TreeWAS – Variant ID: rs6919908

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Showing all nodes without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E10.9 Without complications	1.000	0.000	0.000
K90.0 Coeliac disease	1.000	0.000	0.000
E10 Insulin-dependent diabetes mellitus	1.000	0.000	0.000
E10-E14 Diabetes mellitus	1.000	0.000	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	1.000	0.000	0.000
E78.0 Pure hypercholesterolaemia	1.000	0.000	0.000
E11.9 Without complications	1.000	0.000	0.000
L40.9 Psoriasis, unspecified	1.000	0.000	0.000
E11 Non-insulin-dependent diabetes mellitus	1.000	0.000	0.000
G35 Multiple sclerosis	0.000	0.000	1.000
E00-E07 Disorders of thyroid gland	1.000	0.000	0.000
I25 Chronic ischaemic heart disease	1.000	0.000	0.000
E83.1 Disorders of iron metabolism	0.000	0.000	1.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.999	0.001	0.000
E03 Other hypothyroidism	0.999	0.001	0.000
I25.2 Old myocardial infarction	0.998	0.002	0.000
E03.9 Hypothyroidism, unspecified	0.998	0.002	0.000
E70-E90 Metabolic disorders	0.998	0.002	0.000
I25.1 Atherosclerotic heart disease	0.998	0.002	0.000
E05 Thyrotoxicosis [hyperthyroidism]	0.990	0.010	0.000
M06.9 Rheumatoid arthritis, unspecified	0.989	0.011	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.988	0.012	0.000
E05.9 Thyrotoxicosis, unspecified	0.987	0.013	0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.973	0.027	0.000
I25.8 Other forms of chronic ischaemic heart disease	0.973	0.027	0.000
I20-I25 Ischaemic heart diseases	0.971	0.029	0.000
E14 Unspecified diabetes mellitus	0.971	0.029	0.000
E10.3 With ophthalmic complications	0.966	0.034	0.000
I22 Subsequent myocardial infarction	0.951	0.049	0.000
E11.0 With coma	0.947	0.053	0.000
M45.X9 Ankylosing spondylitis (Site unspecified)	0.000	0.053	0.947
I22.1 Subsequent myocardial infarction of inferior wall	0.937	0.063	0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.937	0.063	0.000
L40 Psoriasis	0.935	0.065	0.000
E78.2 Mixed hyperlipidaemia	0.932	0.068	0.000
E14.9 Without complications	0.929	0.071	0.000
I24 Other acute ischaemic heart diseases	0.902	0.098	0.000
E11.1 With ketoacidosis	0.900	0.100	0.000
E20-E35 Disorders of other endocrine glands	0.900	0.100	0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.889	0.111	0.000
I25.5 Ischaemic cardiomyopathy	0.881	0.119	0.000
E78.8 Other disorders of lipoprotein metabolism	0.881	0.119	0.000
I24.9 Acute ischaemic heart disease, unspecified	0.876	0.124	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.866	0.134	0.000
E10.1 With ketoacidosis	0.860	0.140	0.000
E13 Other specified diabetes mellitus	0.848	0.151	0.000
E74 Other disorders of carbohydrate metabolism	0.844	0.156	0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.844	0.156	0.000
M45 Ankylosing spondylitis	0.000	0.163	0.837
E10.0 With coma	0.836	0.164	0.000
E28 Ovarian dysfunction	0.833	0.167	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.823	0.177	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.819	0.181	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.816	0.184	0.000
I25.0 Atherosclerotic cardiovascular disease, so described	0.814	0.186	0.000
L40.5 Arthropathic psoriasis	0.812	0.188	0.000
E40-E46 Malnutrition	0.811	0.189	0.000
E10.4 With neurological complications	0.806	0.194	0.000
E28.2 Polycystic ovarian syndrome	0.803	0.197	0.000
I25.3 Aneurysm of heart	0.800	0.200	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.799	0.201	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.790	0.210	0.000
E10.6 With other specified complications	0.786	0.214	0.000
M45.X0 Ankylosing spondylitis (Multiple sites in spine)	0.000	0.216	0.784
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.782	0.218	0.000
M06 Other rheumatoid arthritis	0.782	0.218	0.000
E78.1 Pure hyperglyceridaemia	0.775	0.225	0.000
L40-L45 Papulosquamous disorders	0.774	0.226	0.000
E03.8 Other specified hypothyroidism	0.771	0.229	0.000
E16 Other disorders of pancreatic internal secretion	0.770	0.230	0.000
E14.1 With ketoacidosis	0.769	0.231	0.000
E21.3 Hyperparathyroidism, unspecified	0.761	0.239	0.000
E74.3 Other disorders of intestinal carbohydrate absorption	0.759	0.241	0.000
I23 Certain current complications following acute myocardial infarction	0.758	0.241	0.000
K90 Intestinal malabsorption	0.758	0.242	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.754	0.246	0.000
E14.6 With other specified complications	0.752	0.248	0.000
E13.9 Without complications	0.746	0.254	0.000
E24 Cushing's syndrome	0.744	0.256	0.000
E10.8 With unspecified complications	0.740	0.260	0.000
E14.5 With peripheral circulatory complications	0.740	0.260	0.000
E11.6 With other specified complications	0.739	0.261	0.000
L40.8 Other psoriasis	0.739	0.261	0.000
E23 Hypofunction and other disorders of pituitary gland	0.738	0.262	0.000
E89.3 Postprocedural hypopituitarism	0.738	0.262	0.000
E79 Disorders of purine and pyrimidine metabolism	0.736	0.264	0.000
I25.6 Silent myocardial ischaemia	0.736	0.264	0.000
L40.0 Psoriasis vulgaris	0.735	0.265	0.000
E78.4 Other hyperlipidaemia	0.734	0.266	0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.733	0.266	0.000
E11.7 With multiple complications	0.733	0.267	0.000
L43 Lichen planus	0.732	0.268	0.000
E78.6 Lipoprotein deficiency	0.730	0.270	0.000
E14.8 With unspecified complications	0.726	0.274	0.000
E14.2 Withrenal complications	0.723	0.277	0.000
I22.9 Subsequent myocardial infarction of unspecified site	0.718	0.282	0.000
E10.2 With renal complications	0.718	0.282	0.000
E77 Disorders of glycoprotein metabolism	0.718	0.282	0.000
E12 Malnutrition-related diabetes mellitus	0.717	0.283	0.000
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.717	0.283	0.000
E00 Congenital iodine-deficiency syndrome	0.717	0.283	0.000
E03.5 Myxoedema coma	0.716	0.284	0.000
E03.4 Atrophy of thyroid (acquired)	0.716	0.284	0.000
E03.3 Postinfectious hypothyroidism	0.716	0.284	0.000
E80 Disorders of porphyrin and bilirubin metabolism	0.716	0.284	0.000
E76 Disorders of glycosaminoglycan metabolism	0.715	0.285	0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.715	0.285	0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.715	0.285	0.000
M06.98 Rheumatoid arthritis, unspecified (Other)	0.715	0.285	0.000
L40.1 Generalised pustular psoriasis	0.715	0.285	0.000
E11.5 With peripheral circulatory complications	0.714	0.285	0.000
E14.0 With coma	0.713	0.286	0.000
E72 Other disorders of amino-acid metabolism	0.713	0.286	0.000
E07 Other disorders of thyroid	0.711	0.289	0.000
E05.5 Thyroid crisis or storm	0.709	0.290	0.000
E05.4 Thyrotoxicosis factitia	0.709	0.290	0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.709	0.290	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.709	0.291	0.000
M06.3 Rheumatoid nodule	0.708	0.292	0.000
I20 Angina pectoris	0.707	0.293	0.000
M45.X2 Ankylosing spondylitis (Cervical region)	0.000	0.303	0.697
E70 Disorders of aromatic amino-acid metabolism	0.697	0.303	0.000
E14.7 With multiple complications	0.696	0.304	0.000
L43.9 Lichen planus, unspecified	0.696	0.304	0.000
E06 Thyroiditis	0.695	0.304	0.000
E88 Other metabolic disorders	0.694	0.306	0.000
E89.1 Postprocedural hypoinsulinaemia	0.689	0.311	0.000
I22.8 Subsequent myocardial infarction of other sites	0.684	0.316	0.000
E11.2 With renal complications	0.684	0.316	0.000
L40.4 Guttate psoriasis	0.683	0.317	0.000
E03.1 Congenital hypothyroidism without goitre	0.680	0.320	0.000
E46 Unspecified protein-energy malnutrition	0.676	0.324	0.000
I20.9 Angina pectoris, unspecified	0.674	0.326	0.000
E05.8 Other thyrotoxicosis	0.671	0.329	0.000
L40.2 Acrodermatitis continua	0.670	0.330	0.000
E78.3 Hyperchylomicronaemia	0.665	0.335	0.000
G35-G37 Demyelinating diseases of the central nervous system	0.000	0.335	0.665
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.662	0.338	0.000
E10.7 With multiple complications	0.659	0.340	0.000
E14.4 With neurological complications	0.657	0.343	0.000
E16.2 Hypoglycaemia, unspecified	0.656	0.344	0.000
E11.4 With neurological complications	0.655	0.345	0.000
E25 Adrenogenital disorders	0.654	0.346	0.000
E21.4 Other specified disorders of parathyroid gland	0.649	0.351	0.000
E02 Subclinical iodine-deficiency hypothyroidism	0.649	0.351	0.000
E89.6 Postprocedural adrenocortical(-medullary) hypofunction	0.649	0.351	0.000
M45.X6 Ankylosing spondylitis (Lumbar region)	0.000	0.352	0.648
K90.9 Intestinal malabsorption, unspecified	0.648	0.352	0.000
E35 Disorders of endocrine glands in diseases classified elsewhere	0.645	0.355	0.000
E30 Disorders of puberty, not elsewhere classified	0.645	0.355	0.000
E14.3 With ophthalmic complications	0.644	0.356	0.000
E84 Cystic fibrosis	0.644	0.356	0.000
E89.5 Postprocedural testicular hypofunction	0.643	0.357	0.000
E16.1 Other hypoglycaemia	0.641	0.359	0.000
E24.0 Pituitary-dependent Cushing's disease	0.638	0.362	0.000
M06.34 Rheumatoid nodule (Hand)	0.635	0.365	0.000
E32 Diseases of thymus	0.631	0.369	0.000
E89.2 Postprocedural hypoparathyroidism	0.630	0.370	0.000
M06.4 Inflammatory polyarthropathy	0.629	0.370	0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.628	0.372	0.000
E10.5 With peripheral circulatory complications	0.628	0.372	0.000
I22.0 Subsequent myocardial infarction of anterior wall	0.627	0.372	0.000
I25.9 Chronic ischaemic heart disease, unspecified	0.626	0.374	0.000
I24.1 Dressler's syndrome	0.624	0.376	0.000
E78.5 Hyperlipidaemia, unspecified	0.622	0.378	0.000
E15 Nondiabetic hypoglycaemic coma	0.621	0.379	0.000
E26 Hyperaldosteronism	0.620	0.380	0.000
E89.4 Postprocedural ovarian failure	0.619	0.381	0.000
I23.8 Other current complications following acute myocardial infarction	0.617	0.383	0.000
M45.X7 Ankylosing spondylitis (Lumbosacral region)	0.000	0.389	0.611
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.609	0.391	0.000
E13.8 With unspecified complications	0.608	0.392	0.000
E13.7 With multiple complications	0.608	0.392	0.000
E13.6 With other specified complications	0.608	0.392	0.000
E13.5 With peripheral circulatory complications	0.608	0.392	0.000
E13.4 With neurological complications	0.608	0.392	0.000
E13.2 With renal complications	0.608	0.392	0.000
E13.1 With ketoacidosis	0.608	0.392	0.000
E13.0 With coma	0.608	0.392	0.000
M06.8 Other specified rheumatoid arthritis	0.606	0.394	0.000
E74.9 Disorder of carbohydrate metabolism, unspecified	0.605	0.394	0.000
E74.8 Other specified disorders of carbohydrate metabolism	0.605	0.394	0.000
E74.4 Disorders of pyruvate metabolism and gluconeogenesis	0.605	0.394	0.000
E74.2 Disorders of galactose metabolism	0.605	0.394	0.000
E74.1 Disorders of fructose metabolism	0.605	0.394	0.000
E89.9 Postprocedural endocrine and metabolic disorder, unspecified	0.605	0.394	0.000
E31 Polyglandular dysfunction	0.604	0.395	0.000
E89.8 Other postprocedural endocrine and metabolic disorders	0.604	0.395	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.604	0.396	0.000
E23.2 Diabetes insipidus	0.602	0.398	0.000
M45.X8 Ankylosing spondylitis (Sacral and sacrococcygeal region)	0.000	0.400	0.600
M45.X5 Ankylosing spondylitis (Thoracolumbar region)	0.000	0.400	0.600
M45.X4 Ankylosing spondylitis (Thoracic region)	0.000	0.400	0.600
M45.X3 Ankylosing spondylitis (Cervicothoracic region)	0.000	0.400	0.600
M45.X1 Ankylosing spondylitis (Occipito-atlanto-axial region)	0.000	0.400	0.600
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.599	0.400	0.000
E28.9 Ovarian dysfunction, unspecified	0.597	0.403	0.000
E28.8 Other ovarian dysfunction	0.597	0.403	0.000
E28.1 Androgen excess	0.597	0.403	0.000
E28.0 Oestrogen excess	0.597	0.403	0.000
G37 Other demyelinating diseases of central nervous system	0.000	0.405	0.595
E13.3 With ophthalmic complications	0.593	0.406	0.000
K90.8 Other intestinal malabsorption	0.584	0.416	0.000
E80.2 Other porphyria	0.583	0.417	0.000
L42 Pityriasis rosea	0.582	0.418	0.000
E44 Protein-energy malnutrition of moderate and mild degree	0.582	0.418	0.000
E45 Retarded development following protein-energy malnutrition	0.582	0.418	0.000
E43 Unspecified severe protein-energy malnutrition	0.582	0.418	0.000
E42 Marasmic kwashiorkor	0.582	0.418	0.000
E41 Nutritional marasmus	0.582	0.418	0.000
E40 Kwashiorkor	0.582	0.418	0.000
M06.32 Rheumatoid nodule (Upper arm)	0.581	0.419	0.000
M06.1 Adult-onset Still's disease	0.581	0.419	0.000
E23.7 Disorder of pituitary gland, unspecified	0.577	0.423	0.000
E73 Lactose intolerance	0.571	0.429	0.000
L44 Other papulosquamous disorders	0.571	0.429	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.570	0.430	0.000
E83 Disorders of mineral metabolism	0.150	0.430	0.419
E24.2 Drug-induced Cushing's syndrome	0.565	0.435	0.000
E23.6 Other disorders of pituitary gland	0.564	0.436	0.000
L41 Parapsoriasis	0.564	0.436	0.000
L40.3 Pustulosis palmaris et plantaris	0.562	0.438	0.000
M06.2 Rheumatoid bursitis	0.561	0.439	0.000
E11.8 With unspecified complications	0.558	0.442	0.000
L43.0 Hypertrophic lichen planus	0.556	0.444	0.000
E80.6 Other disorders of bilirubin metabolism	0.555	0.445	0.000
L45 Papulosquamous disorders in diseases classified elsewhere	0.555	0.445	0.000
E21.0 Primary hyperparathyroidism	0.554	0.446	0.000
E75.2 Other sphingolipidosis	0.553	0.447	0.000
E16.9 Disorder of pancreatic internal secretion, unspecified	0.552	0.448	0.000
E16.8 Other specified disorders of pancreatic internal secretion	0.552	0.448	0.000
E16.4 Abnormal secretion of gastrin	0.552	0.448	0.000
E16.3 Increased secretion of glucagon	0.552	0.448	0.000
E21.2 Other hyperparathyroidism	0.552	0.448	0.000
E22 Hyperfunction of pituitary gland	0.551	0.449	0.000
E88.2 Lipomatosis, not elsewhere classified	0.551	0.449	0.000
E06.1 Subacute thyroiditis	0.550	0.450	0.000
I21 Acute myocardial infarction	0.549	0.451	0.000
E20 Hypoparathyroidism	0.548	0.451	0.000
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease	0.548	0.451	0.000
E16.0 Drug-induced hypoglycaemia without coma	0.546	0.453	0.000
E06.5 Other chronic thyroiditis	0.546	0.454	0.000
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.544	0.456	0.000
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.544	0.456	0.000
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.544	0.456	0.000
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.544	0.456	0.000
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.544	0.456	0.000
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.544	0.456	0.000
I25.4 Coronary artery aneurysm	0.543	0.456	0.000
K90.3 Pancreatic steatorrhoea	0.543	0.457	0.000
K90.2 Blind loop syndrome, not elsewhere classified	0.543	0.457	0.000
K90.1 Tropical sprue	0.543	0.457	0.000
E88.9 Metabolic disorder, unspecified	0.539	0.461	0.000
E74.0 Glycogen storage disease	0.538	0.461	0.000
E88.8 Other specified metabolic disorders	0.537	0.463	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.533	0.466	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.533	0.467	0.000
E24.3 Ectopic ACTH syndrome	0.533	0.467	0.000
E24.1 Nelson's syndrome	0.533	0.467	0.000
E07.9 Disorder of thyroid, unspecified	0.532	0.468	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.530	0.470	0.000
E23.1 Drug-induced hypopituitarism	0.529	0.471	0.000
L43.8 Other lichen planus	0.529	0.471	0.000
E79.9 Disorder of purine and pyrimidine metabolism, unspecified	0.528	0.472	0.000
E79.8 Other disorders of purine and pyrimidine metabolism	0.528	0.472	0.000
E79.1 Lesch-Nyhan syndrome	0.528	0.472	0.000
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.526	0.473	0.000
E75.6 Lipid storage disorder, unspecified	0.526	0.474	0.000
E75.4 Neuronal ceroid lipofuscinosis	0.526	0.474	0.000
E75.3 Sphingolipidosis, unspecified	0.526	0.474	0.000
E75.1 Other gangliosidosis	0.526	0.474	0.000
E75.0 GM2 gangliosidosis	0.526	0.474	0.000
L43.3 Subacute (active) lichen planus	0.525	0.475	0.000
L43.2 Lichenoid drug reaction	0.525	0.475	0.000
L43.1 Bullous lichen planus	0.525	0.475	0.000
E29 Testicular dysfunction	0.525	0.475	0.000
E72.1 Disorders of sulphur-bearing amino-acid metabolism	0.523	0.477	0.000
E24.9 Cushing's syndrome, unspecified	0.522	0.478	0.000
E50-E64 Other nutritional deficiencies	0.519	0.481	0.000
G37.9 Demyelinating disease of central nervous system, unspecified	0.000	0.481	0.519
E80.1 Porphyria cutanea tarda	0.519	0.481	0.000
E77.8 Other disorders of glycoprotein metabolism	0.517	0.482	0.000
E75.5 Other lipid storage disorders	0.515	0.484	0.000
E77.9 Disorder of glycoprotein metabolism, unspecified	0.515	0.485	0.000
E77.1 Defects in glycoprotein degradation	0.515	0.485	0.000
E77.0 Defects in posttranslational modification of lysosomal enzymes	0.515	0.485	0.000
E12.9 Without complications	0.514	0.486	0.000
E12.8 With unspecified complications	0.514	0.486	0.000
E12.7 With multiple complications	0.514	0.486	0.000
E12.6 With other specified complications	0.514	0.486	0.000
E12.5 With peripheral circulatory complications	0.514	0.486	0.000
E12.4 With neurological complications	0.514	0.486	0.000
E12.3 With ophthalmic complications	0.514	0.486	0.000
E12.2 With renal complications	0.514	0.486	0.000
E12.1 With ketoacidosis	0.514	0.486	0.000
E12.0 With coma	0.514	0.486	0.000
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.514	0.486	0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.514	0.486	0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.514	0.486	0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.514	0.486	0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.514	0.486	0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.514	0.486	0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.514	0.486	0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.514	0.486	0.000
E80.5 Crigler-Najjar syndrome	0.513	0.487	0.000
E80.3 Defects of catalase and peroxydase	0.513	0.487	0.000
E80.0 Hereditary erythropoietic porphyria	0.513	0.487	0.000
E71.3 Disorders of fatty-acid metabolism	0.513	0.487	0.000
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified	0.513	0.487	0.000
E71.1 Other disorders of branched-chain amino-acid metabolism	0.513	0.487	0.000
E71.0 Maple-syrup-urine disease	0.513	0.487	0.000
E76.9 Disorder of glucosaminoglycan metabolism, unspecified	0.513	0.487	0.000
E76.8 Other disorders of glucosaminoglycan metabolism	0.513	0.487	0.000
E76.3 Mucopolysaccharidosis, unspecified	0.513	0.487	0.000
E76.2 Other mucopolysaccharidoses	0.513	0.487	0.000
E76.1 Mucopolysaccharidosis, type II	0.513	0.487	0.000
E76.0 Mucopolysaccharidosis, type I	0.513	0.487	0.000
E72.9 Disorder of amino-acid metabolism, unspecified	0.511	0.488	0.000
E72.8 Other specified disorders of amino-acid metabolism	0.511	0.488	0.000
E72.5 Disorders of glycine metabolism	0.511	0.488	0.000
E72.4 Disorders of ornithine metabolism	0.511	0.488	0.000
E72.3 Disorders of lysine and hydroxylysine metabolism	0.511	0.488	0.000
E72.2 Disorders of urea cycle metabolism	0.511	0.488	0.000
E07.1 Dyshormogenetic goitre	0.510	0.490	0.000
E07.0 Hypersecretion of calcitonin	0.510	0.490	0.000
M06.39 Rheumatoid nodule (Site unspecified)	0.507	0.492	0.000
M06.38 Rheumatoid nodule (Other)	0.507	0.492	0.000
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.507	0.492	0.000
M06.31 Rheumatoid nodule (Shoulder region)	0.507	0.492	0.000
I24.8 Other forms of acute ischaemic heart disease	0.506	0.494	0.000
E34 Other endocrine disorders	0.506	0.494	0.000
I21.4 Acute subendocardial myocardial infarction	0.501	0.499	0.000
E70.9 Disorder of aromatic amino-acid metabolism, unspecified	0.500	0.500	0.000
E70.8 Other disorders of aromatic amino-acid metabolism	0.500	0.500	0.000
E70.2 Disorders of tyrosine metabolism	0.500	0.500	0.000
E70.1 Other hyperphenylalaninaemias	0.500	0.500	0.000
E70.0 Classical phenylketonuria	0.500	0.500	0.000
M06.33 Rheumatoid nodule (Forearm)	0.499	0.501	0.000
E06.4 Drug-induced thyroiditis	0.499	0.501	0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.499	0.501	0.000
E06.0 Acute thyroiditis	0.499	0.501	0.000
M06.36 Rheumatoid nodule (Lower leg)	0.498	0.502	0.000
E72.0 Disorders of amino-acid transport	0.497	0.503	0.000
E24.8 Other Cushing's syndrome	0.495	0.505	0.000
M06.46 Inflammatory polyarthropathy (Lower leg)	0.492	0.508	0.000
E27 Other disorders of adrenal gland	0.491	0.509	0.000
I20.1 Angina pectoris with documented spasm	0.489	0.511	0.000
E80.7 Disorder of bilirubin metabolism, unspecified	0.484	0.516	0.000
E70.3 Albinism	0.481	0.518	0.000
G36 Other acute disseminated demyelination	0.000	0.521	0.479
M06.80 Other specified rheumatoid arthritis (Multiple sites)	0.478	0.521	0.000
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.478	0.522	0.000
E07.8 Other specified disorders of thyroid	0.478	0.522	0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.471	0.529	0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)	0.470	0.530	0.000
G37.8 Other specified demyelinating diseases of central nervous system	0.000	0.530	0.470
M06.30 Rheumatoid nodule (Multiple sites)	0.469	0.531	0.000
E06.9 Thyroiditis, unspecified	0.469	0.531	0.000
E25.9 Adrenogenital disorder, unspecified	0.469	0.531	0.000
E25.8 Other adrenogenital disorders	0.469	0.531	0.000
E26.9 Hyperaldosteronism, unspecified	0.468	0.531	0.000
E85 Amyloidosis	0.464	0.536	0.000
E28.3 Primary ovarian failure	0.463	0.537	0.000
E30.9 Disorder of puberty, unspecified	0.463	0.537	0.000
E30.8 Other disorders of puberty	0.463	0.537	0.000
E30.1 Precocious puberty	0.463	0.537	0.000
E30.0 Delayed puberty	0.463	0.537	0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.463	0.537	0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.463	0.537	0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.463	0.537	0.000
E84.8 Cystic fibrosis with other manifestations	0.461	0.538	0.000
E84.1 Cystic fibrosis with intestinal manifestations	0.461	0.538	0.000
E23.0 Hypopituitarism	0.455	0.545	0.000
E88.3 Tumour lysis syndrome	0.452	0.547	0.000
E05.0 Thyrotoxicosis with diffuse goitre	0.452	0.547	0.000
E32.9 Disease of thymus, unspecified	0.452	0.548	0.000
E32.1 Abscess of thymus	0.452	0.548	0.000
E32.0 Persistent hyperplasia of thymus	0.452	0.548	0.000
M06.48 Inflammatory polyarthropathy (Other)	0.451	0.548	0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)	0.451	0.548	0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)	0.451	0.548	0.000
M06.44 Inflammatory polyarthropathy (Hand)	0.451	0.548	0.000
M06.43 Inflammatory polyarthropathy (Forearm)	0.451	0.548	0.000
M06.42 Inflammatory polyarthropathy (Upper arm)	0.451	0.548	0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)	0.451	0.548	0.000
E26.8 Other hyperaldosteronism	0.445	0.555	0.000
E26.1 Secondary hyperaldosteronism	0.445	0.555	0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.000	0.557	0.443
E84.9 Cystic fibrosis, unspecified	0.441	0.559	0.000
E27.9 Disorder of adrenal gland, unspecified	0.441	0.559	0.000
I21.9 Acute myocardial infarction, unspecified	0.438	0.562	0.000
E32.8 Other diseases of thymus	0.437	0.562	0.000
M06.10 Adult-onset Still's disease (Multiple sites)	0.436	0.563	0.000
M06.89 Other specified rheumatoid arthritis (Site unspecified)	0.435	0.565	0.000
M06.88 Other specified rheumatoid arthritis (Other)	0.434	0.566	0.000
M06.87 Other specified rheumatoid arthritis (Ankle and foot)	0.434	0.566	0.000
M06.86 Other specified rheumatoid arthritis (Lower leg)	0.434	0.566	0.000
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)	0.434	0.566	0.000
M06.84 Other specified rheumatoid arthritis (Hand)	0.434	0.566	0.000
M06.83 Other specified rheumatoid arthritis (Forearm)	0.434	0.566	0.000
M06.82 Other specified rheumatoid arthritis (Upper arm)	0.434	0.566	0.000
M06.81 Other specified rheumatoid arthritis (Shoulder region)	0.434	0.566	0.000
E31.9 Polyglandular dysfunction, unspecified	0.433	0.566	0.000
E31.8 Other polyglandular dysfunction	0.433	0.566	0.000
E31.1 Polyglandular hyperfunction	0.433	0.566	0.000
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone	0.432	0.568	0.000
E61 Deficiency of other nutrient elements	0.430	0.570	0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.428	0.572	0.000
G37.5 Concentric sclerosis [Balo]	0.000	0.574	0.426
G37.4 Subacute necrotising myelitis	0.000	0.574	0.426
G37.2 Central pontine myelinolysis	0.000	0.574	0.426
G37.1 Central demyelination of corpus callosum	0.000	0.574	0.426
G37.0 Diffuse sclerosis	0.000	0.574	0.426
L44.0 Pityriasis rubra pilaris	0.425	0.575	0.000
E44.1 Mild protein-energy malnutrition	0.417	0.583	0.000
E44.0 Moderate protein-energy malnutrition	0.417	0.583	0.000
M06.19 Adult-onset Still's disease (Site unspecified)	0.416	0.583	0.000
M06.18 Adult-onset Still's disease (Other)	0.416	0.583	0.000
M06.17 Adult-onset Still's disease (Ankle and foot)	0.416	0.583	0.000
M06.16 Adult-onset Still's disease (Lower leg)	0.416	0.583	0.000
M06.15 Adult-onset Still's disease (Pelvic region and thigh)	0.416	0.583	0.000
M06.14 Adult-onset Still's disease (Hand)	0.416	0.583	0.000
M06.13 Adult-onset Still's disease (Forearm)	0.416	0.583	0.000
M06.12 Adult-onset Still's disease (Upper arm)	0.416	0.583	0.000
M06.11 Adult-onset Still's disease (Shoulder region)	0.416	0.583	0.000
E84.0 Cystic fibrosis with pulmonary manifestations	0.416	0.584	0.000
L41.1 Pityriasis lichenoides chronica	0.414	0.586	0.000
E88.1 Lipodystrophy, not elsewhere classified	0.413	0.587	0.000
E20.1 Pseudohypoparathyroidism	0.412	0.587	0.000
E73.8 Other lactose intolerance	0.409	0.590	0.000
E73.1 Secondary lactase deficiency	0.409	0.590	0.000
E73.0 Congenital lactase deficiency	0.409	0.590	0.000
L44.9 Papulosquamous disorder, unspecified	0.409	0.591	0.000
L44.8 Other specified papulosquamous disorders	0.409	0.591	0.000
L44.4 Infantile papular acrodermatitis [Giannotti-Crosti]	0.409	0.591	0.000
L44.3 Lichen ruber moniliformis	0.409	0.591	0.000
L44.2 Lichen striatus	0.409	0.591	0.000
L44.1 Lichen nitidus	0.409	0.591	0.000
E83.3 Disorders of phosphorus metabolism	0.047	0.591	0.362
E83.8 Other disorders of mineral metabolism	0.108	0.591	0.301
E83.2 Disorders of zinc metabolism	0.108	0.591	0.301
E83.0 Disorders of copper metabolism	0.108	0.591	0.301
E34.3 Short stature, not elsewhere classified	0.408	0.592	0.000
E83.9 Disorder of mineral metabolism, unspecified	0.105	0.592	0.303
L41.9 Parapsoriasis, unspecified	0.404	0.595	0.000
L41.8 Other parapsoriasis	0.404	0.595	0.000
L41.5 Retiform parapsoriasis	0.404	0.595	0.000
L41.4 Large plaque parapsoriasis	0.404	0.595	0.000
L41.3 Small plaque parapsoriasis	0.404	0.595	0.000
L41.2 Lymphomatoid papulosis	0.404	0.595	0.000
L41.0 Pityriasis lichenoides et varioliformis acuta	0.404	0.595	0.000
E27.3 Drug-induced adrenocortical insufficiency	0.404	0.596	0.000
M06.29 Rheumatoid bursitis (Site unspecified)	0.402	0.598	0.000
M06.28 Rheumatoid bursitis (Other)	0.402	0.598	0.000
M06.27 Rheumatoid bursitis (Ankle and foot)	0.402	0.598	0.000
M06.26 Rheumatoid bursitis (Lower leg)	0.402	0.598	0.000
M06.25 Rheumatoid bursitis (Pelvic region and thigh)	0.402	0.598	0.000
M06.24 Rheumatoid bursitis (Hand)	0.402	0.598	0.000
M06.23 Rheumatoid bursitis (Forearm)	0.402	0.598	0.000
M06.22 Rheumatoid bursitis (Upper arm)	0.402	0.598	0.000
M06.21 Rheumatoid bursitis (Shoulder region)	0.402	0.598	0.000
M06.20 Rheumatoid bursitis (Multiple sites)	0.402	0.598	0.000
M06.0 Seronegative rheumatoid arthritis	0.400	0.600	0.000
E22.8 Other hyperfunction of pituitary gland	0.395	0.605	0.000
I21.X Presumed acute myicardial infaction (unconfirmed)	0.394	0.606	0.000
E20.8 Other hypoparathyroidism	0.393	0.606	0.000
E20.0 Idiopathic hypoparathyroidism	0.393	0.606	0.000
E31.0 Autoimmune polyglandular failure	0.392	0.607	0.000
E26.0 Primary hyperaldosteronism	0.388	0.612	0.000
E63 Other nutritional deficiencies	0.379	0.621	0.000
E29.8 Other testicular dysfunction	0.376	0.623	0.000
E29.0 Testicular hyperfunction	0.376	0.623	0.000
E64 Sequelae of malnutrition and other nutritional deficiencies	0.372	0.628	0.000
E50 Vitamin A deficiency	0.372	0.628	0.000
E60 Dietary zinc deficiency	0.372	0.628	0.000
E59 Dietary selenium deficiency	0.372	0.628	0.000
E52 Niacin deficiency [pellagra]	0.372	0.628	0.000
E22.9 Hyperfunction of pituitary gland, unspecified	0.372	0.628	0.000
E51 Thiamine deficiency	0.371	0.629	0.000
E56 Other vitamin deficiencies	0.370	0.629	0.000
E80.4 Gilbert's syndrome	0.368	0.632	0.000
E58 Dietary calcium deficiency	0.365	0.635	0.000
E34.5 Androgen resistance syndrome	0.363	0.637	0.000
E34.4 Constitutional tall stature	0.363	0.637	0.000
E34.2 Ectopic hormone secretion, not elsewhere classified	0.363	0.637	0.000
E34.1 Other hypersecretion of intestinal hormones	0.363	0.637	0.000
E54 Ascorbic acid deficiency	0.362	0.638	0.000
E65-E68 Obesity and other hyperalimentation	0.361	0.638	0.000
E06.3 Autoimmune thyroiditis	0.358	0.642	0.000
E34.8 Other specified endocrine disorders	0.356	0.644	0.000
E61.1 Iron deficiency	0.354	0.646	0.000
E27.5 Adrenomedullary hyperfunction	0.352	0.648	0.000
E27.0 Other adrenocortical overactivity	0.352	0.648	0.000
E22.0 Acromegaly and pituitary gigantism	0.350	0.649	0.000
I21.2 Acute transmural myocardial infarction of other sites	0.346	0.654	0.000
G36.0 Neuromyelitis optica [Devic]	0.000	0.654	0.346
G36.9 Acute disseminated demyelination, unspecified	0.000	0.656	0.344
G36.8 Other specified acute disseminated demyelination	0.000	0.656	0.344
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]	0.000	0.656	0.344
E29.9 Testicular dysfunction, unspecified	0.343	0.656	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations