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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs75489010
log Bayes Factor = 27.7624
Chromosome 12   position 115,986,702  (GRCh37) Explore rs75489010 on Ensembl!
Variant rs75489010 is part of Cluster X0087

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter XXI Factors influencing health status and contact with health services
1.000 0.000 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
1.000 0.000 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.999 0.001 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.998 0.002 0.000
Chapter VI Diseases of the nervous system
0.998 0.002 0.000
M20-M25 Other joint disorders
0.997 0.003 0.000
R10.4 Other and unspecified abdominal pain
0.995 0.005 0.000
R10 Abdominal and pelvic pain
0.995 0.005 0.000
R91 Abnormal findings on diagnostic imaging of lung
0.995 0.005 0.000
C76-C80 Malignant neoplasms of ill-defined, secondary and unspecified sites
0.994 0.006 0.000
R10-R19 Symptoms and signs involving the digestive system and abdomen
0.994 0.006 0.000
G50-G59 Nerve, nerve root and plexus disorders
0.993 0.007 0.000
C50-C50 Malignant neoplasm of breast
0.992 0.008 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.990 0.010 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.990 0.010 0.000
R40-R46 Symptoms and signs involving cognition, perception, emotional state and behaviour
0.989 0.011 0.000
C50 Malignant neoplasm of breast
0.986 0.014 0.000
G55 Nerve root and plexus compressions in diseases classified elsewhere
0.985 0.015 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.984 0.016 0.000
Z49 Care involving dialysis
0.981 0.019 0.000
E70-E90 Metabolic disorders
0.980 0.020 0.000
Chapter VIII Diseases of the ear and mastoid process
0.980 0.020 0.000
Z91.1 Personal history of noncompliance with medical treatment and regimen
0.977 0.023 0.000
Z88 Personal history of allergy to drugs, medicaments and biologocal substances
0.976 0.024 0.000
M20 Acquired deformities of fingers and toes
0.975 0.025 0.000
Z48 Other surgical follow-up care
0.973 0.027 0.000
Chapter X Diseases of the respiratory system
0.970 0.030 0.000
Z88.8 Personal history of allergy to other drugs, medicaments and biological substances
0.969 0.031 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.967 0.033 0.000
C50.9 Breast, unspecified
0.966 0.034 0.000
R10.1 Pain localised to upper abdomen
0.964 0.036 0.000
Z98 Other postsurgical states
0.963 0.037 0.000
Z95 Presence of cardiac and vascular implants and grafts
0.961 0.039 0.000
G55.1 Nerve root and plexus compressions in intervertebral disk disorders
0.956 0.044 0.000
M25 Other joint disorders, not elsewhere classified
0.955 0.045 0.000
Z50 Care involving use of rehabilitation procedures
0.952 0.048 0.000
C78 Secondary malignant neoplasm of respiratory and digestive organs
0.952 0.048 0.000
R50-R69 General symptoms and signs
0.950 0.050 0.000
Chapter XX External causes of morbidity and mortality
0.949 0.051 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.948 0.052 0.000
R41 Other symptoms and signs involving cognitive functions and awareness
0.945 0.055 0.000
Z42 Follow-up care involving plastic surgery
0.942 0.058 0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias
0.940 0.060 0.000
Z49.0 Preparatory care for dialysis
0.938 0.062 0.000
D70 Agranulocytosis
0.935 0.065 0.000
G90-G99 Other disorders of the nervous system
0.933 0.067 0.000
E78.5 Hyperlipidaemia, unspecified
0.932 0.068 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.931 0.069 0.000
Z95.1 Presence of aortocoronary bypass graft
0.930 0.070 0.000
R41.0 Disorientation, unspecified
0.929 0.071 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.929 0.071 0.000
R00-R09 Symptoms and signs involving the circulatory and respiratory systems
0.926 0.074 0.000
R94 Abnormal results of function studies
0.924 0.076 0.000
C78.0 Secondary malignant neoplasm of lung
0.919 0.081 0.000
Z48.8 Other specified surgical follow-up care
0.919 0.081 0.000
M24 Other specific joint derangements
0.917 0.083 0.000
C15-C26 Malignant neoplasms of digestive organs
0.917 0.083 0.000
H65-H75 Diseases of middle ear and mastoid
0.917 0.083 0.000
T36-T50 Poisoning by drugs, medicaments and biological substances
0.917 0.083 0.000
S80-S89 Injuries to the knee and lower leg
0.916 0.084 0.000
Z45 Adjustment and management of implanted device
0.915 0.085 0.000
M20.4 Other hammer toe(s) (acquired)
0.915 0.085 0.000
C79 Secondary malignant neoplasm of other sites
0.914 0.086 0.000
C50.4 Upper-outer quadrant of breast
0.902 0.098 0.000
R42 Dizziness and giddiness
0.901 0.099 0.000
R47-R49 Symptoms and signs involving speech and voice
0.900 0.100 0.000
Z88.3 Personal history of allergy to other anti-infective agents
0.896 0.104 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.894 0.106 0.000
M45-M49 Spondylopathies
0.894 0.106 0.000
Z98.1 Arthrodesis status
0.893 0.107 0.000
Z49.1 Extracorporeal dialysis
0.893 0.107 0.000
J20-J22 Other acute lower respiratory infections
0.893 0.107 0.000
Z72 Problems related to lifestyle
0.892 0.108 0.000
R17 Unspecified jaundice
0.885 0.115 0.000
M20.1 Hallux valgus (acquired)
0.884 0.116 0.000
Z48.0 Attention to surgical dressings and sutures
0.884 0.116 0.000
Z50.1 Other physical therapy
0.883 0.117 0.000
Z45.8 Adjustment and management of other implanted devices
0.882 0.118 0.000
R00 Abnormalities of heart beat
0.879 0.121 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.879 0.121 0.000
Z50.0 Cardiac rehabilitation
0.876 0.123 0.000
G55.3 Nerve root and plexus compressions in other dorsopathies
0.876 0.124 0.000
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts
0.875 0.125 0.000
E00-E07 Disorders of thyroid gland
0.872 0.128 0.000
Z72.0 Tobacco use
0.871 0.129 0.000
G51 Facial nerve disorders
0.865 0.135 0.000
T66-T78 Other and unspecified effects of external causes
0.864 0.136 0.000
R94.5 Abnormal results of liver function studies
0.864 0.136 0.000
J40-J47 Chronic lower respiratory diseases
0.862 0.138 0.000
T85 Complications of other internal prosthetic devices, implants and grafts
0.862 0.138 0.000
R00.2 Palpitations
0.861 0.139 0.000
D47 Other neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
0.861 0.139 0.000
M48 Other spondylopathies
0.860 0.140 0.000
H90-H95 Other disorders of ear
0.860 0.140 0.000
Z42.0 Follow-up care involving plastic surgery of head and neck
0.857 0.143 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.854 0.146 0.000
J09-J18 Influenza and pneumonia
0.852 0.148 0.000
R53 Malaise and fatigue
0.851 0.149 0.000
Z40 Prophylactic surgery
0.851 0.149 0.000
C80 Malignant neoplasm without specification of site
0.850 0.150 0.000
M24.1 Other articular cartilage disorders
0.844 0.156 0.000
Z92 Personal history of medical treatment
0.841 0.159 0.000
M50-M54 Other dorsopathies
0.837 0.163 0.000
Z91.5 Personal history of self-harm
0.836 0.164 0.000
C79.3 Secondary malignant neoplasm of brain and cerebral meninges
0.833 0.167 0.000
Chapter VII Diseases of the eye and adnexa
0.833 0.167 0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs
0.830 0.170 0.000
E86 Volume depletion
0.830 0.170 0.000
M48.0 Spinal stenosis
0.829 0.171 0.000
R16 Hepatomegaly and splenomegaly, not elsewhere classified
0.828 0.172 0.000
M70-M79 Other soft tissue disorders
0.828 0.172 0.000
J22 Unspecified acute lower respiratory infection
0.828 0.172 0.000
Chapter V Mental and behavioural disorders
0.827 0.173 0.000
E83 Disorders of mineral metabolism
0.826 0.174 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.825 0.175 0.000
Z98.0 Intestinal bypass and anastomosis status
0.825 0.175 0.000
C22 Malignant neoplasm of liver and intrahepatic bile ducts
0.825 0.175 0.000
C69-C72 Malignant neoplasms of eye, brain and other parts of central nervous system
0.824 0.176 0.000
Z93 Artificial opening status
0.823 0.177 0.000
Z94 Transplanted organ and tissue status
0.821 0.179 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.821 0.179 0.000
R59 Enlarged lymph nodes
0.818 0.182 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.818 0.182 0.000
H60-H62 Diseases of external ear
0.817 0.183 0.000
S50-S59 Injuries to the elbow and forearm
0.816 0.184 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.816 0.184 0.000
C77 Secondary and unspecified malignant neoplasm of lymph nodes
0.815 0.185 0.000
M25.5 Pain in joint
0.814 0.186 0.000
G93 Other disorders of brain
0.814 0.186 0.000
C79.7 Secondary malignant neoplasm of adrenal gland
0.813 0.186 0.000
M20.5 Other deformities of toe(s) (acquired)
0.813 0.187 0.000
S70-S79 Injuries to the hip and thigh
0.812 0.188 0.000
Z42.1 Follow-up care involving plastic surgery of breast
0.812 0.188 0.000
G55.2 Nerve root and plexus compressions in spondylosis
0.812 0.188 0.000
R47 Speech disturbances, not elsewhere classified
0.812 0.188 0.000
R04 Haemorrhage from respiratory passages
0.811 0.189 0.000
D73 Diseases of spleen
0.809 0.191 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.808 0.192 0.000
H90 Conductive and sensorineural hearing loss
0.808 0.192 0.000
D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organs
0.807 0.193 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.803 0.197 0.000
R56 Convulsions, not elsewhere classified
0.803 0.197 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.802 0.198 0.000
R83-R89 Abnormal findings on examination of other body fluids, substances and tissues, without diagnosis
0.802 0.198 0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified
0.801 0.199 0.000
C50.1 Central portion of breast
0.799 0.201 0.000
R25-R29 Symptoms and signs involving the nervous and musculoskeletal systems
0.799 0.201 0.000
J00-J06 Acute upper respiratory infections
0.799 0.201 0.000
Z98.8 Other specified postsurgical states
0.798 0.202 0.000
C78.5 Secondary malignant neoplasm of large intestine and rectum
0.797 0.203 0.000
M22 Disorders of patella
0.794 0.206 0.000
M48.06 Spinal stenosis (Lumbar region)
0.793 0.207 0.000
E20-E35 Disorders of other endocrine glands
0.793 0.207 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.792 0.208 0.000
T82.7 Infection and inflammatory reaction due to other cardiac and vascular devices, implants and grafts
0.791 0.209 0.000
C50.5 Lower-outer quadrant of breast
0.790 0.210 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.789 0.210 0.000
G60-G64 Polyneuropathies and other disorders of the peripheral nervous system
0.789 0.210 0.000
Z84 Family history of other conditions
0.787 0.213 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.787 0.213 0.000
R44 Other symptoms and signs involving general sensations and perceptions
0.787 0.213 0.000
S10-S19 Injuries to the neck
0.785 0.214 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.785 0.215 0.000
D72 Other disorders of white blood cells
0.785 0.215 0.000
Z92.3 Personal history of irradiation
0.784 0.216 0.000
Z88.4 Personal history of allergy to anaesthetic agent
0.784 0.216 0.000
Z91.0 Personal history of allergy, other than to drugs and biological substances
0.784 0.216 0.000
G99 Other disorders of nervous system in diseases classified elsewhere
0.783 0.217 0.000
T79-T79 Certain early complications of trauma
0.782 0.217 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.782 0.218 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.782 0.218 0.000
Chapter I Certain infectious and parasitic diseases
0.782 0.218 0.000
M60-M63 Disorders of muscles
0.779 0.221 0.000
R50 Fever of unknown origin
0.778 0.222 0.000
C20 Malignant neoplasm of rectum
0.776 0.224 0.000
Y52 Agents primarily affecting the cardiovascular system
0.775 0.225 0.000
Z95.9 Presence of cardiac and vascular implant and graft, unspecified
0.775 0.225 0.000
G51.0 Bell's palsy
0.774 0.226 0.000
G70-G73 Diseases of myoneural junction and muscle
0.774 0.226 0.000
T85.7 Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
0.774 0.226 0.000
T85.5 Mechanical complication of gastro-intestinal prosthetic devices, implants and grafts
0.771 0.229 0.000
Z95.5 Presence of coronary angioplasty implant and graft
0.771 0.229 0.000
M25.7 Osteophyte
0.770 0.230 0.000
Z99.2 Dependence on renal dialysis
0.770 0.230 0.000
D55-D59 Haemolytic anaemias
0.768 0.232 0.000
H72 Perforation of tympanic membrane
0.768 0.232 0.000
Z81 Family history of mental and behavioural disorders
0.767 0.232 0.000
T78 Adverse effects, not elsewhere classified
0.767 0.233 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.767 0.233 0.000
M31 Other necrotising vasculopathies
0.766 0.234 0.000
H30-H36 Disorders of choroid and retina
0.765 0.235 0.000
M25.4 Effusion of joint
0.765 0.235 0.000
Z83 Family history of other specific disorders
0.764 0.236 0.000
H65 Nonsuppurative otitis media
0.763 0.237 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.763 0.237 0.000
S20-S29 Injuries to the thorax
0.761 0.239 0.000
Z50.8 Care involving use of rehabilitation procedures
0.760 0.239 0.000
M86-M90 Other osteopathies
0.760 0.240 0.000
R05 Cough
0.760 0.240 0.000
R04.2 Haemoptysis
0.760 0.240 0.000
Z74 Problems related to care-provider dependency
0.760 0.240 0.000
R14 Flatulence and related conditions
0.760 0.240 0.000
E65-E68 Obesity and other hyperalimentation
0.758 0.242 0.000
G59 Mononeuropathy in diseases classified elsewhere
0.757 0.243 0.000
G55.0 Nerve root and plexus compressions in neoplastic disease
0.757 0.243 0.000
R61 Hyperhidrosis
0.755 0.244 0.000
E03 Other hypothyroidism
0.752 0.248 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.751 0.249 0.000
C77.0 Lymph nodes of head, face and neck
0.750 0.250 0.000
Z95.4 Presence of other heart-valve replacement
0.750 0.250 0.000
R02 Gangrene, not elsewhere classified
0.749 0.251 0.000
H74 Other disorders of middle ear and mastoid
0.747 0.253 0.000
M25.3 Other instability of joint
0.747 0.253 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.747 0.253 0.000
R69 Unknown and unspecified causes of morbidity
0.746 0.254 0.000
S82 Fracture of lower leg, including ankle
0.746 0.254 0.000
F30-F39 Mood [affective] disorders
0.746 0.254 0.000
Z88.5 Personal history of allergy to narcotic agent
0.746 0.254 0.000
D50-D53 Nutritional anaemias
0.745 0.255 0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs
0.744 0.255 0.000
E87.5 Hyperkalaemia
0.744 0.256 0.000
Z40.0 Prophylactic surgery for risk-factors related to malignant neoplasms
0.744 0.256 0.000
C78.7 Secondary malignant neoplasm of liver
0.743 0.257 0.000
G54 Nerve root and plexus disorders
0.743 0.257 0.000
G80-G83 Cerebral palsy and other paralytic syndromes
0.743 0.257 0.000
Z99.8 Dependence on other enabling machines and devices
0.743 0.257 0.000
Y43 Primarily systemic agents
0.742 0.257 0.000
J84 Other interstitial pulmonary diseases
0.742 0.258 0.000
R40 Somnolence, stupor and coma
0.742 0.258 0.000
J40 Bronchitis, not specified as acute or chronic
0.741 0.259 0.000
E88 Other metabolic disorders
0.740 0.260 0.000
D80-D89 Certain disorders involving the immune mechanism
0.740 0.260 0.000
Z95.3 Presence of xenogenic heart valve
0.740 0.260 0.000
Z88.7 Personal history of allergy to serum and vaccine
0.739 0.261 0.000
Z92.8 Personal history of other medical treatment
0.738 0.262 0.000
J47 Bronchiectasis
0.738 0.262 0.000
M79 Other soft tissue disorders, not elsewhere classified
0.737 0.262 0.000
C78.2 Secondary malignant neoplasm of pleura
0.737 0.263 0.000
R59.0 Localised enlarged lymph nodes
0.735 0.265 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.735 0.265 0.000
G90 Disorders of autonomic nervous system
0.734 0.266 0.000
M21 Other acquired deformities of limbs
0.734 0.266 0.000
S80 Superficial injury of lower leg
0.734 0.266 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.734 0.266 0.000
C79.0 Secondary malignant neoplasm of kidney and renal pelvis
0.733 0.267 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.733 0.267 0.000
M25.8 Other specified joint disorders
0.732 0.267 0.000
R47.0 Dysphasia and aphasia
0.732 0.268 0.000
G30-G32 Other degenerative diseases of the nervous system
0.731 0.269 0.000
D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sites
0.730 0.270 0.000
H35 Other retinal disorders
0.730 0.270 0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances
0.729 0.271 0.000
R60 Oedema, not elsewhere classified
0.729 0.271 0.000
M40-M43 Deforming dorsopathies
0.728 0.272 0.000
M00-M03 Infectious arthropathies
0.728 0.272 0.000
R45 Symptoms and signs involving emotional state
0.728 0.272 0.000
Z97 Presence of other devices
0.727 0.272 0.000
Chapter XXII Codes for special purposes
0.727 0.273 0.000
R41.2 Retrograde amnesia
0.727 0.273 0.000
C16 Malignant neoplasm of stomach
0.727 0.273 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.727 0.273 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.726 0.274 0.000
H80-H83 Diseases of inner ear
0.725 0.275 0.000
S90-S99 Injuries to the ankle and foot
0.724 0.276 0.000
Z89 Acquired absence of limb
0.723 0.277 0.000
D47.4 Osteomyelofibrosis
0.722 0.278 0.000
M91-M94 Chondropathies
0.721 0.279 0.000
C80.0 Malignant neoplasm, primary site unknown, so stated
0.721 0.279 0.000
H71 Cholesteatoma of middle ear
0.721 0.279 0.000
F60-F69 Disorders of adult personality and behaviour
0.718 0.282 0.000
E06 Thyroiditis
0.718 0.282 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
Z54 Convalescence
0.717 0.283 0.000
Z44 Fitting and adjustment of external prosthetic device
0.717 0.283 0.000
T82.3 Mechanical complication of other vascular grafts
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
C22.0 Liver cell carcinoma
0.716 0.283 0.000
R25 Abnormal involuntary movements
0.716 0.284 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.716 0.284 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.716 0.284 0.000
R92 Abnormal findings on diagnostic imaging of breast
0.716 0.284 0.000
G10-G14 Systemic atrophies primarily affecting the central nervous system
0.715 0.284 0.000
G00-G09 Inflammatory diseases of the central nervous system
0.715 0.284 0.000
G56 Mononeuropathies of upper limb
0.715 0.285 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.715 0.285 0.000
M34 Systemic sclerosis
0.715 0.285 0.000
M33 Dermatopolymyositis
0.715 0.285 0.000
M32 Systemic lupus erythematosus
0.715 0.285 0.000
M30 Polyarteritis nodosa and related conditions
0.715 0.285 0.000
T86 Failure and rejection of transplanted organs and tissues
0.715 0.285 0.000
R57 Shock, not elsewhere classified
0.714 0.286 0.000
C76 Malignant neoplasm of other and ill-defined sites
0.713 0.287 0.000
Z45.0 Adjustment and management of cardiac pacemaker
0.713 0.287 0.000
C50.2 Upper-inner quadrant of breast
0.712 0.288 0.000
G58 Other mononeuropathies
0.712 0.288 0.000
G53 Cranial nerve disorders in diseases classified elsewhere
0.712 0.288 0.000
G52 Disorders of other cranial nerves
0.712 0.288 0.000
X20-X29 Contact with venomous animals and plants
0.712 0.288 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.712 0.288 0.000
D47.3 Essential (haemorrhagic) thrombocythaemia
0.711 0.288 0.000
H66 Suppurative and unspecified otitis media
0.711 0.289 0.000
C21 Malignant neoplasm of anus and anal canal
0.711 0.289 0.000
D45 Polycythaemia vera
0.711 0.289 0.000
E40-E46 Malnutrition
0.710 0.290 0.000
Z91.8 Personal history of other specified risk-factors, not elsewhere classified
0.710 0.290 0.000
Z91.7 Personal history of female genital mutilation
0.710 0.290 0.000
Z91.4 Personal history of psychological trauma, not elsewhere classified
0.710 0.290 0.000
Z91.3 Personal history of unhealthy sleep-wake schedule
0.710 0.290 0.000
Z91.2 Personal history of poor personal hygiene
0.710 0.290 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.709 0.290 0.000
G95 Other diseases of spinal cord
0.709 0.291 0.000
R46 Symptoms and signs involving appearance and behaviour
0.709 0.291 0.000
R43 Disturbances of smell and taste
0.709 0.291 0.000
Z50.5 Speech therapy
0.708 0.292 0.000
C50.6 Axillary tail of breast
0.707 0.293 0.000
C50.0 Nipple and areola
0.707 0.293 0.000
Z93.3 Colostomy status
0.707 0.293 0.000
G55.8 Nerve root and plexus compressions in other diseases classified elsewhere
0.706 0.294 0.000
R09 Other symptoms and signs involving the circulatory and respiratory systems
0.706 0.294 0.000
Y57 Other and unspecified drugs and medicaments
0.706 0.294 0.000
S60-S69 Injuries to the wrist and hand
0.705 0.294 0.000
Z52 Donors of organs and tissues
0.705 0.295 0.000
R10.0 Acute abdomen
0.705 0.295 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.704 0.296 0.000
Z49.2 Other dialysis
0.703 0.297 0.000
E85 Amyloidosis
0.702 0.297 0.000
E84 Cystic fibrosis
0.702 0.297 0.000
E79 Disorders of purine and pyrimidine metabolism
0.702 0.297 0.000
E77 Disorders of glycoprotein metabolism
0.702 0.297 0.000
E76 Disorders of glycosaminoglycan metabolism
0.702 0.297 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.702 0.297 0.000
E74 Other disorders of carbohydrate metabolism
0.702 0.297 0.000
E73 Lactose intolerance
0.702 0.297 0.000
E72 Other disorders of amino-acid metabolism
0.702 0.297 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.702 0.297 0.000
E70 Disorders of aromatic amino-acid metabolism
0.702 0.297 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.702 0.297 0.000
M25.56 Pain in joint (Lower leg)
0.702 0.298 0.000
E83.5 Disorders of calcium metabolism
0.702 0.298 0.000
G40-G47 Episodic and paroxysmal disorders
0.702 0.298 0.000
Z41 Procedures for purposes other than remedying health state
0.702 0.298 0.000
Y85-Y89 Sequelae of external causes of morbidity and mortality
0.702 0.298 0.000
X60-X84 Intentional self-harm
0.701 0.298 0.000
D75 Other diseases of blood and blood-forming organs
0.701 0.299 0.000
M25.51 Pain in joint (Shoulder region)
0.700 0.300 0.000
T43.5 Other and unspecified antipsychotics and neuroleptics
0.700 0.300 0.000
M20.3 Other deformity of hallux (acquired)
0.699 0.301 0.000
Z36 Antenatal screening
0.699 0.301 0.000
A30-A49 Other bacterial diseases
0.698 0.302 0.000
C71 Malignant neoplasm of brain
0.697 0.303 0.000
R94.3 Abnormal results of cardiovascular function studies
0.697 0.303 0.000
R56.8 Other and unspecified convulsions
0.697 0.303 0.000
M79.6 Pain in limb
0.697 0.303 0.000
M24.0 Loose body in joint
0.696 0.304 0.000
D73.0 Hyposplenism
0.696 0.304 0.000
Z99.1 Dependence on respirator
0.695 0.305 0.000
J95-J99 Other diseases of the respiratory system
0.694 0.306 0.000
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system
0.694 0.306 0.000
D74 Methaemoglobinaemia
0.694 0.306 0.000
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere
0.694 0.306 0.000
D71 Functional disorders of polymorphonuclear neutrophils
0.694 0.306 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.693 0.307 0.000
H00-H06 Disorders of eyelid, lacrimal system and orbit
0.693 0.307 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.692 0.307 0.000
Z53 Persons encountering health services for specifie procedures, not carried out
0.692 0.308 0.000
M25.50 Pain in joint (Multiple sites)
0.691 0.309 0.000
R49 Voice disturbances
0.691 0.309 0.000
R50.9 Fever, unspecified
0.691 0.309 0.000
S00-S09 Injuries to the head
0.691 0.309 0.000
T82.2 Mechanical complication of coronary artery bypass and valve grafts
0.690 0.310 0.000
Z35 Supervision of high-risk pregnancy
0.690 0.310 0.000
M20.0 Deformity of finger(s)
0.688 0.312 0.000
M20.2 Hallux rigidus
0.687 0.313 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.687 0.313 0.000
T78.4 Allergy, unspecified
0.687 0.313 0.000
Z86 Personal history of certain other diseases
0.686 0.314 0.000
R51 Headache
0.686 0.314 0.000
S40-S49 Injuries to the shoulder and upper arm
0.685 0.315 0.000
M25.9 Joint disorder, unspecified
0.685 0.315 0.000
M25.2 Flail joint
0.685 0.315 0.000
M25.1 Fistula of joint
0.685 0.315 0.000
M25.0 Haemarthrosis
0.685 0.315 0.000
M24.15 Other articular cartilage disorders (Pelvic region and thigh)
0.684 0.316 0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified
0.684 0.316 0.000
Z50.6 Orthoptic training
0.683 0.317 0.000
Z50.4 Psychotherapy, not elsewhere classified
0.683 0.317 0.000
Z50.3 Drug rehabilitation
0.683 0.317 0.000
C78.4 Secondary malignant neoplasm of small intestine
0.682 0.317 0.000
C78.3 Secondary malignant neoplasm of other and unspecified respiratory organs
0.682 0.317 0.000
C78.1 Secondary malignant neoplasm of mediastinum
0.682 0.317 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.681 0.319 0.000
R62 Lack of expected normal physiological development
0.681 0.319 0.000
R64 Cachexia
0.681 0.319 0.000
R58 Haemorrhage, not elsewhere classified
0.681 0.319 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.680 0.319 0.000
Y35-Y36 Legal intervention and operations of war
0.680 0.319 0.000
Y10-Y34 Event of undetermined intent
0.680 0.319 0.000
Y00-Y09 Assault
0.680 0.319 0.000
X85-X99 Assault
0.680 0.319 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.680 0.319 0.000
X50-X57 Overexertion, travel and privation
0.680 0.319 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.680 0.319 0.000
X30-X39 Exposure to forces of nature
0.680 0.319 0.000
X10-X19 Contact with heat and hot substances
0.680 0.319 0.000
X00-X09 Exposure to smoke, fire and flames
0.680 0.319 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.680 0.319 0.000
W75-W84 Other accidental threats to breathing
0.680 0.319 0.000
W65-W74 Accidental drowning and submersion
0.680 0.319 0.000
W50-W64 Exposure to animate mechanical forces
0.680 0.319 0.000
V98-V99 Other and unspecified transport accidents
0.680 0.319 0.000
V95-V97 Air and space transport accidents
0.680 0.319 0.000
V90-V94 Water transport accidents
0.680 0.319 0.000
V80-V89 Other land transport accidents
0.680 0.319 0.000
V70-V79 Bus occupant injured in transport accident
0.680 0.319 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.680 0.319 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.680 0.319 0.000
V40-V49 Car occupant injured in transport accident
0.680 0.319 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.680 0.319 0.000
V01-V09 Pedestrian injured in transport accident
0.680 0.319 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.680 0.320 0.000
Z93.0 Tracheostomy status
0.680 0.320 0.000
D44 Neoplasm of uncertain or unknown behaviour of endocrine glands
0.679 0.320 0.000
D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous system
0.679 0.320 0.000
D42 Neoplasm of uncertain or unknown behaviour of meninges
0.679 0.320 0.000
D40 Neoplasm of uncertain or unknown behaviour of male genital organs
0.679 0.320 0.000
D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organs
0.679 0.320 0.000
G50 Disorders of trigeminal nerve
0.678 0.322 0.000
R41.1 Anterograde amnesia
0.678 0.322 0.000
W20-W49 Exposure to inanimate mechanical forces
0.678 0.322 0.000
Z48.9 Surgical follow-up care, unspecified
0.677 0.322 0.000
J20 Acute bronchitis
0.677 0.323 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.677 0.323 0.000
D39 Neoplasm of uncertain or unknown behaviour of female genital organs
0.677 0.323 0.000
G93.9 Disorder of brain, unspecified
0.676 0.324 0.000
H90.2 Conductive hearing loss, unspecified
0.676 0.324 0.000
Z75 Problems related to medical facilities and other health care
0.675 0.325 0.000
Z42.9 Follow-up care involving plastic surgery, unspecified
0.675 0.325 0.000
Z42.8 Follow-up care involving plastic surgery of other body part
0.675 0.325 0.000
Z42.4 Follow-up care involving plastic surgery of lower extremity
0.675 0.325 0.000
Z42.3 Follow-up care involving plastic surgery of upper extremity
0.675 0.325 0.000
Z42.2 Follow-up care involving plastic surgery of other parts of trunk
0.675 0.325 0.000
H92 Otalgia and effusion of ear
0.675 0.325 0.000
E78.9 Disorder of lipoprotein metabolism, unspecified
0.674 0.326 0.000
E78.8 Other disorders of lipoprotein metabolism
0.674 0.326 0.000
E78.6 Lipoprotein deficiency
0.674 0.326 0.000
E78.4 Other hyperlipidaemia
0.674 0.326 0.000
E78.3 Hyperchylomicronaemia
0.674 0.326 0.000
E78.1 Pure hyperglyceridaemia
0.674 0.326 0.000
Z94.0 Kidney transplant status
0.673 0.327 0.000
D47.1 Chronic myeloproliferative disease
0.673 0.327 0.000
F33 Recurrent depressive disorder
0.672 0.328 0.000
M24.11 Other articular cartilage disorders (Shoulder region)
0.672 0.328 0.000
D46 Myelodysplastic syndromes
0.672 0.328 0.000
T85.6 Mechanical complication of other specified internal prosthetic devices, implants and grafts
0.672 0.328 0.000
J00 Acute nasopharyngitis [common cold]
0.672 0.328 0.000
D00-D09 In situ neoplasms
0.672 0.328 0.000
H55-H59 Other disorders of eye and adnexa
0.672 0.328 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.671 0.329 0.000
M25.75 Osteophyte (Pelvic region and thigh)
0.671 0.329 0.000
D37.5 Rectum
0.670 0.330 0.000
Chapter XIV Diseases of the genitourinary system
0.669 0.331 0.000
G97 Postprocedural disorders of nervous system, not elsewhere classified
0.669 0.331 0.000
G94 Other disorders of brain in diseases classified elsewhere
0.669 0.331 0.000
G98 Other disorders of nervous system, not elsewhere classified
0.669 0.331 0.000
G92 Toxic encephalopathy
0.669 0.331 0.000
M48.5 Collapsed vertebra, not elsewhere classified
0.669 0.331 0.000
G96 Other disorders of central nervous system
0.669 0.331 0.000
D60-D64 Aplastic and other anaemias
0.669 0.331 0.000
Z76 Persons encountering health services in other circumstances
0.668 0.332 0.000
Z70 Counselling related to sexual attitude, behaviour and orientation
0.668 0.332 0.000
M51 Other intervertebral disk disorders
0.667 0.333 0.000
E03.9 Hypothyroidism, unspecified
0.667 0.333 0.000
T63 Toxic effect of contact with venomous animals
0.667 0.333 0.000
T87 Complications peculiar to reattachment and amputation
0.666 0.334 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.666 0.334 0.000
H90.0 Conductive hearing loss, bilateral
0.666 0.334 0.000
R54 Senility
0.665 0.335 0.000
J84.1 Other interstitial pulmonary diseases with fibrosis
0.665 0.335 0.000
H90.5 Sensorineural hearing loss, unspecified
0.665 0.335 0.000
T82.5 Mechanical complication of other cardiac and vascular devices and implants
0.664 0.336 0.000
R16.0 Hepatomegaly, not elsewhere classified
0.664 0.336 0.000
H15-H22 Disorders of sclera, cornea, iris and ciliary body
0.664 0.336 0.000
C82 Follicular [nodular] non-Hodgkin's lymphoma
0.664 0.336 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.663 0.337 0.000
R94.8 Abnormal results of function studies of other organs and systems
0.663 0.337 0.000
R94.7 Abnormal results of other endocrine function studies
0.663 0.337 0.000
R94.6 Abnormal results of thyroid function studies
0.663 0.337 0.000
R94.4 Abnormal results of kidney function studies
0.663 0.337 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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