TreeWAS – Variant ID: rs6446315

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
M25.57 Pain in joint (Ankle and foot)	0.813	0.187	0.000
M25.5 Pain in joint	0.812	0.188	0.000
M25 Other joint disorders, not elsewhere classified	0.809	0.191	0.000
M25.7 Osteophyte	0.783	0.217	0.000
M25.77 Osteophyte (Ankle and foot)	0.781	0.219	0.000
M25.8 Other specified joint disorders	0.777	0.223	0.000
M25.86 Other specified joint disorders (Lower leg)	0.739	0.261	0.000
M25.4 Effusion of joint	0.736	0.264	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.731	0.269	0.000
M25.47 Effusion of joint (Ankle and foot)	0.705	0.295	0.000
M25.51 Pain in joint (Shoulder region)	0.702	0.298	0.000
M25.58 Pain in joint (Other)	0.691	0.309	0.000
M25.53 Pain in joint (Forearm)	0.690	0.310	0.000
M25.52 Pain in joint (Upper arm)	0.679	0.321	0.000
M25.81 Other specified joint disorders (Shoulder region)	0.658	0.342	0.000
M25.43 Effusion of joint (Forearm)	0.634	0.366	0.000
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.634	0.366	0.000
M25.0 Haemarthrosis	0.633	0.367	0.000
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.609	0.391	0.000
M25.71 Osteophyte (Shoulder region)	0.603	0.397	0.000
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.595	0.405	0.000
M25.72 Osteophyte (Upper arm)	0.593	0.407	0.000
M25.74 Osteophyte (Hand)	0.593	0.407	0.000
M25.73 Osteophyte (Forearm)	0.589	0.411	0.000
M25.79 Osteophyte (Site unspecified)	0.588	0.412	0.000
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.587	0.412	0.000
M25.45 Effusion of joint (Pelvic region and thigh)	0.583	0.417	0.000
M25.2 Flail joint	0.580	0.420	0.000
M25.1 Fistula of joint	0.580	0.420	0.000
M25.83 Other specified joint disorders (Forearm)	0.579	0.421	0.000
M25.88 Other specified joint disorders (Other)	0.575	0.425	0.000
M25.42 Effusion of joint (Upper arm)	0.566	0.434	0.000
M25.84 Other specified joint disorders (Hand)	0.564	0.436	0.000
M25.70 Osteophyte (Multiple sites)	0.561	0.439	0.000
M25.54 Pain in joint (Hand)	0.558	0.442	0.000
M25.82 Other specified joint disorders (Upper arm)	0.558	0.442	0.000
M25.89 Other specified joint disorders (Site unspecified)	0.557	0.443	0.000
M25.80 Other specified joint disorders (Multiple sites)	0.557	0.443	0.000
M25.55 Pain in joint (Pelvic region and thigh)	0.554	0.446	0.000
M25.87 Other specified joint disorders (Ankle and foot)	0.547	0.452	0.000
M25.40 Effusion of joint (Multiple sites)	0.530	0.469	0.000
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.528	0.472	0.000
M25.49 Effusion of joint (Site unspecified)	0.528	0.472	0.000
M25.48 Effusion of joint (Other)	0.528	0.472	0.000
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.526	0.474	0.000
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.526	0.474	0.000
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.524	0.476	0.000
M25.06 Haemarthrosis (Lower leg)	0.506	0.494	0.000
M25.3 Other instability of joint	0.484	0.516	0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)	0.472	0.528	0.000
M25.41 Effusion of joint (Shoulder region)	0.466	0.533	0.000
M25.59 Pain in joint (Site unspecified)	0.457	0.543	0.000
M25.09 Haemarthrosis (Site unspecified)	0.454	0.546	0.000
M25.08 Haemarthrosis (Other)	0.454	0.546	0.000
M25.07 Haemarthrosis (Ankle and foot)	0.454	0.546	0.000
M25.05 Haemarthrosis (Pelvic region and thigh)	0.454	0.546	0.000
M25.04 Haemarthrosis (Hand)	0.454	0.546	0.000
M25.03 Haemarthrosis (Forearm)	0.454	0.546	0.000
M25.02 Haemarthrosis (Upper arm)	0.454	0.546	0.000
M25.01 Haemarthrosis (Shoulder region)	0.454	0.546	0.000
M25.00 Haemarthrosis (Multiple sites)	0.454	0.546	0.000
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.439	0.561	0.000
M25.44 Effusion of joint (Hand)	0.423	0.576	0.000
M25.19 Fistula of joint (Site unspecified)	0.416	0.584	0.000
M25.18 Fistula of joint (Other)	0.416	0.584	0.000
M25.17 Fistula of joint (Ankle and foot)	0.416	0.584	0.000
M25.16 Fistula of joint (Lower leg)	0.416	0.584	0.000
M25.15 Fistula of joint (Pelvic region and thigh)	0.416	0.584	0.000
M25.14 Fistula of joint (Hand)	0.416	0.584	0.000
M25.13 Fistula of joint (Forearm)	0.416	0.584	0.000
M25.12 Fistula of joint (Upper arm)	0.416	0.584	0.000
M25.11 Fistula of joint (Shoulder region)	0.416	0.584	0.000
M25.10 Fistula of joint (Multiple sites)	0.416	0.584	0.000
M25.29 Flail joint (Site unspecified)	0.416	0.584	0.000
M25.28 Flail joint (Other)	0.416	0.584	0.000
M25.27 Flail joint (Ankle and foot)	0.416	0.584	0.000
M25.26 Flail joint (Lower leg)	0.416	0.584	0.000
M25.25 Flail joint (Pelvic region and thigh)	0.416	0.584	0.000
M25.24 Flail joint (Hand)	0.416	0.584	0.000
M25.23 Flail joint (Forearm)	0.416	0.584	0.000
M25.22 Flail joint (Upper arm)	0.416	0.584	0.000
M25.21 Flail joint (Shoulder region)	0.416	0.584	0.000
M25.20 Flail joint (Multiple sites)	0.416	0.584	0.000
M25.50 Pain in joint (Multiple sites)	0.415	0.585	0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.406	0.594	0.000
M25.75 Osteophyte (Pelvic region and thigh)	0.397	0.602	0.000
M25.33 Other instability of joint (Forearm)	0.371	0.629	0.000
M25.9 Joint disorder, unspecified	0.366	0.634	0.000
M25.39 Other instability of joint (Site unspecified)	0.347	0.653	0.000
M25.38 Other instability of joint (Other)	0.347	0.653	0.000
M25.35 Other instability of joint (Pelvic region and thigh)	0.347	0.653	0.000
M25.32 Other instability of joint (Upper arm)	0.347	0.653	0.000
M25.30 Other instability of joint (Multiple sites)	0.347	0.653	0.000
M25.78 Osteophyte (Other)	0.342	0.658	0.000
M25.34 Other instability of joint (Hand)	0.342	0.658	0.000
M25.37 Other instability of joint (Ankle and foot)	0.338	0.662	0.000
M25.36 Other instability of joint (Lower leg)	0.319	0.681	0.000
M25.92 Joint disorder, unspecified (Upper arm)	0.274	0.726	0.000
M25.98 Joint disorder, unspecified (Other)	0.271	0.728	0.000
M25.96 Joint disorder, unspecified (Lower leg)	0.271	0.729	0.000
M25.31 Other instability of joint (Shoulder region)	0.270	0.730	0.000
M25.90 Joint disorder, unspecified (Multiple sites)	0.260	0.739	0.000
M25.99 Joint disorder, unspecified (Site unspecified)	0.255	0.745	0.000
M25.56 Pain in joint (Lower leg)	0.255	0.745	0.000
M25.91 Joint disorder, unspecified (Shoulder region)	0.246	0.754	0.000
M25.93 Joint disorder, unspecified (Forearm)	0.245	0.755	0.000
M25.94 Joint disorder, unspecified (Hand)	0.232	0.768	0.000
M25.97 Joint disorder, unspecified (Ankle and foot)	0.215	0.784	0.000
M25.95 Joint disorder, unspecified (Pelvic region and thigh)	0.212	0.788	0.001
M25.46 Effusion of joint (Lower leg)	0.128	0.871	0.000
M25.76 Osteophyte (Lower leg)	0.105	0.894	0.001
S82.40 Fracture of fibula alone (closed)	0.013	0.987	0.000
D13.1 Stomach	0.011	0.989	0.000
R44.1 Visual hallucinations	0.000	0.992	0.008
R44.0 Auditory hallucinations	0.000	0.992	0.008
R44 Other symptoms and signs involving general sensations and perceptions	0.000	0.992	0.008
S82.4 Fracture of fibula alone	0.008	0.992	0.000
R44.3 Hallucinations, unspecified	0.000	0.992	0.008
L29.9 Pruritus, unspecified	0.000	0.992	0.008
Z95.9 Presence of cardiac and vascular implant and graft, unspecified	0.007	0.993	0.000
Z90.2 Acquired absence of lung [part of]	0.007	0.993	0.000
D69.3 Idiopathic thrombocytopenic purpura	0.007	0.993	0.000
Y45.0 Opioids and related analgesics	0.000	0.993	0.007
R44.2 Other hallucinations	0.000	0.994	0.006
S80.9 Superficial injury of lower leg, unspecified	0.006	0.994	0.000
L27.0 Generalised skin eruption due to drugs and medicaments	0.000	0.994	0.006
L29 Pruritus	0.000	0.994	0.006
S82.41 Fracture of fibula alone (open)	0.006	0.994	0.000
D63.8 Anaemia in other chronic diseases classified elsewhere	0.006	0.994	0.000
C43.3 Malignant melanoma of other and unspecified parts of face	0.000	0.994	0.006
D13 Benign neoplasm of other and ill-defined parts of digestive system	0.006	0.994	0.000
L27 Dermatitis due to substances taken internally	0.000	0.994	0.006
D13.3 Other and unspecified parts of small intestine	0.005	0.994	0.000
L20-L30 Dermatitis and eczema	0.000	0.994	0.006
R44.8 Other and unspecified symptoms and signs involving general sensations and perceptions	0.000	0.994	0.005
L29.8 Other pruritus	0.000	0.995	0.005
S80 Superficial injury of lower leg	0.005	0.995	0.000
C43.6 Malignant melanoma of upper limb, including shoulder	0.000	0.995	0.005
L29.2 Pruritus vulvae	0.000	0.995	0.005
S80.1 Contusion of other and unspecified parts of lower leg	0.005	0.995	0.000
D13.9 Ill-defined sites within the digestive system	0.005	0.995	0.000
K70.3 Alcoholic cirrhosis of liver	0.000	0.995	0.005
D13.0 Oesophagus	0.005	0.995	0.000
L29.1 Pruritus scroti	0.000	0.995	0.005
L28 Lichen simplex chronicus and prurigo	0.000	0.995	0.005
L26 Exfoliative dermatitis	0.000	0.995	0.005
Z95.2 Presence of prosthetic heart valve	0.005	0.995	0.000
L30 Other dermatitis	0.000	0.995	0.005
C43 Malignant melanoma of skin	0.000	0.995	0.005
Y45 Analgesics, antipyretics and anti-inflammatory drugs	0.000	0.995	0.005
C43.9 Malignant melanoma of skin, unspecified	0.000	0.995	0.005
D13.6 Pancreas	0.004	0.995	0.000
L21 Seborrhoeic dermatitis	0.000	0.996	0.004
G11.9 Hereditary ataxia, unspecified	0.000	0.996	0.004
L27.9 Dermatitis due to unspecified substance taken internally	0.000	0.996	0.004
L27.8 Dermatitis due to other substances taken internally	0.000	0.996	0.004
L24 Irritant contact dermatitis	0.000	0.996	0.004
L22 Diaper [napkin] dermatitis	0.000	0.996	0.004
D13.2 Duodenum	0.004	0.996	0.000
L23 Allergic contact dermatitis	0.000	0.996	0.004
L30.9 Dermatitis, unspecified	0.000	0.996	0.004
L28.0 Lichen simplex chronicus	0.000	0.996	0.004
D13.7 Endocrine pancreas	0.004	0.996	0.000
L20 Atopic dermatitis	0.000	0.996	0.004
S80.0 Contusion of knee	0.004	0.996	0.000
L25 Unspecified contact dermatitis	0.000	0.996	0.004
D13.5 Extrahepatic bile ducts	0.004	0.996	0.000
Y45.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.000	0.996	0.004
C43.1 Malignant melanoma of eyelid, including canthus	0.000	0.996	0.004
L27.1 Localised skin eruption due to drugs and medicaments	0.000	0.996	0.004
Y45.2 Propionic acid derivatives	0.000	0.996	0.004
S82 Fracture of lower leg, including ankle	0.004	0.996	0.000
L29.3 Anogenital pruritus, unspecified	0.000	0.996	0.004
L27.2 Dermatitis due to ingested food	0.000	0.996	0.004
C43.2 Malignant melanoma of ear and external auricular canal	0.000	0.996	0.004
H90.1 Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side	0.004	0.996	0.000
Z83.4 Family history of other endocrine, nutritional and metabolic diseases	0.000	0.996	0.004
D36.1 Peripheral nerves and autonomic nervous system	0.004	0.996	0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.004	0.996	0.000
L30.3 Infective dermatitis	0.000	0.996	0.004
S80-S89 Injuries to the knee and lower leg	0.004	0.996	0.000
R52.2 Other chronic pain	0.000	0.996	0.004
S83.2 Tear of meniscus, current	0.004	0.996	0.000
L28.2 Other prurigo	0.000	0.996	0.004
L23.1 Allergic contact dermatitis due to adhesives	0.000	0.996	0.004
Y45.5 4-Aminophenol derivatives	0.000	0.996	0.004
Y45.1 Salicylates	0.000	0.996	0.004
B37.9 Candidiasis, unspecified	0.000	0.996	0.004
D13.4 Liver	0.003	0.996	0.000
M20.0 Deformity of finger(s)	0.000	0.996	0.004
Y45.9 Analgesic, antipyretic and anti-inflammatory drug, unspecified	0.000	0.996	0.004
L30.0 Nummular dermatitis	0.000	0.996	0.004
L30.1 Dyshidrosis [pompholyx]	0.000	0.996	0.003
L30.5 Pityriasis alba	0.000	0.996	0.003
L30.2 Cutaneous autosensitisation	0.000	0.996	0.003
C43.8 Overlapping malignant melanoma of skin	0.000	0.996	0.003
L21.9 Seborrhoeic dermatitis, unspecified	0.000	0.996	0.003
L23.8 Allergic contact dermatitis due to other agents	0.000	0.996	0.003
C43.0 Malignant melanoma of lip	0.000	0.996	0.003
L29.0 Pruritus ani	0.000	0.996	0.003
C61 Malignant neoplasm of prostate	0.000	0.996	0.004
Y45.4 Antirheumatics	0.000	0.996	0.003
S80.7 Multiple superficial injuries of lower leg	0.003	0.997	0.000
K70 Alcoholic liver disease	0.000	0.997	0.003
C43.5 Malignant melanoma of trunk	0.000	0.997	0.003
S82.7 Multiple fractures of lower leg	0.003	0.997	0.000
L21.8 Other seborrhoeic dermatitis	0.000	0.997	0.003
L21.1 Seborrhoeic infantile dermatitis	0.000	0.997	0.003
L21.0 Seborrhoea capitis	0.000	0.997	0.003
S83.7 Injury to multiple structures of knee	0.003	0.997	0.000
L28.1 Prurigo nodularis	0.000	0.997	0.003
L30.4 Erythema intertrigo	0.000	0.997	0.003
K59.1 Functional diarrhoea	0.003	0.997	0.000
K70.9 Alcoholic liver disease, unspecified	0.000	0.997	0.003
L24.9 Irritant contact dermatitis, unspecified cause	0.000	0.997	0.003
L24.8 Irritant contact dermatitis due to other agents	0.000	0.997	0.003
L24.7 Irritant contact dermatitis due to plants, except food	0.000	0.997	0.003
L24.6 Irritant contact dermatitis due to food in contact with the skin	0.000	0.997	0.003
L24.5 Irritant contact dermatitis due to other chemical products	0.000	0.997	0.003
L24.4 Irritant contact dermatitis due to drugs in contact with the skin	0.000	0.997	0.003
L24.3 Irritant contact dermatitis due to cosmetics	0.000	0.997	0.003
L24.2 Irritant contact dermatitis due to solvents	0.000	0.997	0.003
L24.1 Irritant contact dermatitis due to oils and greases	0.000	0.997	0.003
L24.0 Irritant contact dermatitis due to detergents	0.000	0.997	0.003
L23.7 Allergic contact dermatitis due to plants, except food	0.000	0.997	0.003
L23.6 Allergic contact dermatitis due to food in contact with the skin	0.000	0.997	0.003
L23.4 Allergic contact dermatitis due to dyes	0.000	0.997	0.003
L23.2 Allergic contact dermatitis due to cosmetics	0.000	0.997	0.003
S82.6 Fracture of lateral malleolus	0.003	0.997	0.000
L23.0 Allergic contact dermatitis due to metals	0.000	0.997	0.003
K70.1 Alcoholic hepatitis	0.000	0.997	0.003
G11 Hereditary ataxia	0.000	0.997	0.003
L20.0 Besnier's prurigo	0.000	0.997	0.003
S83.3 Tear of articular cartilage of knee, current	0.003	0.997	0.000
L20.9 Atopic dermatitis, unspecified	0.000	0.997	0.003
S80.8 Other superficial injuries of lower leg	0.003	0.997	0.000
L25.8 Unspecified contact dermatitis due to other agents	0.000	0.997	0.003
L25.5 Unspecified contact dermatitis due to plants, except food	0.000	0.997	0.003
L25.4 Unspecified contact dermatitis due to food in contact with the skin	0.000	0.997	0.003
L25.3 Unspecified contact dermatitis due to other chemical products	0.000	0.997	0.003
L25.2 Unspecified contact dermatitis due to dyes	0.000	0.997	0.003
L25.1 Unspecified contact dermatitis due to drugs in contact with the skin	0.000	0.997	0.003
L25.0 Unspecified contact dermatitis due to cosmetics	0.000	0.997	0.003
S83.4 Sprain and strain involving (fibular)(tibial) collateral ligamnent of knee	0.003	0.997	0.000
S83.1 Dislocation of knee	0.003	0.997	0.000
Y45.8 Other analgesics and antipyretics	0.000	0.997	0.003
O90.8 Other complications of the puerperium, not elsewhere classified	0.000	0.997	0.003
L20.8 Other atopic dermatitis	0.000	0.997	0.003
L23.3 Allergic contact dermatitis due to drugs in contact with the skin	0.000	0.997	0.003
S82.9 Fracture of lower leg, part unspecified	0.003	0.997	0.000
L25.9 Unspecified contact dermatitis, unspecified cause	0.000	0.997	0.003
G12.2 Motor neuron disease	0.000	0.997	0.003
S82.70 Multiple fractures of lower leg (closed)	0.003	0.997	0.000
L30.8 Other specified dermatitis	0.000	0.997	0.003
L23.9 Allergic contact dermatitis, unspecified cause	0.000	0.997	0.003
S88 Traumatic amputation of lower leg	0.003	0.997	0.000
S82.1 Fracture of upper end of tibia	0.003	0.997	0.000
S85 Injury of blood vessels at lower leg level	0.003	0.997	0.000
L23.5 Allergic contact dermatitis due to other chemical products	0.000	0.997	0.003
S87 Crushing injury of lower leg	0.003	0.997	0.000
S82.60 Fracture of lateral malleolus (closed)	0.003	0.997	0.000
D36.0 Lymph nodes	0.003	0.997	0.000
S82.5 Fracture of medial malleolus	0.003	0.997	0.000
S83.6 Sprain and strain of other and unspecified parts of knee	0.003	0.997	0.000
S89 Other and unspecified injuries of lower leg	0.003	0.997	0.000
K70.2 Alcoholic fibrosis and sclerosis of liver	0.000	0.997	0.003
S83.0 Dislocation of patella	0.003	0.997	0.000
S84 Injury of nerves at lower leg level	0.003	0.997	0.000
D36 Benign neoplasm of other and unspecified sites	0.003	0.997	0.000
G11.1 Early-onset cerebellar ataxia	0.000	0.997	0.003
Q66.8 Other congenital deformities of feet	0.003	0.997	0.000
S82.71 Multiple fractures of lower leg (open)	0.003	0.997	0.000
G97.1 Other reaction to spinal and lumbar puncture	0.003	0.997	0.000
Z95 Presence of cardiac and vascular implants and grafts	0.003	0.997	0.000
S89.8 Other specified injuries of lower leg	0.003	0.997	0.000
S82.11 Fracture of upper end of tibia (open)	0.003	0.997	0.000
I35.9 Aortic valve disorder, unspecified	0.003	0.997	0.000
S86 Injury of muscle and tendon at lower leg level	0.003	0.997	0.000
D36.7 Other specified sites	0.003	0.997	0.000
G11.8 Other hereditary ataxias	0.000	0.997	0.002
G11.3 Cerebellar ataxia with defective DNA repair	0.000	0.997	0.002
G11.2 Late-onset cerebellar ataxia	0.000	0.997	0.002
G11.0 Congenital nonprogressive ataxia	0.000	0.997	0.002
G11.4 Hereditary spastic paraplegia	0.000	0.997	0.002
K70.0 Alcoholic fatty liver	0.000	0.997	0.003
G12 Spinal muscular atrophy and related syndromes	0.000	0.997	0.003
S82.90 Fracture of lower leg, part unspecified (closed)	0.002	0.997	0.000
K70.4 Alcoholic hepatic failure	0.000	0.997	0.002
S82.3 Fracture of lower end of tibia	0.002	0.997	0.000
Z95.4 Presence of other heart-valve replacement	0.003	0.997	0.000
M20-M25 Other joint disorders	0.003	0.997	0.000
S82.61 Fracture of lateral malleolus (open)	0.002	0.998	0.000
D69 Purpura and other haemorrhagic conditions	0.002	0.998	0.000
S82.91 Fracture of lower leg, part unspecified (open)	0.002	0.998	0.000
S88.9 Traumatic amputation of lower leg, level unspecified	0.002	0.998	0.000
S88.1 Traumatic amputation at level between knee and ankle	0.002	0.998	0.000
S88.0 Traumatic amputation at knee level	0.002	0.998	0.000
S82.2 Fracture of shaft of tibia	0.002	0.998	0.000
S85.9 Injury of unspecified blood vessel at lower leg level	0.002	0.998	0.000
S85.8 Injury of other blood vessels at lower leg level	0.002	0.998	0.000
S85.7 Injury of multiple blood vessels at lower leg level	0.002	0.998	0.000
S85.5 Injury of popliteal vein	0.002	0.998	0.000
S85.4 Injury of lesser saphenous vein at lower leg level	0.002	0.998	0.000
S85.3 Injury of greater saphenous vein at lower leg level	0.002	0.998	0.000
S85.2 Injury of peroneal artery	0.002	0.998	0.000
S85.0 Injury of popliteal artery	0.002	0.998	0.000
Z93.3 Colostomy status	0.000	0.998	0.002
S82.0 Fracture of patella	0.002	0.998	0.000
S87.0 Crushing injury of knee	0.002	0.998	0.000
S85.1 Injury of (anterior)(posterior) tibial artery	0.002	0.998	0.000
S81 Open wound of lower leg	0.002	0.998	0.000
D36.9 Benign neoplasm of unspecified site	0.002	0.998	0.000
S84.9 Injury of unspecified nerve at lower leg level	0.002	0.998	0.000
S84.8 Injury of other nerves at lower leg level	0.002	0.998	0.000
S84.7 Injury of multiple nerves at lower leg level	0.002	0.998	0.000
S84.2 Injury of cutaneous sensory nerve at lower leg level	0.002	0.998	0.000
S84.0 Injury of tibial nerve at lower leg level	0.002	0.998	0.000
S87.8 Crushing injury of other and unspecified parts of lower leg	0.002	0.998	0.000
S89.7 Multiple injuries of lower leg	0.002	0.998	0.000
S89.1 Other specified injuries of lower leg	0.002	0.998	0.000
S89.0 Multiple injuries of lower leg	0.002	0.998	0.000
G97.0 Cerebrospinal fluid leak from spinal puncture	0.002	0.998	0.000
S82.51 Fracture of medial malleolus (open)	0.002	0.998	0.000
C02.1 Border of tongue	0.000	0.998	0.002
S86.8 Injury of other muscles and tendons at lower leg level	0.002	0.998	0.000
D69.4 Other primary thrombocytopenia	0.002	0.998	0.000
S84.1 Injury of peroneal nerve at lower leg level	0.002	0.998	0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system	0.000	0.998	0.002
G97.8 Other postprocedural disorders of nervous system	0.002	0.998	0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee	0.002	0.998	0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified	0.002	0.998	0.000
S82.31 Fracture of lower end of tibia (open)	0.002	0.998	0.000
S86.0 Injury of Achilles tendon	0.002	0.998	0.000
S86.7 Injury of multiple muscles and tendons at lower leg level	0.002	0.998	0.000
C43.4 Malignant melanoma of scalp and neck	0.001	0.998	0.001
J15.2 Pneumonia due to staphylococcus	0.002	0.998	0.000
S86.9 Injury of unspecified muscle and tendon at lower leg level	0.002	0.998	0.000
G12.9 Spinal muscular atrophy, unspecified	0.000	0.998	0.002
G12.8 Other spinal muscular atrophies and related syndromes	0.000	0.998	0.002
G12.1 Other inherited spinal muscular atrophy	0.000	0.998	0.002
G12.0 Infantile spinal muscular atrophy, type I [Werdnig-Hoffman]	0.000	0.998	0.002
M77.91 Enthesopathy, unspecified (Shoulder region)	0.000	0.998	0.002
S82.21 Fracture of shaft of tibia (open)	0.002	0.998	0.000
D69.1 Qualitative platelet defects	0.002	0.998	0.000
M31.3 Wegener's granulomatosis	0.002	0.998	0.000
O42.1 Premature rupture of membranes, onset of labour after 24 hours	0.000	0.998	0.002
M31 Other necrotising vasculopathies	0.002	0.998	0.000
S82.50 Fracture of medial malleolus (closed)	0.002	0.998	0.000
S81.0 Open wound of knee	0.002	0.998	0.000
D69.8 Other specified haemorrhagic conditions	0.002	0.998	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.002	0.998	0.000
D69.9 Haemorrhagic condition, unspecified	0.002	0.998	0.000
S86.2 Injury of muscle(s) and tendon(s) of anterior muscle group at lower leg level	0.002	0.998	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.002	0.998	0.000
D69.2 Other nonthrombocytopenic purpura	0.002	0.998	0.000
I35.2 Aortic (valve) stenosis with insufficiency	0.002	0.998	0.000
S81.7 Multiple open wounds of lower leg	0.002	0.998	0.000
S86.3 Injury of muscle(s) and tendon(s) of peroneal muscle group at lower leg level	0.002	0.998	0.000
I49.9 Cardiac arrhythmia, unspecified	0.000	0.998	0.002
K04.0 Pulpitis	0.000	0.998	0.002
M31.7 Microscopic polyangiitis	0.002	0.998	0.000
K04.8 Radicular cyst	0.000	0.998	0.002
M32 Systemic lupus erythematosus	0.002	0.998	0.000
S27.20 Traumatic haemopneumothorax (without open wound into thoracic cavity)	0.000	0.998	0.002
J15.0 Pneumonia due to Klebsiella pneumoniae	0.002	0.998	0.000
Z95.1 Presence of aortocoronary bypass graft	0.002	0.998	0.000
S86.1 Injury of other muscle(s) and tendon(s) of posterior muscle group at lower leg level	0.002	0.998	0.000
K04.6 Periapical abscess with sinus	0.000	0.998	0.002
S82.8 Fractures of other parts of lower leg	0.002	0.998	0.000
S81.9 Open wound of lower leg, part unspecified	0.002	0.998	0.000
M30 Polyarteritis nodosa and related conditions	0.002	0.998	0.000
L84 Corns and callosities	0.002	0.998	0.000
M34 Systemic sclerosis	0.002	0.998	0.000
D69.5 Secondary thrombocytopenia	0.002	0.998	0.000
G97.9 Postprocedural disorder of nervous system, unspecified	0.002	0.998	0.000
G97.2 Intracranial hypotension following ventricular shunting	0.002	0.998	0.000
Z95.0 Presence of cardiac pacemaker	0.002	0.998	0.000
G14 Postpolio syndrome	0.000	0.998	0.002
G10 Huntington's disease	0.000	0.998	0.002
S86.00 Unspecified injury of Achilles tendon	0.002	0.998	0.000
M31.4 Aortic arch syndrome [Takayasu]	0.002	0.998	0.000
G13 Systemic atrophies primarily affecting central nervous system in diseases classified elsewhere	0.000	0.998	0.002
S82.01 Fracture of patella (open)	0.002	0.998	0.000
K04.4 Acute apical periodontitis of pulpal origin	0.000	0.998	0.002
M31.8 Other specified necrotising vasculopathies	0.002	0.998	0.000
M31.2 Lethal midline granuloma	0.002	0.998	0.000
S82.10 Fracture of upper end of tibia (closed)	0.002	0.998	0.000
H20.8 Other iridocyclitis	0.000	0.998	0.002
H93.1 Tinnitus	0.002	0.998	0.000
M31.1 Thrombotic microangiopathy	0.002	0.998	0.000
O63.0 Prolonged first stage (of labour)	0.002	0.998	0.000
D63.1 Anaemia in other chronic diseases classified elsewhere	0.002	0.998	0.000
J15.8 Other bacterial pneumonia	0.002	0.998	0.000
M11.26 Other chondrocalcinosis (Lower leg)	0.000	0.998	0.002
M32.1 Systemic lupus erythematosus with organ or system involvement	0.002	0.998	0.000
M36.4 Arthropathy in hypersensitivity reactions classified elsewhere	0.002	0.998	0.000
M36.3 Arthropathy in other blood disorders	0.002	0.998	0.000
M36.2 Haemophilic arthropathy	0.002	0.998	0.000
M36.1 Arthropathy in neoplastic disease	0.002	0.998	0.000
M36.0 Dermato(poly)myositis in neoplastic disease	0.002	0.998	0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.002	0.998	0.000
M22.3 Other derangements of patella	0.002	0.998	0.000
M32.9 Systemic lupus erythematosus, unspecified	0.001	0.998	0.000
J15 Bacterial pneumonia, not elsewhere classified	0.002	0.998	0.000
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.001	0.998	0.000
K04 Diseases of pulp and periapical tissues	0.000	0.998	0.002
S82.86 Maisonneuve's fracture	0.002	0.998	0.000
F05.9 Delirium, unspecified	0.000	0.998	0.002
Z96.0 Presence of urogenital implants	0.000	0.998	0.002
A49.8 Other bacterial infections of unspecified site	0.002	0.998	0.000
J30.1 Allergic rhinitis due to pollen	0.000	0.998	0.002
M32.8 Other forms of systemic lupus erythematosus	0.001	0.998	0.000
M34.1 CR(E)ST syndrome	0.002	0.998	0.000
M22 Disorders of patella	0.002	0.998	0.000
O90 Complications of the puerperium, not elsewhere classified	0.000	0.998	0.002
M30.3 Mucocutaneous lymph node syndrome [Kawasaki]	0.001	0.998	0.000
M30.2 Juvenile polyarteritis	0.001	0.998	0.000
M30.1 Polyarteritis with lung involvement [Churg-Strauss]	0.001	0.998	0.000
M31.0 Hypersensitivity angiitis	0.001	0.998	0.000
M33 Dermatopolymyositis	0.001	0.998	0.000
M24.37 Pathological dislocation and subluxation of joint, not elsewhere classified (Ankle and foot)	0.002	0.998	0.000
M31.9 Necrotising vasculopathy, unspecified	0.001	0.998	0.000
M34.2 Systemic sclerosis induced by drugs and chemicals	0.001	0.998	0.000
S89.9 Unspecified injury of lower leg	0.001	0.998	0.000
A63.0 Anogenital (venereal) warts	0.000	0.998	0.002
M31.5 Giant cell arteritis with polymyalgia rheumatica	0.001	0.998	0.000
M32.0 Drug-induced systemic lupus erythematosus	0.001	0.998	0.000
G82.2 Paraplegia, unspecified	0.002	0.998	0.000
M34.8 Other forms of systemic sclerosis	0.001	0.998	0.000
S82.81 Fractures of other parts of lower leg (open)	0.001	0.998	0.000
C22.9 Liver, unspecified	0.002	0.998	0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified	0.002	0.998	0.000
C60 Malignant neoplasm of penis	0.000	0.998	0.002
C60.0 Prepuce	0.000	0.998	0.001
G13.8 Systemic atrophy primarily affecting central nervous system in other diseases classified elsewhere	0.000	0.998	0.001
G13.2 Systemic atrophy primarily affecting central nervous system in myxoedema	0.000	0.998	0.001
M24.8 Other specific joint derangements, not elsewhere classified	0.002	0.998	0.000
N90.4 Leukoplakia of vulva	0.000	0.998	0.002
J15.1 Pneumonia due to Pseudomonas	0.001	0.998	0.000
M30.8 Other conditions related to polyarteritis nodosa	0.001	0.998	0.000
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid	0.000	0.998	0.002
M24 Other specific joint derangements	0.002	0.998	0.000
C60.9 Penis, unspecified	0.000	0.998	0.001
D69.0 Allergic purpura	0.001	0.998	0.000
G13.1 Other systemic atrophy primarily affecting central nervous system in neoplastic disease	0.000	0.998	0.001
G13.0 Paraneoplastic neuromyopathy and neuropathy	0.000	0.998	0.001
K04.9 Other and unspecified diseases of pulp and periapical tissues	0.000	0.998	0.001
M34.0 Progressive systemic sclerosis	0.001	0.998	0.000
M32.90 Systemic lupus erythematosus, unspecified, Multiple sites	0.001	0.998	0.000
M71.26 Synovial cyst of popliteal space [Baker]-Lower Leg	0.000	0.998	0.001
J15.6 Pneumonia due to other aerobic Gram-negative bacteria	0.001	0.998	0.000
J15.3 Pneumonia due to streptococcus, group B	0.001	0.998	0.000
M22.0 Recurrent dislocation of patella	0.001	0.998	0.000
M30.0 Polyarteritis nodosa	0.001	0.998	0.000
M31.6 Other giant cell arteritis	0.001	0.998	0.000
S63.4 Traumatic rupture of ligament of finger at metacarpophalangeal and interphalangeal joint(s)	0.001	0.998	0.000
C60-C63 Malignant neoplasms of male genital organs	0.000	0.998	0.001
K04.3 Abnormal hard tissue formation in pulp	0.000	0.998	0.001
K04.2 Pulp degeneration	0.000	0.998	0.001
K04.1 Necrosis of pulp	0.000	0.998	0.001
R59.1 Generalised enlarged lymph nodes	0.000	0.998	0.002
S82.00 Fracture of patella (closed)	0.001	0.999	0.000
C22.0 Liver cell carcinoma	0.001	0.999	0.000
J15.9 Bacterial pneumonia, unspecified	0.001	0.999	0.000
J30.3 Other allergic rhinitis	0.000	0.999	0.001
M22.1 Recurrent subluxation of patella	0.001	0.999	0.000
O90.5 Postpartum thyroiditis	0.000	0.999	0.001
O90.4 Postpartum acute renal failure	0.000	0.999	0.001
O90.3 Cardiomyopathy in the puerperium	0.000	0.999	0.001
Z95.3 Presence of xenogenic heart valve	0.001	0.999	0.000
M24.88 Other specific joint derangements, not elsewhere classified (Other)	0.001	0.999	0.000
M24.86 Other specific joint derangements, not elsewhere classified (Lower leg)	0.001	0.999	0.000
I79.2 Peripheral angiopathy in diseases classified elsewhere	0.001	0.999	0.000
M24.7 Protrusio acetabuli	0.001	0.999	0.000
M24.87 Other specific joint derangements, not elsewhere classified (Ankle and foot)	0.001	0.999	0.000
M24.83 Other specific joint derangements, not elsewhere classified (Forearm)	0.001	0.999	0.000
M33.9 Dermatopolymyositis, unspecified	0.001	0.999	0.000
M33.0 Juvenile dermatomyositis	0.001	0.999	0.000
O90.0 Disruption of Caesarean section wound	0.000	0.999	0.001
Q51.8 Other congenital malformations of uterus and cervix	0.000	0.999	0.001
S02.00 Fracture of vault of skull (closed)	0.000	0.999	0.001
J15.4 Pneumonia due to other streptococci	0.001	0.999	0.000
M34.9 Systemic sclerosis, unspecified	0.001	0.999	0.000
M24.39 Pathological dislocation and subluxation of joint, not elsewhere classified (Site unspecified)	0.001	0.999	0.000
M24.38 Pathological dislocation and subluxation of joint, not elsewhere classified (Other)	0.001	0.999	0.000
M24.36 Pathological dislocation and subluxation of joint, not elsewhere classified (Lower leg)	0.001	0.999	0.000
M24.35 Pathological dislocation and subluxation of joint, not elsewhere classified (Pelvic region and thigh)	0.001	0.999	0.000
M24.34 Pathological dislocation and subluxation of joint, not elsewhere classified (Hand)	0.001	0.999	0.000
M24.33 Pathological dislocation and subluxation of joint, not elsewhere classified (Forearm)	0.001	0.999	0.000
M24.32 Pathological dislocation and subluxation of joint, not elsewhere classified (Upper arm)	0.001	0.999	0.000
M24.31 Pathological dislocation and subluxation of joint, not elsewhere classified (Shoulder region)	0.001	0.999	0.000
M24.30 Pathological dislocation and subluxation of joint, not elsewhere classified (Multiple sites)	0.001	0.999	0.000
M24.67 Ankylosis of joint (Ankle and foot)	0.001	0.999	0.000
M24.84 Other specific joint derangements, not elsewhere classified (Hand)	0.001	0.999	0.000
S72.30 Fracture of shaft of femur (closed)	0.001	0.999	0.000
C60.8 Overlapping lesion of penis	0.000	0.999	0.001
C60.2 Body of penis	0.000	0.999	0.001
J15.5 Pneumonia due to Escherichia coli	0.001	0.999	0.000
M22.9 Disorder of patella, unspecified	0.001	0.999	0.000
O90.1 Disruption of perineal obstetric wound	0.000	0.999	0.001

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations