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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs6941772
log Bayes Factor = 71.6614
Chromosome 6   position 31,048,916  (GRCh37) Explore rs6941772 on Ensembl!

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
1.000 0.000 0.000
K90.0 Coeliac disease
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
R31 Unspecified haematuria
1.000 0.000 0.000
L40.9 Psoriasis, unspecified
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.001 0.999
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.002 0.998
E16.2 Hypoglycaemia, unspecified
0.000 0.002 0.998
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.002 0.998
E10.1 With ketoacidosis
0.000 0.002 0.998
E16 Other disorders of pancreatic internal secretion
0.000 0.002 0.998
E10.9 Without complications
0.000 0.004 0.996
E10.3 With ophthalmic complications
0.000 0.008 0.992
L40 Psoriasis
0.000 0.009 0.991
E00-E07 Disorders of thyroid gland
0.041 0.017 0.941
D86.9 Sarcoidosis, unspecified
0.000 0.018 0.982
D86 Sarcoidosis
0.000 0.018 0.982
L40.5 Arthropathic psoriasis
0.000 0.022 0.978
D80-D89 Certain disorders involving the immune mechanism
0.000 0.028 0.972
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.034 0.966
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.041 0.959
D70 Agranulocytosis
0.000 0.046 0.954
L40.0 Psoriasis vulgaris
0.000 0.047 0.953
E05 Thyrotoxicosis [hyperthyroidism]
0.007 0.053 0.941
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.055 0.945
D50-D53 Nutritional anaemias
0.000 0.058 0.942
D51 Vitamin B12 deficiency anaemia
0.000 0.082 0.918
D86.1 Sarcoidosis of lymph nodes
0.000 0.102 0.898
E10.8 With unspecified complications
0.000 0.106 0.894
E11 Non-insulin-dependent diabetes mellitus
0.000 0.109 0.891
D51.0 Vitamin B12 deficiency anaemia due to intrinsic factor deficiency
0.000 0.131 0.869
E10.2 With renal complications
0.000 0.133 0.867
E10.4 With neurological complications
0.000 0.138 0.862
D86.0 Sarcoidosis of lung
0.000 0.165 0.835
D51.9 Vitamin B12 deficiency anaemia, unspecified
0.000 0.173 0.827
D72 Other disorders of white blood cells
0.000 0.174 0.826
E11.5 With peripheral circulatory complications
0.000 0.176 0.824
E10.5 With peripheral circulatory complications
0.000 0.177 0.823
E50-E64 Other nutritional deficiencies
0.000 0.177 0.822
E10.6 With other specified complications
0.000 0.185 0.815
D53 Other nutritional anaemias
0.000 0.193 0.807
E11.3 With ophthalmic complications
0.000 0.196 0.804
D75 Other diseases of blood and blood-forming organs
0.000 0.208 0.792
D55-D59 Haemolytic anaemias
0.000 0.215 0.785
D86.8 Sarcoidosis of other and combined sites
0.000 0.216 0.784
D80 Immunodeficiency with predominantly antibody defects
0.000 0.221 0.779
E55 Vitamin D deficiency
0.000 0.227 0.773
E11.4 With neurological complications
0.000 0.231 0.769
D83 Common variable immunodeficiency
0.000 0.232 0.768
E03 Other hypothyroidism
0.408 0.234 0.358
L40.4 Guttate psoriasis
0.000 0.235 0.765
D86.3 Sarcoidosis of skin
0.000 0.239 0.760
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes
0.000 0.247 0.753
E10.0 With coma
0.000 0.253 0.747
D72.8 Other specified disorders of white blood cells
0.000 0.253 0.747
L40.1 Generalised pustular psoriasis
0.000 0.261 0.739
D59 Acquired haemolytic anaemia
0.000 0.261 0.739
E55.9 Vitamin D deficiency, unspecified
0.000 0.262 0.738
D50 Iron deficiency anaemia
0.000 0.264 0.736
E11.8 With unspecified complications
0.000 0.270 0.730
E10.7 With multiple complications
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.716
E15 Nondiabetic hypoglycaemic coma
0.000 0.285 0.715
E16.9 Disorder of pancreatic internal secretion, unspecified
0.000 0.285 0.715
E16.8 Other specified disorders of pancreatic internal secretion
0.000 0.285 0.715
E16.4 Abnormal secretion of gastrin
0.000 0.285 0.715
E16.3 Increased secretion of glucagon
0.000 0.285 0.715
L40.3 Pustulosis palmaris et plantaris
0.000 0.289 0.711
L40.2 Acrodermatitis continua
0.000 0.289 0.711
D53.9 Nutritional anaemia, unspecified
0.000 0.291 0.709
E11.1 With ketoacidosis
0.000 0.294 0.706
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.030 0.295 0.675
E00 Congenital iodine-deficiency syndrome
0.030 0.295 0.675
E14 Unspecified diabetes mellitus
0.000 0.298 0.702
D81 Combined immunodeficiencies
0.000 0.303 0.697
E16.0 Drug-induced hypoglycaemia without coma
0.000 0.306 0.694
E06 Thyroiditis
0.022 0.308 0.670
D74 Methaemoglobinaemia
0.000 0.312 0.688
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.312 0.688
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.312 0.688
E13 Other specified diabetes mellitus
0.000 0.313 0.687
E16.1 Other hypoglycaemia
0.000 0.317 0.683
E02 Subclinical iodine-deficiency hypothyroidism
0.029 0.319 0.652
E05.5 Thyroid crisis or storm
0.005 0.321 0.674
E05.4 Thyrotoxicosis factitia
0.005 0.321 0.674
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.005 0.321 0.674
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.005 0.321 0.674
E40-E46 Malnutrition
0.000 0.327 0.673
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.332 0.668
D82 Immunodeficiency associated with other major defects
0.000 0.332 0.667
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.334 0.666
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.339 0.661
D51.8 Other vitamin B12 deficiency anaemias
0.000 0.341 0.658
D51.3 Other dietary vitamin B12 deficiency anaemia
0.000 0.341 0.658
D51.2 Transcobalamin II deficiency
0.000 0.341 0.658
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria
0.000 0.341 0.658
D50.9 Iron deficiency anaemia, unspecified
0.000 0.347 0.653
D80.1 Nonfamilial hypogammaglobulinaemia
0.000 0.347 0.653
D59.1 Other autoimmune haemolytic anaemias
0.000 0.359 0.641
E05.8 Other thyrotoxicosis
0.005 0.360 0.635
E11.7 With multiple complications
0.000 0.361 0.639
E11.6 With other specified complications
0.000 0.363 0.637
E83.1 Disorders of iron metabolism
0.000 0.367 0.633
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.000 0.375 0.625
D83.9 Common variable immunodeficiency, unspecified
0.000 0.378 0.622
D75.0 Familial erythrocytosis
0.000 0.378 0.622
E51 Thiamine deficiency
0.000 0.381 0.619
E70-E90 Metabolic disorders
0.000 0.390 0.610
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
0.000 0.396 0.604
E83 Disorders of mineral metabolism
0.000 0.399 0.601
E14.3 With ophthalmic complications
0.000 0.404 0.596
D50.8 Other iron deficiency anaemias
0.000 0.405 0.595
E53 Deficiency of other B group vitamins
0.000 0.407 0.593
D72.9 Disorder of white blood cells, unspecified
0.000 0.407 0.592
D72.0 Genetic anomalies of leukocytes
0.000 0.407 0.592
D80.2 Selective deficiency of immunoglobulin A [IgA]
0.000 0.408 0.592
D84 Other immunodeficiencies
0.000 0.410 0.590
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.410 0.590
E63 Other nutritional deficiencies
0.000 0.410 0.590
E50 Vitamin A deficiency
0.000 0.410 0.590
E60 Dietary zinc deficiency
0.000 0.410 0.590
E59 Dietary selenium deficiency
0.000 0.410 0.590
E52 Niacin deficiency [pellagra]
0.000 0.410 0.590
E06.9 Thyroiditis, unspecified
0.009 0.416 0.575
D53.8 Other specified nutritional anaemias
0.000 0.422 0.578
D53.2 Scorbutic anaemia
0.000 0.422 0.578
D53.1 Other megaloblastic anaemias, not elsewhere classified
0.000 0.422 0.578
D53.0 Protein deficiency anaemia
0.000 0.422 0.578
D75.2 Essential thrombocytosis
0.000 0.425 0.575
E65-E68 Obesity and other hyperalimentation
0.000 0.428 0.572
D89 Other disorders involving the immune mechanism, not elsewhere classified
0.000 0.432 0.568
E54 Ascorbic acid deficiency
0.000 0.433 0.567
D55 Anaemia due to enzyme disorders
0.000 0.437 0.562
D80.8 Other immunodeficiencies with predominantly antibody defects
0.000 0.441 0.559
D80.7 Transient hypogammaglobulinaemia of infancy
0.000 0.441 0.559
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
0.000 0.441 0.559
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
0.000 0.441 0.559
D80.0 Hereditary hypogammaglobulinaemia
0.000 0.441 0.559
E88 Other metabolic disorders
0.000 0.444 0.556
E55.0 Rickets, active
0.000 0.445 0.554
E85 Amyloidosis
0.000 0.446 0.554
E07 Other disorders of thyroid
0.057 0.446 0.497
D83.8 Other common variable immunodeficiencies
0.000 0.449 0.551
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells
0.000 0.449 0.551
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
0.000 0.449 0.551
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
0.000 0.449 0.551
E03.5 Myxoedema coma
0.292 0.450 0.257
E03.4 Atrophy of thyroid (acquired)
0.292 0.450 0.257
E03.3 Postinfectious hypothyroidism
0.292 0.450 0.257
D72.1 Eosinophilia
0.000 0.453 0.547
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.453 0.547
E58 Dietary calcium deficiency
0.000 0.457 0.543
E14.1 With ketoacidosis
0.000 0.457 0.543
E03.0 Congenital hypothyroidism with diffuse goitre
0.290 0.460 0.251
E14.8 With unspecified complications
0.000 0.461 0.539
E56 Other vitamin deficiencies
0.000 0.463 0.537
D57 Sickle-cell disorders
0.000 0.464 0.536
E03.1 Congenital hypothyroidism without goitre
0.258 0.467 0.275
E05.2 Thyrotoxicosis with toxic multinodular goitre
0.005 0.468 0.527
D59.8 Other acquired haemolytic anaemias
0.000 0.470 0.530
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.470 0.530
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.470 0.530
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.470 0.530
D59.3 Haemolytic-uraemic syndrome
0.000 0.470 0.530
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.470 0.530
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.470 0.530
D66 Hereditary factor VIII deficiency
0.000 0.472 0.528
D50.1 Sideropenic dysphagia
0.000 0.473 0.527
L40.8 Other psoriasis
0.000 0.474 0.526
D75.1 Secondary polycythaemia
0.000 0.477 0.523
D80.9 Immunodeficiency with predominantly antibody defects, unspecified
0.000 0.478 0.522
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.303 0.481 0.216
E14.6 With other specified complications
0.000 0.483 0.517
E12.9 Without complications
0.000 0.486 0.514
E12.8 With unspecified complications
0.000 0.486 0.514
E12.7 With multiple complications
0.000 0.486 0.514
E12.6 With other specified complications
0.000 0.486 0.514
E12.5 With peripheral circulatory complications
0.000 0.486 0.514
E12.4 With neurological complications
0.000 0.486 0.514
E12.3 With ophthalmic complications
0.000 0.486 0.514
E12.2 With renal complications
0.000 0.486 0.514
E12.1 With ketoacidosis
0.000 0.486 0.514
E12.0 With coma
0.000 0.486 0.514
D65 Disseminated intravascular coagulation [defibrination syndrome]
0.000 0.488 0.512
D69 Purpura and other haemorrhagic conditions
0.000 0.488 0.512
E85.4 Organ-limited amyloidosis
0.000 0.490 0.510
E05.9 Thyrotoxicosis, unspecified
0.000 0.490 0.510
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.000 0.491 0.509
E00.9 Congenital iodine-deficiency syndrome, unspecified
0.022 0.495 0.484
E00.2 Congenital iodine-deficiency syndrome, mixed type
0.022 0.495 0.484
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type
0.022 0.495 0.484
E00.0 Congenital iodine-deficiency syndrome, neurological type
0.022 0.495 0.484
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions
0.022 0.495 0.484
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified
0.022 0.495 0.484
E01.1 Iodine-deficiency-related multinodular (endemic) goitre
0.022 0.495 0.484
E01.0 Iodine-deficiency-related diffuse (endemic) goitre
0.022 0.495 0.484
E14.7 With multiple complications
0.000 0.497 0.503
E14.2 Withrenal complications
0.000 0.497 0.503
E14.0 With coma
0.000 0.497 0.503
D58 Other hereditary haemolytic anaemias
0.000 0.499 0.501
D81.9 Combined immunodeficiency, unspecified
0.000 0.500 0.500
D81.8 Other combined immunodeficiencies
0.000 0.500 0.500
D81.7 Major histocompatibility complex class II deficiency
0.000 0.500 0.500
D81.6 Major histocompatibility complex class I deficiency
0.000 0.500 0.500
D81.5 Purine nucleoside phosphorylase [PNP] deficiency
0.000 0.500 0.500
D81.4 Nezelof's syndrome
0.000 0.500 0.500
D81.3 Adenosine deaminase [ADA] deficiency
0.000 0.500 0.500
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
0.000 0.500 0.500
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
0.000 0.500 0.500
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis
0.000 0.500 0.500
E13.9 Without complications
0.000 0.501 0.499
E04 Other non-toxic goitre
0.003 0.501 0.496
E06.4 Drug-induced thyroiditis
0.016 0.504 0.480
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.016 0.504 0.480
E06.0 Acute thyroiditis
0.016 0.504 0.480
D74.9 Methaemoglobinaemia, unspecified
0.000 0.507 0.493
D74.8 Other methaemoglobinaemias
0.000 0.507 0.493
D74.0 Congenital methaemoglobinaemia
0.000 0.507 0.493
E13.8 With unspecified complications
0.000 0.508 0.492
E13.7 With multiple complications
0.000 0.508 0.492
E13.6 With other specified complications
0.000 0.508 0.492
E13.5 With peripheral circulatory complications
0.000 0.508 0.492
E13.4 With neurological complications
0.000 0.508 0.492
E13.2 With renal complications
0.000 0.508 0.492
E13.1 With ketoacidosis
0.000 0.508 0.492
E13.0 With coma
0.000 0.508 0.492
E06.3 Autoimmune thyroiditis
0.008 0.510 0.483
E03.8 Other specified hypothyroidism
0.260 0.512 0.229
D67 Hereditary factor IX deficiency
0.000 0.517 0.483
E44 Protein-energy malnutrition of moderate and mild degree
0.000 0.517 0.482
E45 Retarded development following protein-energy malnutrition
0.000 0.517 0.482
E43 Unspecified severe protein-energy malnutrition
0.000 0.517 0.482
E42 Marasmic kwashiorkor
0.000 0.517 0.482
E41 Nutritional marasmus
0.000 0.517 0.482
E40 Kwashiorkor
0.000 0.517 0.482
D82.9 Immunodeficiency associated with major defect, unspecified
0.000 0.521 0.478
D82.8 Immunodeficiency associated with other specified major defects
0.000 0.521 0.478
D82.4 Hyperimmunoglobulin E [IgE] syndrome
0.000 0.521 0.478
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
0.000 0.521 0.478
D82.2 Immunodeficiency with short-limbed stature
0.000 0.521 0.478
D82.0 Wiskott-Aldrich syndrome
0.000 0.521 0.478
D80.4 Selective deficiency of immunoglobulin M [IgM]
0.000 0.526 0.474
E20-E35 Disorders of other endocrine glands
0.000 0.526 0.474
E51.2 Wernicke's encephalopathy
0.000 0.527 0.473
E27.1 Primary adrenocortical insufficiency
0.000 0.530 0.470
D52 Folate deficiency anaemia
0.000 0.533 0.467
E27 Other disorders of adrenal gland
0.000 0.534 0.466
E14.5 With peripheral circulatory complications
0.000 0.535 0.465
E14.4 With neurological complications
0.000 0.536 0.464
K90 Intestinal malabsorption
0.000 0.537 0.463
D84.1 Defects in the complement system
0.000 0.538 0.462
E79 Disorders of purine and pyrimidine metabolism
0.000 0.540 0.460
E53.9 Vitamin B deficiency, unspecified
0.000 0.543 0.457
E13.3 With ophthalmic complications
0.000 0.545 0.454
D82.1 Di George's syndrome
0.000 0.551 0.449
D76.2 Haemophagocytic syndrome, infection-associated
0.000 0.552 0.448
D76.1 Haemophagocytic lymphohistiocytosis
0.000 0.552 0.448
D76.0 Langerhans' cell histiocytosis, not elsewhere classified
0.000 0.552 0.448
E88.1 Lipodystrophy, not elsewhere classified
0.000 0.552 0.448
E70 Disorders of aromatic amino-acid metabolism
0.000 0.554 0.446
E51.9 Thiamine deficiency, unspecified
0.000 0.556 0.444
E51.8 Other manifestations of thiamine deficiency
0.000 0.556 0.444
E51.1 Beriberi
0.000 0.556 0.444
E46 Unspecified protein-energy malnutrition
0.000 0.560 0.440
E77 Disorders of glycoprotein metabolism
0.000 0.562 0.438
E76 Disorders of glycosaminoglycan metabolism
0.000 0.562 0.438
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.000 0.562 0.438
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.000 0.562 0.438
E88.9 Metabolic disorder, unspecified
0.000 0.564 0.436
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified
0.000 0.568 0.432
E06.1 Subacute thyroiditis
0.018 0.569 0.413
E83.8 Other disorders of mineral metabolism
0.000 0.569 0.431
E83.2 Disorders of zinc metabolism
0.000 0.569 0.431
E83.0 Disorders of copper metabolism
0.000 0.569 0.431
E07.8 Other specified disorders of thyroid
0.028 0.571 0.401
D69.2 Other nonthrombocytopenic purpura
0.000 0.573 0.427
E53.1 Pyridoxine deficiency
0.000 0.575 0.425
E53.0 Riboflavin deficiency
0.000 0.575 0.425
D84.8 Other specified immunodeficiencies
0.000 0.577 0.423
D84.0 Lymphocyte function antigen-1 [LFA-1] defect
0.000 0.577 0.423
E50.9 Vitamin A deficiency, unspecified
0.000 0.577 0.423
E50.8 Other manifestations of vitamin A deficiency
0.000 0.577 0.423
E50.7 Other ocular manifestations of vitamin A deficiency
0.000 0.577 0.423
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
0.000 0.577 0.423
E50.5 Vitamin A deficiency with night blindness
0.000 0.577 0.423
E50.4 Vitamin A deficiency with keratomalacia
0.000 0.577 0.423
E50.3 Vitamin A deficiency with corneal ulceration and xerosis
0.000 0.577 0.423
E50.2 Vitamin A deficiency with corneal xerosis
0.000 0.577 0.423
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
0.000 0.577 0.423
E50.0 Vitamin A deficiency with conjunctival xerosis
0.000 0.577 0.423
E63.9 Nutritional deficiency, unspecified
0.000 0.577 0.423
E63.8 Other specified nutritional deficiencies
0.000 0.577 0.423
E63.1 Imbalance of constituents of food intake
0.000 0.577 0.423
E63.0 Essential fatty acid [EFA] deficiency
0.000 0.577 0.423
E64.9 Sequelae of unspecified nutritional deficiency
0.000 0.577 0.423
E64.8 Sequelae of other nutritional deficiencies
0.000 0.577 0.423
E64.3 Sequelae of rickets
0.000 0.577 0.423
E64.2 Sequelae of vitamin C deficiency
0.000 0.577 0.423
E64.1 Sequelae of vitamin A deficiency
0.000 0.577 0.423
E64.0 Sequelae of protein-energy malnutrition
0.000 0.577 0.423
D69.5 Secondary thrombocytopenia
0.000 0.578 0.422
D89.9 Disorder involving the immune mechanism, unspecified
0.000 0.578 0.422
E85.3 Secondary systemic amyloidosis
0.000 0.580 0.420
D69.6 Thrombocytopenia, unspecified
0.000 0.581 0.419
E04.0 Non-toxic diffuse goitre
0.001 0.585 0.414
E83.9 Disorder of mineral metabolism, unspecified
0.000 0.586 0.413
E67 Other hyperalimentation
0.000 0.590 0.410
E68 Sequelae of hyperalimentation
0.000 0.590 0.410
E84 Cystic fibrosis
0.000 0.590 0.410
D89.3 Immune reconstitution syndrome
0.000 0.593 0.407
D55.9 Anaemia due to enzyme disorder, unspecified
0.000 0.596 0.403
D55.8 Other anaemias due to enzyme disorders
0.000 0.596 0.403
D55.3 Anaemia due to disorders of nucleotide metabolism
0.000 0.596 0.403
D55.2 Anaemia due to disorders of glycolytic enzymes
0.000 0.596 0.403
D55.1 Anaemia due to other disorders of glutathione metabolism
0.000 0.596 0.403
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
0.000 0.596 0.403
E72 Other disorders of amino-acid metabolism
0.000 0.598 0.402
E07.1 Dyshormogenetic goitre
0.041 0.603 0.356
E07.0 Hypersecretion of calcitonin
0.041 0.603 0.356
E85.8 Other amyloidosis
0.000 0.603 0.397
E85.2 Heredofamilial amyloidosis, unspecified
0.000 0.603 0.397
E85.1 Neuropathic heredofamilial amyloidosis
0.000 0.603 0.397
E85.0 Nonneuropathic heredofamilial amyloidosis
0.000 0.603 0.397
E88.3 Tumour lysis syndrome
0.000 0.603 0.397
E61 Deficiency of other nutrient elements
0.000 0.603 0.397
E06.5 Other chronic thyroiditis
0.018 0.603 0.378
E34 Other endocrine disorders
0.000 0.605 0.395
E04.9 Non-toxic goitre, unspecified
0.000 0.607 0.393
D89.1 Cryoglobulinaemia
0.000 0.608 0.392
E66 Obesity
0.000 0.609 0.391
E53.8 Deficiency of other specified B group vitamins
0.000 0.609 0.391
E11.0 With coma
0.001 0.614 0.386
D76.3 Other histiocytosis syndromes
0.000 0.614 0.385
E56.9 Vitamin deficiency, unspecified
0.000 0.615 0.385
E56.8 Deficiency of other vitamins
0.000 0.615 0.385
E56.0 Deficiency of vitamin E
0.000 0.615 0.385
D57.8 Other sickle-cell disorders
0.000 0.615 0.384
D57.3 Sickle-cell trait
0.000 0.615 0.384
D57.2 Double heterozygous sickling disorders
0.000 0.615 0.384
D57.0 Sickle-cell anaemia with crisis
0.000 0.615 0.384
E85.9 Amyloidosis, unspecified
0.000 0.616 0.384
E88.8 Other specified metabolic disorders
0.000 0.622 0.378
D69.9 Haemorrhagic condition, unspecified
0.000 0.622 0.378
K90.9 Intestinal malabsorption, unspecified
0.000 0.625 0.375
E74 Other disorders of carbohydrate metabolism
0.000 0.626 0.374
E20 Hypoparathyroidism
0.000 0.627 0.373
D58.2 Other haemoglobinopathies
0.000 0.629 0.371
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.630 0.370
D69.8 Other specified haemorrhagic conditions
0.000 0.633 0.367
E11.2 With renal complications
0.000 0.640 0.360
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.640 0.359
D58.1 Hereditary elliptocytosis
0.000 0.640 0.359
D57.1 Sickle-cell anaemia without crisis
0.000 0.641 0.358
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.642 0.358
E04.8 Other specified non-toxic goitre
0.002 0.642 0.355
E79.0 Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
0.000 0.647 0.353
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.000 0.647 0.352
E25 Adrenogenital disorders
0.000 0.649 0.351
E34.9 Endocrine disorder, unspecified
0.000 0.650 0.350
D69.1 Qualitative platelet defects
0.000 0.653 0.347
D56 Thalassaemia
0.001 0.653 0.346
E44.1 Mild protein-energy malnutrition
0.000 0.654 0.346
E44.0 Moderate protein-energy malnutrition
0.000 0.654 0.346
E73 Lactose intolerance
0.000 0.657 0.343
E88.2 Lipomatosis, not elsewhere classified
0.000 0.659 0.340
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.660 0.340
E32 Diseases of thymus
0.000 0.660 0.340
E31 Polyglandular dysfunction
0.000 0.660 0.340
E30 Disorders of puberty, not elsewhere classified
0.000 0.660 0.340
D89.0 Polyclonal hypergammaglobulinaemia
0.000 0.665 0.335
D52.8 Other folate deficiency anaemias
0.000 0.665 0.335
D52.1 Drug-induced folate deficiency anaemia
0.000 0.665 0.335
D52.0 Dietary folate deficiency anaemia
0.000 0.665 0.335
E27.5 Adrenomedullary hyperfunction
0.000 0.666 0.334
E27.0 Other adrenocortical overactivity
0.000 0.666 0.334
E56.1 Deficiency of vitamin K
0.000 0.668 0.332
K90.3 Pancreatic steatorrhoea
0.000 0.668 0.332
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.668 0.332
K90.1 Tropical sprue
0.000 0.668 0.332
E27.2 Addisonian crisis
0.000 0.669 0.331
E79.9 Disorder of purine and pyrimidine metabolism, unspecified
0.000 0.670 0.330
E79.8 Other disorders of purine and pyrimidine metabolism
0.000 0.670 0.330
E79.1 Lesch-Nyhan syndrome
0.000 0.670 0.330
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.671 0.329
E66.2 Extreme obesity with alveolar hypoventilation
0.000 0.671 0.329
D89.2 Hypergammaglobulinaemia, unspecified
0.000 0.671 0.328
E70.3 Albinism
0.000 0.672 0.328
E66.0 Obesity due to excess calories
0.000 0.674 0.326
D69.4 Other primary thrombocytopenia
0.000 0.675 0.324
K90.8 Other intestinal malabsorption
0.000 0.680 0.320
E70.9 Disorder of aromatic amino-acid metabolism, unspecified
0.000 0.680 0.320
E70.8 Other disorders of aromatic amino-acid metabolism
0.000 0.680 0.320
E70.2 Disorders of tyrosine metabolism
0.000 0.680 0.320
E70.1 Other hyperphenylalaninaemias
0.000 0.680 0.320
E70.0 Classical phenylketonuria
0.000 0.680 0.320
D58.0 Hereditary spherocytosis
0.000 0.681 0.318
E86 Volume depletion
0.000 0.682 0.318
E34.0 Carcinoid syndrome
0.000 0.684 0.316
E71.3 Disorders of fatty-acid metabolism
0.000 0.686 0.314
E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
0.000 0.686 0.314
E71.1 Other disorders of branched-chain amino-acid metabolism
0.000 0.686 0.314
E71.0 Maple-syrup-urine disease
0.000 0.686 0.314
E76.9 Disorder of glucosaminoglycan metabolism, unspecified
0.000 0.686 0.314
E76.8 Other disorders of glucosaminoglycan metabolism
0.000 0.686 0.314
E76.3 Mucopolysaccharidosis, unspecified
0.000 0.686 0.314
E76.2 Other mucopolysaccharidoses
0.000 0.686 0.314
E76.1 Mucopolysaccharidosis, type II
0.000 0.686 0.314
E76.0 Mucopolysaccharidosis, type I
0.000 0.686 0.314
E77.9 Disorder of glycoprotein metabolism, unspecified
0.000 0.686 0.314
E77.8 Other disorders of glycoprotein metabolism
0.000 0.686 0.314
E77.1 Defects in glycoprotein degradation
0.000 0.686 0.314
E77.0 Defects in posttranslational modification of lysosomal enzymes
0.000 0.686 0.314
E20.9 Hypoparathyroidism, unspecified
0.000 0.700 0.300
E65 Localised adiposity
0.000 0.701 0.298
E27.8 Other specified disorders of adrenal gland
0.000 0.702 0.298
E67.8 Other specified hyperalimentation
0.000 0.706 0.294
E67.3 Hypervitaminosis D
0.000 0.706 0.294
E67.2 Megavitamin-B6 syndrome
0.000 0.706 0.294
E67.1 Hypercarotenaemia
0.000 0.706 0.294
E67.0 Hypervitaminosis A
0.000 0.706 0.294
E84.8 Cystic fibrosis with other manifestations
0.000 0.706 0.294
E84.1 Cystic fibrosis with intestinal manifestations
0.000 0.706 0.294
E84.0 Cystic fibrosis with pulmonary manifestations
0.000 0.706 0.294
K90.4 Malabsorption due to intolerance, not elsewhere classified
0.000 0.706 0.294
E72.9 Disorder of amino-acid metabolism, unspecified
0.000 0.711 0.288
E72.8 Other specified disorders of amino-acid metabolism
0.000 0.711 0.288
E72.5 Disorders of glycine metabolism
0.000 0.711 0.288
E72.4 Disorders of ornithine metabolism
0.000 0.711 0.288
E72.3 Disorders of lysine and hydroxylysine metabolism
0.000 0.711 0.288
E72.2 Disorders of urea cycle metabolism
0.000 0.711 0.288
E72.1 Disorders of sulphur-bearing amino-acid metabolism
0.000 0.711 0.288
E22 Hyperfunction of pituitary gland
0.000 0.713 0.287
E61.9 Deficiency of nutrient element, unspecified
0.000 0.715 0.285
E61.8 Deficiency of other specified nutrient elements
0.000 0.715 0.285
E61.7 Deficiency of multiple nutrient elements
0.000 0.715 0.285
E61.6 Vanadium deficiency
0.000 0.715 0.285
E61.5 Molybdenum deficiency
0.000 0.715 0.285
E61.4 Chromium deficiency
0.000 0.715 0.285
E61.3 Manganese deficiency
0.000 0.715 0.285
E61.0 Copper deficiency
0.000 0.715 0.285
E34.5 Androgen resistance syndrome
0.000 0.717 0.283
E34.4 Constitutional tall stature
0.000 0.717 0.283
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.717 0.283
E34.1 Other hypersecretion of intestinal hormones
0.000 0.717 0.283
E66.1 Drug-induced obesity
0.000 0.719 0.280
E24 Cushing's syndrome
0.000 0.719 0.280
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.721 0.279
E66.8 Other obesity
0.000 0.721 0.279
D73 Diseases of spleen
0.000 0.729 0.271
E74.9 Disorder of carbohydrate metabolism, unspecified
0.000 0.732 0.268
E74.8 Other specified disorders of carbohydrate metabolism
0.000 0.732 0.268
E74.4 Disorders of pyruvate metabolism and gluconeogenesis
0.000 0.732 0.268
E74.2 Disorders of galactose metabolism
0.000 0.732 0.268
E74.1 Disorders of fructose metabolism
0.000 0.732 0.268
E74.0 Glycogen storage disease
0.000 0.732 0.268
E20.8 Other hypoparathyroidism
0.000 0.732 0.267
E20.1 Pseudohypoparathyroidism
0.000 0.732 0.267
E20.0 Idiopathic hypoparathyroidism
0.000 0.732 0.267
E29 Testicular dysfunction
0.000 0.733 0.267
E84.9 Cystic fibrosis, unspecified
0.000 0.733 0.266
M45.X9 Ankylosing spondylitis (Site unspecified)
0.267 0.733 0.000
D60-D64 Aplastic and other anaemias
0.000 0.734 0.266
E34.3 Short stature, not elsewhere classified
0.000 0.736 0.264
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
0.000 0.736 0.263
E75.6 Lipid storage disorder, unspecified
0.000 0.747 0.253
E75.4 Neuronal ceroid lipofuscinosis
0.000 0.747 0.253
E75.3 Sphingolipidosis, unspecified
0.000 0.747 0.253
E75.1 Other gangliosidosis
0.000 0.747 0.253
E75.0 GM2 gangliosidosis
0.000 0.747 0.253
E72.0 Disorders of amino-acid transport
0.000 0.747 0.253
E25.9 Adrenogenital disorder, unspecified
0.000 0.748 0.252
E25.8 Other adrenogenital disorders
0.000 0.748 0.252
D56.9 Thalassaemia, unspecified
0.001 0.751 0.248
D56.8 Other thalassaemias
0.001 0.751 0.248
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.001 0.751 0.248
D56.2 Delta-beta thalassaemia
0.001 0.751 0.248
D56.0 Alpha thalassaemia
0.001 0.751 0.248
E80 Disorders of porphyrin and bilirubin metabolism
0.000 0.752 0.248
E73.8 Other lactose intolerance
0.000 0.754 0.246
E73.1 Secondary lactase deficiency
0.000 0.754 0.246
E73.0 Congenital lactase deficiency
0.000 0.754 0.246
E30.9 Disorder of puberty, unspecified
0.000 0.756 0.244
E30.8 Other disorders of puberty
0.000 0.756 0.244
E30.1 Precocious puberty
0.000 0.756 0.244
E30.0 Delayed puberty
0.000 0.756 0.244
E31.9 Polyglandular dysfunction, unspecified
0.000 0.756 0.244
E31.8 Other polyglandular dysfunction
0.000 0.756 0.244
E31.1 Polyglandular hyperfunction
0.000 0.756 0.244
E31.0 Autoimmune polyglandular failure
0.000 0.756 0.244
E32.9 Disease of thymus, unspecified
0.000 0.756 0.244
E32.8 Other diseases of thymus
0.000 0.756 0.244
E32.1 Abscess of thymus
0.000 0.756 0.244
E32.0 Persistent hyperplasia of thymus
0.000 0.756 0.244
E35.8 Disorders of other endocrine glands in diseases classified elsewhere
0.000 0.756 0.244
E35.1 Disorders of adrenal glands in diseases classified elsewhere
0.000 0.756 0.244
E35.0 Disorders of thyroid gland in diseases classified elsewhere
0.000 0.756 0.244
E14.9 Without complications
0.000 0.761 0.239
E61.2 Magnesium deficiency
0.000 0.761 0.238
M45 Ankylosing spondylitis
0.234 0.766 0.000
D84.9 Immunodeficiency, unspecified
0.001 0.766 0.233

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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