TreeWAS – Variant ID: rs3922435

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	No effect posterior probability	Protective posterior probability
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	0.126	0.874
R50-R69 General symptoms and signs	0.129	0.871
R59 Enlarged lymph nodes	0.152	0.848
# Top node	0.170	0.830
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems	0.175	0.825
Chapter X Diseases of the respiratory system	0.176	0.824
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis	0.176	0.824
J44 Other chronic obstructive pulmonary disease	0.177	0.823
R52 Pain, not elsewhere classified	0.181	0.819
Chapter IX Diseases of the circulatory system	0.181	0.819
J40-J47 Chronic lower respiratory diseases	0.182	0.818
I30-I52 Other forms of heart disease	0.182	0.818
J44.9 Chronic obstructive pulmonary disease, unspecified	0.187	0.813
D50 Iron deficiency anaemia	0.188	0.812
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.191	0.809
D50-D53 Nutritional anaemias	0.191	0.809
R91 Abnormal findings on diagnostic imaging of lung	0.192	0.808
J30-J39 Other diseases of upper respiratory tract	0.198	0.802
R26 Abnormalities of gait and mobility	0.199	0.801
D50.9 Iron deficiency anaemia, unspecified	0.203	0.797
J38 Diseases of vocal cords and larynx, not elsewhere classified	0.205	0.795
R54 Senility	0.213	0.787
R59.0 Localised enlarged lymph nodes	0.216	0.784
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.218	0.782
D50.8 Other iron deficiency anaemias	0.218	0.782
R59.9 Enlarged lymph nodes, unspecified	0.224	0.776
R07.4 Chest pain, unspecified	0.227	0.773
Chapter VIII Diseases of the ear and mastoid process	0.230	0.770
R00-R09 Symptoms and signs involving the circulatory and respiratory systems	0.230	0.770
R07 Pain in throat and chest	0.235	0.765
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection	0.243	0.757
I50 Heart failure	0.244	0.756
J38.3 Other diseases of vocal cords	0.245	0.755
R26.8 Other and unspecified abnormalities of gait and mobility	0.254	0.746
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue	0.261	0.739
I35 Nonrheumatic aortic valve disorders	0.262	0.738
R52.1 Chronic intractable pain	0.268	0.732
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.269	0.731
I45 Other conduction disorders	0.274	0.726
R70-R79 Abnormal findings on examination of blood, without diagnosis	0.276	0.724
R47-R49 Symptoms and signs involving speech and voice	0.278	0.722
J38.7 Other diseases of larynx	0.281	0.719
I44 Atrioventricular and left bundle-branch block	0.283	0.717
Q20-Q28 Congenital malformations of the circulatory system	0.289	0.711
J44.1 Chronic obstructive pulmonary disease with acute exacerbation, unspecified	0.290	0.710
R68 Other general symptoms and signs	0.291	0.709
H65-H75 Diseases of middle ear and mastoid	0.291	0.709
R26.2 Difficulty in walking, not elsewhere classified	0.293	0.706
R56 Convulsions, not elsewhere classified	0.297	0.703
I95-I99 Other and unspecified disorders of the circulatory system	0.297	0.703
I42 Cardiomyopathy	0.300	0.700
J32 Chronic sinusitis	0.306	0.694
Chapter VI Diseases of the nervous system	0.308	0.692
R58 Haemorrhage, not elsewhere classified	0.313	0.687
I80 Phlebitis and thrombophlebitis	0.316	0.684
I50.0 Congestive heart failure	0.317	0.683
Q60-Q64 Congenital malformations of the urinary system	0.318	0.682
J44.8 Other specified chronic obstructive pulmonary disease	0.322	0.678
R52.9 Pain, unspecified	0.325	0.675
R20 Disturbances of skin sensation	0.330	0.670
R64 Cachexia	0.330	0.669
R57 Shock, not elsewhere classified	0.335	0.665
R52.0 Acute pain	0.338	0.662
R05 Cough	0.338	0.662
I45.1 Other and unspecified right bundle-branch block	0.340	0.660
Q21 Congenital malformations of cardiac septa	0.341	0.659
I44.7 Left bundle-branch block, unspecified	0.341	0.659
J38.1 Polyp of vocal cord and larynx	0.342	0.658
I51 Complications and ill-defined descriptions of heart disease	0.345	0.655
R65 Systemic Inflammatory Response Syndrome [SIRS]	0.347	0.653
I84 Haemorrhoids	0.347	0.653
Chapter V Mental and behavioural disorders	0.348	0.652
H90-H95 Other disorders of ear	0.352	0.648
D50.0 Iron deficiency anaemia secondary to blood loss (chronic)	0.352	0.648
R79 Other abnormal findings of blood chemistry	0.355	0.645
J60-J70 Lung diseases due to external agents	0.360	0.640
D55-D59 Haemolytic anaemias	0.366	0.634
R59.1 Generalised enlarged lymph nodes	0.368	0.632
I35.0 Aortic (valve) stenosis	0.368	0.632
J38.4 Oedema of larynx	0.370	0.630
R95-R99 Ill-defined and unknown causes of mortality	0.377	0.623
D50.1 Sideropenic dysphagia	0.377	0.623
J42 Unspecified chronic bronchitis	0.378	0.622
I33 Acute and subacute endocarditis	0.379	0.621
R62 Lack of expected normal physiological development	0.380	0.620
I84.8 Unspecified haemorrhoids with other complications	0.380	0.620
R79.8 Other specified abnormal findings of blood chemistry	0.387	0.613
R61 Hyperhidrosis	0.391	0.609
R63 Symptoms and signs concerning food and fluid intake	0.391	0.609
I95 Hypotension	0.392	0.608
J38.2 Nodules of vocal cords	0.392	0.608
R26.3 Immobility	0.393	0.607
R26.0 Ataxic gait	0.394	0.606
R30-R39 Symptoms and signs involving the urinary system	0.397	0.603
J32.0 Chronic maxillary sinusitis	0.398	0.602
H65 Nonsuppurative otitis media	0.399	0.601
Chapter XXII Codes for special purposes	0.402	0.598
I35.2 Aortic (valve) stenosis with insufficiency	0.403	0.597
I84.5 External haemorrhoids without complication	0.403	0.597
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis	0.403	0.597
R47 Speech disturbances, not elsewhere classified	0.404	0.596
I37 Pulmonary valve disorders	0.404	0.596
J34 Other disorders of nose and nasal sinuses	0.405	0.595
R51 Headache	0.405	0.595
Chapter XVI Certain conditions originating in the perinatal period	0.407	0.593
I50.1 Left ventricular failure	0.408	0.592
I36 Nonrheumatic tricuspid valve disorders	0.408	0.592
Q61 Cystic kidney disease	0.408	0.592
D53 Other nutritional anaemias	0.409	0.591
I43 Cardiomyopathy in diseases classified elsewhere	0.409	0.591
R02 Gangrene, not elsewhere classified	0.410	0.590
I40 Acute myocarditis	0.410	0.590
I70-I79 Diseases of arteries, arterioles and capillaries	0.410	0.590
J31 Chronic rhinitis, nasopharyngitis and pharyngitis	0.411	0.589
R60 Oedema, not elsewhere classified	0.411	0.588
J38.0 Paralysis of vocal cords and larynx	0.412	0.588
I50.9 Heart failure, unspecified	0.412	0.588
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.413	0.587
I52 Other heart disorders in diseases classified elsewhere	0.414	0.586
I48 Atrial fibrillation and flutter	0.414	0.586
I41 Myocarditis in diseases classified elsewhere	0.414	0.586
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.414	0.586
I32 Pericarditis in diseases classified elsewhere	0.414	0.586
R52.2 Other chronic pain	0.415	0.585
R20.8 Other and unspecified disturbances of skin sensation	0.416	0.584
I46 Cardiac arrest	0.416	0.584
Q21.1 Atrial septal defect	0.416	0.584
I05-I09 Chronic rheumatic heart diseases	0.418	0.582
H90 Conductive and sensorineural hearing loss	0.419	0.581
I00-I02 Acute rheumatic fever	0.420	0.580
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities	0.420	0.580
J36 Peritonsillar abscess	0.421	0.579
J09-J18 Influenza and pneumonia	0.421	0.579
I38 Endocarditis, valve unspecified	0.421	0.579
J41 Simple and mucopurulent chronic bronchitis	0.421	0.579
G20-G26 Extrapyramidal and movement disorders	0.421	0.579
I80.1 Phlebitis and thrombophlebitis of femoral vein	0.423	0.576
J47 Bronchiectasis	0.424	0.576
J85-J86 Suppurative and necrotic conditions of lower respiratory tract	0.425	0.575
R29 Other symptoms and signs involving the nervous and musculoskeletal systems	0.425	0.575
J39 Other diseases of upper respiratory tract	0.425	0.575
R26.1 Paralytic gait	0.425	0.574
R50 Fever of unknown origin	0.426	0.574
I42.0 Dilated cardiomyopathy	0.427	0.573
J46 Status asthmaticus	0.427	0.573
R56.8 Other and unspecified convulsions	0.427	0.573
R32 Unspecified urinary incontinence	0.428	0.572
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.429	0.571
H72 Perforation of tympanic membrane	0.429	0.571
R90 Abnormal findings on diagnostic imaging of central nervous system	0.430	0.569
I51.9 Heart disease, unspecified	0.431	0.569
G50-G59 Nerve, nerve root and plexus disorders	0.432	0.568
H66 Suppurative and unspecified otitis media	0.432	0.568
R25 Abnormal involuntary movements	0.433	0.567
I35.8 Other aortic valve disorders	0.434	0.566
I80.3 Phlebitis and thrombophlebitis of lower extremities, unspecified	0.435	0.565
R73 Elevated blood glucose level	0.436	0.564
I31 Other diseases of pericardium	0.436	0.564
Chapter IV Endocrine, nutritional and metabolic diseases	0.437	0.563
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.437	0.563
Q30-Q34 Congenital malformations of the respiratory system	0.437	0.562
J43 Emphysema	0.438	0.562
I45.2 Bifascicular block	0.440	0.560
R20.2 Paraesthesia of skin	0.441	0.559
Q50-Q56 Congenital malformations of genital organs	0.441	0.559
R68.3 Clubbing of fingers	0.442	0.558
Q38-Q45 Other congenital malformations of the digestive system	0.442	0.558
I84.1 Internal haemorrhoids with other complications	0.442	0.558
F00-F09 Organic, including symptomatic, mental disorders	0.443	0.557
H93 Other disorders of ear, not elsewhere classified	0.443	0.557
R92 Abnormal findings on diagnostic imaging of breast	0.444	0.556
I49 Other cardiac arrhythmias	0.444	0.556
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.444	0.556
J38.5 Laryngeal spasm	0.445	0.554
Q24 Other congenital malformations of heart	0.446	0.553
Q35-Q37 Cleft lip and cleft palate	0.447	0.553
R21 Rash and other nonspecific skin eruption	0.447	0.553
D52 Folate deficiency anaemia	0.448	0.552
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.448	0.551
R49 Voice disturbances	0.449	0.551
R68.8 Other specified general symptoms and signs	0.449	0.551
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.449	0.551
I35.9 Aortic valve disorder, unspecified	0.450	0.550
Q28 Other congenital malformations of circulatory system	0.450	0.550
F20-F29 Schizophrenia, schizotypal and delusional disorders	0.451	0.549
J38.6 Stenosis of larynx	0.452	0.548
R93 Abnormal findings on diagnostic imaging of other body structures	0.453	0.547
Q21.0 Ventricular septal defect	0.455	0.545
D51 Vitamin B12 deficiency anaemia	0.457	0.543
I44.4 Left anterior fascicular block	0.457	0.543
I30 Acute pericarditis	0.458	0.542
R80-R82 Abnormal findings on examination of urine, without diagnosis	0.458	0.542
H70 Mastoiditis and related conditions	0.458	0.542
J35 Chronic diseases of tonsils and adenoids	0.458	0.542
I47 Paroxysmal tachycardia	0.459	0.541
I45.6 Preexcitation syndrome	0.460	0.540
I42.9 Cardiomyopathy, unspecified	0.460	0.540
R72 Abnormality of white blood cells, not elsewhere classified	0.460	0.540
J32.8 Other chronic sinusitis	0.460	0.539
J37 Chronic laryngitis and laryngotracheitis	0.463	0.537
Q80-Q89 Other congenital malformations	0.464	0.536
Q00-Q07 Congenital malformations of the nervous system	0.465	0.534
R57.2 Septic shock	0.466	0.534
I42.7 Cardiomyopathy due to drugs and other external agents	0.466	0.534
R03 Abnormal blood-pressure reading, without diagnosis	0.468	0.532
H80-H83 Diseases of inner ear	0.468	0.532
Q22 Congenital malformations of pulmonary and tricuspid valves	0.469	0.531
I45.8 Other specified conduction disorders	0.469	0.531
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.469	0.531
R27 Other lack of coordination	0.470	0.530
Q60 Renal agenesis and other reduction defects of kidney	0.473	0.527
R68.0 Hypothermia, not associated with low environmental temperature	0.473	0.527
I44.6 Other and unspecified fascicular block	0.473	0.527
H74 Other disorders of middle ear and mastoid	0.473	0.527
R35 Polyuria	0.474	0.526
I45.3 Trifascicular block	0.474	0.526
R76 Other abnormal immunological findings in serum	0.475	0.525
G00-G09 Inflammatory diseases of the central nervous system	0.475	0.525
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour	0.478	0.522
I81 Portal vein thrombosis	0.479	0.521
I72 Other aneurysm	0.479	0.521
R55 Syncope and collapse	0.479	0.521
I88 Nonspecific lymphadenitis	0.479	0.520
R47.1 Dysarthria and anarthria	0.480	0.520
R75 Laboratory evidence of human immunodeficiency virus [HIV]	0.480	0.519
H65.3 Chronic mucoid otitis media	0.481	0.519
J32.4 Chronic pansinusitis	0.481	0.519
R56.0 Febrile convulsions	0.481	0.519
H60-H62 Diseases of external ear	0.482	0.518
I84.7 Unspecified thrombosed haemorrhoids	0.482	0.518
I42.2 Other hypertrophic cardiomyopathy	0.483	0.517
I45.9 Conduction disorder, unspecified	0.484	0.516
I95.9 Hypotension, unspecified	0.484	0.516
I45.0 Right fascicular block	0.484	0.516
J18 Pneumonia, organism unspecified	0.485	0.515
I44.5 Left posterior fascicular block	0.486	0.514
I42.1 Obstructive hypertrophic cardiomyopathy	0.486	0.514
I86 Varicose veins of other sites	0.487	0.513
J80-J84 Other respiratory diseases principally affecting the interstitium	0.487	0.513
H71 Cholesteatoma of middle ear	0.487	0.512
J69 Pneumonitis due to solids and liquids	0.488	0.512
R48 Dyslexia and other symbolic dysfunctions, not elsewhere classified	0.488	0.511
I80.8 Phlebitis and thrombophlebitis of other sites	0.489	0.510
I35.1 Aortic (valve) insufficiency	0.490	0.510
Q20 Congenital malformations of cardiac chambers and connexions	0.490	0.510
J32.3 Chronic sphenoidal sinusitis	0.491	0.509
D59 Acquired haemolytic anaemia	0.491	0.509
R68.1 Nonspecific symptoms peculiar to infancy	0.491	0.509
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.491	0.509
H67 Otitis media in diseases classified elsewhere	0.491	0.509
G55 Nerve root and plexus compressions in diseases classified elsewhere	0.492	0.508
R07.0 Pain in throat	0.492	0.508
Q26 Congenital malformations of great veins	0.493	0.507
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.493	0.507
I87 Other disorders of veins	0.493	0.506
I51.8 Other ill-defined heart diseases	0.494	0.506
Chapter XX External causes of morbidity and mortality	0.495	0.505
H68 Eustachian salpingitis and obstruction	0.496	0.504
R71 Abnormality of red blood cells	0.496	0.504
H69 Other disorders of Eustachian tube	0.497	0.503
I44.0 Atrioventricular block, first degree	0.498	0.502
I42.3 Endomyocardial (eosinophilic) disease	0.498	0.502
E70-E90 Metabolic disorders	0.498	0.502
I85 Oesophageal varices	0.499	0.501
H90.5 Sensorineural hearing loss, unspecified	0.499	0.501
R78 Findings of drugs and other substances, not normally found in blood	0.500	0.500
R22 Localised swelling, mass and lump of skin and subcutaneous tissue	0.500	0.500
F03 Unspecified dementia	0.501	0.499
J32.9 Chronic sinusitis, unspecified	0.501	0.499
I44.1 Atrioventricular block, second degree	0.502	0.498
G90-G99 Other disorders of the nervous system	0.502	0.498
H73 Other disorders of tympanic membrane	0.502	0.498
I42.5 Other restrictive cardiomyopathy	0.503	0.497
H93.1 Tinnitus	0.503	0.497
I42.8 Other cardiomyopathies	0.503	0.497
I42.4 Endocardial fibroelastosis	0.503	0.497
I45.4 Nonspecific intraventricular block	0.504	0.496
Q62 Congenital obstructive defects of renal pelvis and congenital malformations of ureter	0.504	0.496
R68.2 Dry mouth, unspecified	0.505	0.495
R63.0 Anorexia	0.507	0.493
I44.3 Other and unspecified atrioventricular block	0.507	0.493
I42.6 Alcoholic cardiomyopathy	0.509	0.491
R65.1 Systemic Inflammatory Response Syndrome of infectious origin with organ failure	0.509	0.490
R94 Abnormal results of function studies	0.510	0.490
I99 Other and unspecified disorders of circulatory system	0.512	0.488
R20.3 Hyperaesthesia	0.512	0.488
Q21.8 Other congenital malformations of cardiac septa	0.512	0.487
R57.1 Hypovolaemic shock	0.513	0.487
I80.9 Phlebitis and thrombophlebitis of unspecified site	0.513	0.487
Q25 Congenital malformations of great arteries	0.513	0.487
Q63 Other congenital malformations of kidney	0.513	0.487
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities	0.513	0.486
I46.9 Cardiac arrest, unspecified	0.514	0.486
I95.0 Idiopathic hypotension	0.515	0.485
I34 Nonrheumatic mitral valve disorders	0.515	0.485
Q64 Other congenital malformations of urinary system	0.515	0.485
I98 Other disorders of circulatory system in diseases classified elsewhere	0.516	0.484
D80-D89 Certain disorders involving the immune mechanism	0.516	0.484
I51.3 Intracardiac thrombosis, not elsewhere classified	0.516	0.484
J67 Hypersensitivity pneumonitis due to organic dust	0.516	0.484
Q21.3 Tetralogy of Fallot	0.516	0.484
R77 Other abnormalities of plasma proteins	0.517	0.483
R20.0 Anaesthesia of skin	0.517	0.483
Q21.9 Congenital malformation of cardiac septum, unspecified	0.517	0.483
F10-F19 Mental and behavioural disorders due to psychoactive substance use	0.518	0.482
R63.1 Polydipsia	0.518	0.482
R65.9 Systemic Inflammatory Response Syndrome, unspecified	0.519	0.481
R70 Elevated erythrocyte sedimentation rate and abnormality of plasma viscosity	0.519	0.481
G40-G47 Episodic and paroxysmal disorders	0.522	0.478
R74 Abnormal serum enzyme levels	0.523	0.477
J32.1 Chronic frontal sinusitis	0.523	0.477
R57.8 Other shock	0.523	0.477
R73.9 Hyperglycaemia, unspecified	0.524	0.476
I51.0 Cardiac septal defect, acquired	0.524	0.476
J18.1 Lobar pneumonia, unspecified	0.524	0.476
I82 Other venous embolism and thrombosis	0.524	0.476
I51.6 Cardiovascular disease, unspecified	0.524	0.475
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.525	0.475
R69 Unknown and unspecified causes of morbidity	0.525	0.475
G54 Nerve root and plexus disorders	0.527	0.473
G50 Disorders of trigeminal nerve	0.527	0.473
Q21.4 Aortopulmonary septal defect	0.527	0.472
Q21.2 Atrioventricular septal defect	0.527	0.472
I33.0 Acute and subacute infective endocarditis	0.527	0.472
D70-D77 Other diseases of blood and blood-forming organs	0.528	0.472
R84 Abnormal findings in specimens from respiratory organs and thorax	0.528	0.472
Q27 Other congenital malformations of peripheral vascular system	0.529	0.471
F90-F98 Behavioural and emotional disorders with onset usually occurring in childhood and adolescence	0.529	0.471
Q66 Congenital deformities of feet	0.529	0.471
G30-G32 Other degenerative diseases of the nervous system	0.530	0.470
I51.2 Rupture of papillary muscle, not elsewhere classified	0.530	0.470
H65.9 Nonsuppurative otitis media, unspecified	0.530	0.470
Q61.0 Congenital single renal cyst	0.530	0.469
E87 Other disorders of fluid, electrolyte and acid-base balance	0.531	0.469
J31.2 Chronic pharyngitis	0.531	0.469
I45.5 Other specified heart block	0.531	0.469
R20.1 Hypoaesthesia of skin	0.531	0.469
R07.1 Chest pain on breathing	0.531	0.468
J34.0 Abscess, furuncle and carbuncle of nose	0.531	0.468
R65.3 Systemic Inflammatory Response Syndrome of non-infectious origin with organ failure	0.531	0.468
R65.2 Systemic Inflammatory Response Syndrome of non-infectious origin without organ failure	0.531	0.468
G25 Other extrapyramidal and movement disorders	0.532	0.468
R63.8 Other symptoms and signs concerning food and fluid intake	0.532	0.468
I44.2 Atrioventricular block, complete	0.532	0.468
J60 Coalworker's pneumoconiosis	0.533	0.467
F80-F89 Disorders of psychological development	0.533	0.467
J32.2 Chronic ethmoidal sinusitis	0.533	0.467
F70-F79 Mental retardation	0.533	0.467
J64 Unspecified pneumoconiosis	0.533	0.467
J20-J22 Other acute lower respiratory infections	0.533	0.467
F99-F99 Unspecified mental disorder	0.534	0.466
J00-J06 Acute upper respiratory infections	0.534	0.466
R57.9 Shock, unspecified	0.535	0.465
H94 Other disorders of ear in diseases classified elsewhere	0.535	0.465
I51.5 Myocardial degeneration	0.535	0.464
D56 Thalassaemia	0.535	0.464
J34.1 Cyst and mucocele of nose and nasal sinus	0.536	0.464
R07.2 Precordial pain	0.536	0.464
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.536	0.463
R65.0 Systemic Inflammatory Response Syndrome of infectious origin without organ failure	0.537	0.462
Q61.9 Cystic kidney disease, unspecified	0.538	0.462
F30-F39 Mood [affective] disorders	0.540	0.460
J70 Respiratory conditions due to other external agents	0.540	0.459
H90.8 Mixed conductive and sensorineural hearing loss, unspecified	0.541	0.459
J68 Respiratory conditions due to inhalation of chemicals, gases, fumes and vapours	0.541	0.459
J66 Airway disease due to specific organic dust	0.541	0.459
J63 Pneumoconiosis due to other inorganic dusts	0.541	0.459
J65 Pneumoconiosis associated with tuberculosis	0.541	0.459
I49.9 Cardiac arrhythmia, unspecified	0.541	0.459
G70-G73 Diseases of myoneural junction and muscle	0.542	0.458
J40 Bronchitis, not specified as acute or chronic	0.542	0.458
H72.2 Other marginal perforations of tympanic membrane	0.543	0.457
I33.9 Acute endocarditis, unspecified	0.544	0.455
J62 Pneumoconiosis due to dust containing silica	0.544	0.455
R47.0 Dysphasia and aphasia	0.545	0.455
G35-G37 Demyelinating diseases of the central nervous system	0.545	0.455
D55 Anaemia due to enzyme disorders	0.545	0.455
I84.3 External thrombosed haemorrhoids	0.545	0.455
G24 Dystonia	0.546	0.454
H65.0 Acute serous otitis media	0.546	0.454
J95-J99 Other diseases of the respiratory system	0.546	0.453
R23 Other skin changes	0.547	0.453
I51.1 Rupture of chordae tendineae, not elsewhere classified	0.547	0.453
R09 Other symptoms and signs involving the circulatory and respiratory systems	0.547	0.453
R57.0 Cardiogenic shock	0.547	0.452
Q23 Congenital malformations of aortic and mitral valves	0.547	0.452
I95.2 Hypotension due to drugs	0.548	0.452
H90.0 Conductive hearing loss, bilateral	0.548	0.452
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.548	0.452
D58 Other hereditary haemolytic anaemias	0.548	0.451
R63.3 Feeding difficulties and mismanagement	0.549	0.451
I84.0 Internal thrombosed haemorrhoids	0.549	0.451
F60-F69 Disorders of adult personality and behaviour	0.549	0.450
H90.4 Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side	0.549	0.450
D57 Sickle-cell disorders	0.551	0.449
E50-E64 Other nutritional deficiencies	0.551	0.449
I05 Rheumatic mitral valve diseases	0.552	0.448
J39.9 Disease of upper respiratory tract, unspecified	0.552	0.448
I74 Arterial embolism and thrombosis	0.552	0.448
R96 Other sudden death, cause unknown	0.553	0.447
R95 Sudden infant death syndrome	0.553	0.447
R98 Unattended death	0.553	0.447
F50-F59 Behavioural syndromes associated with physiological disturbances and physical factors	0.553	0.447
H72.1 Attic perforation of tympanic membrane	0.554	0.446
Q61.2 Polycystic kidney, adult type	0.554	0.445
Q61.5 Medullary cystic kidney	0.555	0.445
R29.6 Tendency to fall, not elsewhere classified	0.555	0.445
R62.9 Lack of expected normal physiological development, unspecified	0.555	0.445
R62.0 Delayed milestone	0.555	0.445
H66.3 Other chronic suppurative otitis media	0.555	0.445
I97.1 Other functional disturbances following cardiac surgery	0.555	0.445
R93.1 Abnormal findings on diagnostic imaging of heart and coronary circulation	0.556	0.444
R61.9 Hyperhidrosis, unspecified	0.556	0.444
Q28.2 Arteriovenous malformation of cerebral vessels	0.557	0.443
I37.1 Pulmonary valve insufficiency	0.557	0.443
R99 Other ill-defined and unspecified causes of mortality	0.557	0.443
Q99 Other chromosome abnormalities, not elsewhere classified	0.559	0.441
R62.8 Other lack of expected normal physiological development	0.559	0.441
I95.1 Orthostatic hypotension	0.559	0.441
F20 Schizophrenia	0.561	0.439
H95 Postprocedural disorders of ear and mastoid process, not elsewhere classified	0.561	0.439
D53.9 Nutritional anaemia, unspecified	0.561	0.438
I84.2 Internal haemorrhoids without complication	0.562	0.438
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use	0.562	0.437
Q96 Turner's syndrome	0.562	0.437
R63.2 Polyphagia	0.563	0.437
R85 Abnormal findings in specimens from digestive organs and abdominal cavity	0.564	0.436
Q61.4 Renal dysplasia	0.564	0.436
G62 Other polyneuropathies	0.565	0.435
I43.1 Cardiomyopathy in metabolic diseases	0.566	0.434
F23 Acute and transient psychotic disorders	0.566	0.434
R61.1 Generalised hyperhidrosis	0.567	0.433
I51.4 Myocarditis, unspecified	0.567	0.433
R83 Abnormal findings in cerebrospinal fluid	0.567	0.433
R50.1 Persistent fever	0.568	0.432
I40.0 Infective myocarditis	0.568	0.432
G40 Epilepsy	0.569	0.431
I36.1 Nonrheumatic tricuspid (valve) insufficiency	0.569	0.431
I78 Diseases of capillaries	0.569	0.431
E87.1 Hypo-osmolality and hyponatraemia	0.569	0.431
Q61.3 Polycystic kidney, unspecified	0.569	0.430
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.570	0.430
I09 Other rheumatic heart diseases	0.570	0.430
I70 Atherosclerosis	0.570	0.430
R50.8 Other specified fever	0.571	0.429
R63.6 Insufficient intake of food and water due to self neglect	0.571	0.429
G21 Secondary Parkinsonism	0.571	0.429
Chapter II Neoplasms	0.571	0.429
H90.3 Sensorineural hearing loss, bilateral	0.572	0.428
I37.9 Pulmonary valve disorder, unspecified	0.572	0.427
I37.8 Other pulmonary valve disorders	0.572	0.427
I37.2 Pulmonary valve stenosis with insufficiency	0.572	0.427
R89 Abnormal findings in specimens from other organs, systems and tissues	0.572	0.427
H66.9 Otitis media, unspecified	0.573	0.427
R25.8 Other and unspecified abnormal involuntary movements	0.573	0.427
G61 Inflammatory polyneuropathy	0.573	0.427
R49.8 Other and unspecified voice disturbances	0.573	0.427
H66.1 Chronic tubotympanic suppurative otitis media	0.574	0.425
P90-P96 Other disorders originating in the perinatal period	0.575	0.425
P80-P83 Conditions involving the integument and temperature regulation of fetus and newborn	0.575	0.425
P75-P78 Digestive system disorders of fetus and newborn	0.575	0.425
P70-P74 Transitory endocrine and metabolic disorders specific to fetus and newborn	0.575	0.425
P50-P61 Haemorrhagic and haematological disorders of fetus and newborn	0.575	0.425
P35-P39 Infections specific to the perinatal period	0.575	0.425
P20-P29 Respiratory and cardiovascular disorders specific to the perinatal period	0.575	0.425
P05-P08 Disorders related to length of gestation and fetal growth	0.575	0.425
P00-P04 Fetus and newborn affected by maternal factors and by complications of pregnancy, labour and delivery	0.575	0.425
J85 Abscess of lung and mediastinum	0.575	0.425
Q24.9 Congenital malformation of the heart, unspecified	0.575	0.425
R01 Cardiac murmurs and other cardiac sounds	0.575	0.425
I47.1 Supraventricular tachycardia	0.575	0.425
I36.9 Nonrheumatic tricuspid valve disorder, unspecified	0.575	0.425
I36.8 Other nonrheumatic tricuspid valve disorders	0.575	0.425
I36.2 Nonrheumatic tricuspid (valve) stenosis with insufficiency	0.575	0.425
I36.0 Nonrheumatic tricuspid (valve) stenosis	0.575	0.425
H65.1 Other acute nonsuppurative otitis media	0.576	0.424
Q61.8 Other cystic kidney diseases	0.576	0.424
Q61.1 Polycystic kidney, infantile type	0.576	0.424
D53.8 Other specified nutritional anaemias	0.576	0.424
D53.2 Scorbutic anaemia	0.576	0.424
D53.0 Protein deficiency anaemia	0.576	0.424
R63.5 Abnormal weight gain	0.576	0.424
I43.2 Cardiomyopathy in nutritional diseases	0.576	0.423
I72.8 Aneurysm of other specified arteries	0.577	0.423
P10-P15 Birth trauma	0.577	0.423
I40.8 Other acute myocarditis	0.577	0.423
I40.1 Isolated myocarditis	0.577	0.423
J90-J94 Other diseases of pleura	0.577	0.423
J10 Influenza due to identified influenza virus	0.578	0.422
I37.0 Pulmonary valve stenosis	0.578	0.422
J34.8 Other specified disorders of nose and nasal sinuses	0.578	0.422
U82-U85 Resistance to antimicrobial and antineoplastic drugs	0.578	0.421
R60.0 Localised oedema	0.579	0.421
R86 Abnormal findings in specimens from male genital organs	0.579	0.421
I43.8 Cardiomyopathy in other diseases classified elsewhere	0.579	0.421
Q97 Other sex chromosome abnormalities, female phenotype, not elsewhere classified	0.579	0.421
Q95 Balanced rearrangements and structural markers, not elsewhere classified	0.579	0.421
Q93 Monosomies and deletions from the autosomes, not elsewhere classified	0.579	0.421
Q92 Other trisomies and partial trisomies of the autosomes, not elsewhere classified	0.579	0.421
Q91 Edwards' syndrome and Patau's syndrome	0.579	0.421

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations