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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs7137828
log Bayes Factor = 136.212
Chromosome 12   position 111,932,800  (GRCh37) Explore rs7137828 on Ensembl!
Variant rs7137828 is listed in the   GWAS Catalog   ⇪

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
E03.9 Hypothyroidism, unspecified
0.000 0.000 1.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.000 0.000 1.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.000 0.000 1.000
I25.1 Atherosclerotic heart disease
0.000 0.000 1.000
K90.0 Coeliac disease
0.000 0.000 1.000
Z95.5 Presence of coronary angioplasty implant and graft
0.000 0.000 1.000
E10 Insulin-dependent diabetes mellitus
0.000 0.000 1.000
I10 Essential (primary) hypertension
0.000 0.000 1.000
I25 Chronic ischaemic heart disease
0.000 0.000 1.000
I21 Acute myocardial infarction
0.000 0.000 1.000
Z95 Presence of cardiac and vascular implants and grafts
0.000 0.000 1.000
E00-E07 Disorders of thyroid gland
0.000 0.000 1.000
I20-I25 Ischaemic heart diseases
0.000 0.000 1.000
Chapter IX Diseases of the circulatory system
0.000 0.000 1.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.000 0.000 1.000
C77.3 Axillary and upper limb lymph nodes
1.000 0.000 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.000 0.000 1.000
I25.9 Chronic ischaemic heart disease, unspecified
0.000 0.000 1.000
I25.2 Old myocardial infarction
0.000 0.000 1.000
E03 Other hypothyroidism
0.000 0.000 1.000
I10-I15 Hypertensive diseases
0.000 0.000 1.000
Z95.1 Presence of aortocoronary bypass graft
0.000 0.000 1.000
E20-E35 Disorders of other endocrine glands
0.000 0.000 1.000
Z95.2 Presence of prosthetic heart valve
0.000 0.000 1.000
E10-E14 Diabetes mellitus
0.000 0.001 0.999
C50 Malignant neoplasm of breast
0.999 0.001 0.000
I20.9 Angina pectoris, unspecified
0.000 0.001 0.999
I20 Angina pectoris
0.000 0.001 0.999
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.000 0.002 0.998
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.998 0.002 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.998 0.002 0.000
Z95.4 Presence of other heart-valve replacement
0.000 0.003 0.997
I70-I79 Diseases of arteries, arterioles and capillaries
0.000 0.004 0.996
# Top node
0.000 0.004 0.996
E05 Thyrotoxicosis [hyperthyroidism]
0.000 0.004 0.996
E05.9 Thyrotoxicosis, unspecified
0.000 0.005 0.995
D55-D59 Haemolytic anaemias
0.000 0.006 0.994
E10.9 Without complications
0.000 0.008 0.992
C50-C50 Malignant neoplasm of breast
0.991 0.009 0.000
I74 Arterial embolism and thrombosis
0.000 0.009 0.991
D70-D77 Other diseases of blood and blood-forming organs
0.000 0.010 0.990
D75 Other diseases of blood and blood-forming organs
0.000 0.010 0.990
I21.9 Acute myocardial infarction, unspecified
0.000 0.012 0.988
E27 Other disorders of adrenal gland
0.000 0.012 0.988
C50.9 Breast, unspecified
0.987 0.013 0.000
Chapter II Neoplasms
0.986 0.014 0.000
C50.4 Upper-outer quadrant of breast
0.985 0.015 0.000
I25.5 Ischaemic cardiomyopathy
0.000 0.017 0.983
M06.9 Rheumatoid arthritis, unspecified
0.000 0.018 0.982
E06 Thyroiditis
0.000 0.018 0.982
E10.5 With peripheral circulatory complications
0.000 0.018 0.982
D75.1 Secondary polycythaemia
0.000 0.019 0.981
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.019 0.981
I22 Subsequent myocardial infarction
0.000 0.022 0.978
C50.8 Overlapping lesion of breast
0.975 0.025 0.000
E27.1 Primary adrenocortical insufficiency
0.000 0.026 0.974
D59 Acquired haemolytic anaemia
0.000 0.029 0.971
E10.1 With ketoacidosis
0.000 0.030 0.970
E10.3 With ophthalmic complications
0.000 0.036 0.964
I74.3 Embolism and thrombosis of arteries of the lower extremities
0.000 0.037 0.963
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.960 0.040 0.000
K90 Intestinal malabsorption
0.000 0.042 0.958
I22.1 Subsequent myocardial infarction of inferior wall
0.000 0.045 0.955
E06.3 Autoimmune thyroiditis
0.000 0.045 0.955
E10.4 With neurological complications
0.000 0.045 0.955
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.045 0.955
D59.1 Other autoimmune haemolytic anaemias
0.000 0.049 0.951
G80-G83 Cerebral palsy and other paralytic syndromes
0.000 0.049 0.951
Chapter VI Diseases of the nervous system
0.000 0.050 0.950
G81.9 Hemiplegia, unspecified
0.000 0.051 0.949
G81 Hemiplegia
0.000 0.051 0.949
M06 Other rheumatoid arthritis
0.000 0.051 0.949
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.949 0.051 0.000
E23 Hypofunction and other disorders of pituitary gland
0.000 0.052 0.948
C78.7 Secondary malignant neoplasm of liver
0.947 0.053 0.000
C77.9 Lymph node, unspecified
0.944 0.056 0.000
Chapter XI Diseases of the digestive system
0.000 0.056 0.944
K90-K93 Other diseases of the digestive system
0.000 0.056 0.944
C50.1 Central portion of breast
0.942 0.058 0.000
K70-K77 Diseases of liver
0.000 0.058 0.942
D75.2 Essential thrombocytosis
0.000 0.058 0.942
C50.0 Nipple and areola
0.941 0.059 0.000
K74 Fibrosis and cirrhosis of liver
0.000 0.059 0.941
C50.2 Upper-inner quadrant of breast
0.937 0.063 0.000
K74.3 Primary biliary cirrhosis
0.000 0.069 0.931
M05-M14 Inflammatory polyarthropathies
0.000 0.069 0.931
Z95.8 Presence of other cardiac and vascular implants and grafts
0.000 0.074 0.926
I73 Other peripheral vascular diseases
0.000 0.075 0.925
C79 Secondary malignant neoplasm of other sites
0.924 0.076 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.000 0.078 0.922
M05 Seropositive rheumatoid arthritis
0.000 0.082 0.918
I74.5 Embolism and thrombosis of iliac artery
0.000 0.084 0.916
G20-G26 Extrapyramidal and movement disorders
0.000 0.088 0.912
I73.9 Peripheral vascular disease, unspecified
0.000 0.089 0.911
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.911 0.089 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.000 0.089 0.911
C84 Peripheral and cutaneous T-cell lymphomas
0.909 0.091 0.000
I74.9 Embolism and thrombosis of unspecified artery
0.000 0.095 0.905
I77 Other disorders of arteries and arterioles
0.000 0.095 0.905
E10.0 With coma
0.000 0.095 0.905
G24 Dystonia
0.000 0.096 0.904
G83 Other paralytic syndromes
0.000 0.096 0.904
K73 Chronic hepatitis, not elsewhere classified
0.000 0.097 0.903
D58 Other hereditary haemolytic anaemias
0.000 0.099 0.901
G70-G73 Diseases of myoneural junction and muscle
0.000 0.100 0.900
E10.2 With renal complications
0.000 0.106 0.894
E28 Ovarian dysfunction
0.000 0.108 0.892
M07 Psoriatic and enteropathic arthropathies
0.000 0.108 0.892
G24.9 Dystonia, unspecified
0.000 0.109 0.891
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.000 0.110 0.890
D56 Thalassaemia
0.000 0.113 0.887
I25.3 Aneurysm of heart
0.000 0.116 0.884
E50-E64 Other nutritional deficiencies
0.000 0.117 0.883
I05-I09 Chronic rheumatic heart diseases
0.000 0.121 0.879
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)
0.000 0.122 0.878
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.000 0.126 0.874
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)
0.000 0.131 0.869
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.000 0.132 0.868
M07.3 Other psoriatic arthropathies
0.000 0.134 0.866
D60-D64 Aplastic and other anaemias
0.000 0.134 0.866
G83.4 Cauda equina syndrome
0.000 0.134 0.866
E34 Other endocrine disorders
0.000 0.135 0.865
E23.6 Other disorders of pituitary gland
0.000 0.138 0.862
E27.2 Addisonian crisis
0.000 0.141 0.859
D63 Anaemia in chronic diseases classified elsewhere
0.000 0.147 0.853
E23.2 Diabetes insipidus
0.000 0.149 0.851
I12 Hypertensive renal disease
0.000 0.150 0.850
K75 Other inflammatory liver diseases
0.000 0.151 0.849
K73.2 Chronic active hepatitis, not elsewhere classified
0.000 0.151 0.849
D63.8 Anaemia in other chronic diseases classified elsewhere
0.000 0.151 0.849
I23 Certain current complications following acute myocardial infarction
0.000 0.152 0.848
E07 Other disorders of thyroid
0.000 0.154 0.846
C85.9 Non-Hodgkin's lymphoma, unspecified type
0.846 0.154 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.841 0.159 0.000
D69 Purpura and other haemorrhagic conditions
0.000 0.161 0.838
D69.3 Idiopathic thrombocytopenic purpura
0.000 0.162 0.838
D75.8 Other specified diseases of blood and blood-forming organs
0.000 0.164 0.836
E06.9 Thyroiditis, unspecified
0.000 0.165 0.835
C15-C26 Malignant neoplasms of digestive organs
0.834 0.166 0.000
I77.6 Arteritis, unspecified
0.000 0.166 0.834
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.833 0.167 0.000
C77.8 Lymph nodes of multiple regions
0.832 0.168 0.000
K74.0 Hepatic fibrosis
0.000 0.168 0.832
I77.1 Stricture of artery
0.000 0.168 0.832
M06.4 Inflammatory polyarthropathy
0.000 0.169 0.831
C76 Malignant neoplasm of other and ill-defined sites
0.831 0.169 0.000
C85.7 Other specified types of non-Hodgkin's lymphoma
0.827 0.173 0.000
E20 Hypoparathyroidism
0.000 0.178 0.822
L40.5 Arthropathic psoriasis
0.000 0.182 0.818
K74.5 Biliary cirrhosis, unspecified
0.000 0.183 0.817
C79.1 Secondary malignant neoplasm of bladder and other and unspecified urinary organs
0.816 0.184 0.000
L40 Psoriasis
0.000 0.184 0.816
E02 Subclinical iodine-deficiency hypothyroidism
0.000 0.184 0.816
D73 Diseases of spleen
0.000 0.186 0.814
I22.0 Subsequent myocardial infarction of anterior wall
0.000 0.186 0.814
E21.3 Hyperparathyroidism, unspecified
0.000 0.187 0.813
E27.8 Other specified disorders of adrenal gland
0.000 0.188 0.812
E22 Hyperfunction of pituitary gland
0.000 0.188 0.812
G72 Other myopathies
0.000 0.189 0.811
E05.0 Thyrotoxicosis with diffuse goitre
0.000 0.189 0.811
D80-D89 Certain disorders involving the immune mechanism
0.000 0.191 0.809
C79.8 Secondary malignant neoplasm of other specified sites
0.809 0.191 0.000
I74.1 Embolism and thrombosis of other and unspecified parts of aorta
0.000 0.193 0.807
C84.0 Mycosis fungoides
0.807 0.193 0.000
L40-L45 Papulosquamous disorders
0.000 0.194 0.806
D58.9 Hereditary haemolytic anaemia, unspecified
0.000 0.195 0.805
E31 Polyglandular dysfunction
0.000 0.202 0.798
M07.30 Other psoriatic arthropathies (Multiple sites)
0.000 0.203 0.797
Chapter XII Diseases of the skin and subcutaneous tissue
0.000 0.206 0.794
D56.3 Thalassaemia trait
0.000 0.207 0.793
C51-C58 Malignant neoplasms of female genital organs
0.792 0.208 0.000
E28.3 Primary ovarian failure
0.000 0.208 0.792
C90 Multiple myeloma and malignant plasma cell neoplasms
0.792 0.208 0.000
G80 Infantile cerebral palsy
0.000 0.209 0.791
M06.92 Rheumatoid arthritis, unspecified (Upper arm)
0.000 0.213 0.787
I07 Rheumatic tricuspid valve diseases
0.000 0.213 0.786
I05 Rheumatic mitral valve diseases
0.000 0.215 0.785
G24.5 Blepharospasm
0.000 0.216 0.784
Z95.3 Presence of xenogenic heart valve
0.000 0.216 0.784
I74.0 Embolism and thrombosis of abdominal aorta
0.000 0.218 0.782
C78.2 Secondary malignant neoplasm of pleura
0.782 0.218 0.000
K75.4 Autoimmune hepatitis
0.000 0.219 0.781
G71 Primary disorders of muscles
0.000 0.219 0.781
M06.98 Rheumatoid arthritis, unspecified (Other)
0.000 0.224 0.776
E07.9 Disorder of thyroid, unspecified
0.000 0.229 0.771
E03.1 Congenital hypothyroidism without goitre
0.000 0.230 0.770
I25.6 Silent myocardial ischaemia
0.000 0.230 0.770
I25.4 Coronary artery aneurysm
0.000 0.230 0.770
C84.5 Other and unspecified T-cell lymphomas
0.767 0.233 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.767 0.233 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.766 0.234 0.000
C79.4 Secondary malignant neoplasm of other and unspecified parts of nervous system
0.766 0.234 0.000
M07.39 Other psoriatic arthropathies (Site unspecified)
0.000 0.235 0.765
E58 Dietary calcium deficiency
0.000 0.239 0.761
C84.4 Peripheral T-cell lymphoma
0.760 0.240 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.760 0.240 0.000
I15 Secondary hypertension
0.000 0.240 0.760
E23.0 Hypopituitarism
0.000 0.243 0.757
E06.1 Subacute thyroiditis
0.000 0.245 0.755
E03.8 Other specified hypothyroidism
0.000 0.246 0.754
L40.9 Psoriasis, unspecified
0.000 0.246 0.754
C20 Malignant neoplasm of rectum
0.752 0.248 0.000
G83.9 Paralytic syndrome, unspecified
0.000 0.248 0.752
D69.4 Other primary thrombocytopenia
0.000 0.252 0.748
G72.9 Myopathy, unspecified
0.000 0.254 0.746
D59.0 Drug-induced autoimmune haemolytic anaemia
0.000 0.255 0.745
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.742 0.258 0.000
D86 Sarcoidosis
0.000 0.258 0.742
D75.9 Disease of blood and blood-forming organs, unspecified
0.000 0.258 0.741
D59.9 Acquired haemolytic anaemia, unspecified
0.000 0.259 0.741
I23.8 Other current complications following acute myocardial infarction
0.000 0.262 0.738
C94 Other leukaemias of specified cell type
0.738 0.262 0.000
E10.8 With unspecified complications
0.000 0.269 0.731
M12 Other specific arthropathies
0.000 0.270 0.730
C21 Malignant neoplasm of anus and anal canal
0.728 0.272 0.000
C86 Other specified types of T/NK-cell lymphoma
0.726 0.274 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.000 0.275 0.725
K74.6 Other and unspecified cirrhosis of liver
0.000 0.276 0.724
C97 Malignant neoplasms of independent (primary) multiple sites
0.723 0.277 0.000
E22.1 Hyperprolactinaemia
0.000 0.279 0.721
C55 Malignant neoplasm of uterus, part unspecified
0.721 0.279 0.000
K73.9 Chronic hepatitis, unspecified
0.000 0.279 0.721
I07.1 Tricuspid insufficiency
0.000 0.280 0.720
E53 Deficiency of other B group vitamins
0.000 0.280 0.720
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)
0.000 0.280 0.720
I12.0 Hypertensive renal disease with renal failure
0.000 0.281 0.719
C79.5 Secondary malignant neoplasm of bone and bone marrow
0.719 0.281 0.000
K73.8 Other chronic hepatitis, not elsewhere classified
0.000 0.282 0.718
I21.X Presumed acute myicardial infaction (unconfirmed)
0.000 0.283 0.717
E01 Iodine-deficiency-related thyroid disorders and allied conditions
0.000 0.283 0.717
E00 Congenital iodine-deficiency syndrome
0.000 0.283 0.717
E03.5 Myxoedema coma
0.000 0.283 0.717
E03.4 Atrophy of thyroid (acquired)
0.000 0.283 0.717
E03.3 Postinfectious hypothyroidism
0.000 0.283 0.717
E35 Disorders of endocrine glands in diseases classified elsewhere
0.000 0.283 0.717
E30 Disorders of puberty, not elsewhere classified
0.000 0.283 0.717
E12 Malnutrition-related diabetes mellitus
0.000 0.283 0.716
E34.0 Carcinoid syndrome
0.000 0.283 0.716
E25 Adrenogenital disorders
0.000 0.284 0.716
C51 Malignant neoplasm of vulva
0.716 0.284 0.000
K40-K46 Hernia
0.000 0.285 0.715
E05.5 Thyroid crisis or storm
0.000 0.286 0.714
E05.4 Thyrotoxicosis factitia
0.000 0.286 0.714
E05.3 Thyrotoxicosis from ectopic thyroid tissue
0.000 0.286 0.714
E03.0 Congenital hypothyroidism with diffuse goitre
0.000 0.286 0.714
C18 Malignant neoplasm of colon
0.713 0.287 0.000
K75.3 Granulomatous hepatitis, not elsewhere classified
0.000 0.287 0.713
D55 Anaemia due to enzyme disorders
0.000 0.287 0.713
E34.9 Endocrine disorder, unspecified
0.000 0.287 0.713
D74 Methaemoglobinaemia
0.000 0.290 0.710
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.000 0.290 0.710
D71 Functional disorders of polymorphonuclear neutrophils
0.000 0.290 0.710
D57 Sickle-cell disorders
0.000 0.290 0.710
I05.0 Mitral stenosis
0.000 0.290 0.710
D58.0 Hereditary spherocytosis
0.000 0.291 0.709
E27.5 Adrenomedullary hyperfunction
0.000 0.292 0.708
E27.0 Other adrenocortical overactivity
0.000 0.292 0.708
G25 Other extrapyramidal and movement disorders
0.000 0.294 0.706
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.705 0.295 0.000
C76.0 Head, face and neck
0.704 0.296 0.000
E06.4 Drug-induced thyroiditis
0.000 0.296 0.704
E06.2 Chronic thyroiditis with transient thyrotoxicosis
0.000 0.296 0.704
E06.0 Acute thyroiditis
0.000 0.296 0.704
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.000 0.298 0.702
D73.3 Abscess of spleen
0.000 0.298 0.702
D75.0 Familial erythrocytosis
0.000 0.299 0.701
I21.4 Acute subendocardial myocardial infarction
0.000 0.300 0.700
E28.2 Polycystic ovarian syndrome
0.000 0.302 0.698
D59.8 Other acquired haemolytic anaemias
0.000 0.304 0.696
D59.6 Haemoglobinuria due to haemolysis from other external causes
0.000 0.304 0.696
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
0.000 0.304 0.696
D59.3 Haemolytic-uraemic syndrome
0.000 0.304 0.696
D59.2 Drug-induced nonautoimmune haemolytic anaemia
0.000 0.304 0.696
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.000 0.304 0.696
C23 Malignant neoplasm of gallbladder
0.696 0.304 0.000
I13 Hypertensive heart and renal disease
0.000 0.305 0.695
G24.1 Idiopathic familial dystonia
0.000 0.305 0.695
C26 Malignant neoplasm of other and ill-defined digestive organs
0.695 0.305 0.000
E20.9 Hypoparathyroidism, unspecified
0.000 0.305 0.694
E32 Diseases of thymus
0.000 0.306 0.694
M05.1 Rheumatoid lung disease
0.000 0.306 0.694
I05.2 Mitral stenosis with insufficiency
0.000 0.307 0.693
C49 Malignant neoplasm of other connective and soft tissue
0.692 0.308 0.000
E40-E46 Malnutrition
0.000 0.310 0.690
K71 Toxic liver disease
0.000 0.310 0.689
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)
0.000 0.311 0.689
I77.2 Rupture of artery
0.000 0.311 0.689
C96 Other and unspecified malignant neoplasms of lymphoid, haematopoietic and related tissue
0.688 0.312 0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)
0.000 0.312 0.688
K90.3 Pancreatic steatorrhoea
0.000 0.313 0.687
K90.2 Blind loop syndrome, not elsewhere classified
0.000 0.313 0.687
K90.1 Tropical sprue
0.000 0.313 0.687
G80.9 Infantile cerebral palsy, unspecified
0.000 0.314 0.686
M06.93 Rheumatoid arthritis, unspecified (Forearm)
0.000 0.315 0.685
I22.9 Subsequent myocardial infarction of unspecified site
0.000 0.315 0.685
I77.0 Arteriovenous fistula, acquired
0.000 0.315 0.685
M07.36 Other psoriatic arthropathies (Lower leg)
0.000 0.316 0.684
D56.1 Beta thalassaemia
0.000 0.316 0.684
K41 Femoral hernia
0.000 0.319 0.681
G70 Myasthenia gravis and other myoneural disorders
0.000 0.319 0.681
E05.1 Thyrotoxicosis with toxic single thyroid nodule
0.000 0.319 0.680
G81.0 Flaccid hemiplegia
0.000 0.319 0.680
M06.2 Rheumatoid bursitis
0.000 0.320 0.680
M06.1 Adult-onset Still's disease
0.000 0.320 0.680
E23.3 Hypothalamic dysfunction, not elsewhere classified
0.000 0.320 0.680
E23.1 Drug-induced hypopituitarism
0.000 0.320 0.680
E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
0.000 0.320 0.680
E10.6 With other specified complications
0.000 0.321 0.679
Chapter XVI Certain conditions originating in the perinatal period
0.000 0.322 0.678
K93 Disorders of other digestive organs in diseases classified elsewhere
0.000 0.323 0.676
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)
0.000 0.324 0.676
C18.2 Ascending colon
0.675 0.325 0.000
E21.0 Primary hyperparathyroidism
0.000 0.325 0.675
D86.9 Sarcoidosis, unspecified
0.000 0.325 0.675
K74.4 Secondary biliary cirrhosis
0.000 0.325 0.675
K74.2 Hepatic fibrosis with hepatic sclerosis
0.000 0.325 0.675
C78.4 Secondary malignant neoplasm of small intestine
0.674 0.326 0.000
K77 Liver disorders in diseases classified elsewhere
0.000 0.327 0.673
E06.5 Other chronic thyroiditis
0.000 0.327 0.673
E55 Vitamin D deficiency
0.000 0.328 0.672
C95 Leukaemia of unspecified cell type
0.670 0.330 0.000
I22.8 Subsequent myocardial infarction of other sites
0.000 0.332 0.668
D58.2 Other haemoglobinopathies
0.000 0.332 0.668
M08 Juvenile arthritis
0.000 0.333 0.667
M09 Juvenile arthritis in diseases classified elsewhere
0.000 0.333 0.667
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere
0.000 0.334 0.666
C90.1 Plasma cell leukaemia
0.666 0.334 0.000
E51 Thiamine deficiency
0.000 0.336 0.664
K41.9 Unilateral or unspecified femoral hernia, without obstruction or gangrene
0.000 0.337 0.663
G71.1 Myotonic disorders
0.000 0.337 0.663
M06.49 Inflammatory polyarthropathy (Site unspecified)
0.000 0.338 0.662
M07.34 Other psoriatic arthropathies (Hand)
0.000 0.338 0.662
C51.9 Vulva, unspecified
0.661 0.339 0.000
G83.1 Monoplegia of lower limb
0.000 0.340 0.660
M05.3 Rheumatoid arthritis with involvement of other organs and systems
0.000 0.342 0.658
M05.0 Felty's syndrome
0.000 0.342 0.658
C93 Monocytic leukaemia
0.658 0.342 0.000
I73.1 Thromboangiitis obliterans [Buerger]
0.000 0.342 0.658
K44 Diaphragmatic hernia
0.000 0.343 0.657
E26 Hyperaldosteronism
0.000 0.344 0.656
E21.5 Disorder of parathyroid gland, unspecified
0.000 0.344 0.656
I00-I02 Acute rheumatic fever
0.000 0.344 0.656
M05.8 Other seropositive rheumatoid arthritis
0.000 0.345 0.655
E03.2 Hypothyroidism due to medicaments and other exogenous substances
0.000 0.345 0.655
G26 Extrapyramidal and movement disorders in diseases classified elsewhere
0.000 0.346 0.654
G22 Parkinsonism in diseases classified elsewhere
0.000 0.346 0.654
E27.4 Other and unspecified adrenocortical insufficiency
0.000 0.346 0.654
I12.9 Hypertensive renal disease without renal failure
0.000 0.346 0.654
E31.0 Autoimmune polyglandular failure
0.000 0.346 0.654
C85.0 Lymphosarcoma
0.653 0.347 0.000
E61 Deficiency of other nutrient elements
0.000 0.347 0.653
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)
0.000 0.347 0.653
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.347 0.653
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)
0.000 0.347 0.653
C81 Hodgkin's disease
0.652 0.347 0.000
L42 Pityriasis rosea
0.000 0.348 0.652
C84.9 Mature T/NK-cell lymphoma, unspecified
0.652 0.348 0.000
C84.7 Anaplastic large cell lymphoma, ALK-negative
0.652 0.348 0.000
C84.6 Anaplastic large cell lymphoma, ALK-positive
0.652 0.348 0.000
C84.3 Lymphoepithelioid lymphoma
0.652 0.348 0.000
C84.2 T-zone lymphoma
0.652 0.348 0.000
C84.1 Sezary's diease
0.652 0.348 0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.000 0.349 0.651
C18.9 Colon, unspecified
0.651 0.349 0.000
K90.8 Other intestinal malabsorption
0.000 0.349 0.651
I77.5 Necrosis of artery
0.000 0.351 0.649
I77.4 Coeliac artery compression syndrome
0.000 0.351 0.649
G24.4 Idiopathic orofacial dystonia
0.000 0.352 0.648
G24.2 Idiopathic nonfamilial dystonia
0.000 0.352 0.648
G83.5 Locked-in syndrome
0.000 0.352 0.648
G83.3 Monoplegia, unspecified
0.000 0.352 0.648
G83.0 Diplegia of upper limbs
0.000 0.352 0.648
K73.1 Chronic lobular hepatitis, not elsewhere classified
0.000 0.352 0.648
K73.0 Chronic persistent hepatitis, not elsewhere classified
0.000 0.352 0.648
M10 Gout
0.000 0.352 0.648
C77.2 Intra-abdominal lymph nodes
0.647 0.353 0.000
D58.8 Other specified hereditary haemolytic anaemias
0.000 0.354 0.646
D58.1 Hereditary elliptocytosis
0.000 0.354 0.646
D73.4 Cyst of spleen
0.000 0.354 0.646
G73 Disorders of myoneural junction and muscle in diseases classified elsewhere
0.000 0.355 0.645
G80.2 Infantile hemiplegia
0.000 0.355 0.645
C21.8 Overlapping lesion of rectum, anus and anal canal
0.645 0.355 0.000
C77.4 Inguinal and lower limb lymph nodes
0.644 0.356 0.000
D73.1 Hypersplenism
0.000 0.356 0.644
C88 Malignant immunoproliferative diseases
0.643 0.357 0.000
M07.37 Other psoriatic arthropathies (Ankle and foot)
0.000 0.357 0.643
G72.8 Other specified myopathies
0.000 0.359 0.641
K74.1 Hepatic sclerosis
0.000 0.359 0.641
M06.8 Other specified rheumatoid arthritis
0.000 0.360 0.640
E28.9 Ovarian dysfunction, unspecified
0.000 0.360 0.640
E28.8 Other ovarian dysfunction
0.000 0.360 0.640
E28.1 Androgen excess
0.000 0.360 0.640
E28.0 Oestrogen excess
0.000 0.360 0.640
M07.5 Arthropathy in ulcerative colitis
0.000 0.360 0.639
M07.4 Arthropathy in Crohn's disease [regional enteritis]
0.000 0.360 0.639
M07.2 Psoriatic spondylitis
0.000 0.360 0.639
M07.1 Arthritis mutilans
0.000 0.360 0.639
M07.0 Distal interphalangeal psoriatic arthropathy
0.000 0.360 0.639
M06.46 Inflammatory polyarthropathy (Lower leg)
0.000 0.361 0.639
C82.9 Follicular non-Hodgkin's lymphoma, unspecified
0.639 0.361 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.638 0.362 0.000
G24.3 Spasmodic torticollis
0.000 0.362 0.638
D59.4 Other nonautoimmune haemolytic anaemias
0.000 0.363 0.637
D56.9 Thalassaemia, unspecified
0.000 0.364 0.636
D56.8 Other thalassaemias
0.000 0.364 0.636
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]
0.000 0.364 0.636
D56.2 Delta-beta thalassaemia
0.000 0.364 0.636
D56.0 Alpha thalassaemia
0.000 0.364 0.636
D86.0 Sarcoidosis of lung
0.000 0.364 0.636
I21.2 Acute transmural myocardial infarction of other sites
0.000 0.365 0.635
E21.2 Other hyperparathyroidism
0.000 0.366 0.634
E64 Sequelae of malnutrition and other nutritional deficiencies
0.000 0.367 0.633
E63 Other nutritional deficiencies
0.000 0.367 0.633
E50 Vitamin A deficiency
0.000 0.367 0.633
E60 Dietary zinc deficiency
0.000 0.367 0.633
E59 Dietary selenium deficiency
0.000 0.367 0.633
E52 Niacin deficiency [pellagra]
0.000 0.367 0.633
G23 Other degenerative diseases of basal ganglia
0.000 0.367 0.633
M06.3 Rheumatoid nodule
0.000 0.368 0.632
C76.1 Thorax
0.632 0.368 0.000
C49.3 Connective and soft tissue of thorax
0.632 0.368 0.000
C74 Malignant neoplasm of adrenal gland
0.631 0.369 0.000
K90.9 Intestinal malabsorption, unspecified
0.000 0.370 0.630
I70 Atherosclerosis
0.000 0.371 0.629
D73.9 Disease of spleen, unspecified
0.000 0.373 0.627
K44.9 Diaphragmatic hernia without obstruction or gangrene
0.000 0.375 0.625
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)
0.000 0.376 0.624
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.624 0.376 0.000
E10.7 With multiple complications
0.000 0.376 0.624
C84.8 Cutaneous T-cell lymphoma, unspecified
0.624 0.376 0.000
K75.8 Other specified inflammatory liver diseases
0.000 0.377 0.623
E21.1 Secondary hyperparathyroidism, not elsewhere classified
0.000 0.377 0.623
L40.1 Generalised pustular psoriasis
0.000 0.377 0.623
M07.33 Other psoriatic arthropathies (Forearm)
0.000 0.379 0.621
M07.32 Other psoriatic arthropathies (Upper arm)
0.000 0.379 0.621
M07.31 Other psoriatic arthropathies (Shoulder region)
0.000 0.379 0.621
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.000 0.379 0.621
E34.5 Androgen resistance syndrome
0.000 0.380 0.620
E34.4 Constitutional tall stature
0.000 0.380 0.620
E34.2 Ectopic hormone secretion, not elsewhere classified
0.000 0.380 0.620
E34.1 Other hypersecretion of intestinal hormones
0.000 0.380 0.620
I20.1 Angina pectoris with documented spasm
0.000 0.381 0.619
M07.6 Other enteropathic arthropathies
0.000 0.381 0.619
E34.3 Short stature, not elsewhere classified
0.000 0.382 0.618
G24.8 Other dystonia
0.000 0.382 0.618
G24.0 Drug-induced dystonia
0.000 0.382 0.618
M07.35 Other psoriatic arthropathies (Pelvic region and thigh)
0.000 0.383 0.617
I72 Other aneurysm
0.000 0.383 0.617
C80 Malignant neoplasm without specification of site
0.616 0.384 0.000
L43 Lichen planus
0.000 0.384 0.616
E27.3 Drug-induced adrenocortical insufficiency
0.000 0.385 0.615
E05.8 Other thyrotoxicosis
0.000 0.385 0.615
I74.4 Embolism and thrombosis of arteries of extremities, unspecified
0.000 0.385 0.615
C82.0 Small cleaved cell, follicular
0.615 0.385 0.000
C26.9 Ill-defined sites within the digestive system
0.614 0.386 0.000
D83 Common variable immunodeficiency
0.000 0.388 0.612
D63.1 Anaemia in other chronic diseases classified elsewhere
0.000 0.388 0.612
C76.2 Abdomen
0.611 0.389 0.000
E34.8 Other specified endocrine disorders
0.000 0.390 0.610
C17 Malignant neoplasm of small intestine
0.610 0.390 0.000
K75.2 Nonspecific reactive hepatitis
0.000 0.391 0.609
K75.1 Phlebitis of portal vein
0.000 0.391 0.609
I25.0 Atherosclerotic cardiovascular disease, so described
0.000 0.392 0.608
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction
0.000 0.392 0.608
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction
0.000 0.392 0.608
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction
0.000 0.392 0.608
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction
0.000 0.392 0.608
I23.2 Ventricular septal defect as current complication following acute myocardial infarction
0.000 0.392 0.608
I23.1 Atrial septal defect as current complication following acute myocardial infarction
0.000 0.392 0.608
I23.0 Haemopericardium as current complication following acute myocardial infarction
0.000 0.392 0.608
E07.1 Dyshormogenetic goitre
0.000 0.393 0.607
E07.0 Hypersecretion of calcitonin
0.000 0.393 0.607
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.000 0.395 0.605
G35-G37 Demyelinating diseases of the central nervous system
0.000 0.395 0.605
I74.2 Embolism and thrombosis of arteries of the upper extremities
0.000 0.395 0.605
E27.9 Disorder of adrenal gland, unspecified
0.000 0.396 0.603
C85.2 Mediastinal (thymic) large B-cell lymphoma
0.603 0.397 0.000
D66 Hereditary factor VIII deficiency
0.000 0.397 0.603
E53.9 Vitamin B deficiency, unspecified
0.000 0.399 0.601
M12.2 Villonodular synovitis (pigmented)
0.000 0.399 0.601
C49.1 Connective and soft tissue of upper limb, including shoulder
0.600 0.400 0.000
D69.8 Other specified haemorrhagic conditions
0.000 0.400 0.600
G71.3 Mitochondrial myopathy, not elsewhere classified
0.000 0.403 0.597
C79.2 Secondary malignant neoplasm of skin
0.597 0.403 0.000
E56 Other vitamin deficiencies
0.000 0.403 0.596
M06.48 Inflammatory polyarthropathy (Other)
0.000 0.404 0.596
M06.47 Inflammatory polyarthropathy (Ankle and foot)
0.000 0.404 0.596
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)
0.000 0.404 0.596
M06.44 Inflammatory polyarthropathy (Hand)
0.000 0.404 0.596
M06.43 Inflammatory polyarthropathy (Forearm)
0.000 0.404 0.596
M06.42 Inflammatory polyarthropathy (Upper arm)
0.000 0.404 0.596
M06.41 Inflammatory polyarthropathy (Shoulder region)
0.000 0.404 0.596
C76.8 Overlapping lesion of other and ill-defined sites
0.596 0.404 0.000
C76.7 Other ill-defined sites
0.596 0.404 0.000
C76.5 Lower limb
0.596 0.404 0.000
C76.4 Upper limb
0.596 0.404 0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)
0.000 0.405 0.594
G25.0 Essential tremor
0.000 0.406 0.594
E14 Unspecified diabetes mellitus
0.000 0.406 0.594
D82 Immunodeficiency associated with other major defects
0.000 0.406 0.594

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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