TreeWAS – Variant ID: rs41314453

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
# Top node	1.000	0.000	0.000
Chapter VI Diseases of the nervous system	1.000	0.000	0.000
G40-G47 Episodic and paroxysmal disorders	1.000	0.000	0.000
Chapter IX Diseases of the circulatory system	0.999	0.001	0.000
Chapter XX External causes of morbidity and mortality	0.998	0.002	0.000
G40 Epilepsy	0.997	0.003	0.000
G40.9 Epilepsy, unspecified	0.996	0.004	0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use	0.995	0.005	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.994	0.006	0.000
I30-I52 Other forms of heart disease	0.989	0.011	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.979	0.021	0.000
Y43 Primarily systemic agents	0.971	0.029	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	0.964	0.036	0.000
Y43.3 Other antineoplastic drugs	0.955	0.045	0.000
G45 Transient cerebral ischaemic attacks and related syndromes	0.949	0.051	0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.949	0.051	0.000
I20-I25 Ischaemic heart diseases	0.945	0.055	0.000
Chapter I Certain infectious and parasitic diseases	0.940	0.060	0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system	0.938	0.062	0.000
G47 Sleep disorders	0.937	0.063	0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.930	0.070	0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts	0.927	0.073	0.000
I50 Heart failure	0.927	0.073	0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere	0.924	0.076	0.000
S80-S89 Injuries to the knee and lower leg	0.911	0.089	0.000
I05-I09 Chronic rheumatic heart diseases	0.910	0.090	0.000
I60-I69 Cerebrovascular diseases	0.901	0.099	0.000
I45 Other conduction disorders	0.894	0.106	0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.893	0.107	0.000
M70-M79 Other soft tissue disorders	0.892	0.108	0.000
B95-B98 Bacterial, viral and other infectious agents	0.890	0.110	0.000
G45.9 Transient cerebral ischaemic attack, unspecified	0.888	0.112	0.000
I24 Other acute ischaemic heart diseases	0.885	0.115	0.000
Chapter II Neoplasms	0.884	0.115	0.000
I46 Cardiac arrest	0.883	0.117	0.000
D69 Purpura and other haemorrhagic conditions	0.880	0.120	0.000
Chapter XXI Factors influencing health status and contact with health services	0.879	0.121	0.000
B95 Streptococcus and staphylococcus as the cause of diseases classified to other chapters	0.875	0.125	0.000
I25 Chronic ischaemic heart disease	0.875	0.125	0.000
I70-I79 Diseases of arteries, arterioles and capillaries	0.875	0.125	0.000
M65-M68 Disorders of synovium and tendon	0.873	0.127	0.000
Y95 Nosocomial condition	0.871	0.129	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.867	0.133	0.000
I35 Nonrheumatic aortic valve disorders	0.864	0.136	0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites	0.863	0.137	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	0.859	0.141	0.000
Y52 Agents primarily affecting the cardiovascular system	0.856	0.144	0.000
I50.0 Congestive heart failure	0.853	0.147	0.000
G62 Other polyneuropathies	0.847	0.153	0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status	0.844	0.156	0.000
C79 Secondary malignant neoplasm of other sites	0.838	0.162	0.000
M79 Other soft tissue disorders, not elsewhere classified	0.835	0.165	0.000
I08 Multiple valve diseases	0.834	0.166	0.000
I63 Cerebral infarction	0.833	0.167	0.000
D69.6 Thrombocytopenia, unspecified	0.833	0.167	0.000
G90-G99 Other disorders of the nervous system	0.832	0.168	0.000
G45.3 Amaurosis fugax	0.829	0.171	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.828	0.172	0.000
I24.8 Other forms of acute ischaemic heart disease	0.825	0.175	0.000
Chapter XXII Codes for special purposes	0.825	0.175	0.000
T84.0 Mechanical complication of internal joint prosthesis	0.824	0.176	0.000
Z86 Personal history of certain other diseases	0.822	0.178	0.000
I46.0 Cardiac arrest with successful resuscitation	0.821	0.179	0.000
Z92 Personal history of medical treatment	0.820	0.180	0.000
B95.6 Staphylococcus aureus as the cause of diseases classified to other chapters	0.816	0.184	0.000
S82 Fracture of lower leg, including ankle	0.816	0.184	0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.814	0.186	0.000
D70-D77 Other diseases of blood and blood-forming organs	0.813	0.187	0.000
G47.9 Sleep disorder, unspecified	0.810	0.190	0.000
Y40 Systemic antibiotics	0.809	0.191	0.000
D50-D53 Nutritional anaemias	0.807	0.193	0.000
G61 Inflammatory polyneuropathy	0.804	0.196	0.000
I77 Other disorders of arteries and arterioles	0.804	0.196	0.000
Z86.7 Personal history of diseases of the circulatory system	0.801	0.199	0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality	0.800	0.199	0.000
M50-M54 Other dorsopathies	0.800	0.200	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.799	0.201	0.000
M15-M19 Arthrosis	0.796	0.204	0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction	0.795	0.205	0.000
T84.8 Other complications of internal orthopaedic prosthetic devices, implants and grafts	0.795	0.205	0.000
M79.6 Pain in limb	0.794	0.206	0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.794	0.206	0.000
G47.3 Sleep apnoea	0.793	0.207	0.000
I44 Atrioventricular and left bundle-branch block	0.791	0.209	0.000
Chapter XV Pregnancy, childbirth and the puerperium	0.790	0.210	0.000
C79.5 Secondary malignant neoplasm of bone and bone marrow	0.789	0.211	0.000
Z82 Family history of certain disabilities and chronic diseases leading to disablement	0.786	0.214	0.000
I50.9 Heart failure, unspecified	0.785	0.215	0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions	0.785	0.215	0.000
M65 Synovitis and tenosynovitis	0.782	0.218	0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis	0.781	0.219	0.000
I08.3 Combined disorders of mitral, aortic and tricuspid valves	0.781	0.219	0.000
S40-S49 Injuries to the shoulder and upper arm	0.780	0.220	0.000
T15-T19 Effects of foreign body entering through natural orifice	0.779	0.221	0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.775	0.225	0.000
Z86.5 Personal history of other mental and behavioural disorders	0.775	0.225	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.774	0.226	0.000
M79.66 Pain in limb (Lower leg)	0.774	0.226	0.000
V40-V49 Car occupant injured in transport accident	0.772	0.228	0.000
I33 Acute and subacute endocarditis	0.772	0.228	0.000
Y57 Other and unspecified drugs and medicaments	0.770	0.230	0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]	0.770	0.230	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.769	0.230	0.000
I37 Pulmonary valve disorders	0.768	0.232	0.000
I22 Subsequent myocardial infarction	0.767	0.233	0.000
K80-K87 Disorders of gallbladder, biliary tract and pancreas	0.767	0.233	0.000
Z86.1 Personal history of infectious and parasitic diseases	0.767	0.233	0.000
K80 Cholelithiasis	0.766	0.234	0.000
Chapter XI Diseases of the digestive system	0.765	0.235	0.000
B95.4 Other streptococcus as the cause of diseases classified to other chapters	0.763	0.237	0.000
I45.1 Other and unspecified right bundle-branch block	0.763	0.237	0.000
E10-E14 Diabetes mellitus	0.763	0.237	0.000
Z92.3 Personal history of irradiation	0.762	0.238	0.000
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system	0.761	0.239	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.760	0.240	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.759	0.241	0.000
X60-X84 Intentional self-harm	0.759	0.241	0.000
T88 Other complications of surgical and medical care, not elsewhere classified	0.757	0.243	0.000
Chapter V Mental and behavioural disorders	0.756	0.244	0.000
Y52.3 Coronary vasodilators, not elsewhere classified	0.756	0.244	0.000
M72 Fibroblastic disorders	0.752	0.248	0.000
I63.9 Cerebral infarction, unspecified	0.752	0.248	0.000
G40.2 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures	0.750	0.250	0.000
K80.2 Calculus of gallbladder without cholecystitis	0.750	0.250	0.000
M86-M90 Other osteopathies	0.749	0.251	0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue	0.749	0.251	0.000
B95.0 Streptococcus, group A, as the cause of diseases classified to other chapters	0.747	0.253	0.000
S90-S99 Injuries to the ankle and foot	0.744	0.256	0.000
V10-V19 Pedal cyclist injured in transport accident	0.743	0.257	0.000
D60-D64 Aplastic and other anaemias	0.743	0.257	0.000
S82.8 Fractures of other parts of lower leg	0.742	0.258	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.741	0.259	0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs	0.741	0.259	0.000
D68 Other coagulation defects	0.739	0.261	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.739	0.261	0.000
I25.5 Ischaemic cardiomyopathy	0.739	0.261	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.737	0.263	0.000
I35.2 Aortic (valve) stenosis with insufficiency	0.736	0.264	0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs	0.735	0.265	0.000
I77.9 Disorder of arteries and arterioles, unspecified	0.734	0.266	0.000
D00-D09 In situ neoplasms	0.734	0.266	0.000
V80-V89 Other land transport accidents	0.733	0.267	0.000
G47.1 Disorders of excessive somnolence [hypersomnias]	0.732	0.268	0.000
Y44 Agents primarily affecting blood constituents	0.731	0.269	0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.731	0.269	0.000
S10-S19 Injuries to the neck	0.730	0.270	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.730	0.270	0.000
M54 Dorsalgia	0.730	0.270	0.000
I45.8 Other specified conduction disorders	0.729	0.271	0.000
T80 Complications following infusion, transfusion and therapeutic injection	0.728	0.271	0.000
D51 Vitamin B12 deficiency anaemia	0.728	0.272	0.000
D69.5 Secondary thrombocytopenia	0.728	0.272	0.000
C79.8 Secondary malignant neoplasm of other specified sites	0.728	0.272	0.000
Z35 Supervision of high-risk pregnancy	0.727	0.273	0.000
L80-L99 Other disorders of the skin and subcutaneous tissue	0.727	0.273	0.000
S70-S79 Injuries to the hip and thigh	0.726	0.274	0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts	0.725	0.275	0.000
Z92.6 Personal history of chemotherapy for neoplastic disease	0.724	0.276	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.724	0.276	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.724	0.276	0.000
E20-E35 Disorders of other endocrine glands	0.723	0.277	0.000
S20-S29 Injuries to the thorax	0.721	0.278	0.000
T66-T78 Other and unspecified effects of external causes	0.720	0.279	0.000
D80-D89 Certain disorders involving the immune mechanism	0.720	0.280	0.000
G40.3 Generalised idiopathic epilepsy and epileptic syndromes	0.720	0.280	0.000
G93 Other disorders of brain	0.718	0.282	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.717	0.283	0.000
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283	0.000
G00-G09 Inflammatory diseases of the central nervous system	0.717	0.283	0.000
G46 Vascular syndromes of brain in cerebrovascular diseases	0.717	0.283	0.000
G41 Status epilepticus	0.717	0.283	0.000
I00-I02 Acute rheumatic fever	0.716	0.283	0.000
I62 Other nontraumatic intracranial haemorrhage	0.716	0.284	0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use	0.716	0.284	0.000
Y35-Y36 Legal intervention and operations of war	0.716	0.284	0.000
Y10-Y34 Event of undetermined intent	0.716	0.284	0.000
Y00-Y09 Assault	0.716	0.284	0.000
X85-X99 Assault	0.716	0.284	0.000
X58-X59 Accidental exposure to other and unspecified factors	0.716	0.284	0.000
X50-X57 Overexertion, travel and privation	0.716	0.284	0.000
X40-X49 Accidental poisoning by and exposure to noxious substances	0.716	0.284	0.000
X30-X39 Exposure to forces of nature	0.716	0.284	0.000
X20-X29 Contact with venomous animals and plants	0.716	0.284	0.000
X10-X19 Contact with heat and hot substances	0.716	0.284	0.000
X00-X09 Exposure to smoke, fire and flames	0.716	0.284	0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure	0.716	0.284	0.000
W75-W84 Other accidental threats to breathing	0.716	0.284	0.000
W65-W74 Accidental drowning and submersion	0.716	0.284	0.000
W50-W64 Exposure to animate mechanical forces	0.716	0.284	0.000
V98-V99 Other and unspecified transport accidents	0.716	0.284	0.000
V95-V97 Air and space transport accidents	0.716	0.284	0.000
V90-V94 Water transport accidents	0.716	0.284	0.000
V70-V79 Bus occupant injured in transport accident	0.716	0.284	0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident	0.716	0.284	0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident	0.716	0.284	0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident	0.716	0.284	0.000
V01-V09 Pedestrian injured in transport accident	0.716	0.284	0.000
M19 Other arthrosis	0.716	0.284	0.000
G40.8 Other epilepsy	0.715	0.285	0.000
G40.7 Petit mal, unspecified, without grand mal seizures	0.715	0.285	0.000
G40.5 Special epileptic syndromes	0.715	0.285	0.000
G40.4 Other generalised epilepsy and epileptic syndromes	0.715	0.285	0.000
G40.1 Localisation-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures	0.715	0.285	0.000
G40.0 Localisation-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localised onset	0.715	0.285	0.000
G47.0 Disorders of initiating and maintaining sleep [insomnias]	0.715	0.285	0.000
Y59 Other and unspecified vaccines and biological substances	0.713	0.287	0.000
Y58 Bacterial vaccines	0.713	0.287	0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs	0.713	0.287	0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system	0.713	0.287	0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism	0.713	0.287	0.000
Y53 Agents primarily affecting the gastro-intestinal system	0.713	0.287	0.000
Y51 Drugs primarily affecting the autonomic nervous system	0.713	0.287	0.000
Y50 Central nervous system stimulants, not elsewhere classified	0.713	0.287	0.000
Y49 Psychotropic drugs, not elsewhere classified	0.713	0.287	0.000
Y48 Anaesthetics and therapeutic gases	0.713	0.287	0.000
Y47 Sedatives, hypnotics and antianxiety drugs	0.713	0.287	0.000
Y46 Antiepileptics and anti-Parkinsonism drugs	0.713	0.287	0.000
Y41 Other systemic anti-infectives and antiparasitics	0.713	0.287	0.000
M05-M14 Inflammatory polyarthropathies	0.713	0.287	0.000
T33-T35 Frostbite	0.713	0.287	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.713	0.287	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.713	0.287	0.000
T00-T07 Injuries involving multiple body regions	0.713	0.287	0.000
E50-E64 Other nutritional deficiencies	0.712	0.288	0.000
I67 Other cerebrovascular diseases	0.709	0.291	0.000
I52 Other heart disorders in diseases classified elsewhere	0.709	0.291	0.000
I48 Atrial fibrillation and flutter	0.709	0.291	0.000
I43 Cardiomyopathy in diseases classified elsewhere	0.709	0.291	0.000
I41 Myocarditis in diseases classified elsewhere	0.709	0.291	0.000
I40 Acute myocarditis	0.709	0.291	0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.709	0.291	0.000
I36 Nonrheumatic tricuspid valve disorders	0.709	0.291	0.000
I32 Pericarditis in diseases classified elsewhere	0.709	0.291	0.000
I30 Acute pericarditis	0.709	0.291	0.000
K50-K52 Noninfective enteritis and colitis	0.709	0.291	0.000
K80.1 Calculus of gallbladder with other cholecystitis	0.709	0.291	0.000
G61.0 Guillain-Barre syndrome	0.708	0.292	0.000
G62.9 Polyneuropathy, unspecified	0.707	0.293	0.000
Y60-Y69 Misadventures to patients during surgical and medical care	0.705	0.295	0.000
T84.4 Mechanical complication of other internal orthopaedic devices, imnplants and grafts	0.703	0.297	0.000
B90-B94 Sequelae of infectious and parasitic diseases	0.703	0.297	0.000
D55-D59 Haemolytic anaemias	0.702	0.298	0.000
Z96 Presence of other functional implants	0.701	0.299	0.000
U00-U49 Provisional assignment of new diseases of uncertain etiology or emergency use	0.700	0.300	0.000
I31 Other diseases of pericardium	0.700	0.300	0.000
Z36 Antenatal screening	0.699	0.301	0.000
M67 Other disorders of synovium and tendon	0.699	0.301	0.000
V20-V29 Motorcycle rider injured in transport accident	0.698	0.301	0.000
S80 Superficial injury of lower leg	0.698	0.302	0.000
G70-G73 Diseases of myoneural junction and muscle	0.698	0.302	0.000
M65.4 Radial styloid tenosynovitis [de Quervain]	0.697	0.303	0.000
Y43.9 Primarily systemic agent, unspecified	0.696	0.303	0.000
Y43.8 Other primarily systemic agents, not elsewhere classified	0.696	0.303	0.000
Y43.6 Enzymes, not elsewhere classified	0.696	0.303	0.000
Y43.5 Acidifying and alkalising agents	0.696	0.303	0.000
Y43.4 Immunosuppressive agents	0.696	0.303	0.000
Y43.2 Antineoplastic natural products	0.696	0.303	0.000
Y43.1 Antineoplastic antimetabolites	0.696	0.303	0.000
Y43.0 Antiallergic and antiemetic drugs	0.696	0.303	0.000
T79-T79 Certain early complications of trauma	0.695	0.304	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.695	0.305	0.000
B25-B34 Other viral diseases	0.695	0.305	0.000
I07 Rheumatic tricuspid valve diseases	0.695	0.305	0.000
Z94 Transplanted organ and tissue status	0.694	0.306	0.000
B15-B19 Viral hepatitis	0.694	0.306	0.000
G30-G32 Other degenerative diseases of the nervous system	0.693	0.307	0.000
I45.6 Preexcitation syndrome	0.693	0.307	0.000
M91-M94 Chondropathies	0.693	0.307	0.000
G62.0 Drug-induced polyneuropathy	0.691	0.309	0.000
M60-M63 Disorders of muscles	0.691	0.309	0.000
M00-M03 Infectious arthropathies	0.691	0.309	0.000
K50 Crohn's disease [regional enteritis]	0.689	0.311	0.000
B35-B49 Mycoses	0.689	0.311	0.000
S82.80 Fractures of other parts of lower leg (closed)	0.689	0.311	0.000
Y86 Sequelae of other accidents	0.687	0.313	0.000
T86 Failure and rejection of transplanted organs and tissues	0.685	0.315	0.000
G20-G26 Extrapyramidal and movement disorders	0.684	0.316	0.000
M77 Other enthesopathies	0.684	0.316	0.000
G63 Polyneuropathy in diseases classified elsewhere	0.683	0.317	0.000
K83 Other diseases of biliary tract	0.682	0.318	0.000
I63.3 Cerebral infarction due to thrombosis of cerebral arteries	0.681	0.319	0.000
L20-L30 Dermatitis and eczema	0.681	0.319	0.000
G45.8 Other transient cerebral ischaemic attacks and related syndromes	0.680	0.320	0.000
G45.2 Multiple and bilateral precerebral artery syndromes	0.680	0.320	0.000
G45.1 Carotid artery syndrome (hemispheric)	0.680	0.320	0.000
G45.0 Vertebro-basilar artery syndrome	0.680	0.320	0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx	0.680	0.320	0.000
T87 Complications peculiar to reattachment and amputation	0.680	0.320	0.000
G80-G83 Cerebral palsy and other paralytic syndromes	0.680	0.320	0.000
I73 Other peripheral vascular diseases	0.679	0.321	0.000
I35.1 Aortic (valve) insufficiency	0.679	0.321	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.678	0.322	0.000
I23 Certain current complications following acute myocardial infarction	0.678	0.322	0.000
I38 Endocarditis, valve unspecified	0.677	0.323	0.000
Z92.2 Personal history of long-term (current) use of other medicaments	0.676	0.324	0.000
G62.8 Other specified polyneuropathies	0.676	0.324	0.000
Y40.0 Penicillins	0.676	0.324	0.000
B99-B99 Other infectious diseases	0.674	0.326	0.000
B85-B89 Pediculosis, acariasis and other infestations	0.674	0.326	0.000
B65-B83 Helminthiases	0.674	0.326	0.000
B50-B64 Protozoal diseases	0.674	0.326	0.000
B20-B24 Human immunodeficiency virus [HIV] disease	0.674	0.326	0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers	0.674	0.326	0.000
A80-A89 Viral infections of the central nervous system	0.674	0.326	0.000
A75-A79 Rickettsioses	0.674	0.326	0.000
A70-A74 Other diseases caused by chlamydiae	0.674	0.326	0.000
A65-A69 Other spirochaetal diseases	0.674	0.326	0.000
A50-A64 Infections with a predominantly sexual mode of transmission	0.674	0.326	0.000
A20-A28 Certain zoonotic bacterial diseases	0.674	0.326	0.000
A15-A19 Tuberculosis	0.674	0.326	0.000
M54.5 Low back pain	0.673	0.327	0.000
G60 Hereditary and idiopathic neuropathy	0.673	0.327	0.000
G64 Other disorders of peripheral nervous system	0.673	0.327	0.000
M70 Soft tissue disorders related to use, overuse and pressure	0.672	0.328	0.000
M19.9 Arthrosis, unspecified	0.672	0.328	0.000
G47.8 Other sleep disorders	0.672	0.328	0.000
G47.4 Narcolepsy and cataplexy	0.672	0.328	0.000
G47.2 Disorders of the sleep-wake schedule	0.672	0.328	0.000
I51 Complications and ill-defined descriptions of heart disease	0.672	0.328	0.000
Chapter VIII Diseases of the ear and mastoid process	0.671	0.328	0.000
M71 Other bursopathies	0.671	0.328	0.000
Z89 Acquired absence of limb	0.671	0.329	0.000
B97 Viral agents as the cause of diseases classified to other chapters	0.669	0.330	0.000
C79.6 Secondary malignant neoplasm of ovary	0.669	0.331	0.000
I25.1 Atherosclerotic heart disease	0.669	0.331	0.000
G40.6 Grand mal seizures, unspecified (with or without petit mal)	0.669	0.331	0.000
I69 Sequelae of cerebrovascular disease	0.669	0.331	0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases	0.668	0.331	0.000
T82.0 Mechanical complication of heart valve prosthesis	0.667	0.333	0.000
I35.9 Aortic valve disorder, unspecified	0.667	0.333	0.000
D67 Hereditary factor IX deficiency	0.666	0.333	0.000
D66 Hereditary factor VIII deficiency	0.666	0.333	0.000
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.666	0.333	0.000
Z08.0 Follow-up examination after surgery for malignant neoplasm	0.000	0.334	0.666
Z96.6 Presence of orthopaedic joint implants	0.666	0.334	0.000
Z08 Follow-up examination after treatment for malignant neoplasm	0.000	0.335	0.665
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft	0.665	0.335	0.000
T84.3 Mechanical complication of other bone devices, implants and grafts	0.665	0.335	0.000
K82 Other diseases of gallbladder	0.665	0.335	0.000
I61 Intracerebral haemorrhage	0.663	0.337	0.000
Y91 Evidence of alcohol involvement determined by level of intoxication	0.663	0.337	0.000
Y90 Evidence of alcohol involvement determined by blood alcohol level	0.663	0.337	0.000
Y98 Lifestyle-related condition	0.663	0.337	0.000
Y97 Environmental-pollution-related condition	0.663	0.337	0.000
Y96 Work-related condition	0.663	0.337	0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]	0.663	0.337	0.000
D52 Folate deficiency anaemia	0.662	0.338	0.000
Y45.0 Opioids and related analgesics	0.661	0.338	0.000
I25.3 Aneurysm of heart	0.661	0.339	0.000
M79.65 Pain in limb (Pelvic region and thigh)	0.661	0.339	0.000
M79.2 Neuralgia and neuritis, unspecified	0.661	0.339	0.000
L97 Ulcer of lower limb, not elsewhere classified	0.660	0.340	0.000
K50.1 Crohn's disease of large intestine	0.660	0.340	0.000
Y42 Hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.659	0.341	0.000
S81 Open wound of lower leg	0.659	0.341	0.000
I63.4 Cerebral infarction due to embolism of cerebral arteries	0.658	0.342	0.000
B95.5 Unspecified streptococcus as the cause of diseases classified to other chapters	0.658	0.342	0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes	0.657	0.343	0.000
G44 Other headache syndromes	0.655	0.345	0.000
Z33 Pregnant state, incidental	0.655	0.345	0.000
I44.7 Left bundle-branch block, unspecified	0.654	0.346	0.000
Z83 Family history of other specific disorders	0.654	0.346	0.000
T88.7 Unspecified adverse effect of drug or medicament	0.654	0.346	0.000
S88 Traumatic amputation of lower leg	0.653	0.346	0.000
S87 Crushing injury of lower leg	0.653	0.346	0.000
S86 Injury of muscle and tendon at lower leg level	0.653	0.346	0.000
S85 Injury of blood vessels at lower leg level	0.653	0.346	0.000
S84 Injury of nerves at lower leg level	0.653	0.346	0.000
D70 Agranulocytosis	0.654	0.346	0.000
I09 Other rheumatic heart diseases	0.653	0.347	0.000
I06 Rheumatic aortic valve diseases	0.653	0.347	0.000
I05 Rheumatic mitral valve diseases	0.653	0.347	0.000
B07 Viral warts	0.652	0.348	0.000
Z92.0 Personal history of contraception	0.652	0.348	0.000
I08.1 Disorders of both mitral and tricuspid valves	0.651	0.349	0.000
M72.0 Palmar fascial fibromatosis [Dupuytren]	0.651	0.349	0.000
B95.8 Unspecified staphylococcus as the cause of diseases classified to other chapters	0.650	0.350	0.000
B95.3 Streptococcus pneumoniae as the cause of diseases classified to other chapters	0.649	0.351	0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified	0.649	0.351	0.000
M19.90 Arthrosis, unspecified (Multiple sites)	0.649	0.351	0.000
L90 Atrophic disorders of skin	0.648	0.352	0.000
D75 Other diseases of blood and blood-forming organs	0.648	0.352	0.000
E14 Unspecified diabetes mellitus	0.648	0.352	0.000
Z00-Z13 Persons encountering health services for examination and investigation	0.004	0.353	0.644
I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarction	0.647	0.353	0.000
Z97 Presence of other devices	0.647	0.353	0.000
I42 Cardiomyopathy	0.647	0.353	0.000
S60-S69 Injuries to the wrist and hand	0.647	0.353	0.000
Z09 Follow-up examination after treatment for conditions other than malignant neoplasms	0.000	0.354	0.645
I68 Cerebrovascular disorders in diseases classified elsewhere	0.646	0.354	0.000
I66 Occlusion and stenosis of cerebral arteries, not resulting in cerebral infarction	0.646	0.354	0.000
M54.59 Low back pain (Site unspecified)	0.645	0.355	0.000
M40-M43 Deforming dorsopathies	0.645	0.355	0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure	0.645	0.355	0.000
T38.3 Insulin and oral hypoglycaemic [antidiabetic] drugs	0.645	0.355	0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts	0.644	0.355	0.000
E10 Insulin-dependent diabetes mellitus	0.644	0.356	0.000
I27 Other pulmonary heart diseases	0.644	0.356	0.000
T84.2 Mechanical complication of internal fixation device of other bones	0.643	0.357	0.000
S82.6 Fracture of lateral malleolus	0.643	0.357	0.000
C79.2 Secondary malignant neoplasm of skin	0.643	0.357	0.000
D03 Melanoma in situ	0.643	0.357	0.000
M65.9 Synovitis and tenosynovitis, unspecified	0.643	0.357	0.000
D12 Benign neoplasm of colon, rectum, anus and anal canal	0.000	0.357	0.643
D12.5 Sigmoid colon	0.000	0.358	0.642
I45.9 Conduction disorder, unspecified	0.641	0.359	0.000
I45.5 Other specified heart block	0.641	0.359	0.000
I45.4 Nonspecific intraventricular block	0.641	0.359	0.000
I45.3 Trifascicular block	0.641	0.359	0.000
I45.2 Bifascicular block	0.641	0.359	0.000
I45.0 Right fascicular block	0.641	0.359	0.000
I77.8 Other specified disorders of arteries and arterioles	0.641	0.359	0.000
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified	0.640	0.360	0.000
Y45.8 Other analgesics and antipyretics	0.640	0.360	0.000
Y45.5 4-Aminophenol derivatives	0.640	0.360	0.000
Y45.4 Antirheumatics	0.640	0.360	0.000
Y45.2 Propionic acid derivatives	0.640	0.360	0.000
Y45.1 Salicylates	0.640	0.360	0.000
M76 Enthesopathies of lower limb, excluding foot	0.640	0.360	0.000
M73 Soft tissue disorders in diseases classified elsewhere	0.640	0.360	0.000
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency	0.640	0.360	0.000
K80.5 Calculus of bile duct without cholangitis or cholecystitis	0.639	0.361	0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum	0.639	0.361	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.638	0.362	0.000
L50-L54 Urticaria and erythema	0.638	0.362	0.000
I50.1 Left ventricular failure	0.635	0.365	0.000
D62 Acute posthaemorrhagic anaemia	0.635	0.365	0.000
I24.1 Dressler's syndrome	0.635	0.365	0.000
K65-K67 Diseases of peritoneum	0.635	0.365	0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites	0.634	0.366	0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system	0.634	0.366	0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue	0.634	0.366	0.000
C40-C41 Malignant neoplasms of bone and articular cartilage	0.634	0.366	0.000
F40-F48 Neurotic, stress-related and somatoform disorders	0.634	0.366	0.000
B95.1 Streptococcus, group B, as the cause of diseases classified to other chapters	0.633	0.367	0.000
I46.1 Sudden cardiac death, so described	0.633	0.367	0.000
Z92.4 Personal history of major surgery, not elsewhere classified	0.633	0.367	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.633	0.367	0.000
M80-M85 Disorders of bone density and structure	0.632	0.368	0.000
T50.9 Other and unspecified drugs, medicaments and biological substances	0.632	0.368	0.000
Z90 Acquired absence of organs, not elsewhere classified	0.632	0.368	0.000
D69.9 Haemorrhagic condition, unspecified	0.631	0.369	0.000
D69.8 Other specified haemorrhagic conditions	0.631	0.369	0.000
D69.4 Other primary thrombocytopenia	0.631	0.369	0.000
D69.2 Other nonthrombocytopenic purpura	0.631	0.369	0.000
D69.1 Qualitative platelet defects	0.631	0.369	0.000
D69.0 Allergic purpura	0.631	0.369	0.000
Z35.2 Supervision of pregnancy with other poor reproductive or obstetric history	0.631	0.369	0.000
I71 Aortic aneurysm and dissection	0.631	0.369	0.000
C50-C50 Malignant neoplasm of breast	0.631	0.369	0.000
S89 Other and unspecified injuries of lower leg	0.630	0.370	0.000
E13 Other specified diabetes mellitus	0.630	0.370	0.000
I77.1 Stricture of artery	0.629	0.371	0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee	0.628	0.372	0.000
C34 Malignant neoplasm of bronchus and lung	0.628	0.372	0.000
B95.2 Streptococcus, group D, as the cause of diseases classified to other chapters	0.628	0.372	0.000
I25.6 Silent myocardial ischaemia	0.627	0.373	0.000
I25.4 Coronary artery aneurysm	0.627	0.373	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.627	0.373	0.000
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.627	0.373	0.000
I72 Other aneurysm	0.627	0.373	0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands	0.627	0.373	0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.626	0.374	0.000
M66 Spontaneous rupture of synovium and tendon	0.626	0.374	0.000
I22.1 Subsequent myocardial infarction of inferior wall	0.623	0.377	0.000
T17 Foreign body in respiratory tract	0.622	0.378	0.000
S82.1 Fracture of upper end of tibia	0.622	0.378	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.622	0.378	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.622	0.378	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.622	0.378	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.622	0.378	0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified	0.622	0.378	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.622	0.378	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.622	0.378	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.622	0.378	0.000
T36 Poisoning by systemic antibiotics	0.622	0.378	0.000
I44.1 Atrioventricular block, second degree	0.621	0.379	0.000
M54.1 Radiculopathy	0.621	0.379	0.000
I74 Arterial embolism and thrombosis	0.620	0.380	0.000
I35.8 Other aortic valve disorders	0.619	0.380	0.000
G35 Multiple sclerosis	0.619	0.381	0.000
C76 Malignant neoplasm of other and ill-defined sites	0.619	0.381	0.000
Z09.8 Follow-up examination after other treatment for other conditions	0.000	0.381	0.618
Z86.3 Personal history of endocrine, nutritional and metabolic diseases	0.618	0.382	0.000
Z36.9 Antenatal screening, unspecified	0.618	0.382	0.000
Z09.9 Follow-up examination after unspecified treatment for other conditions	0.000	0.383	0.617
G37 Other demyelinating diseases of central nervous system	0.617	0.383	0.000
T14 Injury of unspecified body region	0.617	0.383	0.000
I33.0 Acute and subacute infective endocarditis	0.617	0.383	0.000
Z32 Pregnancy examination and test	0.616	0.384	0.000
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.616	0.384	0.000
E40-E46 Malnutrition	0.616	0.384	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.616	0.384	0.000
G93.1 Anoxic brain damage, not elsewhere classified	0.615	0.385	0.000
M79.7 Fibromyalgia	0.614	0.385	0.000
O60-O75 Complications of labour and delivery	0.614	0.386	0.000
S82.3 Fracture of lower end of tibia	0.614	0.386	0.000
B95.7 Other staphylococcus as the cause of diseases classified to other chapters	0.614	0.386	0.000
Y52.9 Other and unspecified agents primarily affecting the cardiovascular system	0.614	0.386	0.000
Y52.8 Antivaricose drugs, including sclerosing agents	0.614	0.386	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations