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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs6901869
log Bayes Factor = 32.9011
Chromosome 6   position 31,210,265  (GRCh37) Explore rs6901869 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.008 0.992
E10-E14 Diabetes mellitus
0.000 0.008 0.992
E10.3 With ophthalmic complications
0.000 0.015 0.985
E11 Non-insulin-dependent diabetes mellitus
0.000 0.026 0.974
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.036 0.964
E16.2 Hypoglycaemia, unspecified
0.000 0.036 0.964
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.038 0.962
E16 Other disorders of pancreatic internal secretion
0.000 0.038 0.962
E11.4 With neurological complications
0.000 0.074 0.926
E13 Other specified diabetes mellitus
0.000 0.119 0.881
E10.2 With renal complications
0.000 0.122 0.878
E10.4 With neurological complications
0.000 0.150 0.850
E11.6 With other specified complications
0.000 0.175 0.825
E00-E07 Disorders of thyroid gland
0.025 0.177 0.798
E11.8 With unspecified complications
0.000 0.181 0.818
E11.5 With peripheral circulatory complications
0.000 0.188 0.812
E10.9 Without complications
0.000 0.198 0.802
E13.9 Without complications
0.000 0.199 0.801
E14 Unspecified diabetes mellitus
0.000 0.200 0.800
E10.1 With ketoacidosis
0.000 0.206 0.794
E11.2 With renal complications
0.000 0.209 0.791
E11.3 With ophthalmic complications
0.000 0.210 0.790
E65-E68 Obesity and other hyperalimentation
0.000 0.213 0.787
E10.8 With unspecified complications
0.000 0.227 0.773
E05 Thyrotoxicosis [hyperthyroidism]
0.003 0.228 0.769
E40-E46 Malnutrition
0.000 0.243 0.757
E10.6 With other specified complications
0.000 0.246 0.754
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.258 0.741
E03 Other hypothyroidism
0.457 0.259 0.283
E14.3 With ophthalmic complications
0.000 0.270 0.730
M13.99 Arthritis, unspecified (Site unspecified)
0.000 0.276 0.724
E11.1 With ketoacidosis
0.000 0.284 0.716
E10.7 With multiple complications
0.000 0.289 0.711
E12 Malnutrition-related diabetes mellitus
0.000 0.289 0.711
E10.5 With peripheral circulatory complications
0.000 0.293 0.707
E10.0 With coma
0.000 0.301 0.699
E11.7 With multiple complications
0.000 0.302 0.698
E15 Nondiabetic hypoglycaemic coma
0.000 0.310 0.690
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.310 0.690
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.310 0.690
E16.4 Abnormal secretion of gastrin
0.000 0.310 0.690
E16.3 Increased secretion of glucagon
0.000 0.310 0.690
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.310 0.690
E06 Thyroiditis
0.011 0.312 0.677
E50-E64 Other nutritional deficiencies
0.000 0.318 0.682
E11.0 With coma
0.000 0.320 0.680
E13.8 With unspecified complications
0.000 0.368 0.631
E13.7 With multiple complications
0.000 0.368 0.631
E13.6 With other specified complications
0.000 0.368 0.631
E13.5 With peripheral circulatory complications
0.000 0.368 0.631
E13.4 With neurological complications
0.000 0.368 0.631
E13.3 With ophthalmic complications
0.000 0.368 0.631
E13.2 With renal complications
0.000 0.368 0.631
E13.1 With ketoacidosis
0.000 0.368 0.631
E13.0 With coma
0.000 0.368 0.631
E16.1 Other hypoglycaemia
0.000 0.372 0.628
E65 Localised adiposity
0.000 0.377 0.623
E66 Obesity
0.000 0.385 0.615
E46 Unspecified protein-energy malnutrition
0.000 0.391 0.609
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.002 0.391 0.607
E06.9 Thyroiditis, unspecified
0.005 0.394 0.601
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.018 0.410 0.572
E00 Congenital iodine-deficiency syndrome
0.018 0.410 0.572
E14.8 With unspecified complications
0.000 0.426 0.574
E14.7 With multiple complications
0.000 0.426 0.574
E14.5 With peripheral circulatory complications
0.000 0.426 0.574
E14.4 With neurological complications
0.000 0.426 0.574
E14.2 Withrenal complications
0.000 0.426 0.574
E14.1 With ketoacidosis
0.000 0.426 0.574
E14.0 With coma
0.000 0.426 0.574
E66.8 Other obesity
0.000 0.435 0.565
E67 Other hyperalimentation
0.000 0.435 0.564
E68 Sequelae of hyperalimentation
0.000 0.435 0.564
E02 Subclinical iodine-deficiency hypothyroidism
0.019 0.438 0.544
E05.9 Thyrotoxicosis, unspecified
0.000 0.445 0.554
E05.8 Other thyrotoxicosis
0.003 0.446 0.551
E05.5 Thyroid crisis or storm
0.003 0.446 0.551
E05.4 Thyrotoxicosis factitia
0.003 0.446 0.551
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.003 0.446 0.551
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.003 0.446 0.551
E55 Vitamin D deficiency
0.000 0.454 0.546
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.457 0.543
E45 Retarded development following protein-energy malnutrition
0.000 0.457 0.543
E43 Unspecified severe protein-energy malnutrition
0.000 0.457 0.543
E42 Marasmic kwashiorkor
0.000 0.457 0.543
E41 Nutritional marasmus
0.000 0.457 0.543
E40 Kwashiorkor
0.000 0.457 0.543
E14.6 With other specified complications
0.000 0.464 0.536
E03.5 Myxoedema coma
0.328 0.469 0.203
E03.4 Atrophy of thyroid (acquired)
0.328 0.469 0.203
E03.3 Postinfectious hypothyroidism
0.328 0.469 0.203
E03.1 Congenital hypothyroidism without goitre
0.328 0.469 0.203
E03.0 Congenital hypothyroidism with diffuse goitre
0.328 0.469 0.203
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.323 0.482 0.195
E12.9 Without complications
0.000 0.490 0.510
E12.8 With unspecified complications
0.000 0.490 0.510
E12.7 With multiple complications
0.000 0.490 0.510
E12.6 With other specified complications
0.000 0.490 0.510
E12.5 With peripheral circulatory complications
0.000 0.490 0.510
E12.4 With neurological complications
0.000 0.490 0.510
E12.3 With ophthalmic complications
0.000 0.490 0.510
E12.2 With renal complications
0.000 0.490 0.510
E12.1 With ketoacidosis
0.000 0.490 0.510
E12.0 With coma
0.000 0.490 0.510
E03.8 Other specified hypothyroidism
0.324 0.492 0.184
E06.5 Other chronic thyroiditis
0.008 0.506 0.485
E06.4 Drug-induced thyroiditis
0.008 0.506 0.485
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.008 0.506 0.485
E06.1 Subacute thyroiditis
0.008 0.506 0.485
E06.0 Acute thyroiditis
0.008 0.506 0.485
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.508 0.492
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.511 0.489
E63 Other nutritional deficiencies
0.000 0.511 0.489
E56 Other vitamin deficiencies
0.000 0.511 0.489
E51 Thiamine deficiency
0.000 0.511 0.489
E50 Vitamin A deficiency
0.000 0.511 0.489
E60 Dietary zinc deficiency
0.000 0.511 0.489
E59 Dietary selenium deficiency
0.000 0.511 0.489
E58 Dietary calcium deficiency
0.000 0.511 0.489
E54 Ascorbic acid deficiency
0.000 0.511 0.489
E52 Niacin deficiency [pellagra]
0.000 0.511 0.489
K90 Intestinal malabsorption
0.000 0.515 0.485
E06.3 Autoimmune thyroiditis
0.006 0.536 0.457
E53 Deficiency of other B group vitamins
0.000 0.548 0.452
E55.9 Vitamin D deficiency, unspecified
0.000 0.552 0.448
E66.1 Drug-induced obesity
0.000 0.559 0.441
E66.0 Obesity due to excess calories
0.000 0.559 0.441
E61 Deficiency of other nutrient elements
0.000 0.559 0.441
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.013 0.577 0.410
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.013 0.577 0.410
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.013 0.577 0.410
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.013 0.577 0.410
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.013 0.577 0.410
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.013 0.577 0.410
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.013 0.577 0.410
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.013 0.577 0.410
E14.9 Without complications
0.000 0.578 0.422
E07 Other disorders of thyroid
0.021 0.580 0.399
E67.8 Other specified hyperalimentation
0.000 0.595 0.405
E67.3 Hypervitaminosis D
0.000 0.595 0.405
E67.2 Megavitamin-B6 syndrome
0.000 0.595 0.405
E67.1 Hypercarotenaemia
0.000 0.595 0.405
E67.0 Hypervitaminosis A
0.000 0.595 0.405
E55.0 Rickets, active
0.000 0.609 0.391
E44.1 Mild protein-energy malnutrition
0.000 0.610 0.389
E44.0 Moderate protein-energy malnutrition
0.000 0.610 0.389
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.638 0.361
K90.8 Other intestinal malabsorption
0.000 0.649 0.351
E50.9 Vitamin A deficiency, unspecified
0.000 0.649 0.350
E50.8 Other manifestations of vitamin A deficiency
0.000 0.649 0.350
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.649 0.350
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.649 0.350
E50.5 Vitamin A deficiency with night blindness
0.000 0.649 0.350
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.649 0.350
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.649 0.350
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.649 0.350
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.649 0.350
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.649 0.350
E51.9 Thiamine deficiency, unspecified
0.000 0.649 0.350
E51.8 Other manifestations of thiamine deficiency
0.000 0.649 0.350
E51.2 Wernicke's encephalopathy
0.000 0.649 0.350
E51.1 Beriberi
0.000 0.649 0.350
E56.9 Vitamin deficiency, unspecified
0.000 0.649 0.350
E56.8 Deficiency of other vitamins
0.000 0.649 0.350
E56.1 Deficiency of vitamin K
0.000 0.649 0.350
E56.0 Deficiency of vitamin E
0.000 0.649 0.350
E63.9 Nutritional deficiency, unspecified
0.000 0.649 0.350
E63.8 Other specified nutritional deficiencies
0.000 0.649 0.350
E63.1 Imbalance of constituents of food intake
0.000 0.649 0.350
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.649 0.350
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.649 0.350
E64.8 Sequelae of other nutritional deficiencies
0.000 0.649 0.350
E64.3 Sequelae of rickets
0.000 0.649 0.350
E64.2 Sequelae of vitamin C deficiency
0.000 0.649 0.350
E64.1 Sequelae of vitamin A deficiency
0.000 0.649 0.350
E64.0 Sequelae of protein-energy malnutrition
0.000 0.649 0.350
K90.3 Pancreatic steatorrhoea
0.000 0.652 0.348
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.652 0.348
K90.1 Tropical sprue
0.000 0.652 0.348
K90.9 Intestinal malabsorption, unspecified
0.000 0.653 0.346
E53.9 Vitamin B deficiency, unspecified
0.000 0.676 0.324
E53.1 Pyridoxine deficiency
0.000 0.676 0.324
E53.0 Riboflavin deficiency
0.000 0.676 0.324
E61.9 Deficiency of nutrient element, unspecified
0.000 0.684 0.316
E61.8 Deficiency of other specified nutrient elements
0.000 0.684 0.316
E61.7 Deficiency of multiple nutrient elements
0.000 0.684 0.316
E61.6 Vanadium deficiency
0.000 0.684 0.316
E61.5 Molybdenum deficiency
0.000 0.684 0.316
E61.4 Chromium deficiency
0.000 0.684 0.316
E61.3 Manganese deficiency
0.000 0.684 0.316
E61.2 Magnesium deficiency
0.000 0.684 0.316
E61.0 Copper deficiency
0.000 0.684 0.316
E07.8 Other specified disorders of thyroid
0.014 0.695 0.291
E07.1 Dyshormogenetic goitre
0.015 0.699 0.286
E07.0 Hypersecretion of calcitonin
0.015 0.699 0.286
E53.8 Deficiency of other specified B group vitamins
0.000 0.713 0.287
E61.1 Iron deficiency
0.000 0.732 0.268
M13.9 Arthritis, unspecified
0.000 0.795 0.204
E20-E35 Disorders of other endocrine glands
0.000 0.806 0.194
M13.91 Arthritis, unspecified (Shoulder region)
0.000 0.837 0.163
M13.93 Arthritis, unspecified (Forearm)
0.000 0.843 0.157
E34 Other endocrine disorders
0.000 0.845 0.155
M13.94 Arthritis, unspecified (Hand)
0.000 0.846 0.154
M13.96 Arthritis, unspecified (Lower leg)
0.000 0.848 0.152
M13.97 Arthritis, unspecified (Ankle and foot)
0.000 0.848 0.152
M13.92 Arthritis, unspecified (Upper arm)
0.000 0.848 0.152
E04 Other non-toxic goitre
0.013 0.850 0.137
E26 Hyperaldosteronism
0.000 0.852 0.148
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.861 0.139
E32 Diseases of thymus
0.000 0.861 0.139
E31 Polyglandular dysfunction
0.000 0.861 0.139
E30 Disorders of puberty, not elsewhere classified
0.000 0.861 0.139
E25 Adrenogenital disorders
0.000 0.861 0.139
E24 Cushing's syndrome
0.000 0.862 0.138
E20 Hypoparathyroidism
0.000 0.868 0.132
E29 Testicular dysfunction
0.000 0.874 0.126
E22 Hyperfunction of pituitary gland
0.000 0.875 0.124
I84.9 Unspecified haemorrhoids without complication
0.120 0.880 0.000
E07.9 Disorder of thyroid, unspecified
0.019 0.881 0.100
E34.8 Other specified endocrine disorders
0.000 0.881 0.119
E34.0 Carcinoid syndrome
0.000 0.881 0.119
E34.9 Endocrine disorder, unspecified
0.000 0.885 0.115
E26.0 Primary hyperaldosteronism
0.000 0.885 0.115
E27 Other disorders of adrenal gland
0.000 0.887 0.113
E34.5 Androgen resistance syndrome
0.000 0.888 0.111
E34.4 Constitutional tall stature
0.000 0.888 0.111
E34.3 Short stature, not elsewhere classified
0.000 0.888 0.111
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.888 0.111
E34.1 Other hypersecretion of intestinal hormones
0.000 0.888 0.111
E04.0 Non-toxic diffuse goitre
0.008 0.891 0.100
E04.8 Other specified non-toxic goitre
0.009 0.892 0.098
E26.9 Hyperaldosteronism, unspecified
0.000 0.894 0.106
E26.8 Other hyperaldosteronism
0.000 0.894 0.106
E26.1 Secondary hyperaldosteronism
0.000 0.894 0.106
E24.9 Cushing's syndrome, unspecified
0.000 0.895 0.104
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.898 0.102
E25.9 Adrenogenital disorder, unspecified
0.000 0.900 0.100
E25.8 Other adrenogenital disorders
0.000 0.900 0.100
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.900 0.100
E30.9 Disorder of puberty, unspecified
0.000 0.900 0.100
E30.8 Other disorders of puberty
0.000 0.900 0.100
E30.1 Precocious puberty
0.000 0.900 0.100
E30.0 Delayed puberty
0.000 0.900 0.100
E31.9 Polyglandular dysfunction, unspecified
0.000 0.900 0.100
E31.8 Other polyglandular dysfunction
0.000 0.900 0.100
E31.1 Polyglandular hyperfunction
0.000 0.900 0.100
E31.0 Autoimmune polyglandular failure
0.000 0.900 0.100
E32.9 Disease of thymus, unspecified
0.000 0.900 0.100
E32.8 Other diseases of thymus
0.000 0.900 0.100
E32.1 Abscess of thymus
0.000 0.900 0.100
E32.0 Persistent hyperplasia of thymus
0.000 0.900 0.100
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.900 0.100
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.900 0.100
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.900 0.100
E24.8 Other Cushing's syndrome
0.000 0.901 0.099
E24.4 Alcohol-induced pseudo-Cushing's syndrome
0.000 0.901 0.099
E24.3 Ectopic ACTH syndrome
0.000 0.901 0.099
E24.1 Nelson's syndrome
0.000 0.901 0.099
E24.0 Pituitary-dependent Cushing's disease
0.000 0.901 0.099
M13 Other arthritis
0.002 0.901 0.098
E22.1 Hyperprolactinaemia
0.000 0.901 0.099
M13.90 Arthritis, unspecified (Multiple sites)
0.000 0.903 0.097
E23 Hypofunction and other disorders of pituitary gland
0.000 0.904 0.095
E20.8 Other hypoparathyroidism
0.000 0.905 0.095
E20.1 Pseudohypoparathyroidism
0.000 0.905 0.095
E20.0 Idiopathic hypoparathyroidism
0.000 0.905 0.095
E22.0 Acromegaly and pituitary gigantism
0.000 0.905 0.095
E27.1 Primary adrenocortical insufficiency
0.000 0.906 0.094
E24.2 Drug-induced Cushing's syndrome
0.000 0.907 0.092
E29.9 Testicular dysfunction, unspecified
0.000 0.909 0.091
E29.8 Other testicular dysfunction
0.000 0.909 0.091
E29.0 Testicular hyperfunction
0.000 0.909 0.091
E22.9 Hyperfunction of pituitary gland, unspecified
0.000 0.910 0.089
E22.8 Other hyperfunction of pituitary gland
0.000 0.910 0.089
E20.9 Hypoparathyroidism, unspecified
0.000 0.912 0.088
M13.95 Arthritis, unspecified (Pelvic region and thigh)
0.000 0.917 0.082
E27.5 Adrenomedullary hyperfunction
0.000 0.919 0.081
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.919 0.081
E27.0 Other adrenocortical overactivity
0.000 0.919 0.081
E29.1 Testicular hypofunction
0.000 0.922 0.078
M06.9 Rheumatoid arthritis, unspecified
0.077 0.923 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.077 0.923 0.000
M13.0 Polyarthritis, unspecified
0.001 0.923 0.076
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.924 0.076
M13.98 Arthritis, unspecified (Other)
0.000 0.924 0.075
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.925 0.075
E28 Ovarian dysfunction
0.001 0.925 0.074
E23.6 Other disorders of pituitary gland
0.000 0.926 0.074
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.926 0.073
E21.4 Other specified disorders of parathyroid gland
0.000 0.926 0.073
E21.2 Other hyperparathyroidism
0.000 0.926 0.073
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.073 0.927 0.000
E70-E90 Metabolic disorders
0.000 0.927 0.073
E27.2 Addisonian crisis
0.000 0.927 0.072
K90-K93 Other diseases of the digestive system
0.000 0.928 0.072
M13.1 Monoarthritis, not elsewhere classified
0.001 0.928 0.071
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.071 0.929 0.000
E27.8 Other specified disorders of adrenal gland
0.000 0.930 0.070
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.931 0.068
E23.1 Drug-induced hypopituitarism
0.000 0.931 0.068
E23.7 Disorder of pituitary gland, unspecified
0.000 0.932 0.068
E27.9 Disorder of adrenal gland, unspecified
0.000 0.932 0.068
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.065 0.935 0.000
E21.0 Primary hyperparathyroidism
0.000 0.936 0.064
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.062 0.938 0.000
M13.8 Other specified arthritis
0.002 0.940 0.058
M13.09 Polyarthritis, unspecified (Site unspecified)
0.001 0.941 0.058
E04.1 Non-toxic single thyroid nodule
0.009 0.941 0.050
E85 Amyloidosis
0.000 0.941 0.059
E83 Disorders of mineral metabolism
0.000 0.942 0.058
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.058 0.942 0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.058 0.942 0.000
E83.1 Disorders of iron metabolism
0.000 0.942 0.058
M13.00 Polyarthritis, unspecified (Multiple sites)
0.001 0.943 0.056
E04.2 Non-toxic multinodular goitre
0.007 0.945 0.048
M13.08 Polyarthritis, unspecified (Other)
0.001 0.945 0.054
M13.07 Polyarthritis, unspecified (Ankle and foot)
0.001 0.945 0.054
M13.06 Polyarthritis, unspecified (Lower leg)
0.001 0.945 0.054
M13.05 Polyarthritis, unspecified (Pelvic region and thigh)
0.001 0.945 0.054
M13.04 Polyarthritis, unspecified (Hand)
0.001 0.945 0.054
M13.03 Polyarthritis, unspecified (Forearm)
0.001 0.945 0.054
M13.02 Polyarthritis, unspecified (Upper arm)
0.001 0.945 0.054
M13.01 Polyarthritis, unspecified (Shoulder region)
0.001 0.945 0.054
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.054 0.946 0.000
E28.9 Ovarian dysfunction, unspecified
0.001 0.946 0.053
E28.8 Other ovarian dysfunction
0.001 0.946 0.053
E28.1 Androgen excess
0.001 0.946 0.053
E28.0 Oestrogen excess
0.001 0.946 0.053
M13.16 Monoarthritis, not elsewhere classified (Lower leg)
0.001 0.947 0.052
E84 Cystic fibrosis
0.000 0.948 0.052
E79 Disorders of purine and pyrimidine metabolism
0.000 0.948 0.052
E77 Disorders of glycoprotein metabolism
0.000 0.948 0.052
E76 Disorders of glycosaminoglycan metabolism
0.000 0.948 0.052
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.948 0.052
E72 Other disorders of amino-acid metabolism
0.000 0.948 0.052
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.948 0.052
E70 Disorders of aromatic amino-acid metabolism
0.000 0.948 0.052
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.948 0.052
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.948 0.052
M13.19 Monoarthritis, not elsewhere classified (Site unspecified)
0.001 0.948 0.051
M13.18 Monoarthritis, not elsewhere classified (Other)
0.001 0.948 0.051
M13.17 Monoarthritis, not elsewhere classified (Ankle and foot)
0.001 0.948 0.051
M13.15 Monoarthritis, not elsewhere classified (Pelvic region and thigh)
0.001 0.948 0.051
M13.14 Monoarthritis, not elsewhere classified (Hand)
0.001 0.948 0.051
M13.13 Monoarthritis, not elsewhere classified (Forearm)
0.001 0.948 0.051
M13.12 Monoarthritis, not elsewhere classified (Upper arm)
0.001 0.948 0.051
M13.11 Monoarthritis, not elsewhere classified (Shoulder region)
0.001 0.948 0.051
M13.10 Monoarthritis, not elsewhere classified (Multiple sites)
0.001 0.948 0.051
E23.0 Hypopituitarism
0.000 0.949 0.051
E74 Other disorders of carbohydrate metabolism
0.000 0.949 0.051
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.000 0.949 0.051
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.050 0.950 0.000
M06.98 Rheumatoid arthritis, unspecified (Other)
0.050 0.950 0.000
E04.9 Non-toxic goitre, unspecified
0.009 0.950 0.040
E88 Other metabolic disorders
0.000 0.951 0.048
E11.9 Without complications
0.000 0.952 0.048
E21.3 Hyperparathyroidism, unspecified
0.000 0.952 0.048
E85.4 Organ-limited amyloidosis
0.000 0.952 0.048
K91 Postprocedural disorders of digestive system, not elsewhere classified
0.000 0.953 0.047
M06 Other rheumatoid arthritis
0.041 0.953 0.006
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.954 0.046
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.001 0.955 0.044
M13.89 Other specified arthritis (Site unspecified)
0.001 0.957 0.042
M13.88 Other specified arthritis (Other)
0.001 0.957 0.042
M13.87 Other specified arthritis (Ankle and foot)
0.001 0.957 0.042
M13.85 Other specified arthritis (Pelvic region and thigh)
0.001 0.957 0.042
M13.84 Other specified arthritis (Hand)
0.001 0.957 0.042
M13.83 Other specified arthritis (Forearm)
0.001 0.957 0.042
M13.82 Other specified arthritis (Upper arm)
0.001 0.957 0.042
M13.81 Other specified arthritis (Shoulder region)
0.001 0.957 0.042
E85.9 Amyloidosis, unspecified
0.000 0.957 0.043
K91.8 Other postprocedural disorders of digestive system, not elsewhere classified
0.000 0.957 0.043
E85.8 Other amyloidosis
0.000 0.958 0.042
E85.3 Secondary systemic amyloidosis
0.000 0.958 0.042
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.958 0.042
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.958 0.042
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.958 0.042
E23.2 Diabetes insipidus
0.001 0.958 0.042
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.958 0.042
E83.8 Other disorders of mineral metabolism
0.000 0.958 0.042
E83.2 Disorders of zinc metabolism
0.000 0.958 0.042
E83.0 Disorders of copper metabolism
0.000 0.958 0.042
M13.80 Other specified arthritis (Multiple sites)
0.002 0.961 0.038
M06.3 Rheumatoid nodule
0.036 0.961 0.003
E89.2 Postprocedural hypoparathyroidism
0.000 0.961 0.039
E73 Lactose intolerance
0.001 0.962 0.037
G35 Multiple sclerosis
0.000 0.962 0.038
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.962 0.038
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.962 0.038
E70.3 Albinism
0.000 0.962 0.038
E70.2 Disorders of tyrosine metabolism
0.000 0.962 0.038
E70.1 Other hyperphenylalaninaemias
0.000 0.962 0.038
E70.0 Classical phenylketonuria
0.000 0.962 0.038
E71.3 Disorders of fatty-acid metabolism
0.000 0.962 0.038
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.962 0.038
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.962 0.038
E71.0 Maple-syrup-urine disease
0.000 0.962 0.038
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.962 0.038
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.962 0.038
E72.5 Disorders of glycine metabolism
0.000 0.962 0.038
E72.4 Disorders of ornithine metabolism
0.000 0.962 0.038
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.962 0.038
E72.2 Disorders of urea cycle metabolism
0.000 0.962 0.038
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.962 0.038
E72.0 Disorders of amino-acid transport
0.000 0.962 0.038
E75.6 Lipid storage disorder, unspecified
0.000 0.962 0.038
E75.5 Other lipid storage disorders
0.000 0.962 0.038
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.962 0.038
E75.3 Sphingolipidosis, unspecified
0.000 0.962 0.038
E75.2 Other sphingolipidosis
0.000 0.962 0.038
E75.1 Other gangliosidosis
0.000 0.962 0.038
E75.0 GM2 gangliosidosis
0.000 0.962 0.038
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.962 0.038
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.962 0.038
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.962 0.038
E76.2 Other mucopolysaccharidoses
0.000 0.962 0.038
E76.1 Mucopolysaccharidosis, type II
0.000 0.962 0.038
E76.0 Mucopolysaccharidosis, type I
0.000 0.962 0.038
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.962 0.038
E77.8 Other disorders of glycoprotein metabolism
0.000 0.962 0.038
E77.1 Defects in glycoprotein degradation
0.000 0.962 0.038
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.962 0.038
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.962 0.038
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.962 0.038
E79.1 Lesch-Nyhan syndrome
0.000 0.962 0.038
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.962 0.038
E84.9 Cystic fibrosis, unspecified
0.000 0.962 0.038
E84.8 Cystic fibrosis with other manifestations
0.000 0.962 0.038
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.962 0.038
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.962 0.038
K93.8 Disorders of other specified digestive organs in diseases classified elsewhere
0.000 0.962 0.037
K93.1 Megacolon in Chagas' disease
0.000 0.962 0.037
K93.0 Tuberculous disorders of intestines, peritoneum and mesenteric glands
0.000 0.962 0.037
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.963 0.036
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.963 0.036
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.963 0.036
E74.2 Disorders of galactose metabolism
0.000 0.963 0.036
E74.1 Disorders of fructose metabolism
0.000 0.963 0.036
E74.0 Glycogen storage disease
0.000 0.963 0.036
M13.86 Other specified arthritis (Lower leg)
0.002 0.963 0.035
E89.3 Postprocedural hypopituitarism
0.000 0.963 0.036
E89.9 Postprocedural endocrine and metabolic disorder, unspecified
0.000 0.964 0.036
E89.8 Other postprocedural endocrine and metabolic disorders
0.000 0.964 0.036
E89.5 Postprocedural testicular hypofunction
0.000 0.964 0.036
E89.4 Postprocedural ovarian failure
0.000 0.964 0.036
E89.1 Postprocedural hypoinsulinaemia
0.000 0.964 0.036
E83.5 Disorders of calcium metabolism
0.000 0.964 0.036
E89.6 Postprocedural adrenocortical(-medullary) hypofunction
0.000 0.965 0.035
E74.3 Other disorders of intestinal carbohydrate absorption
0.000 0.965 0.035
E88.9 Metabolic disorder, unspecified
0.000 0.965 0.035
E88.8 Other specified metabolic disorders
0.000 0.965 0.035
E88.3 Tumour lysis syndrome
0.000 0.965 0.035
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.965 0.035
E28.3 Primary ovarian failure
0.001 0.965 0.034
K91.2 Postsurgical malabsorption, not elsewhere classified
0.000 0.966 0.034
E88.2 Lipomatosis, not elsewhere classified
0.000 0.966 0.034
K91.9 Postprocedural disorder of digestive system, unspecified
0.000 0.966 0.034
M06.8 Other specified rheumatoid arthritis
0.030 0.966 0.004
M06.2 Rheumatoid bursitis
0.030 0.966 0.004
M06.1 Adult-onset Still's disease
0.030 0.966 0.004
M06.34 Rheumatoid nodule (Hand)
0.032 0.966 0.001
E80.7 Disorder of bilirubin metabolism, unspecified
0.000 0.967 0.033
E80.6 Other disorders of bilirubin metabolism
0.000 0.967 0.033
E80.5 Crigler-Najjar syndrome
0.000 0.967 0.033
E80.3 Defects of catalase and peroxydase
0.000 0.967 0.033
E80.2 Other porphyria
0.000 0.967 0.033
E80.1 Porphyria cutanea tarda
0.000 0.967 0.033
E80.0 Hereditary erythropoietic porphyria
0.000 0.967 0.033
M05-M14 Inflammatory polyarthropathies
0.005 0.967 0.028
E89.0 Postprocedural hypothyroidism
0.000 0.967 0.033
K91.0 Vomiting following gastro-intestinal surgery
0.000 0.968 0.032
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.968 0.032
K91.5 Postcholecystectomy syndrome
0.000 0.968 0.031
K91.1 Postgastric surgery syndromes
0.000 0.969 0.031
M06.4 Inflammatory polyarthropathy
0.026 0.970 0.004
E28.2 Polycystic ovarian syndrome
0.001 0.970 0.029
M06.0 Seronegative rheumatoid arthritis
0.026 0.970 0.003
K91.4 Colostomy and enterostomy malfunction
0.000 0.971 0.029
M06.37 Rheumatoid nodule (Ankle and foot)
0.027 0.971 0.002
E83.4 Disorders of magnesium metabolism
0.000 0.971 0.028
M06.39 Rheumatoid nodule (Site unspecified)
0.026 0.972 0.002
M06.38 Rheumatoid nodule (Other)
0.026 0.972 0.002
M06.36 Rheumatoid nodule (Lower leg)
0.026 0.972 0.002
M06.35 Rheumatoid nodule (Pelvic region and thigh)
0.026 0.972 0.002
M06.33 Rheumatoid nodule (Forearm)
0.026 0.972 0.002
M06.31 Rheumatoid nodule (Shoulder region)
0.026 0.972 0.002
M06.30 Rheumatoid nodule (Multiple sites)
0.026 0.972 0.002
M06.32 Rheumatoid nodule (Upper arm)
0.026 0.972 0.002
E73.8 Other lactose intolerance
0.001 0.972 0.027
E73.1 Secondary lactase deficiency
0.001 0.972 0.027
E73.0 Congenital lactase deficiency
0.001 0.972 0.027
K91.3 Postoperative intestinal obstruction
0.000 0.973 0.027
E80.4 Gilbert's syndrome
0.000 0.973 0.027
C77.2 Intra-abdominal lymph nodes
0.026 0.974 0.000
M11 Other crystal arthropathies
0.003 0.975 0.022
M14 Arthropathies in other diseases classified elsewhere
0.003 0.975 0.022
M07 Psoriatic and enteropathic arthropathies
0.003 0.975 0.022
M06.19 Adult-onset Still's disease (Site unspecified)
0.021 0.975 0.003

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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