TreeWAS – Variant ID: rs7970490

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	0.000	1.000
E00-E07 Disorders of thyroid gland	0.000	1.000
E03 Other hypothyroidism	0.000	1.000
E05 Thyrotoxicosis [hyperthyroidism]	0.003	0.997
E05.9 Thyrotoxicosis, unspecified	0.005	0.995
E07 Other disorders of thyroid	0.010	0.990
E06 Thyroiditis	0.011	0.989
I10 Essential (primary) hypertension	0.013	0.987
E07.9 Disorder of thyroid, unspecified	0.017	0.983
E06.3 Autoimmune thyroiditis	0.031	0.969
E06.9 Thyroiditis, unspecified	0.125	0.875
I10-I15 Hypertensive diseases	0.131	0.869
E03.8 Other specified hypothyroidism	0.160	0.840
I12 Hypertensive renal disease	0.187	0.813
I12.9 Hypertensive renal disease without renal failure	0.214	0.786
E04 Other non-toxic goitre	0.224	0.776
Z95.4 Presence of other heart-valve replacement	0.228	0.772
Z95 Presence of cardiac and vascular implants and grafts	0.238	0.762
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.241	0.759
I15 Secondary hypertension	0.247	0.753
Z95.2 Presence of prosthetic heart valve	0.254	0.746
Z95.5 Presence of coronary angioplasty implant and graft	0.258	0.742
E02 Subclinical iodine-deficiency hypothyroidism	0.274	0.726
E05.8 Other thyrotoxicosis	0.282	0.718
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.283	0.717
E00 Congenital iodine-deficiency syndrome	0.283	0.717
E03.5 Myxoedema coma	0.283	0.717
E03.4 Atrophy of thyroid (acquired)	0.283	0.717
E03.3 Postinfectious hypothyroidism	0.283	0.717
E03.1 Congenital hypothyroidism without goitre	0.283	0.717
E03.0 Congenital hypothyroidism with diffuse goitre	0.283	0.717
E07.8 Other specified disorders of thyroid	0.285	0.715
E05.5 Thyroid crisis or storm	0.285	0.715
E05.4 Thyrotoxicosis factitia	0.285	0.715
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.285	0.715
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.285	0.715
E06.5 Other chronic thyroiditis	0.290	0.710
E07.1 Dyshormogenetic goitre	0.290	0.710
E07.0 Hypersecretion of calcitonin	0.290	0.710
E06.4 Drug-induced thyroiditis	0.291	0.709
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.291	0.709
E06.1 Subacute thyroiditis	0.291	0.709
E06.0 Acute thyroiditis	0.291	0.709
Z95.1 Presence of aortocoronary bypass graft	0.302	0.698
I15.1 Hypertension secondary to other renal disorders	0.315	0.685
E04.1 Non-toxic single thyroid nodule	0.316	0.684
Z95.8 Presence of other cardiac and vascular implants and grafts	0.325	0.675
E05.0 Thyrotoxicosis with diffuse goitre	0.329	0.671
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.336	0.663
E04.9 Non-toxic goitre, unspecified	0.352	0.648
I13 Hypertensive heart and renal disease	0.377	0.623
I11 Hypertensive heart disease	0.397	0.603
E04.8 Other specified non-toxic goitre	0.443	0.556
I15.0 Renovascular hypertension	0.449	0.551
I15.8 Other secondary hypertension	0.460	0.540
I15.2 Hypertension secondary to endocrine disorders	0.460	0.540
E04.0 Non-toxic diffuse goitre	0.466	0.534
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.486	0.514
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.486	0.514
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.486	0.514
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.486	0.514
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.486	0.514
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.486	0.514
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.486	0.514
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.486	0.514
D89.2 Hypergammaglobulinaemia, unspecified	0.487	0.513
D89 Other disorders involving the immune mechanism, not elsewhere classified	0.489	0.511
D80-D89 Certain disorders involving the immune mechanism	0.489	0.511
D86 Sarcoidosis	0.495	0.505
D86.0 Sarcoidosis of lung	0.506	0.494
D59 Acquired haemolytic anaemia	0.516	0.484
D59.1 Other autoimmune haemolytic anaemias	0.517	0.483
D55-D59 Haemolytic anaemias	0.517	0.483
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.520	0.480
I15.9 Seconday hypertension, unspecified	0.525	0.475
I12.0 Hypertensive renal disease with renal failure	0.528	0.472
D86.9 Sarcoidosis, unspecified	0.531	0.469
I11.9 Hypertensive heart disease without (congestive) heart failure	0.548	0.452
I13.9 Hypertensive heart and renal disease, unspecified	0.553	0.447
I13.2 Hypertensive heart and renal disease with both (congestive) heart failure and renal failure	0.553	0.447
I13.1 Hypertensive heart and renal disease with renal failure	0.553	0.447
I13.0 Hypertensive heart and renal disease with (congestive) heart failure	0.553	0.447
D59.9 Acquired haemolytic anaemia, unspecified	0.600	0.400
D89.0 Polyclonal hypergammaglobulinaemia	0.602	0.398
I11.0 Hypertensive heart disease with (congestive) heart failure	0.611	0.388
D89.9 Disorder involving the immune mechanism, unspecified	0.612	0.388
D70-D77 Other diseases of blood and blood-forming organs	0.617	0.383
D56 Thalassaemia	0.618	0.382
D83 Common variable immunodeficiency	0.618	0.382
D58 Other hereditary haemolytic anaemias	0.619	0.381
D86.1 Sarcoidosis of lymph nodes	0.623	0.377
D72 Other disorders of white blood cells	0.627	0.373
D89.3 Immune reconstitution syndrome	0.633	0.367
D81 Combined immunodeficiencies	0.634	0.366
D89.8 Other specified disorders involving the immune mechanism, not elsewhere classified	0.634	0.366
D72.8 Other specified disorders of white blood cells	0.636	0.364
D84 Other immunodeficiencies	0.640	0.360
D60-D64 Aplastic and other anaemias	0.641	0.359
Z95.3 Presence of xenogenic heart valve	0.642	0.358
D59.8 Other acquired haemolytic anaemias	0.653	0.347
D59.6 Haemoglobinuria due to haemolysis from other external causes	0.653	0.347
D59.5 Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]	0.653	0.347
D59.4 Other nonautoimmune haemolytic anaemias	0.653	0.347
D59.3 Haemolytic-uraemic syndrome	0.653	0.347
D59.2 Drug-induced nonautoimmune haemolytic anaemia	0.653	0.347
D59.0 Drug-induced autoimmune haemolytic anaemia	0.653	0.347
D55 Anaemia due to enzyme disorders	0.654	0.346
D86.8 Sarcoidosis of other and combined sites	0.654	0.346
D57 Sickle-cell disorders	0.655	0.345
D82 Immunodeficiency associated with other major defects	0.658	0.342
D58.9 Hereditary haemolytic anaemia, unspecified	0.665	0.335
D86.2 Sarcoidosis of lung with sarcoidosis of lymph nodes	0.673	0.327
Z95.9 Presence of cardiac and vascular implant and graft, unspecified	0.677	0.322
D86.3 Sarcoidosis of skin	0.683	0.316
D89.1 Cryoglobulinaemia	0.684	0.316
D56.3 Thalassaemia trait	0.696	0.304
D75 Other diseases of blood and blood-forming organs	0.698	0.302
D63 Anaemia in chronic diseases classified elsewhere	0.703	0.297
D83.9 Common variable immunodeficiency, unspecified	0.711	0.289
D72.1 Eosinophilia	0.713	0.286
D56.1 Beta thalassaemia	0.718	0.282
D80 Immunodeficiency with predominantly antibody defects	0.720	0.280
D62 Acute posthaemorrhagic anaemia	0.720	0.280
D74 Methaemoglobinaemia	0.726	0.274
D77 Other disorders of blood and blood-forming organs in diseases classified elsewhere	0.726	0.274
D71 Functional disorders of polymorphonuclear neutrophils	0.726	0.274
D56.9 Thalassaemia, unspecified	0.726	0.274
D56.8 Other thalassaemias	0.726	0.274
D56.4 Hereditary persistence of foetal haemoglobin [HPFH]	0.726	0.274
D56.2 Delta-beta thalassaemia	0.726	0.274
D56.0 Alpha thalassaemia	0.726	0.274
D83.8 Other common variable immunodeficiencies	0.726	0.274
D83.2 Common variable immunodeficiency with autoantibodies to B- or T-cells	0.726	0.274
D83.1 Common variable immunodeficiency with predominant immunoregulatory T-cell disorders	0.726	0.274
D83.0 Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function	0.726	0.274
D58.8 Other specified hereditary haemolytic anaemias	0.727	0.273
D58.1 Hereditary elliptocytosis	0.727	0.273
D76 Certain diseases involving lymphoreticular tissue and reticulohistiocytic system	0.730	0.270
D72.9 Disorder of white blood cells, unspecified	0.733	0.267
D72.0 Genetic anomalies of leukocytes	0.733	0.267
D81.9 Combined immunodeficiency, unspecified	0.737	0.263
D81.8 Other combined immunodeficiencies	0.737	0.263
D81.7 Major histocompatibility complex class II deficiency	0.737	0.263
D81.6 Major histocompatibility complex class I deficiency	0.737	0.263
D81.5 Purine nucleoside phosphorylase [PNP] deficiency	0.737	0.263
D81.4 Nezelof's syndrome	0.737	0.263
D81.3 Adenosine deaminase [ADA] deficiency	0.737	0.263
D81.2 Severe combined immunodeficiency [SCID] with low or normal B-cell numbers	0.737	0.263
D81.1 Severe combined immunodeficiency [SCID] with low T- and B-cell numbers	0.737	0.263
D81.0 Severe combined immunodeficiency [SCID] with reticular dysgenesis	0.737	0.263
D84.8 Other specified immunodeficiencies	0.741	0.258
D84.0 Lymphocyte function antigen-1 [LFA-1] defect	0.741	0.258
D84.9 Immunodeficiency, unspecified	0.742	0.258
D60 Acquired pure red cell aplasia [erythroblastopenia]	0.743	0.257
D75.2 Essential thrombocytosis	0.745	0.255
D84.1 Defects in the complement system	0.746	0.253
D50-D53 Nutritional anaemias	0.748	0.252
D58.2 Other haemoglobinopathies	0.749	0.250
D55.9 Anaemia due to enzyme disorder, unspecified	0.752	0.248
D55.8 Other anaemias due to enzyme disorders	0.752	0.248
D55.3 Anaemia due to disorders of nucleotide metabolism	0.752	0.248
D55.2 Anaemia due to disorders of glycolytic enzymes	0.752	0.248
D55.1 Anaemia due to other disorders of glutathione metabolism	0.752	0.248
D55.0 Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency	0.752	0.248
D57.8 Other sickle-cell disorders	0.752	0.248
D57.3 Sickle-cell trait	0.752	0.248
D57.2 Double heterozygous sickling disorders	0.752	0.248
D57.0 Sickle-cell anaemia with crisis	0.752	0.248
D57.1 Sickle-cell anaemia without crisis	0.753	0.247
D82.9 Immunodeficiency associated with major defect, unspecified	0.755	0.245
D82.8 Immunodeficiency associated with other specified major defects	0.755	0.245
D82.4 Hyperimmunoglobulin E [IgE] syndrome	0.755	0.245
D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus	0.755	0.245
D82.2 Immunodeficiency with short-limbed stature	0.755	0.245
D82.0 Wiskott-Aldrich syndrome	0.755	0.245
D58.0 Hereditary spherocytosis	0.760	0.239
D63.0 Anaemia in neoplastic disease	0.762	0.238
I21.1 Acute transmural myocardial infarction of inferior wall	0.764	0.236
D63.8 Anaemia in other chronic diseases classified elsewhere	0.767	0.233
D75.1 Secondary polycythaemia	0.768	0.232
D75.0 Familial erythrocytosis	0.775	0.225
D61 Other aplastic anaemias	0.776	0.224
D64 Other anaemias	0.779	0.221
D82.1 Di George's syndrome	0.779	0.220
D63.1 Anaemia in other chronic diseases classified elsewhere	0.787	0.213
I21 Acute myocardial infarction	0.787	0.213
D80.2 Selective deficiency of immunoglobulin A [IgA]	0.797	0.203
I21.4 Acute subendocardial myocardial infarction	0.798	0.202
D80.8 Other immunodeficiencies with predominantly antibody defects	0.799	0.201
D80.7 Transient hypogammaglobulinaemia of infancy	0.799	0.201
D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia	0.799	0.201
D80.5 Immunodeficiency with increased immunoglobulin M [IgM]	0.799	0.201
D80.4 Selective deficiency of immunoglobulin M [IgM]	0.799	0.201
D80.0 Hereditary hypogammaglobulinaemia	0.799	0.201
D80.9 Immunodeficiency with predominantly antibody defects, unspecified	0.802	0.198
D74.9 Methaemoglobinaemia, unspecified	0.803	0.197
D74.8 Other methaemoglobinaemias	0.803	0.197
D74.0 Congenital methaemoglobinaemia	0.803	0.197
D51 Vitamin B12 deficiency anaemia	0.804	0.196
D75.9 Disease of blood and blood-forming organs, unspecified	0.806	0.194
D76.2 Haemophagocytic syndrome, infection-associated	0.806	0.193
D76.1 Haemophagocytic lymphohistiocytosis	0.806	0.193
D76.0 Langerhans' cell histiocytosis, not elsewhere classified	0.806	0.193
D75.8 Other specified diseases of blood and blood-forming organs	0.807	0.193
D76.3 Other histiocytosis syndromes	0.811	0.189
D61.1 Drug-induced aplastic anaemia	0.811	0.189
E04.2 Non-toxic multinodular goitre	0.812	0.188
D52 Folate deficiency anaemia	0.814	0.186
D51.9 Vitamin B12 deficiency anaemia, unspecified	0.815	0.185
D60.9 Acquired pure red cell aplasia, unspecified	0.815	0.184
D60.8 Other acquired pure red cell aplasias	0.815	0.184
D60.1 Transient acquired pure red cell aplasia	0.815	0.184
D60.0 Chronic acquired pure red cell aplasia	0.815	0.184
D64.8 Other specified anaemias	0.815	0.185
I21.0 Acute transmural myocardial infarction of anterior wall	0.816	0.184
D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses	0.818	0.181
D53 Other nutritional anaemias	0.818	0.182
D61.8 Other specified aplastic anaemias	0.839	0.161
D61.3 Idiopathic aplastic anaemia	0.839	0.161
D61.2 Aplastic anaemia due to other external agents	0.839	0.161
D61.0 Constitutional aplastic anaemia	0.841	0.159
D65-D69 Coagulation defects, purpura and other haemorrhagic conditions	0.841	0.159
D64.4 Congenital dyserythropoietic anaemia	0.842	0.158
D64.3 Other sideroblastic anaemias	0.842	0.158
D64.2 Secondary sideroblastic anaemia due to drugs and toxins	0.842	0.158
D64.1 Secondary sideroblastic anaemia due to disease	0.842	0.158
D64.0 Hereditary sideroblastic anaemia	0.842	0.158
I20-I25 Ischaemic heart diseases	0.842	0.158
Chapter IX Diseases of the circulatory system	0.845	0.155
I21.X Presumed acute myicardial infaction (unconfirmed)	0.847	0.153
D80.1 Nonfamilial hypogammaglobulinaemia	0.851	0.148
D51.8 Other vitamin B12 deficiency anaemias	0.859	0.140
D51.2 Transcobalamin II deficiency	0.859	0.140
D51.1 Vitamin B12 deficiency anaemia due to selective vitamin B12 malabsorption with proteinuria	0.859	0.140
D52.9 Folate deficiency anaemia, unspecified	0.861	0.139
I21.2 Acute transmural myocardial infarction of other sites	0.863	0.137
D52.8 Other folate deficiency anaemias	0.866	0.134
D52.1 Drug-induced folate deficiency anaemia	0.866	0.134
D52.0 Dietary folate deficiency anaemia	0.866	0.134
I22 Subsequent myocardial infarction	0.866	0.134
D53.9 Nutritional anaemia, unspecified	0.869	0.131
D53.8 Other specified nutritional anaemias	0.870	0.130
D53.2 Scorbutic anaemia	0.870	0.130
D53.1 Other megaloblastic anaemias, not elsewhere classified	0.870	0.130
D53.0 Protein deficiency anaemia	0.870	0.130
D73 Diseases of spleen	0.870	0.129
D51.3 Other dietary vitamin B12 deficiency anaemia	0.871	0.128
I70-I79 Diseases of arteries, arterioles and capillaries	0.872	0.128
I22.0 Subsequent myocardial infarction of anterior wall	0.874	0.126
I23 Certain current complications following acute myocardial infarction	0.880	0.119
D65 Disseminated intravascular coagulation [defibrination syndrome]	0.881	0.119
I21.3 Acute transmural myocardial infarction of unspecified site	0.881	0.118
D67 Hereditary factor IX deficiency	0.886	0.114
I71 Aortic aneurysm and dissection	0.886	0.114
I00-I02 Acute rheumatic fever	0.886	0.113
D66 Hereditary factor VIII deficiency	0.889	0.111
I21.9 Acute myocardial infarction, unspecified	0.890	0.110
I71.9 Aortic aneurysm of unspecified site, without mention of rupture	0.891	0.109
I70 Atherosclerosis	0.892	0.108
I71.2 Thoracic aortic aneurysm, without mention of rupture	0.895	0.105
I95-I99 Other and unspecified disorders of the circulatory system	0.900	0.100
I78 Diseases of capillaries	0.902	0.098
I70.2 Atherosclerosis of arteries of the extremities	0.906	0.094
D73.9 Disease of spleen, unspecified	0.907	0.093
D73.3 Abscess of spleen	0.907	0.093
D73.2 Chronic congestive splenomegaly	0.907	0.093
I79 Disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.907	0.093
I23.8 Other current complications following acute myocardial infarction	0.908	0.092
I99 Other and unspecified disorders of circulatory system	0.908	0.092
I22.8 Subsequent myocardial infarction of other sites	0.909	0.091
D73.0 Hyposplenism	0.910	0.090
I77 Other disorders of arteries and arterioles	0.910	0.090
I71.0 Dissection of aorta [any part]	0.910	0.090
I72 Other aneurysm	0.911	0.089
I74 Arterial embolism and thrombosis	0.911	0.089
D73.4 Cyst of spleen	0.912	0.088
I22.1 Subsequent myocardial infarction of inferior wall	0.912	0.088
I23.6 Thrombosis of atrium, auricular appendage and ventricle as current complications following acute myocardial infarction	0.914	0.086
I23.5 Rupture of papillary muscle as current complication following acute myocardial infarction	0.914	0.086
I23.4 Rupture of chordae tendineae as current complication following acute myocardial infarction	0.914	0.086
I23.3 Rupture of cardiac wall without haemopericardium as current complication following acute myocardial infarction	0.914	0.086
I23.2 Ventricular septal defect as current complication following acute myocardial infarction	0.914	0.086
I23.1 Atrial septal defect as current complication following acute myocardial infarction	0.914	0.086
I23.0 Haemopericardium as current complication following acute myocardial infarction	0.914	0.086
Chapter IV Endocrine, nutritional and metabolic diseases	0.915	0.085
I00 Rheumatic fever without mention of heart involvement	0.916	0.084
D73.1 Hypersplenism	0.917	0.082
I71.8 Aortic aneurysm of unspecified site, ruptured	0.918	0.082
I71.5 Thoracoabdominal aortic aneurysm, ruptured	0.918	0.082
I71.1 Thoracic aortic aneurysm, ruptured	0.918	0.082
I02 Rheumatic chorea	0.918	0.081
I01 Rheumatic fever with heart involvement	0.918	0.081
I77.6 Arteritis, unspecified	0.918	0.082
I71.6 Thoracoabdominal aortic aneurysm, without mention of rupture	0.919	0.080
I74.5 Embolism and thrombosis of iliac artery	0.920	0.080
I70.20 Atherosclerosis of arteries of extremities (without gangrene)	0.920	0.080
I70.8 Atherosclerosis of other arteries	0.920	0.080
I72.2 Aneurysm of renal artery	0.921	0.079
E50-E64 Other nutritional deficiencies	0.921	0.079
I35.0 Aortic (valve) stenosis	0.921	0.079
I78.1 Naevus, nonneoplastic	0.922	0.078
I70.9 Generalised and unspecified atherosclerosis	0.922	0.078
I35 Nonrheumatic aortic valve disorders	0.923	0.077
I70.0 Atherosclerosis of aorta	0.923	0.077
I22.9 Subsequent myocardial infarction of unspecified site	0.924	0.076
I97 Postprocedural disorders of circulatory system, not elsewhere classified	0.924	0.076
I70.21 Atherosclerosis of arteries of extremities (with gangrene)	0.924	0.076
I35.2 Aortic (valve) stenosis with insufficiency	0.924	0.076
I70.1 Atherosclerosis of renal artery	0.925	0.075
I63.8 Other cerebral infarction	0.929	0.071
I72.3 Aneurysm of iliac artery	0.929	0.071
E53 Deficiency of other B group vitamins	0.929	0.071
I24 Other acute ischaemic heart diseases	0.930	0.070
I78.8 Other diseases of capillaries	0.930	0.070
I77.1 Stricture of artery	0.930	0.070
I78.9 Disease of capillaries, unspecified	0.930	0.070
E55 Vitamin D deficiency	0.930	0.069
D73.8 Other diseases of spleen	0.931	0.069
I63 Cerebral infarction	0.931	0.069
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	0.932	0.068
I79.8 Other disorders of arteries, arterioles and capillaries in diseases classified elsewhere	0.932	0.068
E53.8 Deficiency of other specified B group vitamins	0.933	0.067
I79.1 Aortitis in diseases classified elsewhere	0.933	0.067
I79.0 Aneurysm of aorta in diseases classified elsewhere	0.933	0.067
I79.2 Peripheral angiopathy in diseases classified elsewhere	0.933	0.067
I78.0 Hereditary haemorrhagic telangiectasia	0.933	0.067
I63.5 Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries	0.934	0.066
I97.1 Other functional disturbances following cardiac surgery	0.934	0.066
I35.1 Aortic (valve) insufficiency	0.934	0.066
I77.5 Necrosis of artery	0.935	0.065
I77.4 Coeliac artery compression syndrome	0.935	0.065
I77.3 Arterial fibromuscular dysplasia	0.935	0.065
I26-I28 Pulmonary heart disease and diseases of pulmonary circulation	0.935	0.065
I74.9 Embolism and thrombosis of unspecified artery	0.935	0.064
I63.2 Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries	0.936	0.064
I72.6 Aneurysm and dissection of vertebral artery	0.936	0.064
I72.5 Aneurysm and dissection of other precerebral arteries	0.936	0.064
I74.1 Embolism and thrombosis of other and unspecified parts of aorta	0.937	0.063
E55.9 Vitamin D deficiency, unspecified	0.937	0.063
D69 Purpura and other haemorrhagic conditions	0.937	0.063
I74.4 Embolism and thrombosis of arteries of extremities, unspecified	0.938	0.062
I74.8 Embolism and thrombosis of other arteries	0.939	0.061
I72.9 Aneurysm of unspecified site	0.939	0.061
I72.8 Aneurysm of other specified arteries	0.939	0.060
I63.4 Cerebral infarction due to embolism of cerebral arteries	0.940	0.060
I70.80 Atherosclerosis of other arteries (without gangrene)	0.940	0.060
I72.0 Aneurysm of carotid artery	0.940	0.060
I74.3 Embolism and thrombosis of arteries of the lower extremities	0.940	0.060
D73.5 Infarction of spleen	0.940	0.059
I77.2 Rupture of artery	0.941	0.059
I01.9 Acute rheumatic heart disease, unspecified	0.941	0.059
I01.8 Other acute rheumatic heart disease	0.941	0.059
I01.2 Acute rheumatic myocarditis	0.941	0.059
I01.1 Acute rheumatic endocarditis	0.941	0.059
I01.0 Acute rheumatic pericarditis	0.941	0.059
I02.9 Rheumatic chorea without heart involvement	0.941	0.059
I02.0 Rheumatic chorea with heart involvement	0.941	0.059
I70.81 Atherosclerosis of other arteries (with gangrene)	0.942	0.057
I30-I52 Other forms of heart disease	0.943	0.057
E64 Sequelae of malnutrition and other nutritional deficiencies	0.943	0.057
E63 Other nutritional deficiencies	0.943	0.057
E50 Vitamin A deficiency	0.943	0.057
E60 Dietary zinc deficiency	0.943	0.057
E59 Dietary selenium deficiency	0.943	0.057
E58 Dietary calcium deficiency	0.943	0.057
E54 Ascorbic acid deficiency	0.943	0.057
E52 Niacin deficiency [pellagra]	0.943	0.057
I77.0 Arteriovenous fistula, acquired	0.943	0.056
E16 Other disorders of pancreatic internal secretion	0.944	0.056
I70.91 Generalized and unspecified atherosclerosis (with gangrene)	0.944	0.056
I70.90 Generalized and unspecified atherosclerosis (without gangrene)	0.944	0.056
I70.01 Atherosclerosis of aorta (with gangrene)	0.944	0.055
I77.8 Other specified disorders of arteries and arterioles	0.944	0.056
D61.9 Aplastic anaemia, unspecified	0.945	0.055
I70.00 Atherosclerosis of aorta (without gangrene)	0.945	0.055
I24.0 Coronary thrombosis not resulting in myocardial infarction	0.945	0.055
I97.0 Postcardiotomy syndrome	0.945	0.055
E51 Thiamine deficiency	0.946	0.054
I70.11 Atherosclerosis of renal artery (with gangrene)	0.946	0.054
E61 Deficiency of other nutrient elements	0.946	0.054
E56 Other vitamin deficiencies	0.946	0.053
I35.8 Other aortic valve disorders	0.947	0.053
I97.8 Other postprocedural disorders of circulatory system, not elsewhere classified	0.947	0.053
I74.0 Embolism and thrombosis of abdominal aorta	0.947	0.053
I35.9 Aortic valve disorder, unspecified	0.947	0.053
I97.2 Postmastectomy lymphoedema syndrome	0.947	0.053
I24.1 Dressler's syndrome	0.948	0.052
E16.2 Hypoglycaemia, unspecified	0.948	0.052
I72.1 Aneurysm of artery of upper extremity	0.948	0.051
E53.1 Pyridoxine deficiency	0.949	0.051
E53.0 Riboflavin deficiency	0.949	0.051
I70.10 Atherosclerosis of renal artery (without gangrene)	0.949	0.051
I28 Other diseases of pulmonary vessels	0.949	0.051
D64.9 Anaemia, unspecified	0.950	0.050
E55.0 Rickets, active	0.950	0.050
I63.6 Cerebral infarction due to cerebral venous thrombosis, nonpyogenic	0.950	0.050
I63.1 Cerebral infarction due to embolism of precerebral arteries	0.950	0.050
D69.9 Haemorrhagic condition, unspecified	0.950	0.050
I63.0 Cerebral infarction due to thrombosis of precerebral arteries	0.950	0.049
I60-I69 Cerebrovascular diseases	0.951	0.049
E15 Nondiabetic hypoglycaemic coma	0.951	0.049
I97.9 Postprocedural disorder of circulatory system, unspecified	0.953	0.047
I74.2 Embolism and thrombosis of arteries of the upper extremities	0.953	0.047
I36 Nonrheumatic tricuspid valve disorders	0.953	0.047
E53.9 Vitamin B deficiency, unspecified	0.953	0.046
I72.4 Aneurysm of artery of lower extremity	0.953	0.046
I51.7 Cardiomegaly	0.954	0.046
I42 Cardiomyopathy	0.954	0.046
D69.5 Secondary thrombocytopenia	0.954	0.046
I51 Complications and ill-defined descriptions of heart disease	0.955	0.045
D69.8 Other specified haemorrhagic conditions	0.955	0.045
D69.1 Qualitative platelet defects	0.955	0.045
D68 Other coagulation defects	0.955	0.045
D69.4 Other primary thrombocytopenia	0.956	0.044
D69.3 Idiopathic thrombocytopenic purpura	0.956	0.044
I77.9 Disorder of arteries and arterioles, unspecified	0.957	0.043
E16.1 Other hypoglycaemia	0.957	0.043
D69.2 Other nonthrombocytopenic purpura	0.957	0.043
I33 Acute and subacute endocarditis	0.957	0.043
I98 Other disorders of circulatory system in diseases classified elsewhere	0.958	0.042
E40-E46 Malnutrition	0.958	0.041
I42.9 Cardiomyopathy, unspecified	0.958	0.042
I52 Other heart disorders in diseases classified elsewhere	0.959	0.041
I48 Atrial fibrillation and flutter	0.959	0.041
I43 Cardiomyopathy in diseases classified elsewhere	0.959	0.041
I41 Myocarditis in diseases classified elsewhere	0.959	0.041
I39 Endocarditis and heart valve disorders in diseases classified elsewhere	0.959	0.041
I32 Pericarditis in diseases classified elsewhere	0.959	0.041
I28.8 Other specified diseases of pulmonary vessels	0.959	0.041
E50.9 Vitamin A deficiency, unspecified	0.959	0.041
E50.8 Other manifestations of vitamin A deficiency	0.959	0.041
E50.7 Other ocular manifestations of vitamin A deficiency	0.959	0.041
E50.6 Vitamin A deficiency with xerophthalmic scars of cornea	0.959	0.041
E50.5 Vitamin A deficiency with night blindness	0.959	0.041
E50.4 Vitamin A deficiency with keratomalacia	0.959	0.041
E50.3 Vitamin A deficiency with corneal ulceration and xerosis	0.959	0.041
E50.2 Vitamin A deficiency with corneal xerosis	0.959	0.041
E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis	0.959	0.041
E50.0 Vitamin A deficiency with conjunctival xerosis	0.959	0.041
E63.9 Nutritional deficiency, unspecified	0.959	0.041
E63.8 Other specified nutritional deficiencies	0.959	0.041
E63.1 Imbalance of constituents of food intake	0.959	0.041
E63.0 Essential fatty acid [EFA] deficiency	0.959	0.041
E64.9 Sequelae of unspecified nutritional deficiency	0.959	0.041
E64.8 Sequelae of other nutritional deficiencies	0.959	0.041
E64.3 Sequelae of rickets	0.959	0.041
E64.2 Sequelae of vitamin C deficiency	0.959	0.041
E64.1 Sequelae of vitamin A deficiency	0.959	0.041
E64.0 Sequelae of protein-energy malnutrition	0.959	0.041
E16.9 Disorder of pancreatic internal secretion, unspecified	0.959	0.041
E16.8 Other specified disorders of pancreatic internal secretion	0.959	0.041
E16.4 Abnormal secretion of gastrin	0.959	0.041
E16.3 Increased secretion of glucagon	0.959	0.041
E61.2 Magnesium deficiency	0.960	0.040
I36.1 Nonrheumatic tricuspid (valve) insufficiency	0.960	0.040
I45 Other conduction disorders	0.960	0.040
Z95.0 Presence of cardiac pacemaker	0.960	0.040
E10-E14 Diabetes mellitus	0.961	0.039
E51.9 Thiamine deficiency, unspecified	0.961	0.039
E51.8 Other manifestations of thiamine deficiency	0.961	0.039
E51.1 Beriberi	0.961	0.039
E61.9 Deficiency of nutrient element, unspecified	0.961	0.039
E61.8 Deficiency of other specified nutrient elements	0.961	0.039
E61.7 Deficiency of multiple nutrient elements	0.961	0.039
E61.6 Vanadium deficiency	0.961	0.039
E61.5 Molybdenum deficiency	0.961	0.039
E61.4 Chromium deficiency	0.961	0.039
E61.3 Manganese deficiency	0.961	0.039
E61.0 Copper deficiency	0.961	0.039
E10.3 With ophthalmic complications	0.961	0.039
I42.1 Obstructive hypertrophic cardiomyopathy	0.961	0.039
E56.9 Vitamin deficiency, unspecified	0.961	0.038
E56.8 Deficiency of other vitamins	0.961	0.038
E56.0 Deficiency of vitamin E	0.961	0.038
D68.5 Primary Thrombophilia	0.961	0.039
I40 Acute myocarditis	0.962	0.038
I51.3 Intracardiac thrombosis, not elsewhere classified	0.962	0.038
D69.0 Allergic purpura	0.962	0.038
I51.4 Myocarditis, unspecified	0.962	0.038
I38 Endocarditis, valve unspecified	0.962	0.038
E10 Insulin-dependent diabetes mellitus	0.962	0.038
I37 Pulmonary valve disorders	0.963	0.037
I63.3 Cerebral infarction due to thrombosis of cerebral arteries	0.963	0.037
E51.2 Wernicke's encephalopathy	0.963	0.037
I28.9 Disease of pulmonary vessels, unspecified	0.963	0.037
I28.1 Aneurysm of pulmonary artery	0.963	0.037
I28.0 Arteriovenous fistula of pulmonary vessels	0.963	0.037
I62 Other nontraumatic intracranial haemorrhage	0.963	0.037
D68.3 Haemorrhagic disorder due to circulating anticoagulants	0.964	0.036
E20-E35 Disorders of other endocrine glands	0.964	0.036
E56.1 Deficiency of vitamin K	0.964	0.035
D68.1 Hereditary factor XI deficiency	0.965	0.035
I24.8 Other forms of acute ischaemic heart disease	0.965	0.035
I42.8 Other cardiomyopathies	0.966	0.034
E22 Hyperfunction of pituitary gland	0.966	0.034
I33.9 Acute endocarditis, unspecified	0.966	0.034
I42.2 Other hypertrophic cardiomyopathy	0.966	0.034
I26 Pulmonary embolism	0.966	0.034
E61.1 Iron deficiency	0.966	0.034
I49.3 Ventricular premature depolarisation	0.966	0.034

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations