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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs78227251
log Bayes Factor = 17.4957
Chromosome 2   position 88,977,848  (GRCh37) Explore rs78227251 on Ensembl!
Variant rs78227251 is part of Cluster X0212

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
Chapter IX Diseases of the circulatory system
1.000 0.000 0.000
# Top node
1.000 0.000 0.000
Chapter XXI Factors influencing health status and contact with health services
1.000 0.000 0.000
I30-I52 Other forms of heart disease
1.000 0.000 0.000
Chapter X Diseases of the respiratory system
0.998 0.002 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.998 0.002 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.998 0.002 0.000
Z86 Personal history of certain other diseases
0.994 0.006 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.993 0.007 0.000
J09-J18 Influenza and pneumonia
0.992 0.008 0.000
Chapter I Certain infectious and parasitic diseases
0.992 0.008 0.000
Z70-Z76 Persons encountering health services in other circumstances
0.991 0.009 0.000
J18 Pneumonia, organism unspecified
0.988 0.012 0.000
I50 Heart failure
0.987 0.013 0.000
Z72 Problems related to lifestyle
0.984 0.016 0.000
I20-I25 Ischaemic heart diseases
0.984 0.016 0.000
Z86.6 Personal history of diseases of the nervous system and sense organs
0.984 0.016 0.000
O60-O75 Complications of labour and delivery
0.982 0.018 0.000
M20-M25 Other joint disorders
0.981 0.019 0.000
J18.9 Pneumonia, unspecified
0.981 0.019 0.000
A00-A09 Intestinal infectious diseases
0.978 0.022 0.000
Z87 Personal history of other diseases and conditions
0.974 0.026 0.000
Z86.7 Personal history of diseases of the circulatory system
0.969 0.031 0.000
I25 Chronic ischaemic heart disease
0.968 0.032 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
0.966 0.034 0.000
Chapter IV Endocrine, nutritional and metabolic diseases
0.965 0.035 0.000
Z72.1 Alcohol use
0.962 0.038 0.000
Z92 Personal history of medical treatment
0.961 0.039 0.000
J40-J47 Chronic lower respiratory diseases
0.959 0.041 0.000
I50.0 Congestive heart failure
0.956 0.044 0.000
I47 Paroxysmal tachycardia
0.952 0.048 0.000
Chapter XVIII Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
0.952 0.048 0.000
M05-M14 Inflammatory polyarthropathies
0.951 0.049 0.000
I35 Nonrheumatic aortic valve disorders
0.950 0.050 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.948 0.052 0.000
R50-R69 General symptoms and signs
0.946 0.054 0.000
J44 Other chronic obstructive pulmonary disease
0.944 0.056 0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.943 0.057 0.000
Z92.1 Personal history of long-term (current) use of anticoagulants
0.936 0.064 0.000
I25.2 Old myocardial infarction
0.931 0.069 0.000
Z87.1 Personal history of diseases of the digestive system
0.931 0.069 0.000
Z72.0 Tobacco use
0.927 0.073 0.000
A09.9 Gastroenteritis and colitis of unspecified origin
0.927 0.073 0.000
I49 Other cardiac arrhythmias
0.918 0.082 0.000
J44.9 Chronic obstructive pulmonary disease, unspecified
0.916 0.084 0.000
Chapter XII Diseases of the skin and subcutaneous tissue
0.915 0.085 0.000
D60-D64 Aplastic and other anaemias
0.914 0.086 0.000
E70-E90 Metabolic disorders
0.913 0.087 0.000
I25.8 Other forms of chronic ischaemic heart disease
0.911 0.089 0.000
Chapter XI Diseases of the digestive system
0.907 0.093 0.000
R90-R94 Abnormal findings on diagnostic imaging and in function studies, without diagnosis
0.898 0.102 0.000
O66 Other obstructed labour
0.892 0.107 0.000
M24 Other specific joint derangements
0.888 0.112 0.000
M25 Other joint disorders, not elsewhere classified
0.886 0.114 0.000
I25.5 Ischaemic cardiomyopathy
0.885 0.115 0.000
M06 Other rheumatoid arthritis
0.883 0.117 0.000
R56 Convulsions, not elsewhere classified
0.882 0.118 0.000
S40-S49 Injuries to the shoulder and upper arm
0.881 0.119 0.000
R51 Headache
0.881 0.119 0.000
Z87.3 Personal history of diseases of the musculoskeletal system and connective tissue
0.880 0.120 0.000
D64 Other anaemias
0.878 0.122 0.000
A04 Other bacterial intestinal infections
0.870 0.130 0.000
I60-I69 Cerebrovascular diseases
0.869 0.131 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.868 0.132 0.000
Chapter XX External causes of morbidity and mortality
0.866 0.134 0.000
O70 Perineal laceration during delivery
0.865 0.135 0.000
E87 Other disorders of fluid, electrolyte and acid-base balance
0.865 0.135 0.000
I50.1 Left ventricular failure
0.861 0.139 0.000
I47.2 Ventricular tachycardia
0.861 0.139 0.000
I70-I79 Diseases of arteries, arterioles and capillaries
0.860 0.140 0.000
K55-K64 Other diseases of intestines
0.859 0.141 0.000
M20 Acquired deformities of fingers and toes
0.856 0.144 0.000
I21 Acute myocardial infarction
0.856 0.144 0.000
I49.9 Cardiac arrhythmia, unspecified
0.853 0.147 0.000
D64.9 Anaemia, unspecified
0.852 0.148 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.850 0.150 0.000
I47.1 Supraventricular tachycardia
0.850 0.150 0.000
L80-L99 Other disorders of the skin and subcutaneous tissue
0.844 0.156 0.000
J44.0 Chronic obstructive pulmonary disease with acute lower respiratory infection
0.843 0.157 0.000
M80-M85 Disorders of bone density and structure
0.841 0.159 0.000
J90-J94 Other diseases of pleura
0.838 0.162 0.000
I95-I99 Other and unspecified disorders of the circulatory system
0.838 0.162 0.000
R56.8 Other and unspecified convulsions
0.837 0.163 0.000
M06.9 Rheumatoid arthritis, unspecified
0.835 0.165 0.000
O63 Long labour
0.830 0.170 0.000
Z83 Family history of other specific disorders
0.829 0.171 0.000
O66.5 Failed application of vacuum extractor and forceps, unspecified
0.829 0.171 0.000
I35.2 Aortic (valve) stenosis with insufficiency
0.828 0.172 0.000
Z30-Z39 Persons encountering health services in circumstances related to reproduction
0.827 0.173 0.000
I31 Other diseases of pericardium
0.826 0.174 0.000
Chapter II Neoplasms
0.826 0.174 0.000
Chapter V Mental and behavioural disorders
0.824 0.176 0.000
M23 Internal derangement of knee
0.822 0.178 0.000
J18.1 Lobar pneumonia, unspecified
0.822 0.178 0.000
M24.1 Other articular cartilage disorders
0.822 0.178 0.000
Z90 Acquired absence of organs, not elsewhere classified
0.821 0.179 0.000
K50-K52 Noninfective enteritis and colitis
0.821 0.179 0.000
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation
0.821 0.179 0.000
E20-E35 Disorders of other endocrine glands
0.820 0.180 0.000
I05-I09 Chronic rheumatic heart diseases
0.819 0.181 0.000
I35.1 Aortic (valve) insufficiency
0.818 0.182 0.000
R50 Fever of unknown origin
0.818 0.182 0.000
M13 Other arthritis
0.817 0.183 0.000
Z87.0 Personal history of diseases of the respiratory system
0.816 0.184 0.000
R55 Syncope and collapse
0.815 0.185 0.000
M25.7 Osteophyte
0.815 0.185 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.811 0.189 0.000
R20-R23 Symptoms and signs involving the skin and subcutaneous tissue
0.811 0.189 0.000
E87.6 Hypokalaemia
0.809 0.191 0.000
R93 Abnormal findings on diagnostic imaging of other body structures
0.808 0.192 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.808 0.192 0.000
M20.5 Other deformities of toe(s) (acquired)
0.805 0.195 0.000
K61 Abscess of anal and rectal regions
0.803 0.197 0.000
M86-M90 Other osteopathies
0.802 0.198 0.000
I71 Aortic aneurysm and dissection
0.802 0.198 0.000
Z92.4 Personal history of major surgery, not elsewhere classified
0.800 0.200 0.000
E00-E07 Disorders of thyroid gland
0.799 0.201 0.000
S50-S59 Injuries to the elbow and forearm
0.798 0.202 0.000
I50.9 Heart failure, unspecified
0.798 0.202 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.797 0.203 0.000
O68 Labour and delivery complicated by foetal stress [distress]
0.794 0.206 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.792 0.208 0.000
B95-B98 Bacterial, viral and other infectious agents
0.788 0.212 0.000
I38 Endocarditis, valve unspecified
0.787 0.213 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.787 0.213 0.000
K60 Fissure and fistula of anal and rectal regions
0.786 0.214 0.000
L60-L75 Disorders of skin appendages
0.783 0.217 0.000
I24 Other acute ischaemic heart diseases
0.781 0.219 0.000
Z87.8 Personal history of other specified conditions
0.780 0.220 0.000
Z73 Problems related to life-management difficulty
0.776 0.224 0.000
S42 Fracture of shoulder and upper arm
0.774 0.226 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.774 0.226 0.000
M24.16 Other articular cartilage disorders (Lower leg)
0.774 0.226 0.000
K70-K77 Diseases of liver
0.771 0.229 0.000
R52 Pain, not elsewhere classified
0.769 0.231 0.000
L98 Other disorders of skin and subcutaneous tissue, not elsewhere classified
0.768 0.232 0.000
J18.0 Bronchopneumonia, unspecified
0.767 0.233 0.000
I35.9 Aortic valve disorder, unspecified
0.767 0.233 0.000
K20-K31 Diseases of oesophagus, stomach and duodenum
0.767 0.233 0.000
O75 Other complications of labour and delivery, not elsewhere classified
0.766 0.234 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.765 0.235 0.000
R90 Abnormal findings on diagnostic imaging of central nervous system
0.765 0.235 0.000
K56 Paralytic ileus and intestinal obstruction without hernia
0.764 0.236 0.000
M45-M49 Spondylopathies
0.763 0.237 0.000
Z86.5 Personal history of other mental and behavioural disorders
0.763 0.237 0.000
M40-M43 Deforming dorsopathies
0.763 0.237 0.000
K61.0 Anal abscess
0.762 0.238 0.000
M31 Other necrotising vasculopathies
0.762 0.238 0.000
F10-F19 Mental and behavioural disorders due to psychoactive substance use
0.759 0.241 0.000
R61 Hyperhidrosis
0.759 0.241 0.000
B35-B49 Mycoses
0.758 0.242 0.000
T66-T78 Other and unspecified effects of external causes
0.755 0.245 0.000
E86 Volume depletion
0.754 0.246 0.000
I80-I89 Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified
0.754 0.246 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.753 0.247 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.753 0.247 0.000
J45 Asthma
0.751 0.249 0.000
Z86.2 Personal history of diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
0.750 0.250 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.750 0.250 0.000
I21.1 Acute transmural myocardial infarction of inferior wall
0.748 0.252 0.000
O70.1 Second degree perineal laceration during delivery
0.748 0.252 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.747 0.253 0.000
O72 Postpartum haemorrhage
0.747 0.253 0.000
S70-S79 Injuries to the hip and thigh
0.746 0.254 0.000
R91 Abnormal findings on diagnostic imaging of lung
0.746 0.254 0.000
A08 Viral and other specified intestinal infections
0.745 0.255 0.000
I45 Other conduction disorders
0.744 0.256 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.744 0.256 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.743 0.257 0.000
E50-E64 Other nutritional deficiencies
0.743 0.257 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.741 0.259 0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle
0.740 0.259 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.738 0.262 0.000
I49.1 Atrial premature depolarisation
0.737 0.263 0.000
S20-S29 Injuries to the thorax
0.736 0.264 0.000
Z97 Presence of other devices
0.736 0.264 0.000
I71.4 Abdominal aortic aneurysm, without mention of rupture
0.733 0.267 0.000
M25.77 Osteophyte (Ankle and foot)
0.732 0.268 0.000
O63.1 Prolonged second stage (of labour)
0.731 0.269 0.000
O64 Obstructed labour due to malposition and malpresentation of foetus
0.731 0.269 0.000
M50-M54 Other dorsopathies
0.730 0.270 0.000
R57 Shock, not elsewhere classified
0.730 0.270 0.000
A04.7 Enterocolitis due to Clostridium difficile
0.730 0.270 0.000
R22 Localised swelling, mass and lump of skin and subcutaneous tissue
0.729 0.271 0.000
A04.8 Other specified bacterial intestinal infections
0.729 0.271 0.000
E87.5 Hyperkalaemia
0.728 0.272 0.000
M07 Psoriatic and enteropathic arthropathies
0.727 0.273 0.000
F10 Mental and behavioural disorders due to use of alcohol
0.727 0.273 0.000
L40-L45 Papulosquamous disorders
0.726 0.274 0.000
I31.3 Pericardial effusion (noninflammatory)
0.726 0.274 0.000
D62 Acute posthaemorrhagic anaemia
0.725 0.275 0.000
J44.8 Other specified chronic obstructive pulmonary disease
0.724 0.276 0.000
O69 Labour and delivery complicated by umbilical cord complications
0.724 0.276 0.000
J93 Pneumothorax
0.723 0.277 0.000
M23.2 Derangement of meniscus due to old tear or injury
0.722 0.278 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.722 0.278 0.000
I80 Phlebitis and thrombophlebitis
0.721 0.279 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.721 0.279 0.000
Chapter XXII Codes for special purposes
0.721 0.279 0.000
I34 Nonrheumatic mitral valve disorders
0.720 0.279 0.000
M13.9 Arthritis, unspecified
0.720 0.280 0.000
M65-M68 Disorders of synovium and tendon
0.720 0.280 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.720 0.280 0.000
K60.2 Anal fissure, unspecified
0.720 0.280 0.000
O48 Prolonged pregnancy
0.720 0.280 0.000
M20.2 Hallux rigidus
0.720 0.280 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.719 0.281 0.000
I95 Hypotension
0.719 0.281 0.000
I00-I02 Acute rheumatic fever
0.717 0.283 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
I52 Other heart disorders in diseases classified elsewhere
0.717 0.283 0.000
I48 Atrial fibrillation and flutter
0.717 0.283 0.000
I43 Cardiomyopathy in diseases classified elsewhere
0.717 0.283 0.000
I41 Myocarditis in diseases classified elsewhere
0.717 0.283 0.000
I40 Acute myocarditis
0.717 0.283 0.000
I39 Endocarditis and heart valve disorders in diseases classified elsewhere
0.717 0.283 0.000
I37 Pulmonary valve disorders
0.717 0.283 0.000
I36 Nonrheumatic tricuspid valve disorders
0.717 0.283 0.000
I33 Acute and subacute endocarditis
0.717 0.283 0.000
I32 Pericarditis in diseases classified elsewhere
0.717 0.283 0.000
I30 Acute pericarditis
0.717 0.283 0.000
I10-I15 Hypertensive diseases
0.716 0.284 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.716 0.284 0.000
Z90.0 Acquired absence of part of head and neck
0.716 0.284 0.000
Z89 Acquired absence of limb
0.715 0.284 0.000
Z84 Family history of other conditions
0.715 0.284 0.000
Z81 Family history of mental and behavioural disorders
0.715 0.284 0.000
M91-M94 Chondropathies
0.715 0.285 0.000
M60-M63 Disorders of muscles
0.715 0.285 0.000
M00-M03 Infectious arthropathies
0.715 0.285 0.000
I35.0 Aortic (valve) stenosis
0.714 0.286 0.000
S00-S09 Injuries to the head
0.713 0.287 0.000
J81 Pulmonary oedema
0.713 0.287 0.000
I42 Cardiomyopathy
0.712 0.288 0.000
O85-O92 Complications predominantly related to the puerperium
0.712 0.288 0.000
J17 Pneumonia in diseases classified elsewhere
0.711 0.288 0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.711 0.288 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.711 0.288 0.000
J12 Viral pneumonia, not elsewhere classified
0.711 0.288 0.000
J11 Influenza, virus not identified
0.711 0.288 0.000
J10 Influenza due to identified influenza virus
0.711 0.288 0.000
J14 Pneumonia due to Haemophilus influenzae
0.711 0.288 0.000
J09 Influenza due to certain identified influenza virus
0.711 0.288 0.000
K52 Other non-infective gastro-enteritis and colitis
0.711 0.289 0.000
Z90.5 Acquired absence of kidney
0.711 0.289 0.000
B99-B99 Other infectious diseases
0.711 0.289 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.711 0.289 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.711 0.289 0.000
B65-B83 Helminthiases
0.711 0.289 0.000
B50-B64 Protozoal diseases
0.711 0.289 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.711 0.289 0.000
B15-B19 Viral hepatitis
0.711 0.289 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.711 0.289 0.000
A80-A89 Viral infections of the central nervous system
0.711 0.289 0.000
A75-A79 Rickettsioses
0.711 0.289 0.000
A70-A74 Other diseases caused by chlamydiae
0.711 0.289 0.000
A65-A69 Other spirochaetal diseases
0.711 0.289 0.000
A20-A28 Certain zoonotic bacterial diseases
0.711 0.289 0.000
A15-A19 Tuberculosis
0.711 0.289 0.000
M81 Osteoporosis without pathological fracture
0.711 0.289 0.000
Z76 Persons encountering health services in other circumstances
0.710 0.290 0.000
Z70 Counselling related to sexual attitude, behaviour and orientation
0.710 0.290 0.000
I63 Cerebral infarction
0.709 0.291 0.000
I69 Sequelae of cerebrovascular disease
0.709 0.291 0.000
J18.8 Other pneumonia, organism unspecified
0.708 0.292 0.000
J18.2 Hypostatic pneumonia, unspecified
0.708 0.292 0.000
L72 Follicular cysts of skin and subcutaneous tissue
0.708 0.292 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.708 0.292 0.000
Z72.9 Problem related to lifestyle, unspecified
0.706 0.294 0.000
Z72.8 Other problems related to lifestyle
0.706 0.294 0.000
Z72.6 Gambling and betting
0.706 0.294 0.000
Z72.5 High-risk sexual behaviour
0.706 0.294 0.000
Z72.4 Inappropriate diet and eating habits
0.706 0.294 0.000
Z72.3 Lack of physical exercise
0.706 0.294 0.000
Z72.2 Drug use
0.706 0.294 0.000
I23 Certain current complications following acute myocardial infarction
0.705 0.294 0.000
R93.7 Abnormal findings on diagnostic imaging of other parts of musculoskeletal system
0.705 0.295 0.000
O74 Complications of anaesthesia during labour and delivery
0.704 0.296 0.000
O73 Retained placenta and membranes, without haemorrhage
0.704 0.296 0.000
O71 Other obstetric trauma
0.704 0.296 0.000
O67 Labour and delivery complicated by intrapartum haemorrhage, not elsewhere classified
0.704 0.296 0.000
O65 Obstructed labour due to maternal pelvic abnormality
0.704 0.296 0.000
O62 Abnormalities of forces of labour
0.704 0.296 0.000
O61 Failed induction of labour
0.704 0.296 0.000
O60 Preterm delivery
0.704 0.296 0.000
I67 Other cerebrovascular diseases
0.704 0.296 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.703 0.296 0.000
M34 Systemic sclerosis
0.703 0.296 0.000
M33 Dermatopolymyositis
0.703 0.296 0.000
M32 Systemic lupus erythematosus
0.703 0.296 0.000
M30 Polyarteritis nodosa and related conditions
0.703 0.296 0.000
M21 Other acquired deformities of limbs
0.703 0.296 0.000
A07 Other protozoal intestinal diseases
0.701 0.299 0.000
A06 Amoebiasis
0.701 0.299 0.000
A05 Other bacterial foodborne intoxications
0.701 0.299 0.000
A03 Shigellosis
0.701 0.299 0.000
A02 Other Salmonella infections
0.701 0.299 0.000
A01 Typhoid and paratyphoid fevers
0.701 0.299 0.000
A00 Cholera
0.701 0.299 0.000
Z83.3 Family history of diabetes mellitus
0.701 0.299 0.000
O68.2 Labour and delivery complicated by foetal heart rate anomaly with meconium in amniotic fluid
0.701 0.299 0.000
Z36 Antenatal screening
0.701 0.299 0.000
I22 Subsequent myocardial infarction
0.700 0.300 0.000
Z75 Problems related to medical facilities and other health care
0.699 0.301 0.000
Z87.6 Personal history of certain conditions arising in the perinatal period
0.698 0.301 0.000
Z87.5 Personal history of complications of pregnancy, childbirth and the puerperium
0.698 0.301 0.000
Z90.7 Acquired absence of genital organ(s)
0.698 0.302 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.698 0.302 0.000
O36 Maternal care for other known or suspected foetal problems
0.697 0.302 0.000
J60-J70 Lung diseases due to external agents
0.696 0.304 0.000
I25.6 Silent myocardial ischaemia
0.694 0.306 0.000
I25.4 Coronary artery aneurysm
0.694 0.306 0.000
I25.3 Aneurysm of heart
0.694 0.306 0.000
I25.0 Atherosclerotic cardiovascular disease, so described
0.694 0.306 0.000
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions
0.693 0.307 0.000
R50.9 Fever, unspecified
0.693 0.307 0.000
T79-T79 Certain early complications of trauma
0.692 0.308 0.000
T33-T35 Frostbite
0.692 0.308 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.692 0.308 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.692 0.308 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.692 0.308 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.692 0.308 0.000
T00-T07 Injuries involving multiple body regions
0.692 0.308 0.000
S10-S19 Injuries to the neck
0.692 0.308 0.000
E80 Disorders of porphyrin and bilirubin metabolism
0.692 0.308 0.000
E40-E46 Malnutrition
0.692 0.308 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.691 0.309 0.000
R47-R49 Symptoms and signs involving speech and voice
0.691 0.309 0.000
O70.0 First degree perineal laceration during delivery
0.691 0.309 0.000
D63 Anaemia in chronic diseases classified elsewhere
0.690 0.310 0.000
I08 Multiple valve diseases
0.690 0.310 0.000
Z92.9 Personal history of medical treatment, unspecified
0.689 0.311 0.000
Z92.8 Personal history of other medical treatment
0.689 0.311 0.000
Z92.5 Personal history of rehabilitation measures
0.689 0.311 0.000
Z92.0 Personal history of contraception
0.689 0.311 0.000
S90-S99 Injuries to the ankle and foot
0.688 0.312 0.000
O13 Gestational [pregnancy-induced] hypertension without significant proteinuria
0.688 0.312 0.000
J41 Simple and mucopurulent chronic bronchitis
0.688 0.312 0.000
J46 Status asthmaticus
0.688 0.312 0.000
J42 Unspecified chronic bronchitis
0.688 0.312 0.000
E83 Disorders of mineral metabolism
0.687 0.313 0.000
R69 Unknown and unspecified causes of morbidity
0.686 0.314 0.000
Z94 Transplanted organ and tissue status
0.685 0.315 0.000
B25-B34 Other viral diseases
0.684 0.316 0.000
K29 Gastritis and duodenitis
0.684 0.316 0.000
Z87.7 Personal history of congenital malformations, deformations and chromosomal abnormalities
0.684 0.316 0.000
K57 Diverticular disease of intestine
0.684 0.316 0.000
S80-S89 Injuries to the knee and lower leg
0.683 0.317 0.000
K22 Other diseases of oesophagus
0.683 0.317 0.000
I47.9 Paroxysmal tachycardia, unspecified
0.682 0.318 0.000
I47.0 Reentry ventricular arrhythmia
0.682 0.318 0.000
R95-R99 Ill-defined and unknown causes of mortality
0.682 0.318 0.000
R80-R82 Abnormal findings on examination of urine, without diagnosis
0.682 0.318 0.000
M14 Arthropathies in other diseases classified elsewhere
0.682 0.318 0.000
M12 Other specific arthropathies
0.682 0.318 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.682 0.318 0.000
M08 Juvenile arthritis
0.682 0.318 0.000
M05 Seropositive rheumatoid arthritis
0.682 0.318 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.682 0.318 0.000
I35.8 Other aortic valve disorders
0.681 0.319 0.000
A09.0 Other and unspecified gastroenteritis and colitis of infectious origin
0.680 0.320 0.000
Z90.8 Acquired absence of other organs
0.680 0.320 0.000
E89 Postprocedural endocrine and metabolic disorders, not elsewhere classified
0.678 0.322 0.000
R65 Systemic Inflammatory Response Syndrome [SIRS]
0.678 0.322 0.000
R62 Lack of expected normal physiological development
0.678 0.322 0.000
R64 Cachexia
0.678 0.322 0.000
R58 Haemorrhage, not elsewhere classified
0.678 0.322 0.000
Z92.3 Personal history of irradiation
0.678 0.322 0.000
Z47 Other orthopaedic follow-up care
0.677 0.323 0.000
M22 Disorders of patella
0.677 0.323 0.000
I80.2 Phlebitis and thrombophlebitis of other deep vessels of lower extremities
0.676 0.324 0.000
D55-D59 Haemolytic anaemias
0.676 0.324 0.000
R68 Other general symptoms and signs
0.676 0.324 0.000
M11 Other crystal arthropathies
0.676 0.324 0.000
C51-C58 Malignant neoplasms of female genital organs
0.676 0.324 0.000
I21.2 Acute transmural myocardial infarction of other sites
0.675 0.324 0.000
D70-D77 Other diseases of blood and blood-forming organs
0.674 0.325 0.000
I24.9 Acute ischaemic heart disease, unspecified
0.674 0.326 0.000
C34 Malignant neoplasm of bronchus and lung
0.674 0.326 0.000
O42 Premature rupture of membranes
0.673 0.327 0.000
Z71 Persons encountering health services for other counselling and medical advice, not elsewhere classified
0.673 0.327 0.000
A30-A49 Other bacterial diseases
0.672 0.328 0.000
V20-V29 Motorcycle rider injured in transport accident
0.671 0.328 0.000
D61 Other aplastic anaemias
0.671 0.329 0.000
R63 Symptoms and signs concerning food and fluid intake
0.670 0.330 0.000
C60-C63 Malignant neoplasms of male genital organs
0.669 0.331 0.000
Z74 Problems related to care-provider dependency
0.669 0.331 0.000
M25.76 Osteophyte (Lower leg)
0.669 0.331 0.000
L89 Decubitus ulcer
0.669 0.331 0.000
L85 Other epidermal thickening
0.669 0.331 0.000
B96 Other bacterial agents as the cause of diseases classified to other chapters
0.668 0.332 0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
0.666 0.333 0.000
Y95 Nosocomial condition
0.666 0.334 0.000
E28 Ovarian dysfunction
0.666 0.334 0.000
S60-S69 Injuries to the wrist and hand
0.666 0.334 0.000
J84 Other interstitial pulmonary diseases
0.665 0.335 0.000
I26 Pulmonary embolism
0.665 0.335 0.000
K76 Other diseases of liver
0.664 0.336 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.664 0.336 0.000
L81 Other disorders of pigmentation
0.663 0.336 0.000
I71.2 Thoracic aortic aneurysm, without mention of rupture
0.663 0.337 0.000
D80-D89 Certain disorders involving the immune mechanism
0.663 0.337 0.000
Z47.0 Follow-up care involving removal of fracture plate and other internal fixation device
0.663 0.337 0.000
E88 Other metabolic disorders
0.662 0.338 0.000
T93 Sequelae of injuries of lower limb
0.662 0.338 0.000
L50-L54 Urticaria and erythema
0.662 0.338 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
0.662 0.338 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.662 0.338 0.000
W20-W49 Exposure to inanimate mechanical forces
0.661 0.339 0.000
I49.0 Ventricular fibrillation and flutter
0.660 0.339 0.000
Z92.2 Personal history of long-term (current) use of other medicaments
0.661 0.339 0.000
I49.4 Other and unspecified premature depolarisation
0.658 0.341 0.000
I49.2 Junctional premature depolarisation
0.658 0.341 0.000
I49.3 Ventricular premature depolarisation
0.658 0.342 0.000
L20-L30 Dermatitis and eczema
0.657 0.343 0.000
L10-L14 Bullous disorders
0.656 0.344 0.000
K51 Ulcerative colitis
0.656 0.344 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.655 0.345 0.000
D60 Acquired pure red cell aplasia [erythroblastopenia]
0.655 0.345 0.000
I21.9 Acute myocardial infarction, unspecified
0.654 0.345 0.000
E85 Amyloidosis
0.654 0.346 0.000
E84 Cystic fibrosis
0.654 0.346 0.000
E79 Disorders of purine and pyrimidine metabolism
0.654 0.346 0.000
E77 Disorders of glycoprotein metabolism
0.654 0.346 0.000
E76 Disorders of glycosaminoglycan metabolism
0.654 0.346 0.000
E75 Disorders of sphingolipid metabolism and other lipid storage disorders
0.654 0.346 0.000
E74 Other disorders of carbohydrate metabolism
0.654 0.346 0.000
E73 Lactose intolerance
0.654 0.346 0.000
E72 Other disorders of amino-acid metabolism
0.654 0.346 0.000
E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
0.654 0.346 0.000
E70 Disorders of aromatic amino-acid metabolism
0.654 0.346 0.000
E90 Nutritional and metabolic disorders in diseases classified elsewhere
0.654 0.346 0.000
M70-M79 Other soft tissue disorders
0.653 0.347 0.000
K56.6 Other and unspecified intestinal obstruction
0.653 0.347 0.000
L98.9 Disorder of skin and subcutaneous tissue, unspecified
0.652 0.348 0.000
Z91 Personal history of risk-factors, not elsewhere classified
0.652 0.348 0.000
O80-O84 Delivery
0.652 0.348 0.000
Chapter VII Diseases of the eye and adnexa
0.652 0.348 0.000
K90-K93 Other diseases of the digestive system
0.651 0.349 0.000
F10.3 Withdrawal state
0.651 0.349 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.650 0.350 0.000
Z86.3 Personal history of endocrine, nutritional and metabolic diseases
0.650 0.350 0.000
D37-D48 Neoplasms of uncertain or unknown behaviour
0.648 0.352 0.000
J43 Emphysema
0.648 0.352 0.000
O99 Other maternal diseases classifiable elsewhere but complicating pregnancy, childbirth and the puerperium
0.648 0.352 0.000
R50.0 Fever with chills
0.648 0.352 0.000
E87.1 Hypo-osmolality and hyponatraemia
0.645 0.354 0.000
M20.6 Acquired deformity of toe(s), unspecified
0.645 0.355 0.000
M10 Gout
0.644 0.356 0.000
R92 Abnormal findings on diagnostic imaging of breast
0.643 0.356 0.000
R90.8 Other abnormal findings on diagnostic imaging of central nervous system
0.643 0.357 0.000
Z83.7 Family history of diseases of the digestive system
0.643 0.357 0.000
I64 Stroke, not specified as haemorrhage or infarction
0.642 0.357 0.000
W00-W19 Falls
0.642 0.358 0.000
R93.3 Abnormal findings on diagnostic imaging of other parts of digestive tract
0.641 0.359 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.641 0.359 0.000
K26 Duodenal ulcer
0.641 0.359 0.000
Q10-Q18 Congenital malformations of eye, ear, face and neck
0.641 0.359 0.000
Z87.2 Personal history of diseases of the skin and subcutaneous tissue
0.641 0.359 0.000
R54 Senility
0.641 0.359 0.000
S42.0 Fracture of clavicle
0.640 0.359 0.000
Z98 Other postsurgical states
0.640 0.360 0.000
M23.8 Other internal derangements of knee
0.640 0.360 0.000
J90 Pleural effusion, not elsewhere classified
0.640 0.360 0.000
O66.9 Obstructed labour, unspecified
0.640 0.360 0.000
O66.8 Other specified obstructed labour
0.640 0.360 0.000
O66.4 Failed trial of labour, unspecified
0.640 0.360 0.000
O66.3 Obstructed labour due to other abnormalities of foetus
0.640 0.360 0.000
O66.2 Obstructed labour due to unusually large foetus
0.640 0.360 0.000
O66.1 Obstructed labour due to locked twins
0.640 0.360 0.000
O66.0 Obstructed labour due to shoulder dystocia
0.640 0.360 0.000
M13.97 Arthritis, unspecified (Ankle and foot)
0.640 0.360 0.000
J93.9 Pneumothorax, unspecified
0.640 0.360 0.000
S43.0 Dislocation of shoulder joint
0.640 0.360 0.000
M25.4 Effusion of joint
0.639 0.361 0.000
O30 Multiple gestation
0.638 0.362 0.000
K22.1 Ulcer of oesophagus
0.637 0.363 0.000
M24.9 Joint derangement, unspecified
0.637 0.363 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.637 0.363 0.000
M24.7 Protrusio acetabuli
0.637 0.363 0.000
M24.6 Ankylosis of joint
0.637 0.363 0.000
M24.5 Contracture of joint
0.637 0.363 0.000
M24.4 Recurrent dislocation and subluxation of joint
0.637 0.363 0.000
M24.3 Pathological dislocation and subluxation of joint, not elsewhere classified
0.637 0.363 0.000
M24.2 Disorder of ligament
0.637 0.363 0.000
M24.0 Loose body in joint
0.637 0.363 0.000
K50 Crohn's disease [regional enteritis]
0.637 0.363 0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland
0.636 0.364 0.000
I95.9 Hypotension, unspecified
0.636 0.364 0.000
M25.9 Joint disorder, unspecified
0.635 0.365 0.000
M25.8 Other specified joint disorders
0.635 0.365 0.000
M25.3 Other instability of joint
0.635 0.365 0.000
M25.2 Flail joint
0.635 0.365 0.000
M25.1 Fistula of joint
0.635 0.365 0.000
M25.0 Haemarthrosis
0.635 0.365 0.000
M87 Osteonecrosis
0.635 0.365 0.000
M85 Other disorders of bone density and structure
0.635 0.365 0.000
A04.5 Campylobacter enteritis
0.634 0.366 0.000
K29.6 Other gastritis
0.634 0.366 0.000
E05 Thyrotoxicosis [hyperthyroidism]
0.633 0.366 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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