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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs72718363
log Bayes Factor = 14.5907
Chromosome 4   position 141,545,867  (GRCh37) Explore rs72718363 on Ensembl!
Variant rs72718363 is part of Cluster X0178

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter II Neoplasms
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XXI Factors influencing health status and contact with health services
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Z00-Z13 Persons encountering health services for examination and investigation
1.000 0.000 0.000
D10-D36 Benign neoplasms
0.999 0.001 0.000
I20-I25 Ischaemic heart diseases
0.999 0.001 0.000
Chapter IX Diseases of the circulatory system
0.998 0.002 0.000
C15-C26 Malignant neoplasms of digestive organs
0.998 0.002 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.996 0.004 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.995 0.005 0.000
I25 Chronic ischaemic heart disease
0.991 0.009 0.000
C20 Malignant neoplasm of rectum
0.991 0.009 0.000
Z09 Follow-up examination after treatment for conditions other than malignant neoplasms
0.989 0.011 0.000
Z09.0 Follow-up examination after surgery for other conditions
0.988 0.012 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.981 0.019 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.975 0.025 0.000
D22 Melanocytic naevi
0.974 0.026 0.000
T81 Complications of procedures, not elsewhere classified
0.973 0.027 0.000
I21 Acute myocardial infarction
0.973 0.027 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.969 0.031 0.000
I25.1 Atherosclerotic heart disease
0.965 0.035 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.964 0.036 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.963 0.037 0.000
D12 Benign neoplasm of colon, rectum, anus and anal canal
0.963 0.037 0.000
Chapter XX External causes of morbidity and mortality
0.963 0.037 0.000
S00-S09 Injuries to the head
0.961 0.039 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.959 0.041 0.000
D23 Other benign neoplasms of skin
0.958 0.042 0.000
Z95.1 Presence of aortocoronary bypass graft
0.958 0.042 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.955 0.045 0.000
C78.7 Secondary malignant neoplasm of liver
0.952 0.048 0.000
D12.8 Rectum
0.952 0.048 0.000
I21.9 Acute myocardial infarction, unspecified
0.947 0.053 0.000
E70-E90 Metabolic disorders
0.933 0.067 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.932 0.068 0.000
T81.3 Disruption of operation wound, not elsewhere classified
0.930 0.070 0.000
Z02 Examination and encounter for administrative purposes
0.929 0.071 0.000
E10-E14 Diabetes mellitus
0.928 0.072 0.000
I25.9 Chronic ischaemic heart disease, unspecified
0.927 0.073 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.926 0.074 0.000
Z93 Artificial opening status
0.924 0.076 0.000
I20 Angina pectoris
0.922 0.078 0.000
Chapter XIV Diseases of the genitourinary system
0.922 0.078 0.000
D22.3 Melanocytic naevi of other and unspecified parts of face
0.915 0.085 0.000
Z08 Follow-up examination after treatment for malignant neoplasm
0.913 0.087 0.000
S01 Open wound of head
0.908 0.092 0.000
N17-N19 Renal failure
0.907 0.093 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.907 0.093 0.000
I21.4 Acute subendocardial myocardial infarction
0.902 0.098 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.900 0.100 0.000
Z12 Special screening examination for neoplasms
0.897 0.102 0.000
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts
0.895 0.105 0.000
D25 Leiomyoma of uterus
0.890 0.110 0.000
Z90 Acquired absence of organs, not elsewhere classified
0.884 0.116 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.879 0.121 0.000
M80-M85 Disorders of bone density and structure
0.879 0.121 0.000
Z02.8 Other examinations for administrative purposes
0.879 0.121 0.000
D00-D09 In situ neoplasms
0.871 0.129 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.868 0.132 0.000
N18 Chronic renal failure
0.866 0.134 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.864 0.136 0.000
C77.9 Lymph node, unspecified
0.861 0.139 0.000
Z45 Adjustment and management of implanted device
0.860 0.140 0.000
N70-N77 Inflammatory diseases of female pelvic organs
0.858 0.142 0.000
M05-M14 Inflammatory polyarthropathies
0.857 0.143 0.000
C77.2 Intra-abdominal lymph nodes
0.857 0.143 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.856 0.144 0.000
Z08.0 Follow-up examination after surgery for malignant neoplasm
0.851 0.149 0.000
D23.1 Skin of eyelid, including canthus
0.848 0.152 0.000
T81.8 Other complications of procedures, not elsewhere classified
0.847 0.153 0.000
T40 Poisoning by narcotics and psychodysleptics [hallucinogens]
0.846 0.154 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.846 0.154 0.000
Z95.5 Presence of coronary angioplasty implant and graft
0.841 0.159 0.000
E78.5 Hyperlipidaemia, unspecified
0.841 0.159 0.000
Chapter V Mental and behavioural disorders
0.839 0.161 0.000
E11 Non-insulin-dependent diabetes mellitus
0.837 0.163 0.000
Z90.7 Acquired absence of genital organ(s)
0.834 0.166 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.834 0.166 0.000
I20.9 Angina pectoris, unspecified
0.834 0.166 0.000
Z85 Personal history of malignant neoplasm
0.834 0.166 0.000
Z01 Other special examinations and investigations of persons without complaint or reported diagnosis
0.832 0.168 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.832 0.168 0.000
D23.3 Skin of other and unspecified parts of face
0.831 0.169 0.000
Z45.2 Adjustment and management of vascular access device
0.831 0.169 0.000
C43 Malignant melanoma of skin
0.828 0.172 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.826 0.174 0.000
Z12.1 Special screening examination for neoplasm of intestinal tract
0.824 0.176 0.000
D22.6 Melanocytic naevi of upper limb, including shoulder
0.824 0.176 0.000
M50-M54 Other dorsopathies
0.822 0.178 0.000
S01.0 Open wound of scalp
0.820 0.180 0.000
D12.0 Caecum
0.818 0.182 0.000
Z85.8 Personal history of malignant neoplasms of other organs and systems
0.816 0.184 0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified
0.815 0.185 0.000
Z93.3 Colostomy status
0.815 0.185 0.000
S02 Fracture of skull and facial bones
0.814 0.186 0.000
Z98 Other postsurgical states
0.810 0.190 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.810 0.190 0.000
C44 Other malignant neoplasms of skin
0.808 0.192 0.000
D22.5 Melanocytic naevi of trunk
0.805 0.195 0.000
Z93.2 Ileostomy status
0.803 0.196 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.803 0.197 0.000
E11.9 Without complications
0.802 0.198 0.000
C18 Malignant neoplasm of colon
0.801 0.198 0.000
C78.0 Secondary malignant neoplasm of lung
0.801 0.199 0.000
Z08.7 Follow-up examination after combined treatment for malignant neoplasm
0.801 0.199 0.000
D22.0 Melanocytic naevi of lip
0.799 0.201 0.000
S80-S89 Injuries to the knee and lower leg
0.796 0.204 0.000
E50-E64 Other nutritional deficiencies
0.795 0.205 0.000
I20.0 Unstable angina
0.795 0.205 0.000
D27 Benign neoplasm of ovary
0.791 0.209 0.000
C25 Malignant neoplasm of pancreas
0.788 0.212 0.000
I10-I15 Hypertensive diseases
0.785 0.215 0.000
N19 Unspecified renal failure
0.785 0.215 0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics
0.784 0.216 0.000
N80-N98 Noninflammatory disorders of female genital tract
0.784 0.216 0.000
D12.7 Rectosigmoid junction
0.781 0.219 0.000
M15-M19 Arthrosis
0.781 0.219 0.000
D23.7 Skin of lower limb, including hip
0.780 0.220 0.000
C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
0.780 0.220 0.000
M80 Osteoporosis with pathological fracture
0.780 0.220 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.778 0.222 0.000
N18.3 Chronic kidney disease, stage 3
0.778 0.222 0.000
D36 Benign neoplasm of other and unspecified sites
0.777 0.223 0.000
N72 Inflammatory disease of cervix uteri
0.777 0.223 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.777 0.223 0.000
X60-X84 Intentional self-harm
0.776 0.223 0.000
E10 Insulin-dependent diabetes mellitus
0.776 0.224 0.000
Z09.8 Follow-up examination after other treatment for other conditions
0.775 0.225 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.774 0.226 0.000
D35 Benign neoplasm of other and unspecified endocrine glands
0.773 0.227 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.771 0.229 0.000
I05-I09 Chronic rheumatic heart diseases
0.769 0.231 0.000
Chapter XXII Codes for special purposes
0.768 0.232 0.000
N17 Acute renal failure
0.768 0.232 0.000
D11 Benign neoplasm of major salivary glands
0.766 0.234 0.000
S40-S49 Injuries to the shoulder and upper arm
0.764 0.236 0.000
D23.2 Skin of ear and external auricular canal
0.763 0.237 0.000
C77.5 Intrapelvic lymph nodes
0.762 0.238 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.761 0.239 0.000
Z13 Special screening examination for other diseases and disorders
0.761 0.239 0.000
D25.9 Leiomyoma of uterus, unspecified
0.758 0.242 0.000
Z93.5 Cystostomy status
0.757 0.243 0.000
I24 Other acute ischaemic heart diseases
0.757 0.243 0.000
C43.6 Malignant melanoma of upper limb, including shoulder
0.756 0.244 0.000
Z71 Persons encountering health services for other counselling and medical advice, not elsewhere classified
0.755 0.245 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.755 0.245 0.000
T40.4 Other synthetic narcotics
0.755 0.245 0.000
Y40 Systemic antibiotics
0.753 0.247 0.000
D22.1 Melanocytic naevi of eyelid, including canthus
0.753 0.247 0.000
E88 Other metabolic disorders
0.752 0.248 0.000
C77.8 Lymph nodes of multiple regions
0.752 0.248 0.000
S01.9 Open wound of head, part unspecified
0.750 0.250 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.748 0.252 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.747 0.253 0.000
M51 Other intervertebral disk disorders
0.745 0.255 0.000
Z94 Transplanted organ and tissue status
0.745 0.255 0.000
C77.0 Lymph nodes of head, face and neck
0.745 0.255 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.744 0.256 0.000
D25.2 Subserosal leiomyoma of uterus
0.743 0.256 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.742 0.258 0.000
Z85.7 Personal history of other malignant neoplasms of lymphoid, haematopoietic and related tissues
0.741 0.259 0.000
E78.0 Pure hypercholesterolaemia
0.741 0.259 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.740 0.260 0.000
T66-T78 Other and unspecified effects of external causes
0.739 0.261 0.000
S20-S29 Injuries to the thorax
0.739 0.261 0.000
C51-C58 Malignant neoplasms of female genital organs
0.738 0.261 0.000
E14 Unspecified diabetes mellitus
0.737 0.263 0.000
Z95.3 Presence of xenogenic heart valve
0.736 0.264 0.000
M91-M94 Chondropathies
0.735 0.264 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.735 0.265 0.000
C32 Malignant neoplasm of larynx
0.734 0.266 0.000
D34 Benign neoplasm of thyroid gland
0.731 0.269 0.000
Z45.0 Adjustment and management of cardiac pacemaker
0.730 0.270 0.000
Y60 Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care
0.728 0.272 0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.728 0.272 0.000
S90-S99 Injuries to the ankle and foot
0.726 0.274 0.000
Z45.1 Adjustment and management of infusion pump
0.725 0.275 0.000
Z40 Prophylactic surgery
0.723 0.277 0.000
D23.4 Skin of scalp and neck
0.723 0.277 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.723 0.277 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.722 0.278 0.000
C78.8 Secondary malignant neoplasm of other and unspecified digestive organs
0.722 0.278 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.722 0.278 0.000
C44.2 Skin of ear and external auricular canal
0.720 0.280 0.000
S01.8 Open wound of other parts of head
0.719 0.281 0.000
M81 Osteoporosis without pathological fracture
0.717 0.283 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.717 0.283 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
T79-T79 Certain early complications of trauma
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
S10-S19 Injuries to the neck
0.717 0.283 0.000
Z10 Routine general health check-up of defined subpopulation
0.717 0.283 0.000
Z04 Examination and observation for other reasons
0.717 0.283 0.000
D33 Benign neoplasm of brain and other parts of central nervous system
0.716 0.283 0.000
D32 Benign neoplasm of meninges
0.716 0.283 0.000
D31 Benign neoplasm of eye and adnexa
0.716 0.283 0.000
D30 Benign neoplasm of urinary organs
0.716 0.283 0.000
D29 Benign neoplasm of male genital organs
0.716 0.283 0.000
D28 Benign neoplasm of other and unspecified female genital organs
0.716 0.283 0.000
D26 Other benign neoplasms of uterus
0.716 0.283 0.000
D21 Other benign neoplasms of connective and other soft tissue
0.716 0.283 0.000
D20 Benign neoplasm of soft tissue of retroperitoneum and peritoneum
0.716 0.283 0.000
D19 Benign neoplasm of mesothelial tissue
0.716 0.283 0.000
D16 Benign neoplasm of bone and articular cartilage
0.716 0.283 0.000
D15 Benign neoplasm of other and unspecified intrathoracic organs
0.716 0.283 0.000
D14 Benign neoplasm of middle ear and respiratory system
0.716 0.283 0.000
D10 Benign neoplasm of mouth and pharynx
0.716 0.283 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.716 0.284 0.000
I23 Certain current complications following acute myocardial infarction
0.716 0.284 0.000
I00-I02 Acute rheumatic fever
0.716 0.284 0.000
T81.0 Haemorrhage and haematoma complicating a procedure, not elsewhere classified
0.716 0.284 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.715 0.284 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.715 0.284 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.715 0.284 0.000
C21 Malignant neoplasm of anus and anal canal
0.715 0.284 0.000
C17 Malignant neoplasm of small intestine
0.715 0.284 0.000
C16 Malignant neoplasm of stomach
0.715 0.284 0.000
C23 Malignant neoplasm of gallbladder
0.715 0.284 0.000
D03 Melanoma in situ
0.715 0.284 0.000
N92 Excessive, frequent and irregular menstruation
0.714 0.286 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.714 0.286 0.000
T87 Complications peculiar to reattachment and amputation
0.714 0.286 0.000
T86 Failure and rejection of transplanted organs and tissues
0.714 0.286 0.000
M06 Other rheumatoid arthritis
0.714 0.286 0.000
C80 Malignant neoplasm without specification of site
0.713 0.286 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.713 0.286 0.000
M40-M43 Deforming dorsopathies
0.713 0.287 0.000
Z90.4 Acquired absence of other parts of digestive tract
0.712 0.288 0.000
F20-F29 Schizophrenia, schizotypal and delusional disorders
0.712 0.288 0.000
I25.6 Silent myocardial ischaemia
0.711 0.289 0.000
I25.5 Ischaemic cardiomyopathy
0.711 0.289 0.000
I25.4 Coronary artery aneurysm
0.711 0.289 0.000
I25.3 Aneurysm of heart
0.711 0.289 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.711 0.289 0.000
Z09.7 Follow-up examination after combined treatment for other conditions
0.709 0.291 0.000
Z09.4 Follow-up examination after treatment of fracture
0.709 0.291 0.000
Z09.3 Follow-up examination after psychotherapy
0.709 0.291 0.000
Z09.1 Follow-up examination after radiotherapy for other conditions
0.709 0.291 0.000
Z90.3 Acquired absence of part of stomach
0.709 0.291 0.000
D25.1 Intramural leiomyoma of uterus
0.709 0.291 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.708 0.292 0.000
Z01.4 Gynaecological examination (general)(routine)
0.707 0.293 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.707 0.293 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.706 0.294 0.000
S50-S59 Injuries to the elbow and forearm
0.705 0.295 0.000
E40-E46 Malnutrition
0.704 0.296 0.000
M86-M90 Other osteopathies
0.702 0.297 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.702 0.297 0.000
Z90.5 Acquired absence of kidney
0.702 0.298 0.000
Z46 Fitting and adjustment of other devices
0.700 0.300 0.000
M10 Gout
0.699 0.301 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.699 0.301 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.699 0.301 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.699 0.301 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.699 0.301 0.000
D22.9 Melanocytic naevi, unspecified
0.699 0.301 0.000
D22.2 Melanocytic naevi of ear and external auricular canal
0.699 0.301 0.000
Z43 Attention to artificial openings
0.699 0.301 0.000
T81.9 Unspecified complication of procedure
0.698 0.302 0.000
T81.7 Vascular complications following a procedure, not elsewhere classified
0.698 0.302 0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure
0.698 0.302 0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure
0.698 0.302 0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified
0.698 0.302 0.000
I21.X Presumed acute myicardial infaction (unconfirmed)
0.698 0.302 0.000
I21.3 Acute transmural myocardial infarction of unspecified site
0.698 0.302 0.000
N92.1 Excessive and frequent menstruation with irregular cycle
0.697 0.303 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.697 0.303 0.000
T40.2 Other opioids
0.697 0.303 0.000
N89 Other noninflammatory disorders of vagina
0.696 0.304 0.000
C34 Malignant neoplasm of bronchus and lung
0.695 0.305 0.000
M60-M63 Disorders of muscles
0.695 0.305 0.000
M00-M03 Infectious arthropathies
0.695 0.305 0.000
E20-E35 Disorders of other endocrine glands
0.694 0.306 0.000
Z73 Problems related to life-management difficulty
0.694 0.306 0.000
S70-S79 Injuries to the hip and thigh
0.694 0.306 0.000
D06 Carcinoma in situ of cervix uteri
0.693 0.307 0.000
S00 Superficial injury of head
0.693 0.307 0.000
S01.3 Open wound of ear
0.692 0.307 0.000
Z49 Care involving dialysis
0.692 0.308 0.000
S01.1 Open wound of eyelid and periocular area
0.692 0.308 0.000
D23.6 Skin of upper limb, including shoulder
0.692 0.308 0.000
N18.0 End-stage renal disease
0.691 0.309 0.000
T39.1 4-Aminophenol derivatives
0.691 0.309 0.000
N70 Salpingitis and oophoritis
0.691 0.309 0.000
Z89 Acquired absence of limb
0.691 0.309 0.000
Z84 Family history of other conditions
0.691 0.309 0.000
Z81 Family history of mental and behavioural disorders
0.691 0.309 0.000
T82.9 Unspecified complication of cardiac and vascular prosthetic device, implant and graft
0.691 0.309 0.000
T82.6 Infection and inflammatory reaction due to cardiac valve prosthesis
0.691 0.309 0.000
T82.4 Mechanical complication of vascular dialysis catheter
0.691 0.309 0.000
T82.3 Mechanical complication of other vascular grafts
0.691 0.309 0.000
T82.1 Mechanical complication of cardiac electronic device
0.691 0.309 0.000
T82.0 Mechanical complication of heart valve prosthesis
0.691 0.309 0.000
D12.9 Anus and anal canal
0.691 0.309 0.000
D12.1 Appendix
0.691 0.309 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.691 0.309 0.000
Y35-Y36 Legal intervention and operations of war
0.691 0.309 0.000
Y10-Y34 Event of undetermined intent
0.691 0.309 0.000
Y00-Y09 Assault
0.691 0.309 0.000
X85-X99 Assault
0.691 0.309 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.691 0.309 0.000
X50-X57 Overexertion, travel and privation
0.691 0.309 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.691 0.309 0.000
X30-X39 Exposure to forces of nature
0.691 0.309 0.000
X20-X29 Contact with venomous animals and plants
0.691 0.309 0.000
X10-X19 Contact with heat and hot substances
0.691 0.309 0.000
X00-X09 Exposure to smoke, fire and flames
0.691 0.309 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.691 0.309 0.000
W75-W84 Other accidental threats to breathing
0.691 0.309 0.000
W65-W74 Accidental drowning and submersion
0.691 0.309 0.000
W50-W64 Exposure to animate mechanical forces
0.691 0.309 0.000
V98-V99 Other and unspecified transport accidents
0.691 0.309 0.000
V95-V97 Air and space transport accidents
0.691 0.309 0.000
V90-V94 Water transport accidents
0.691 0.309 0.000
V80-V89 Other land transport accidents
0.691 0.309 0.000
V70-V79 Bus occupant injured in transport accident
0.691 0.309 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.691 0.309 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.691 0.309 0.000
V40-V49 Car occupant injured in transport accident
0.691 0.309 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.691 0.309 0.000
V20-V29 Motorcycle rider injured in transport accident
0.691 0.309 0.000
V01-V09 Pedestrian injured in transport accident
0.691 0.309 0.000
I25.2 Old myocardial infarction
0.690 0.310 0.000
M51.2 Other specified intervertebral disk displacement
0.690 0.310 0.000
N71 Inflammatory disease of uterus, except cervix
0.689 0.311 0.000
S08 Traumatic amputation of part of head
0.689 0.311 0.000
S07 Crushing injury of head
0.689 0.311 0.000
S06 Intracranial injury
0.689 0.311 0.000
S05 Injury of eye and orbit
0.689 0.311 0.000
S04 Injury of cranial nerves
0.689 0.311 0.000
S03 Dislocation, sprain and strain of joints and ligaments of head
0.689 0.311 0.000
Z99.1 Dependence on respirator
0.689 0.311 0.000
N18.9 Chronic renal failure, unspecified
0.689 0.311 0.000
M65-M68 Disorders of synovium and tendon
0.688 0.312 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.688 0.312 0.000
N80 Endometriosis
0.688 0.312 0.000
Z11 Special screening examination for infectious and parasitic diseases
0.688 0.312 0.000
S09 Other and unspecified injuries of head
0.688 0.312 0.000
D23.9 Skin, unspecified
0.687 0.313 0.000
D23.0 Skin of lip
0.687 0.313 0.000
T93 Sequelae of injuries of lower limb
0.686 0.314 0.000
M80.9 Unspecified osteoporosis with pathological fracture
0.685 0.315 0.000
C77.4 Inguinal and lower limb lymph nodes
0.684 0.315 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.684 0.316 0.000
C43.9 Malignant melanoma of skin, unspecified
0.683 0.317 0.000
E61 Deficiency of other nutrient elements
0.683 0.317 0.000
Z93.1 Gastrostomy status
0.681 0.319 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.681 0.319 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.680 0.319 0.000
I95 Hypotension
0.679 0.321 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.678 0.322 0.000
M50 Cervical disk disorders
0.678 0.322 0.000
W00-W19 Falls
0.675 0.325 0.000
N18.5 Chronic kidney disease, stage 5
0.674 0.326 0.000
Z93.6 Other artificial openings of urinary tract status
0.673 0.327 0.000
M16 Coxarthrosis [arthrosis of hip]
0.672 0.328 0.000
Z98.0 Intestinal bypass and anastomosis status
0.670 0.330 0.000
S02.3 Fracture of orbital floor
0.670 0.330 0.000
E85 Amyloidosis
0.669 0.331 0.000
E84 Cystic fibrosis
0.669 0.331 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.669 0.331 0.000
E79 Disorders of purine and pyrimidine metabolism
0.669 0.331 0.000
E77 Disorders of glycoprotein metabolism
0.669 0.331 0.000
E76 Disorders of glycosaminoglycan metabolism
0.669 0.331 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.669 0.331 0.000
E74 Other disorders of carbohydrate metabolism
0.669 0.331 0.000
E73 Lactose intolerance
0.669 0.331 0.000
E72 Other disorders of amino-acid metabolism
0.669 0.331 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.669 0.331 0.000
E70 Disorders of aromatic amino-acid metabolism
0.669 0.331 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.669 0.331 0.000
W20-W49 Exposure to inanimate mechanical forces
0.669 0.331 0.000
D05 Carcinoma in situ of breast
0.669 0.331 0.000
N17.9 Acute renal failure, unspecified
0.669 0.331 0.000
Z13.1 Special screening examination for diabetes mellitus
0.668 0.332 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.668 0.332 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.668 0.332 0.000
C18.9 Colon, unspecified
0.667 0.333 0.000
E10.9 Without complications
0.667 0.333 0.000
Z02.9 Examination for administrative purposes, unspecified
0.666 0.334 0.000
Z02.7 Issue of medical certificate
0.666 0.334 0.000
Z02.6 Examination for insurance purposes
0.666 0.334 0.000
Z02.5 Examination for participation in sport
0.666 0.334 0.000
Z02.4 Examination for driving licence
0.666 0.334 0.000
Z02.3 Examination for recruitment to armed forces
0.666 0.334 0.000
Z02.2 Examination for admission to residential institution
0.666 0.334 0.000
Z02.1 Pre-employment examination
0.666 0.334 0.000
Z02.0 Examination for admission to educational institution
0.666 0.334 0.000
C79 Secondary malignant neoplasm of other sites
0.665 0.334 0.000
E13 Other specified diabetes mellitus
0.665 0.335 0.000
E12 Malnutrition-related diabetes mellitus
0.665 0.335 0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs
0.664 0.336 0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system
0.664 0.336 0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system
0.664 0.336 0.000
T46 Poisoning by agents primarily affecting the cardiovascular system
0.664 0.336 0.000
T45 Poisoning by primarily systemic and haematological agents, not elsewhere classified
0.664 0.336 0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system
0.664 0.336 0.000
T41 Poisoning by anaesthetics and therapeutic gases
0.664 0.336 0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified
0.664 0.336 0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics
0.664 0.336 0.000
T36 Poisoning by systemic antibiotics
0.664 0.336 0.000
C64-C68 Malignant neoplasms of urinary tract
0.664 0.336 0.000
M11 Other crystal arthropathies
0.663 0.336 0.000
Z93.9 Artificial opening status, unspecified
0.662 0.338 0.000
Z93.8 Other artificial opening status
0.662 0.338 0.000
Z93.4 Other artificial openings of gastro-intestinal tract status
0.662 0.338 0.000
Z93.0 Tracheostomy status
0.662 0.338 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.662 0.338 0.000
I20.1 Angina pectoris with documented spasm
0.661 0.339 0.000
Z97 Presence of other devices
0.661 0.339 0.000
N18.4 Chronic kidney disease, stage 4
0.661 0.339 0.000
F60-F69 Disorders of adult personality and behaviour
0.660 0.340 0.000
D12.3 Transverse colon
0.659 0.341 0.000
Y60.0 During surgical operation
0.658 0.342 0.000
C77.1 Intrathoracic lymph nodes
0.657 0.343 0.000
V10-V19 Pedal cyclist injured in transport accident
0.655 0.345 0.000
Z00 General examination and investigation of persons without complaint or reported diagnosis
0.655 0.345 0.000
Z08.8 Follow-up examination after other treatment for malignant neoplasm
0.654 0.345 0.000
Z08.2 Follow-up examination after chemotherapy for malignant neoplasm
0.654 0.345 0.000
Z08.1 Follow-up examination after radiotherapy for malignant neoplasm
0.654 0.345 0.000
C44.4 Skin of scalp and neck
0.654 0.346 0.000
M45-M49 Spondylopathies
0.652 0.348 0.000
D22.4 Melanocytic naevi of scalp and neck
0.652 0.348 0.000
Z52 Donors of organs and tissues
0.651 0.349 0.000
S01.7 Multiple open wounds of head
0.651 0.349 0.000
S01.4 Open wound of cheek and temporomandibular area
0.651 0.349 0.000
S01.2 Open wound of nose
0.651 0.349 0.000
T90 Sequelae of injuries of head
0.649 0.350 0.000
C15 Malignant neoplasm of oesophagus
0.649 0.351 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.649 0.351 0.000
Y40.0 Penicillins
0.647 0.353 0.000
T92 Sequelae of injuries of upper limb
0.645 0.355 0.000
E78.8 Other disorders of lipoprotein metabolism
0.645 0.355 0.000
E78.6 Lipoprotein deficiency
0.645 0.355 0.000
E78.4 Other hyperlipidaemia
0.645 0.355 0.000
E78.3 Hyperchylomicronaemia
0.645 0.355 0.000
E78.2 Mixed hyperlipidaemia
0.645 0.355 0.000
E78.1 Pure hyperglyceridaemia
0.645 0.355 0.000
Z71.9 Counselling, unspecified
0.645 0.355 0.000
C44.3 Skin of other and unspecified parts of face
0.644 0.356 0.000
Z12.9 Special screening examination for neoplasm, unspecified
0.643 0.356 0.000
Z12.8 Special screening examination for neoplasm of other sites
0.643 0.356 0.000
Z12.6 Special screening examination for neoplasm of bladder
0.643 0.356 0.000
Z12.5 Special screening examination for neoplasm of prostate
0.643 0.356 0.000
Z12.4 Special screening examination for neoplasm of cervix
0.643 0.356 0.000
Z12.3 Special screening examination for neoplasm of breast
0.643 0.356 0.000
Z12.2 Special screening examination for neoplasm of respiratory organs
0.643 0.356 0.000
Z12.0 Special screening examination for neoplasm of stomach
0.643 0.356 0.000
X62 Intentional self-poisoning by and exposure to narcotics and psychodysleptics [hallucinogens], not elsewhere classified
0.643 0.357 0.000
I22 Subsequent myocardial infarction
0.641 0.358 0.000
Z01.8 Other specified special examinations
0.639 0.361 0.000
Z48 Other surgical follow-up care
0.638 0.362 0.000
C25.9 Pancreas, unspecified
0.638 0.362 0.000
Z98.1 Arthrodesis status
0.637 0.363 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.637 0.363 0.000
I21.0 Acute transmural myocardial infarction of anterior wall
0.637 0.363 0.000
N99-N99 Other disorders of the genitourinary system
0.635 0.365 0.000
Z90.6 Acquired absence of other parts of urinary tract
0.635 0.365 0.000
I12 Hypertensive renal disease
0.634 0.366 0.000
N87 Dysplasia of cervix uteri
0.634 0.366 0.000
Z99.2 Dependence on renal dialysis
0.634 0.366 0.000
Z90.8 Acquired absence of other organs
0.634 0.366 0.000
Z90.0 Acquired absence of part of head and neck
0.634 0.366 0.000
S81 Open wound of lower leg
0.633 0.367 0.000
T85.8 Other complications of internal prosthetic devices, implants and grafts, not elsewhere classified
0.631 0.368 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.631 0.369 0.000
Z54 Convalescence
0.630 0.369 0.000
Z44 Fitting and adjustment of external prosthetic device
0.630 0.369 0.000
M85 Other disorders of bone density and structure
0.630 0.370 0.000
M84 Disorders of continuity of bone
0.630 0.370 0.000
M83 Adult osteomalacia
0.630 0.370 0.000
M82 Osteoporosis in diseases classified elsewhere
0.630 0.370 0.000
Y43 Primarily systemic agents
0.628 0.371 0.000
C44.5 Skin of trunk
0.627 0.373 0.000
Y83.6 Removal of other organ (partial) (total)
0.627 0.373 0.000
D12.4 Descending colon
0.626 0.374 0.000
I74 Arterial embolism and thrombosis
0.626 0.374 0.000
E86 Volume depletion
0.625 0.375 0.000
I77 Other disorders of arteries and arterioles
0.625 0.375 0.000
D09 Carcinoma in situ of other and unspecified sites
0.625 0.375 0.000
D07 Carcinoma in situ of other and unspecified genital organs
0.625 0.375 0.000
D04 Carcinoma in situ of skin
0.625 0.375 0.000
D02 Carcinoma in situ of middle ear and respiratory system
0.625 0.375 0.000
D01 Carcinoma in situ of other and unspecified digestive organs
0.625 0.375 0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.625 0.375 0.000
E87.5 Hyperkalaemia
0.624 0.376 0.000
S02.4 Fracture of malar and maxillary bones
0.623 0.377 0.000
D13 Benign neoplasm of other and ill-defined parts of digestive system
0.623 0.377 0.000
T80.2 Infections following infusion, transfusion and therapeutic injection
0.623 0.377 0.000
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
0.622 0.377 0.000
C39 Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs
0.622 0.377 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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