TreeWAS – Variant ID: rs77542162

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability
E78.0 Pure hypercholesterolaemia	1.000	0.000
Chapter IX Diseases of the circulatory system	1.000	0.000
# Top node	1.000	0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue	1.000	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	1.000	0.000
I20-I25 Ischaemic heart diseases	1.000	0.000
M20-M25 Other joint disorders	1.000	0.000
E78 Disorders of lipoprotein metabolism and other lipidaemias	0.999	0.001
M20 Acquired deformities of fingers and toes	0.998	0.002
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified	0.995	0.005
I70-I79 Diseases of arteries, arterioles and capillaries	0.994	0.006
I25 Chronic ischaemic heart disease	0.994	0.006
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.990	0.010
Chapter XXI Factors influencing health status and contact with health services	0.990	0.010
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status	0.989	0.011
M80-M85 Disorders of bone density and structure	0.986	0.014
Z86 Personal history of certain other diseases	0.986	0.014
Chapter IV Endocrine, nutritional and metabolic diseases	0.985	0.015
Z86.7 Personal history of diseases of the circulatory system	0.985	0.015
E70-E90 Metabolic disorders	0.985	0.015
I26 Pulmonary embolism	0.982	0.018
I20 Angina pectoris	0.981	0.019
Z95 Presence of cardiac and vascular implants and grafts	0.981	0.019
E78.5 Hyperlipidaemia, unspecified	0.977	0.023
I26.9 Pulmonary embolism without mention of acute cor pulmonale	0.977	0.023
S60-S69 Injuries to the wrist and hand	0.976	0.024
I80 Phlebitis and thrombophlebitis	0.976	0.024
Z82 Family history of certain disabilities and chronic diseases leading to disablement	0.974	0.026
I25.1 Atherosclerotic heart disease	0.970	0.030
Z95.1 Presence of aortocoronary bypass graft	0.969	0.031
M81 Osteoporosis without pathological fracture	0.963	0.037
I20.9 Angina pectoris, unspecified	0.962	0.038
Z82.4 Family history of ischaemic heart disease and other diseases of the circulatory system	0.960	0.040
S80-S89 Injuries to the knee and lower leg	0.956	0.044
M20.2 Hallux rigidus	0.951	0.049
M20.1 Hallux valgus (acquired)	0.950	0.050
I71 Aortic aneurysm and dissection	0.949	0.051
M81.9 Osteoporosis, unspecified	0.948	0.052
M20.4 Other hammer toe(s) (acquired)	0.945	0.055
S82 Fracture of lower leg, including ankle	0.939	0.061
I73 Other peripheral vascular diseases	0.939	0.061
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities	0.938	0.062
M81.99 Osteoporosis, unspecified (Site unspecified)	0.934	0.066
I21 Acute myocardial infarction	0.928	0.072
Z83 Family history of other specific disorders	0.925	0.075
Z20-Z29 Persons with potential health hazards related to communicable diseases	0.912	0.088
Z95.8 Presence of other cardiac and vascular implants and grafts	0.909	0.091
I73.9 Peripheral vascular disease, unspecified	0.907	0.093
M35 Other systemic involvement of connective tissue	0.906	0.094
I25.2 Old myocardial infarction	0.902	0.098
I71.4 Abdominal aortic aneurysm, without mention of rupture	0.901	0.099
I21.9 Acute myocardial infarction, unspecified	0.898	0.102
I83 Varicose veins of lower extremities	0.898	0.102
S50-S59 Injuries to the elbow and forearm	0.896	0.104
I95-I99 Other and unspecified disorders of the circulatory system	0.896	0.104
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.893	0.107
S20-S29 Injuries to the thorax	0.893	0.107
Chapter VII Diseases of the eye and adnexa	0.882	0.118
Z86.2 Personal history of diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.882	0.118
I80.1 Phlebitis and thrombophlebitis of femoral vein	0.879	0.121
I25.8 Other forms of chronic ischaemic heart disease	0.871	0.129
S82.2 Fracture of shaft of tibia	0.867	0.133
S90-S99 Injuries to the ankle and foot	0.865	0.135
M65-M68 Disorders of synovium and tendon	0.861	0.139
S66 Injury of muscle and tendon at wrist and hand level	0.860	0.140
Z29 Need for other prophylactic measures	0.857	0.143
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.856	0.144
Chapter XV Pregnancy, childbirth and the puerperium	0.852	0.148
I22 Subsequent myocardial infarction	0.850	0.149
M35.3 Polymyalgia rheumatica	0.849	0.151
Z95.9 Presence of cardiac and vascular implant and graft, unspecified	0.849	0.151
S64 Injury of nerves at wrist and hand level	0.848	0.152
I83.1 Varicose veins of lower extremities with inflammation	0.845	0.155
S82.0 Fracture of patella	0.837	0.162
Z83.7 Family history of diseases of the digestive system	0.830	0.170
M20.3 Other deformity of hallux (acquired)	0.829	0.171
Z87 Personal history of other diseases and conditions	0.827	0.173
S82.6 Fracture of lateral malleolus	0.823	0.177
M21 Other acquired deformities of limbs	0.822	0.178
S52 Fracture of forearm	0.821	0.179
H53-H54 Visual disturbances and blindness	0.818	0.182
M20.6 Acquired deformity of toe(s), unspecified	0.816	0.184
M84 Disorders of continuity of bone	0.816	0.184
S40-S49 Injuries to the shoulder and upper arm	0.816	0.184
S82.20 Fracture of shaft of tibia (closed)	0.815	0.185
I77 Other disorders of arteries and arterioles	0.814	0.186
Chapter VIII Diseases of the ear and mastoid process	0.812	0.188
E78.9 Disorder of lipoprotein metabolism, unspecified	0.810	0.190
I80.0 Phlebitis and thrombophlebitis of superficial vessels of lower extremities	0.809	0.191
Z86.3 Personal history of endocrine, nutritional and metabolic diseases	0.804	0.196
M05-M14 Inflammatory polyarthropathies	0.804	0.196
Z87.0 Personal history of diseases of the respiratory system	0.802	0.198
I81 Portal vein thrombosis	0.802	0.198
I20.1 Angina pectoris with documented spasm	0.802	0.198
I85 Oesophageal varices	0.796	0.204
I25.3 Aneurysm of heart	0.795	0.205
S22 Fracture of rib(s), sternum and thoracic spine	0.795	0.205
M25 Other joint disorders, not elsewhere classified	0.794	0.206
I71.3 Abdominal aortic aneurysm, ruptured	0.793	0.207
H40-H42 Glaucoma	0.789	0.211
I89 Other non-infective disorders of lymphatic vessels and lymph nodes	0.788	0.212
Z86.1 Personal history of infectious and parasitic diseases	0.787	0.213
I74 Arterial embolism and thrombosis	0.787	0.213
T36-T50 Poisoning by drugs, medicaments and biological substances	0.785	0.215
M85 Other disorders of bone density and structure	0.784	0.216
S62 Fracture at wrist and hand level	0.783	0.217
S70-S79 Injuries to the hip and thigh	0.781	0.219
S82.8 Fractures of other parts of lower leg	0.777	0.223
H53 Visual disturbances	0.776	0.224
I95 Hypotension	0.775	0.225
M45-M49 Spondylopathies	0.773	0.227
S10-S19 Injuries to the neck	0.772	0.228
S65 Injury of blood vessels at wrist and hand level	0.772	0.228
M70-M79 Other soft tissue disorders	0.769	0.231
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.768	0.232
S52.5 Fracture of lower end of radius	0.766	0.234
S82.00 Fracture of patella (closed)	0.764	0.236
S00-S09 Injuries to the head	0.764	0.236
E78.8 Other disorders of lipoprotein metabolism	0.763	0.237
Z29.0 Isolation	0.762	0.238
I72 Other aneurysm	0.760	0.240
Z82.7 Family history of congenital malformations, deformations and chromosomal abnormalities	0.759	0.241
I21.1 Acute transmural myocardial infarction of inferior wall	0.758	0.242
E88 Other metabolic disorders	0.757	0.243
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.756	0.244
M31 Other necrotising vasculopathies	0.755	0.245
Chapter XXII Codes for special purposes	0.753	0.247
I27 Other pulmonary heart diseases	0.752	0.248
Z83.5 Family history of eye and ear disorders	0.752	0.248
Z29.8 Other specified prophylactic measures	0.751	0.249
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.750	0.249
S69 Other and unspecified injuries of wrist and hand	0.750	0.250
H15-H22 Disorders of sclera, cornea, iris and ciliary body	0.746	0.254
M00-M03 Infectious arthropathies	0.746	0.254
M60-M63 Disorders of muscles	0.745	0.255
M86-M90 Other osteopathies	0.745	0.255
T93 Sequelae of injuries of lower limb	0.743	0.257
E00-E07 Disorders of thyroid gland	0.743	0.257
I82 Other venous embolism and thrombosis	0.742	0.258
M20.5 Other deformities of toe(s) (acquired)	0.740	0.260
S82.60 Fracture of lateral malleolus (closed)	0.739	0.261
I20.8 Other forms of angina pectoris	0.739	0.261
E40-E46 Malnutrition	0.738	0.262
H65-H75 Diseases of middle ear and mastoid	0.738	0.262
M91-M94 Chondropathies	0.737	0.263
M06 Other rheumatoid arthritis	0.737	0.263
I71.0 Dissection of aorta [any part]	0.733	0.267
S60 Superficial injury of wrist and hand	0.732	0.268
Z87.3 Personal history of diseases of the musculoskeletal system and connective tissue	0.731	0.269
Z83.3 Family history of diabetes mellitus	0.730	0.270
I70 Atherosclerosis	0.729	0.270
S61 Open wound of wrist and hand	0.729	0.271
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium	0.729	0.271
T80-T88 Complications of surgical and medical care, not elsewhere classified	0.729	0.271
Z81 Family history of mental and behavioural disorders	0.726	0.274
T79-T79 Certain early complications of trauma	0.726	0.274
S92 Fracture of foot, except ankle	0.723	0.276
M24 Other specific joint derangements	0.722	0.278
H40 Glaucoma	0.722	0.278
Z82.3 Family history of stroke	0.721	0.279
I86 Varicose veins of other sites	0.720	0.280
S68 Traumatic amputation of wrist and hand	0.720	0.280
T15-T19 Effects of foreign body entering through natural orifice	0.720	0.280
I00-I02 Acute rheumatic fever	0.717	0.283
Chapter XVI Certain conditions originating in the perinatal period	0.717	0.283
T33-T35 Frostbite	0.717	0.283
T26-T28 Burns and corrosions confined to eye and internal organs	0.717	0.283
T20-T25 Burns and corrosions of external body surface, specified by site	0.717	0.283
T00-T07 Injuries involving multiple body regions	0.717	0.283
I23 Certain current complications following acute myocardial infarction	0.717	0.283
I95.9 Hypotension, unspecified	0.717	0.283
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.717	0.283
M34 Systemic sclerosis	0.717	0.283
M33 Dermatopolymyositis	0.717	0.283
M32 Systemic lupus erythematosus	0.717	0.283
M30 Polyarteritis nodosa and related conditions	0.717	0.283
E78.6 Lipoprotein deficiency	0.716	0.284
E78.4 Other hyperlipidaemia	0.716	0.284
E78.3 Hyperchylomicronaemia	0.716	0.284
E78.1 Pure hyperglyceridaemia	0.716	0.284
Chapter I Certain infectious and parasitic diseases	0.715	0.285
H53.1 Subjective visual disturbances	0.714	0.286
S64.3 Injury of digital nerve of thumb	0.714	0.286
I88 Nonspecific lymphadenitis	0.714	0.286
S66.1 Injury of flexor muscle and tendon of other finger at wrist and hand level	0.714	0.286
S82.4 Fracture of fibula alone	0.713	0.287
I25.6 Silent myocardial ischaemia	0.713	0.287
I25.4 Coronary artery aneurysm	0.713	0.287
I25.0 Atherosclerotic cardiovascular disease, so described	0.713	0.287
M65 Synovitis and tenosynovitis	0.712	0.288
S27 Injury of other and unspecified intrathoracic organs	0.712	0.288
I99 Other and unspecified disorders of circulatory system	0.711	0.289
M81.90 Osteoporosis, unspecified (Multiple sites)	0.710	0.289
I28 Other diseases of pulmonary vessels	0.710	0.290
Z84 Family history of other conditions	0.709	0.291
I80.9 Phlebitis and thrombophlebitis of unspecified site	0.709	0.291
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.708	0.292
M83 Adult osteomalacia	0.707	0.293
M82 Osteoporosis in diseases classified elsewhere	0.707	0.293
E85 Amyloidosis	0.706	0.294
E84 Cystic fibrosis	0.706	0.294
E79 Disorders of purine and pyrimidine metabolism	0.706	0.294
E77 Disorders of glycoprotein metabolism	0.706	0.294
E76 Disorders of glycosaminoglycan metabolism	0.706	0.294
E75 Disorders of sphingolipid metabolism and other lipid storage disorders	0.706	0.294
E74 Other disorders of carbohydrate metabolism	0.706	0.294
E73 Lactose intolerance	0.706	0.294
E72 Other disorders of amino-acid metabolism	0.706	0.294
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism	0.706	0.294
E70 Disorders of aromatic amino-acid metabolism	0.706	0.294
E90 Nutritional and metabolic disorders in diseases classified elsewhere	0.706	0.294
I26.0 Pulmonary embolism with mention of acute cor pulmonale	0.704	0.296
E78.2 Mixed hyperlipidaemia	0.703	0.296
M79 Other soft tissue disorders, not elsewhere classified	0.703	0.297
Z97 Presence of other devices	0.703	0.297
S22.0 Fracture of thoracic vertebra	0.702	0.298
S52.50 Fracture of lower end of radius (closed)	0.702	0.298
S67 Crushing injury of wrist and hand	0.700	0.300
S63 Dislocation, sprain and strain of joints and ligaments at wrist and hand level	0.700	0.300
Z93 Artificial opening status	0.700	0.300
I80.8 Phlebitis and thrombophlebitis of other sites	0.700	0.300
T82 Complications of cardiac and vascular prosthetic devices, implants and grafts	0.700	0.300
Z82.8 Family history of other disabilities and chronic diseases leading to disablement, not elsewhere classified	0.698	0.302
Z82.6 Family history of arthritis and other diseases of the musculoskeletal system and connective tissue	0.698	0.302
Z82.5 Family history of asthma and other chronic lower respiratory diseases	0.698	0.302
Z82.2 Family history of deafness and hearing loss	0.698	0.302
Z82.1 Family history of blindness and visual loss	0.698	0.302
Z95.4 Presence of other heart-valve replacement	0.697	0.303
M80 Osteoporosis with pathological fracture	0.697	0.303
M67 Other disorders of synovium and tendon	0.697	0.303
T91 Sequelae of injuries of neck and trunk	0.696	0.304
H55-H59 Other disorders of eye and adnexa	0.695	0.305
T92 Sequelae of injuries of upper limb	0.695	0.305
S49 Other and unspecified injuries of shoulder and upper arm	0.694	0.306
Z95.2 Presence of prosthetic heart valve	0.694	0.306
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.694	0.306
I22.1 Subsequent myocardial infarction of inferior wall	0.694	0.306
S66.3 Injury of extensor muscle and tendon of other finger at wrist and hand level	0.693	0.307
I87 Other disorders of veins	0.691	0.309
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems	0.691	0.309
M81.8 Other osteoporosis	0.691	0.309
M81.6 Localised osteoporosis [Lequesne]	0.691	0.309
M81.5 Idiopathic osteoporosis	0.691	0.309
M81.4 Drug-induced osteoporosis	0.691	0.309
M81.3 Postsurgical malabsorption osteoporosis	0.691	0.309
M81.2 Osteoporosis of disuse	0.691	0.309
M81.1 Postoophorectomy osteoporosis	0.691	0.309
M81.0 Postmenopausal osteoporosis	0.691	0.309
M81.98 Osteoporosis, unspecified (Other)	0.690	0.310
S81 Open wound of lower leg	0.688	0.312
I22.9 Subsequent myocardial infarction of unspecified site	0.686	0.314
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system	0.686	0.314
M79.6 Pain in limb	0.686	0.314
S88 Traumatic amputation of lower leg	0.685	0.315
S87 Crushing injury of lower leg	0.685	0.315
S86 Injury of muscle and tendon at lower leg level	0.685	0.315
S85 Injury of blood vessels at lower leg level	0.685	0.315
S84 Injury of nerves at lower leg level	0.685	0.315
I83.0 Varicose veins of lower extremities with ulcer	0.684	0.316
S64.4 Injury of digital nerve of other finger	0.684	0.316
Q80-Q89 Other congenital malformations	0.684	0.316
O20-O29 Other maternal disorders predominantly related to pregnancy	0.682	0.318
I98 Other disorders of circulatory system in diseases classified elsewhere	0.681	0.319
T90 Sequelae of injuries of head	0.681	0.319
I71.8 Aortic aneurysm of unspecified site, ruptured	0.680	0.320
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.680	0.320
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.680	0.320
I71.1 Thoracic aortic aneurysm, ruptured	0.680	0.320
M81.97 Osteoporosis, unspecified (Ankle and foot)	0.679	0.321
M81.96 Osteoporosis, unspecified (Lower leg)	0.679	0.321
M81.95 Osteoporosis, unspecified (Pelvic region and thigh)	0.679	0.321
M81.94 Osteoporosis, unspecified (Hand)	0.679	0.321
M81.93 Osteoporosis, unspecified (Forearm)	0.679	0.321
M81.92 Osteoporosis, unspecified (Upper arm)	0.679	0.321
M81.91 Osteoporosis, unspecified (Shoulder region)	0.679	0.321
Z86.5 Personal history of other mental and behavioural disorders	0.679	0.321
Z94 Transplanted organ and tissue status	0.677	0.323
I77.9 Disorder of arteries and arterioles, unspecified	0.675	0.325
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.675	0.325
Q00-Q07 Congenital malformations of the nervous system	0.674	0.326
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.674	0.326
S82.9 Fracture of lower leg, part unspecified	0.674	0.326
S82.7 Multiple fractures of lower leg	0.674	0.326
I73.8 Other specified peripheral vascular diseases	0.673	0.327
I73.1 Thromboangiitis obliterans [Buerger]	0.673	0.327
M22 Disorders of patella	0.671	0.329
M84.1 Nonunion of fracture [pseudarthrosis]	0.670	0.330
E03 Other hypothyroidism	0.669	0.331
Z70-Z76 Persons encountering health services in other circumstances	0.668	0.332
H53.2 Diplopia	0.667	0.333
I21.X Presumed acute myicardial infaction (unconfirmed)	0.665	0.335
I21.3 Acute transmural myocardial infarction of unspecified site	0.665	0.335
S66.0 Injury of long flexor muscle and tendon of thumb at wrist and hand level	0.663	0.337
Z83.6 Family history of diseases of the respiratory system	0.663	0.337
Z83.4 Family history of other endocrine, nutritional and metabolic diseases	0.663	0.337
Z83.2 Family history of diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.663	0.337
Z83.1 Family history of other infectious and parasitic diseases	0.663	0.337
Z83.0 Family history of human immunodeficiency virus [HIV]	0.663	0.337
M25.6 Stiffness of joint, not elsewhere classified	0.663	0.337
Z99 Dependence on enabling machines and devices, not elsewhere classified	0.663	0.337
M25.7 Osteophyte	0.663	0.337
M06.9 Rheumatoid arthritis, unspecified	0.663	0.337
S82.80 Fractures of other parts of lower leg (closed)	0.661	0.339
Z82.0 Family history of epilepsy and other diseases of the nervous system	0.659	0.341
T82.8 Other complications of cardiac and vascular prosthetic devices, implants and grafts	0.658	0.341
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria	0.655	0.345
Q60-Q64 Congenital malformations of the urinary system	0.654	0.345
Z28 Immunisation not carried out	0.654	0.346
Z27 Need for immunisation against combinations of infectious diseases	0.654	0.346
Z26 Need for immunisation against other single infectious diseases	0.654	0.346
Z25 Need for immunisation against other single viral diseases	0.654	0.346
Z24 Need for immunisation against certain single viral diseases	0.654	0.346
Z23 Need for immunisation against single bacterial diseases	0.654	0.346
Z20 Contact with and exposure to communicable diseases	0.654	0.346
Z21 Asymptomatic human immunodeficiency virus [HIV] infection status	0.654	0.346
Z22 Carrier of infectious disease	0.654	0.346
I60-I69 Cerebrovascular diseases	0.654	0.346
O80-O84 Delivery	0.653	0.347
I74.3 Embolism and thrombosis of arteries of the lower extremities	0.652	0.347
M21.3 Wrist or foot drop (acquired)	0.650	0.349
Z89 Acquired absence of limb	0.650	0.349
I25.5 Ischaemic cardiomyopathy	0.650	0.350
H00-H06 Disorders of eyelid, lacrimal system and orbit	0.650	0.350
M35.9 Systemic involvement of connective tissue, unspecified	0.649	0.351
M35.8 Other specified systemic involvement of connective tissue	0.649	0.351
M35.7 Hypermobility syndrome	0.649	0.351
M35.6 Relapsing panniculitis [Weber-Christian]	0.649	0.351
M35.5 Multifocal fibrosclerosis	0.649	0.351
M35.4 Diffuse (eosinophilic) fasciitis	0.649	0.351
M35.2 Behcet's disease	0.649	0.351
M35.1 Other overlap syndromes	0.649	0.351
M40-M43 Deforming dorsopathies	0.649	0.351
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.649	0.351
H73 Other disorders of tympanic membrane	0.649	0.351
S99 Other and unspecified injuries of ankle and foot	0.648	0.352
S50 Superficial injury of forearm	0.647	0.353
I83.2 Varicose veins of lower extremities with both ulcer and inflammation	0.644	0.356
I20.0 Unstable angina	0.643	0.357
S59 Other and unspecified injuries of forearm	0.642	0.357
S58 Traumatic amputation of forearm	0.642	0.357
S57 Crushing injury of forearm	0.642	0.357
S56 Injury of muscle and tendon at forearm level	0.642	0.357
S55 Injury of blood vessels at forearm level	0.642	0.357
S54 Injury of nerves at forearm level	0.642	0.357
S53 Dislocation, sprain and strain of joints and ligaments of elbow	0.642	0.357
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.642	0.358
S51 Open wound of forearm	0.641	0.359
S01 Open wound of head	0.641	0.359
T98 Sequelae of other and unspecified effects of external causes	0.640	0.360
T95 Sequelae of burns, corrosions and frostbite	0.640	0.360
T94 Sequelae of injuries involving multiple and unspecified body regions	0.640	0.360
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.640	0.360
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.640	0.360
S61.9 Open wound of wrist and hand, part unspecified	0.640	0.360
S29 Other and unspecified injuries of thorax	0.640	0.360
S28 Crushing injury of thorax and traumatic amputation of part of thorax	0.640	0.360
S26 Injury of heart	0.640	0.360
S25 Injury of blood vessels of thorax	0.640	0.360
S24 Injury of nerves and spinal cord at thorax level	0.640	0.360
S23 Dislocation, sprain and strain of joints and ligaments of thorax	0.640	0.360
S21 Open wound of thorax	0.640	0.360
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified	0.640	0.360
Chapter V Mental and behavioural disorders	0.639	0.361
M85.8 Other specified disorders of bone density and structure	0.639	0.361
B25-B34 Other viral diseases	0.638	0.362
S82.5 Fracture of medial malleolus	0.637	0.362
H71 Cholesteatoma of middle ear	0.637	0.363
S40 Superficial injury of shoulder and upper arm	0.636	0.364
S22.00 Fracture of thoracic vertebra (closed)	0.635	0.365
M21.0 Valgus deformity, not elsewhere classified	0.635	0.365
S52.51 Fracture of lower end of radius (open)	0.633	0.367
H46-H48 Disorders of optic nerve and visual pathways	0.632	0.367
S22.2 Fracture of sternum	0.631	0.369
M45 Ankylosing spondylitis	0.631	0.369
I21.4 Acute subendocardial myocardial infarction	0.631	0.369
T36 Poisoning by systemic antibiotics	0.628	0.372
S62.4 Multiple fractures of metacarpal bones	0.628	0.372
T66-T78 Other and unspecified effects of external causes	0.627	0.373
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.626	0.373
S65.5 Injury of blood vessel(s) of other finger	0.626	0.374
Z29.2 Other prophylactic chemotherapy	0.626	0.374
S89 Other and unspecified injuries of lower leg	0.625	0.375
E20-E35 Disorders of other endocrine glands	0.625	0.375
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.624	0.375
Q38-Q45 Other congenital malformations of the digestive system	0.623	0.376
M84.0 Malunion of fracture	0.623	0.377
I77.6 Arteritis, unspecified	0.622	0.378
S79 Other and unspecified injuries of hip and thigh	0.622	0.378
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.622	0.378
S82.21 Fracture of shaft of tibia (open)	0.621	0.378
I85.0 Oesophageal varices with bleeding	0.621	0.379
E65-E68 Obesity and other hyperalimentation	0.621	0.379
S98 Traumatic amputation of ankle and foot	0.620	0.380
S97 Crushing injury of ankle and foot	0.620	0.380
S96 Injury of muscle and tendon at ankle and foot level	0.620	0.380
S95 Injury of blood vessels at ankle and foot level	0.620	0.380
S94 Injury of nerves at ankle and foot level	0.620	0.380
S91 Open wound of ankle and foot	0.620	0.380
S90 Superficial injury of ankle and foot	0.620	0.380
O36 Maternal care for other known or suspected foetal problems	0.620	0.380
M77 Other enthesopathies	0.619	0.381
I27.2 Other secondary pulmonary hypertension	0.619	0.381
Z98 Other postsurgical states	0.618	0.382
M68 Disorders of synovium and tendon in diseases classified elsewhere	0.617	0.383
M66 Spontaneous rupture of synovium and tendon	0.617	0.383
S66.9 Injury of unspecified muscle and tendon at wrist and hand level	0.617	0.383
S66.8 Injury of other muscles and tendons at wrist and hand level	0.617	0.383
S66.7 Injury of multiple extensor muscles and tendons at wrist and hand level	0.617	0.383
S66.6 Injury of multiple flexor muscles and tendons at wrist and hand level	0.617	0.383
S66.5 Injury of intrinsic muscle and tendon of other finger at wrist and hand level	0.617	0.383
S66.4 Injury of intrinsic muscle and tendon of thumb at wrist and hand level	0.617	0.383
H49-H52 Disorders of ocular muscles, binocular movement, accommodation and refraction	0.617	0.383
Z93.3 Colostomy status	0.616	0.384
E03.9 Hypothyroidism, unspecified	0.616	0.384
Z29.9 Prophylactic measure, unspecified	0.614	0.385
Z29.1 Prophylactic immunotherapy	0.614	0.385
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle	0.614	0.385
S20 Superficial injury of thorax	0.614	0.386
Q50-Q56 Congenital malformations of genital organs	0.614	0.386
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.614	0.386
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.614	0.386
Q35-Q37 Cleft lip and cleft palate	0.614	0.386
Q30-Q34 Congenital malformations of the respiratory system	0.614	0.386
Q10-Q18 Congenital malformations of eye, ear, face and neck	0.614	0.386
I85.9 Oesophageal varices without bleeding	0.612	0.387
S66.2 Injury of extensor muscle and tendon of thumb at wrist and hand level	0.612	0.388
I21.2 Acute transmural myocardial infarction of other sites	0.612	0.388
E80 Disorders of porphyrin and bilirubin metabolism	0.611	0.389
M25.9 Joint disorder, unspecified	0.611	0.389
S80 Superficial injury of lower leg	0.611	0.389
Z95.0 Presence of cardiac pacemaker	0.611	0.389
O85-O92 Complications predominantly related to the puerperium	0.610	0.389
I22.8 Subsequent myocardial infarction of other sites	0.610	0.390
I22.0 Subsequent myocardial infarction of anterior wall	0.610	0.390
S09 Other and unspecified injuries of head	0.610	0.390
I89.1 Lymphangitis	0.609	0.391
S64.9 Injury of unspecified nerve at wrist and hand level	0.608	0.392
S64.8 Injury of other nerves at wrist and hand level	0.608	0.392
S64.7 Injury of multiple nerves at wrist and hand level	0.608	0.392
S64.2 Injury of radial nerve at wrist and hand level	0.608	0.392
S64.1 Injury of median nerve at wrist and hand level	0.608	0.392
S64.0 Injury of ulnar nerve at wrist and hand level	0.608	0.392
I73.0 Raynaud's syndrome	0.607	0.392
H40.1 Primary open-angle glaucoma	0.607	0.393
S49.9 Unspecified injury of shoulder and upper arm	0.607	0.393
M21.1 Varus deformity, not elsewhere classified	0.607	0.393
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.606	0.394
S92.2 Fracture of other tarsal bone(s)	0.606	0.394
S82.1 Fracture of upper end of tibia	0.605	0.395
H10-H13 Disorders of conjunctiva	0.604	0.396
M11 Other crystal arthropathies	0.604	0.396
I95.2 Hypotension due to drugs	0.604	0.396
H40.2 Primary angle-closure glaucoma	0.603	0.397
T93.0 Sequelae of open wound of lower limb	0.603	0.397
H53.9 Visual disturbance, unspecified	0.603	0.397
H60-H62 Diseases of external ear	0.602	0.398
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.602	0.398
I89.0 Lymphoedema, not elsewhere classified	0.602	0.398
M05 Seropositive rheumatoid arthritis	0.601	0.398
Z95.3 Presence of xenogenic heart valve	0.601	0.399
I74.2 Embolism and thrombosis of arteries of the upper extremities	0.601	0.399
S82.01 Fracture of patella (open)	0.600	0.399
H20 Iridocyclitis	0.600	0.400
M35.0 Sicca syndrome [Sjogren]	0.599	0.400
T93.2 Sequelae of other fractures of lower limb	0.599	0.401
M65.3 Trigger finger	0.598	0.402
H40.9 Glaucoma, unspecified	0.597	0.403
Z86.6 Personal history of diseases of the nervous system and sense organs	0.597	0.403
H53.4 Visual field defects	0.597	0.403
M79.66 Pain in limb (Lower leg)	0.597	0.403
S52.6 Fracture of lower end of both ulna and radius	0.596	0.404
M79.69 Pain in limb (Site unspecified)	0.596	0.404
S05 Injury of eye and orbit	0.596	0.404
I78 Diseases of capillaries	0.595	0.405
E88.0 Disorders of plasma-protein metabolism, not elsewhere classified	0.594	0.406
S82.3 Fracture of lower end of tibia	0.594	0.406
I72.3 Aneurysm of iliac artery	0.593	0.407
Z87.6 Personal history of certain conditions arising in the perinatal period	0.593	0.407
I25.9 Chronic ischaemic heart disease, unspecified	0.593	0.407
S72 Fracture of femur	0.593	0.407
H21 Other disorders of iris and ciliary body	0.593	0.407
Z80 Family history of malignant neoplasm	0.592	0.408
S62.6 Fracture of other finger	0.592	0.408
S82.61 Fracture of lateral malleolus (open)	0.590	0.410
S52.1 Fracture of upper end of radius	0.589	0.411
M21.9 Acquired deformity of limb, unspecified	0.589	0.411
M21.8 Other specified acquired deformities of limbs	0.589	0.411
M21.7 Unequal limb length (acquired)	0.589	0.411
M21.6 Other acquired deformities of ankle and foot	0.589	0.411
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.589	0.411
M21.4 Flat foot [pes planus] (acquired)	0.589	0.411
M21.2 Flexion deformity	0.589	0.411
Z30-Z39 Persons encountering health services in circumstances related to reproduction	0.589	0.411
S52.9 Fracture of forearm, part unspecified	0.588	0.411
S52.8 Fracture of other parts of forearm	0.588	0.411
S52.7 Multiple fractures of forearm	0.588	0.411
S52.4 Fracture of shafts of both ulna and radius	0.588	0.411
S52.3 Fracture of shaft of radius	0.588	0.411
S52.2 Fracture of shaft of ulna	0.588	0.411
S69.9 Unspecified injury of wrist and hand	0.587	0.413

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations