multiple fractures involving skull and facial bones (open)	0.041	0.959	0.000
S09.0 Injury of blood vessels of head, not elsewhere classified	0.040	0.959	0.000
E74 Other disorders of carbohydrate metabolism	0.040	0.960	0.000
S02.70 Multiple fractures involving skull and facial bones (closed)	0.040	0.960	0.000
S02.91 Fracture of skull and facial bones, part unspecified (open)	0.040	0.960	0.000
S02.5 Fracture of tooth	0.039	0.961	0.001
E87 Other disorders of fluid, electrolyte and acid-base balance	0.039	0.961	0.000
S02.81 Fractures of other skull and facial bones (open)	0.039	0.961	0.000
S02.10 Fracture of base of skull (closed)	0.039	0.961	0.000
S02.4 Fracture of malar and maxillary bones	0.038	0.962	0.000
E83 Disorders of mineral metabolism	0.038	0.962	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.037	0.963	0.000
S02.90 Fracture of skull and facial bones, part unspecified (closed)	0.037	0.963	0.000
E83.4 Disorders of magnesium metabolism	0.037	0.963	0.000
E70 Disorders of aromatic amino-acid metabolism	0.037	0.963	0.000
E75.5 Other lipid storage disorders	0.036	0.964	0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.036	0.964	0.000
E73 Lactose intolerance	0.035	0.964	0.000
E72.0 Disorders of amino-acid transport	0.035	0.965	0.000
E75.2 Other sphingolipidosis	0.035	0.965	0.000
S02.80 Fractures of other skull and facial bones (closed)	0.035	0.965	0.000
E79 Disorders of purine and pyrimidine metabolism	0.035	0.965	0.000
S02.11 Fracture of base of skull (open)	0.034	0.965	0.000
S06.81 Other intracranial injuries (with open intracranial wound)	0.033	0.966	0.000
E84.0 Cystic fibrosis with pulmonary manifestations	0.034	0.966	0.000
E88.3 Tumour lysis syndrome	0.034	0.966	0.000
E75.6 Lipid storage disorder, unspecified	0.033	0.967	0.000
E75.4 Neuronal ceroid lipofuscinosis	0.033	0.967	0.000
E75.3 Sphingolipidosis, unspecified	0.033	0.967	0.000
E75.1 Other gangliosidosis	0.033	0.967	0.000
E75.0 GM2 gangliosidosis	0.033	0.967	0.000
E84.9 Cystic fibrosis, unspecified	0.033	0.967	0.000
S06.01 Concussion (with open intracranial wound)	0.033	0.967	0.000
E80.6 Other disorders of bilirubin metabolism	0.032	0.968	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.032	0.968	0.000
E72.9 Disorder of amino-acid metabolism, unspecified	0.032	0.968	0.000
E72.8 Other specified disorders of amino-acid metabolism	0.032	0.968	0.000
E72.5 Disorders of glycine metabolism	0.032	0.968	0.000
E72.4 Disorders of ornithine metabolism	0.032	0.968	0.000
E72.3 Disorders of lysine and hydroxylysine metabolism	0.032	0.968	0.000
E72.2 Disorders of urea cycle metabolism	0.032	0.968	0.000
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.032	0.968	0.000
E84.8 Cystic fibrosis with other manifestations	0.032	0.968	0.000
E84.1 Cystic fibrosis with intestinal manifestations	0.032	0.968	0.000
S02.31 Fracture of orbital floor (open)	0.031	0.968	0.000
E77.8 Other disorders of glycoprotein metabolism	0.031	0.969	0.000
E86 Volume depletion	0.030	0.970	0.000
E77.9 Disorder of glycoprotein metabolism, unspecified	0.030	0.970	0.000
E77.1 Defects in glycoprotein degradation	0.030	0.970	0.000
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.030	0.970	0.000
E71.3 Disorders of fatty-acid metabolism	0.030	0.970	0.000
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.030	0.970	0.000
E71.1 Other disorders of branched-chain amino-acid metabolism	0.030	0.970	0.000
E71.0 Maple-syrup-urine disease	0.030	0.970	0.000
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.030	0.970	0.000
E76.8 Other disorders of glucosaminoglycan metabolism	0.030	0.970	0.000
E76.3 Mucopolysaccharidosis, unspecified	0.030	0.970	0.000
E76.2 Other mucopolysaccharidoses	0.030	0.970	0.000
E76.1 Mucopolysaccharidosis, type II	0.030	0.970	0.000
E76.0 Mucopolysaccharidosis, type I	0.030	0.970	0.000
E80.7 Disorder of bilirubin metabolism, unspecified	0.029	0.971	0.000
E74.9 Disorder of carbohydrate metabolism, unspecified	0.029	0.971	0.000
E74.8 Other specified disorders of carbohydrate metabolism	0.029	0.971	0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.029	0.971	0.000
E74.2 Disorders of galactose metabolism	0.029	0.971	0.000
E74.1 Disorders of fructose metabolism	0.029	0.971	0.000
E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified	0.028	0.972	0.000
E74.0 Glycogen storage disease	0.028	0.972	0.000
S02.51 Fracture of tooth (open)	0.028	0.972	0.001
E87.4 Mixed disorder of acid-base balance	0.028	0.972	0.000
E74.3 Other disorders of intestinal carbohydrate absorption	0.028	0.972	0.000
E83.8 Other disorders of mineral metabolism	0.027	0.972	0.000
E83.2 Disorders of zinc metabolism	0.027	0.972	0.000
E83.0 Disorders of copper metabolism	0.027	0.972	0.000
E87.0 Hyperosmolality and hypernatraemia	0.027	0.973	0.000
E83.9 Disorder of mineral metabolism, unspecified	0.027	0.973	0.000
E88.1 Lipodystrophy, not elsewhere classified	0.027	0.973	0.000
E80.5 Crigler-Najjar syndrome	0.027	0.973	0.000
E80.3 Defects of catalase and peroxydase	0.027	0.973	0.000
E80.0 Hereditary erythropoietic porphyria	0.027	0.973	0.000
E88.8 Other specified metabolic disorders	0.027	0.973	0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.026	0.973	0.000
E70.8 Other disorders of aromatic amino-acid metabolism	0.026	0.973	0.000
E70.2 Disorders of tyrosine metabolism	0.026	0.973	0.000
E70.1 Other hyperphenylalaninaemias	0.026	0.973	0.000
E70.0 Classical phenylketonuria	0.026	0.973	0.000
S02.41 Fracture of malar and maxillary bones (open)	0.026	0.974	0.000
E73.8 Other lactose intolerance	0.025	0.974	0.000
E73.1 Secondary lactase deficiency	0.025	0.974	0.000
E73.0 Congenital lactase deficiency	0.025	0.974	0.000
S01.8 Open wound of other parts of head	0.025	0.975	0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.025	0.975	0.000
E79.8 Other disorders of purine and pyrimidine metabolism	0.025	0.975	0.000
E79.1 Lesch-Nyhan syndrome	0.025	0.975	0.000
E89.3 Postprocedural hypopituitarism	0.025	0.975	0.000
E88.2 Lipomatosis, not elsewhere classified	0.024	0.975	0.000
E80.1 Porphyria cutanea tarda	0.024	0.975	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.024	0.976	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.023	0.977	0.000
E89.5 Postprocedural testicular hypofunction	0.023	0.977	0.000
E83.5 Disorders of calcium metabolism	0.023	0.977	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.023	0.977	0.000
E88.9 Metabolic disorder, unspecified	0.023	0.977	0.000
E83.3 Disorders of phosphorus metabolism	0.023	0.977	0.000
E80.2 Other porphyria	0.023	0.977	0.000
E89.1 Postprocedural hypoinsulinaemia	0.023	0.977	0.000
E89.4 Postprocedural ovarian failure	0.022	0.977	0.000
E87.3 Alkalosis	0.022	0.978	0.000
E70.3 Albinism	0.022	0.978	0.000
E85 Amyloidosis	0.021	0.978	0.000
E89.0 Postprocedural hypothyroidism	0.021	0.979	0.000
E87.6 Hypokalaemia	0.021	0.979	0.000
S06.80 Other intracranial injuries (without open intracranial wound)	0.021	0.979	0.000
E73.9 Lactose intolerance, unspecified	0.020	0.980	0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.018	0.981	0.001
S06.00 Concussion (without open intracranial wound)	0.019	0.981	0.000
E87.1 Hypo-osmolality and hyponatraemia	0.019	0.981	0.000
S02.30 Fracture of orbital floor (closed)	0.017	0.982	0.000
E89.2 Postprocedural hypoparathyroidism	0.017	0.983	0.000
E80.4 Gilbert's syndrome	0.016	0.984	0.000
E85.2 Heredofamilial amyloidosis, unspecified	0.015	0.984	0.000
E85.1 Neuropathic heredofamilial amyloidosis	0.015	0.984	0.000
E85.0 Nonneuropathic heredofamilial amyloidosis	0.015	0.984	0.000
E04.2 Non-toxic multinodular goitre	0.000	0.984	0.016
S09.9 Unspecified injury of head	0.015	0.985	0.000
E85.8 Other amyloidosis	0.014	0.985	0.000
E85.4 Organ-limited amyloidosis	0.014	0.985	0.000
E87.2 Acidosis	0.013	0.987	0.000
Y52.4 Angiotensin-converting-enzyme inhibitors	0.013	0.987	0.000
E85.3 Secondary systemic amyloidosis	0.012	0.987	0.001
S01.0 Open wound of scalp	0.012	0.988	0.000
S02.40 Fracture of malar and maxillary bones (closed)	0.011	0.989	0.000
Y52 Agents primarily affecting the cardiovascular system	0.011	0.989	0.000
S02.50 Fracture of tooth (closed)	0.009	0.990	0.001
E85.9 Amyloidosis, unspecified	0.009	0.990	0.001
Y52.2 Other antidysrhythmic drugs, not elsewhere classified	0.010	0.990	0.000
Y52.3 Coronary vasodilators, not elsewhere classified	0.010	0.990	0.000
Y52.0 Cardiac-stimulant glycosides and drugs of similar action	0.009	0.991	0.000
Y52.7 Peripheral vasodilators	0.009	0.991	0.000
Y52.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.009	0.991	0.000
Y52.1 Calcium-channel blockers	0.009	0.991	0.000
Y52.8 Antivaricose drugs, including sclerosing agents	0.008	0.992	0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.008	0.992	0.000
E87.5 Hyperkalaemia	0.008	0.992	0.000
Y45.1 Salicylates	0.008	0.992	0.000
Z35.1 Supervision of pregnancy with history of abortive outcome	0.000	0.993	0.007
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.007	0.993	0.000
S99.9 Unspecified injury of ankle and foot	0.007	0.993	0.000
Y45.2 Propionic acid derivatives	0.006	0.994	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.006	0.994	0.000
Y52.5 Other antihypertensive drugs, not elsewhere classified	0.006	0.994	0.000
I26.9 Pulmonary embolism without mention of acute cor pulmonale	0.000	0.994	0.006
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.006	0.994	0.000
Y45.8 Other analgesics and antipyretics	0.006	0.994	0.000
L89.1 Stage II decubitus ulcer	0.006	0.994	0.000
Y54.1 Mineralocorticoid antagonists [aldosterone antagonists]	0.006	0.994	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.006	0.994	0.000
S99 Other and unspecified injuries of ankle and foot	0.006	0.994	0.000
S90 Superficial injury of ankle and foot	0.006	0.994	0.000
Y41 Other systemic anti-infectives and antiparasitics	0.006	0.994	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.006	0.994	0.000
Y53.4 Other laxatives	0.006	0.994	0.000
S90.8 Other superficial injuries of ankle and foot	0.005	0.995	0.000
C71.9 Brain, unspecified	0.005	0.995	0.000
C71 Malignant neoplasm of brain	0.005	0.995	0.000
C49 Malignant neoplasm of other connective and soft tissue	0.005	0.995	0.000
C49.1 Connective and soft tissue of upper limb, including shoulder	0.005	0.995	0.000
Y45.5 4-Aminophenol derivatives	0.005	0.995	0.000
C49.5 Connective and soft tissue of pelvis	0.005	0.995	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.005	0.995	0.000
Y45.4 Antirheumatics	0.005	0.995	0.000
B17.1 Acute hepatitis C	0.005	0.995	0.000
C71.8 Overlapping lesion of brain	0.005	0.995	0.000
Y45.0 Opioids and related analgesics	0.005	0.995	0.000
B17 Other acute viral hepatitis	0.005	0.995	0.000
B18.1 Chronic viral hepatitis B without delta-agent	0.005	0.995	0.000
S90.9 Superficial injury of ankle and foot, unspecified	0.005	0.995	0.000
S90.0 Contusion of ankle	0.005	0.995	0.000
B18 Chronic viral hepatitis	0.005	0.995	0.000
S90-S99 Injuries to the ankle and foot	0.005	0.995	0.000
Y59 Other and unspecified vaccines and biological substances	0.005	0.995	0.000
Y54.3 Benzothiadiazine derivatives	0.005	0.995	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.005	0.995	0.000
C71.1 Frontal lobe	0.005	0.995	0.000
C49.0 Connective and soft tissue of head, face and neck	0.005	0.995	0.000
Y41.1 Antimycobacterial drugs	0.005	0.995	0.000
Y46.4 Iminostilbenes	0.005	0.995	0.000
M07.30 Other psoriatic arthropathies (Multiple sites)	0.005	0.995	0.000
B15-B19 Viral hepatitis	0.005	0.995	0.000
C71.3 Parietal lobe	0.005	0.995	0.000
S92.50 Fracture of other toe (closed)	0.005	0.995	0.000
Y46.2 Hydantoin derivatives	0.005	0.995	0.000
C71.0 Cerebrum, except lobes and ventricles	0.005	0.995	0.000
Y54.7 Agents affecting calcification	0.005	0.995	0.000
B15.9 Hepatitis A without hepatic coma	0.005	0.995	0.000
S90.1 Contusion of toe(s) without damage to nail	0.005	0.995	0.000
Y41.2 Antimalarials and drugs acting on other blood protozoa	0.005	0.995	0.000
Y54.9 Mineral salts, not elsewhere classified	0.005	0.995	0.000
Y54.6 Electrolytic, caloric and water-balance agents	0.005	0.995	0.000
Y54.2 Carbonic-anhydrase inhibitors	0.005	0.995	0.000
Y54.0 Mineralocorticoids	0.005	0.995	0.000
Y46.7 Anti-Parkinsonism drugs	0.005	0.995	0.000
B15 Acute hepatitis A	0.005	0.995	0.000
C49.3 Connective and soft tissue of thorax	0.005	0.995	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.005	0.995	0.000
C71.2 Temporal lobe	0.005	0.995	0.000
Y54.5 Other diuretics	0.005	0.995	0.000
Y54.4 Loop [high-ceiling] diuretics	0.004	0.995	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.004	0.995	0.000
Y53.8 Other agents primarily affecting the gastro-intestinal system	0.004	0.995	0.000
E28.2 Polycystic ovarian syndrome	0.000	0.995	0.005
Y48 Anaesthetics and therapeutic gases	0.004	0.995	0.000
K05.3 Chronic periodontitis	0.000	0.995	0.005
Y53.2 Stimulant laxatives	0.004	0.995	0.000
Y41.5 Antiviral drugs	0.004	0.995	0.000
S92.5 Fracture of other toe	0.004	0.996	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.004	0.996	0.000
S99.8 Other specified injuries of ankle and foot	0.004	0.996	0.000
Y58 Bacterial vaccines	0.004	0.996	0.000
B18.2 Chronic viral hepatitis C	0.004	0.996	0.000
Y53.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.004	0.996	0.000
Y53.7 Emetics	0.004	0.996	0.000
Y53.5 Digestants	0.004	0.996	0.000
Y53.0 Histamine H2-receptor antagonists	0.004	0.996	0.000
S92 Fracture of foot, except ankle	0.004	0.996	0.000
L27.0 Generalised skin eruption due to drugs and medicaments	0.004	0.996	0.000
S90.7 Multiple superficial injuries of ankle and foot	0.004	0.996	0.000
S90.2 Contusion of toe(s) with damage to nail	0.004	0.996	0.000
S99.7 Multiple injuries of ankle and foot	0.004	0.996	0.000
Y41.9 Systemic anti-infective and antiparasitic, unspecified	0.004	0.996	0.000
Y41.4 Anthelminthics	0.004	0.996	0.000
Y41.3 Other antiprotozoal drugs	0.004	0.996	0.000
Y41.0 Sulphonamides	0.004	0.996	0.000
Y41.8 Other specified systemic anti-infectives and antiparasitics	0.004	0.996	0.000
C49.9 Connective and soft tissue, unspecified	0.004	0.996	0.000
Y46.8 Antispasticity drugs	0.004	0.996	0.000
Y46.5 Valproic acid	0.004	0.996	0.000
Y46.3 Deoxybarbiturates	0.004	0.996	0.000
Y46.1 Oxazolidinediones	0.004	0.996	0.000
Y46.0 Succinimides	0.004	0.996	0.000
Y54.8 Agents affecting uric acid metabolism	0.004	0.996	0.000
Y55.4 Expectorants	0.004	0.996	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.004	0.996	0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified	0.004	0.996	0.000
Y53.6 Antidiarrhoeal drugs	0.004	0.996	0.000
Y53.3 Saline and osmotic laxatives	0.004	0.996	0.000
Y55.0 Oxytocic drugs	0.004	0.996	0.000
B17.9 Acute viral hepatitis, unspecified	0.004	0.996	0.000
C49.6 Connective and soft tissue of trunk, unspecified	0.004	0.996	0.000
S98 Traumatic amputation of ankle and foot	0.004	0.996	0.000
S90.3 Contusion of other and unspecified parts of foot	0.004	0.996	0.000
S92.1 Fracture of talus	0.004	0.996	0.000
C49.2 Connective and soft tissue of lower limb, including hip	0.004	0.996	0.000
T45.5 Anticoagulants	0.004	0.996	0.000
U51.1 Previously admitted to a psychiatric hospital of the provider	0.004	0.996	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.004	0.996	0.000
C49.8 Overlapping lesion of connective and soft tissue	0.004	0.996	0.000
Y55.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.004	0.996	0.000
C71.5 Cerebral ventricle	0.004	0.996	0.000
R00.8 Other and unspecified abnormalities of heart beat	0.004	0.996	0.000
Y55.7 Other and unspecified agents primarily acting on the respiratory system	0.004	0.996	0.000
Y55.5 Anticommon cold drugs	0.004	0.996	0.000
Y55.3 Antitussives	0.004	0.996	0.000
Y55.2 Other and unspecified agents primarily acting on muscles	0.004	0.996	0.000
B19 Unspecified viral hepatitis	0.004	0.996	0.000
B17.8 Other specified acute viral hepatitis	0.004	0.996	0.000
D16.2 Long bones of lower limb	0.004	0.996	0.000
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.004	0.996	0.000
Y44 Agents primarily affecting blood constituents	0.004	0.996	0.000
Y46.6 Other and unspecified antiepileptics	0.004	0.996	0.000
B17.2 Acute hepatitis E	0.004	0.996	0.000
T45.2 Vitamins, not elsewhere classified	0.004	0.996	0.000
Y59.0 Viral vaccines	0.004	0.996	0.000
B17.0 Acute delta-(super) infection of hepatitis B carrier	0.004	0.996	0.000
S92.10 Fracture of talus (closed)	0.004	0.996	0.000
B18.8 Other chronic viral hepatitis	0.004	0.996	0.000
B18.0 Chronic viral hepatitis B with delta-agent	0.004	0.996	0.000
T44.7 Beta-Adrenoreceeptor antagonists, not elsewhere classified	0.004	0.996	0.000
S95 Injury of blood vessels at ankle and foot level	0.004	0.996	0.000
S94 Injury of nerves at ankle and foot level	0.004	0.996	0.000
Y59.9 Vaccine or biological substance, unspecified	0.004	0.996	0.000
Y59.8 Other specified vaccines and biological substances	0.004	0.996	0.000
Y59.2 Protozoal vaccines	0.004	0.996	0.000
Y59.1 Rickettsial vaccines	0.004	0.996	0.000
Y57 Other and unspecified drugs and medicaments	0.004	0.996	0.000
C49.4 Connective and soft tissue of abdomen	0.004	0.996	0.000
D16 Benign neoplasm of bone and articular cartilage	0.004	0.996	0.000
B18.9 Chronic viral hepatitis, unspecified	0.004	0.996	0.000
Y59.3 Immunoglobulin	0.004	0.996	0.000
C71.7 Brain stem	0.004	0.996	0.000
Y47.9 Sedative, hypnotic and antianxiety drug, unspecified	0.004	0.996	0.000
Y47.8 Other sedatives, hypnotics and antianxiety drugs	0.004	0.996	0.000
Y47.5 Mixed sedatives and hypnotics, not elsewhere classified	0.004	0.996	0.000
Y47.4 Bromine compounds	0.004	0.996	0.000
Y47.3 Paraldehyde	0.004	0.996	0.000
Y47.2 Chloral derivatives	0.004	0.996	0.000
Y47.0 Barbiturates, not elsewhere classified	0.004	0.996	0.000
C71.6 Cerebellum	0.004	0.996	0.000
S97 Crushing injury of ankle and foot	0.004	0.996	0.000
Y47.1 Benzodiazepines	0.004	0.996	0.000
D16.0 Scapula and long bones of upper limb	0.004	0.996	0.000
T47.1 Other antacids and anti-gastric-secretion drugs	0.004	0.996	0.000
Y49.3 Phenothiazine antipsychotics and neuroleptics	0.004	0.996	0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.004	0.996	0.000
Y56.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.004	0.996	0.000
S98.1 Traumatic amputation of one toe	0.004	0.996	0.000
Y55.6 Antiasthmatics, not elsewhere classified	0.003	0.996	0.000
M54.16 Radiculopathy (Lumbar region)	0.000	0.996	0.004
D16.3 Short bones of lower limb	0.004	0.996	0.000
T45.1 Antineoplastic and immunosuppressive drugs	0.004	0.996	0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.004	0.996	0.000
Y48.2 Other and unspecified general anaesthetics	0.004	0.996	0.000
Y43 Primarily systemic agents	0.004	0.996	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations