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Variant clusters
Hospitalization Episode Statistics (HES)
Genetic variants: 36,212
Diagnostic terms: × 19,155
Association results: = 693,640,860
Self-Reported Statistics (SRS)
Genetic variants: 28,458
Diagnostic terms: × 474
Association results: = 13,489,092
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Variant-specific associations

rs8142548
log Bayes Factor = 11.8001
Chromosome 22   position 37,365,039  (GRCh37) Explore rs8142548 on Ensembl!
Variant rs8142548 is part of Cluster X0210

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)
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Results table
Term Risk
posterior probability
 No effect
posterior probability
 Protective
posterior probability
  
# Top node
1.000 0.000 0.000
Chapter II Neoplasms
1.000 0.000 0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes
1.000 0.000 0.000
C43-C44 Melanoma and other malignant neoplasms of skin
1.000 0.000 0.000
Chapter XIII Diseases of the musculoskeletal system and connective tissue
0.999 0.001 0.000
C44 Other malignant neoplasms of skin
0.999 0.001 0.000
T80-T88 Complications of surgical and medical care, not elsewhere classified
0.999 0.001 0.000
Chapter XX External causes of morbidity and mortality
0.999 0.001 0.000
Chapter XV Pregnancy, childbirth and the puerperium
0.998 0.002 0.000
Chapter XXI Factors influencing health status and contact with health services
0.997 0.003 0.000
O30-O48 Maternal care related to the fetus and amniotic cavity and possible delivery problems
0.997 0.003 0.000
M20-M25 Other joint disorders
0.994 0.006 0.000
Chapter I Certain infectious and parasitic diseases
0.994 0.006 0.000
C44.3 Skin of other and unspecified parts of face
0.992 0.008 0.000
C44.6 Skin of upper limb, including shoulder
0.983 0.017 0.000
M25 Other joint disorders, not elsewhere classified
0.981 0.019 0.000
O46 Antepartum haemorrhage, not elsewhere classified
0.980 0.020 0.000
A00-A09 Intestinal infectious diseases
0.977 0.023 0.000
T81 Complications of procedures, not elsewhere classified
0.976 0.024 0.000
Y83-Y84 Surgical and other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.974 0.026 0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes
0.970 0.030 0.000
Chapter X Diseases of the respiratory system
0.969 0.031 0.000
O46.9 Antepartum haemorrhage, unspecified
0.968 0.032 0.000
Z40-Z54 Persons encountering health services for specific procedures and health care
0.963 0.037 0.000
M05-M14 Inflammatory polyarthropathies
0.962 0.038 0.000
Y40-Y59 Drugs, medicaments and biological substances causing adverse effects in therapeutic use
0.960 0.040 0.000
T81.8 Other complications of procedures, not elsewhere classified
0.960 0.040 0.000
Z50 Care involving use of rehabilitation procedures
0.957 0.043 0.000
Z00-Z13 Persons encountering health services for examination and investigation
0.947 0.053 0.000
D00-D09 In situ neoplasms
0.946 0.054 0.000
A04 Other bacterial intestinal infections
0.945 0.055 0.000
Z80-Z99 Persons with potential health hazards related to family and personal history and certain conditions influencing health status
0.942 0.058 0.000
Z08.0 Follow-up examination after surgery for malignant neoplasm
0.940 0.060 0.000
Z88 Personal history of allergy to drugs, medicaments and biologocal substances
0.940 0.060 0.000
C15-C26 Malignant neoplasms of digestive organs
0.940 0.060 0.000
Z08 Follow-up examination after treatment for malignant neoplasm
0.939 0.061 0.000
Y84 Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.938 0.062 0.000
M22 Disorders of patella
0.931 0.069 0.000
Z88.0 Personal history of allergy to penicillin
0.931 0.069 0.000
M65-M68 Disorders of synovium and tendon
0.927 0.073 0.000
J09-J18 Influenza and pneumonia
0.926 0.074 0.000
M06 Other rheumatoid arthritis
0.925 0.075 0.000
Z93 Artificial opening status
0.920 0.080 0.000
O36 Maternal care for other known or suspected foetal problems
0.917 0.083 0.000
Z50.1 Other physical therapy
0.913 0.087 0.000
T83 Complications of genito-urinary prosthetic devices, implants and grafts
0.911 0.089 0.000
Z01 Other special examinations and investigations of persons without complaint or reported diagnosis
0.906 0.094 0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities
0.903 0.097 0.000
M25.8 Other specified joint disorders
0.901 0.099 0.000
Y84.2 Radiological procedure and radiotherapy
0.901 0.099 0.000
T86 Failure and rejection of transplanted organs and tissues
0.900 0.100 0.000
T88 Other complications of surgical and medical care, not elsewhere classified
0.896 0.104 0.000
M06.9 Rheumatoid arthritis, unspecified
0.896 0.104 0.000
O20-O29 Other maternal disorders predominantly related to pregnancy
0.896 0.104 0.000
A30-A49 Other bacterial diseases
0.894 0.106 0.000
C43 Malignant melanoma of skin
0.894 0.106 0.000
Z88.2 Personal history of allergy to sulphonamides
0.882 0.118 0.000
T84 Complications of internal orthopaedic prosthetic devices, implants and grafts
0.881 0.119 0.000
M25.3 Other instability of joint
0.876 0.124 0.000
D04 Carcinoma in situ of skin
0.874 0.126 0.000
T93 Sequelae of injuries of lower limb
0.872 0.128 0.000
Z50.9 Care involving use of rehabilitation procedure, unspecified
0.869 0.131 0.000
Z94 Transplanted organ and tissue status
0.868 0.132 0.000
Y40 Systemic antibiotics
0.867 0.133 0.000
S80-S89 Injuries to the knee and lower leg
0.867 0.133 0.000
C81-C96 Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue
0.863 0.137 0.000
C73-C75 Malignant neoplasms of thyroid and other endocrine glands
0.862 0.138 0.000
M22.8 Other disorders of patella
0.862 0.138 0.000
O10-O16 Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
0.862 0.138 0.000
W00-W19 Falls
0.860 0.140 0.000
Y43 Primarily systemic agents
0.859 0.141 0.000
Z93.1 Gastrostomy status
0.858 0.142 0.000
M25.4 Effusion of joint
0.857 0.143 0.000
J15 Bacterial pneumonia, not elsewhere classified
0.856 0.144 0.000
A04.8 Other specified bacterial intestinal infections
0.855 0.145 0.000
T81.3 Disruption of operation wound, not elsewhere classified
0.855 0.145 0.000
Z50.7 Occupational therapy and vocational rehabilitation, not elsewhere classified
0.853 0.147 0.000
Z80 Family history of malignant neoplasm
0.850 0.150 0.000
C15 Malignant neoplasm of oesophagus
0.848 0.152 0.000
M25.5 Pain in joint
0.845 0.155 0.000
T81.2 Accidental puncture and laceration during a procedure, not elsewhere classified
0.843 0.157 0.000
M21 Other acquired deformities of limbs
0.843 0.157 0.000
B25-B34 Other viral diseases
0.843 0.157 0.000
M24 Other specific joint derangements
0.842 0.158 0.000
Y83 Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
0.841 0.159 0.000
M91-M94 Chondropathies
0.840 0.160 0.000
A08 Viral and other specified intestinal infections
0.837 0.163 0.000
A04.7 Enterocolitis due to Clostridium difficile
0.837 0.163 0.000
Z93.3 Colostomy status
0.833 0.167 0.000
M67 Other disorders of synovium and tendon
0.832 0.168 0.000
Z01.8 Other specified special examinations
0.831 0.169 0.000
J30-J39 Other diseases of upper respiratory tract
0.831 0.169 0.000
J80-J84 Other respiratory diseases principally affecting the interstitium
0.830 0.170 0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee
0.829 0.171 0.000
Y83.2 Surgical operation with anastomosis, bypass or graft
0.827 0.173 0.000
O40 Polyhydramnios
0.824 0.176 0.000
D03 Melanoma in situ
0.822 0.177 0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis
0.821 0.179 0.000
Z01.6 Radiological examination, not elsewhere classified
0.820 0.179 0.000
M86-M90 Other osteopathies
0.818 0.182 0.000
V10-V19 Pedal cyclist injured in transport accident
0.817 0.183 0.000
O41 Other disorders of amniotic fluid and membranes
0.815 0.185 0.000
T98 Sequelae of other and unspecified effects of external causes
0.813 0.187 0.000
J90-J94 Other diseases of pleura
0.810 0.190 0.000
M31 Other necrotising vasculopathies
0.810 0.190 0.000
Q60-Q64 Congenital malformations of the urinary system
0.806 0.194 0.000
T84.5 Infection and inflammatory reaction due to internal joint prosthesis
0.806 0.194 0.000
Z40 Prophylactic surgery
0.804 0.196 0.000
T92 Sequelae of injuries of upper limb
0.803 0.197 0.000
Z50.5 Speech therapy
0.802 0.198 0.000
C19 Malignant neoplasm of rectosigmoid junction
0.802 0.198 0.000
Z20-Z29 Persons with potential health hazards related to communicable diseases
0.801 0.199 0.000
O35 Maternal care for known or suspected foetal abnormality and damage
0.801 0.199 0.000
O36.8 Maternal care for other specified foetal problems
0.799 0.201 0.000
T80 Complications following infusion, transfusion and therapeutic injection
0.796 0.204 0.000
Z43 Attention to artificial openings
0.796 0.204 0.000
M60-M63 Disorders of muscles
0.796 0.204 0.000
M13 Other arthritis
0.796 0.204 0.000
C26 Malignant neoplasm of other and ill-defined digestive organs
0.796 0.204 0.000
X40-X49 Accidental poisoning by and exposure to noxious substances
0.795 0.205 0.000
C21 Malignant neoplasm of anus and anal canal
0.794 0.205 0.000
W20-W49 Exposure to inanimate mechanical forces
0.794 0.206 0.000
M80-M85 Disorders of bone density and structure
0.794 0.206 0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region
0.793 0.207 0.000
C00-C14 Malignant neoplasms of lip, oral cavity and pharynx
0.793 0.207 0.000
Z94.0 Kidney transplant status
0.792 0.208 0.000
Z85 Personal history of malignant neoplasm
0.792 0.208 0.000
O33 Maternal care for known or suspected disproportion
0.790 0.210 0.000
C44.0 Skin of lip
0.788 0.212 0.000
M25.84 Other specified joint disorders (Hand)
0.788 0.212 0.000
Z49 Care involving dialysis
0.788 0.212 0.000
M06.94 Rheumatoid arthritis, unspecified (Hand)
0.787 0.213 0.000
C44.5 Skin of trunk
0.787 0.213 0.000
B00-B09 Viral infections characterized by skin and mucous membrane lesions
0.786 0.214 0.000
O32 Maternal care for known or suspected malpresentation of foetus
0.786 0.214 0.000
S83.5 Sprain and strain involving (anterior)(posterior) cruciate ligament of knee
0.785 0.214 0.000
A02 Other Salmonella infections
0.785 0.215 0.000
J38 Diseases of vocal cords and larynx, not elsewhere classified
0.784 0.216 0.000
M05 Seropositive rheumatoid arthritis
0.783 0.217 0.000
T83.0 Mechanical complication of urinary (indwelling) catheter
0.783 0.217 0.000
T88.7 Unspecified adverse effect of drug or medicament
0.782 0.218 0.000
Z80.9 Family history of malignant neoplasm, unspecified
0.781 0.219 0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)
0.781 0.219 0.000
T86.1 Kidney transplant failure and rejection
0.781 0.219 0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract
0.780 0.220 0.000
Z55-Z65 Persons with potential health hazards related to socioeconomic and psychosocial circumstances
0.779 0.221 0.000
T90 Sequelae of injuries of head
0.778 0.222 0.000
O36.6 Maternal care for excessive foetal growth
0.776 0.224 0.000
M25.59 Pain in joint (Site unspecified)
0.775 0.225 0.000
C15.5 Lower third of oesophagus
0.775 0.225 0.000
Z88.1 Personal history of allergy to other antibiotic agents
0.775 0.225 0.000
A04.5 Campylobacter enteritis
0.775 0.225 0.000
Z50.8 Care involving use of rehabilitation procedures
0.774 0.226 0.000
J15.7 Pneumonia due to Mycoplasma pneumoniae
0.774 0.226 0.000
Y43.0 Antiallergic and antiemetic drugs
0.773 0.227 0.000
J34 Other disorders of nose and nasal sinuses
0.772 0.228 0.000
B90-B94 Sequelae of infectious and parasitic diseases
0.771 0.229 0.000
Y44 Agents primarily affecting blood constituents
0.769 0.231 0.000
M22.4 Chondromalacia patellae
0.768 0.232 0.000
Y40.9 Systemic antibiotic, unspecified
0.768 0.232 0.000
C43.7 Malignant melanoma of lower limb, including hip
0.767 0.233 0.000
O36.5 Maternal care for poor foetal growth
0.767 0.233 0.000
Y84.9 Medical procedure, unspecified
0.767 0.233 0.000
T83.4 Mechanical complication of other prosthetic devices, implants and grafts in genital tract
0.767 0.233 0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source
0.765 0.235 0.000
T81.9 Unspecified complication of procedure
0.764 0.236 0.000
A41 Other septicaemia
0.763 0.237 0.000
C73 Malignant neoplasm of thyroid gland
0.763 0.237 0.000
Z97 Presence of other devices
0.763 0.237 0.000
T81.7 Vascular complications following a procedure, not elsewhere classified
0.761 0.239 0.000
O26 Maternal care for other conditions predominantly related to pregnancy
0.761 0.239 0.000
S70-S79 Injuries to the hip and thigh
0.759 0.241 0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue
0.759 0.241 0.000
B65-B83 Helminthiases
0.759 0.241 0.000
S50-S59 Injuries to the elbow and forearm
0.759 0.241 0.000
M65 Synovitis and tenosynovitis
0.757 0.243 0.000
T93.9 Sequelae of unspecified injury of lower limb
0.757 0.243 0.000
X50-X57 Overexertion, travel and privation
0.756 0.244 0.000
Z88.5 Personal history of allergy to narcotic agent
0.755 0.245 0.000
C44.7 Skin of lower limb, including hip
0.752 0.248 0.000
C44.4 Skin of scalp and neck
0.752 0.248 0.000
Z93.0 Tracheostomy status
0.752 0.248 0.000
A40 Streptococcal septicaemia
0.751 0.249 0.000
Y90-Y98 Supplementary factors related to causes of morbidity and mortality classified elsewhere
0.751 0.249 0.000
Y84.6 Urinary catheterisation
0.750 0.250 0.000
T86.8 Failure and rejection of other transplanted organs and tissues
0.750 0.250 0.000
C17 Malignant neoplasm of small intestine
0.749 0.251 0.000
Z88.3 Personal history of allergy to other anti-infective agents
0.748 0.252 0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)
0.748 0.252 0.000
Z80.1 Family history of malignant neoplasm of trachea, bronchus and lung
0.747 0.253 0.000
D04.3 Skin of other and unspecified parts of face
0.747 0.253 0.000
O24 Diabetes mellitus in pregnancy
0.746 0.254 0.000
Z47 Other orthopaedic follow-up care
0.745 0.255 0.000
Z11 Special screening examination for infectious and parasitic diseases
0.743 0.257 0.000
M67.8 Other specified disorders of synovium and tendon
0.741 0.259 0.000
T93.2 Sequelae of other fractures of lower limb
0.740 0.260 0.000
V40-V49 Car occupant injured in transport accident
0.739 0.261 0.000
A80-A89 Viral infections of the central nervous system
0.738 0.262 0.000
Y60-Y69 Misadventures to patients during surgical and medical care
0.738 0.262 0.000
M06.96 Rheumatoid arthritis, unspecified (Lower leg)
0.738 0.262 0.000
A08.4 Viral intestinal infection, unspecified
0.737 0.262 0.000
Z42 Follow-up care involving plastic surgery
0.737 0.263 0.000
J14 Pneumonia due to Haemophilus influenzae
0.736 0.264 0.000
D05 Carcinoma in situ of breast
0.736 0.264 0.000
B34 Viral infection of unspecified site
0.735 0.265 0.000
C44.9 Malignant neoplasm of skin, unspecified
0.734 0.266 0.000
O16 Unspecified maternal hypertension
0.734 0.266 0.000
J38.3 Other diseases of vocal cords
0.733 0.267 0.000
M25.37 Other instability of joint (Ankle and foot)
0.733 0.267 0.000
C51-C58 Malignant neoplasms of female genital organs
0.732 0.268 0.000
J93 Pneumothorax
0.732 0.268 0.000
Z88.7 Personal history of allergy to serum and vaccine
0.731 0.269 0.000
T84.9 Unspecified complication of internal orthopaedic prosthetic device, implant and graft
0.731 0.269 0.000
M25.6 Stiffness of joint, not elsewhere classified
0.731 0.269 0.000
Y48 Anaesthetics and therapeutic gases
0.731 0.269 0.000
C43.5 Malignant melanoma of trunk
0.730 0.270 0.000
O43 Placental disorders
0.730 0.270 0.000
C30-C39 Malignant neoplasms of respiratory and intrathoracic organs
0.728 0.272 0.000
Y41 Other systemic anti-infectives and antiparasitics
0.728 0.272 0.000
Z81 Family history of mental and behavioural disorders
0.728 0.272 0.000
B20-B24 Human immunodeficiency virus [HIV] disease
0.727 0.273 0.000
M00-M03 Infectious arthropathies
0.726 0.273 0.000
Z41 Procedures for purposes other than remedying health state
0.726 0.274 0.000
Z80.5 Family history of malignant neoplasm of urinary tract
0.725 0.275 0.000
O42 Premature rupture of membranes
0.725 0.275 0.000
M25.34 Other instability of joint (Hand)
0.723 0.277 0.000
M25.47 Effusion of joint (Ankle and foot)
0.723 0.277 0.000
D06 Carcinoma in situ of cervix uteri
0.722 0.278 0.000
J34.3 Hypertrophy of nasal turbinates
0.722 0.278 0.000
T91 Sequelae of injuries of neck and trunk
0.722 0.278 0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)
0.721 0.279 0.000
Y84.4 Aspiration of fluid
0.721 0.279 0.000
J95-J99 Other diseases of the respiratory system
0.721 0.279 0.000
Z93.6 Other artificial openings of urinary tract status
0.720 0.280 0.000
C24 Malignant neoplasm of other and unspecified parts of biliary tract
0.719 0.281 0.000
Chapter XVI Certain conditions originating in the perinatal period
0.717 0.283 0.000
C40-C41 Malignant neoplasms of bone and articular cartilage
0.717 0.283 0.000
T33-T35 Frostbite
0.717 0.283 0.000
T26-T28 Burns and corrosions confined to eye and internal organs
0.717 0.283 0.000
T20-T25 Burns and corrosions of external body surface, specified by site
0.717 0.283 0.000
T00-T07 Injuries involving multiple body regions
0.717 0.283 0.000
Z93.5 Cystostomy status
0.717 0.283 0.000
C44.8 Overlapping lesion of skin
0.716 0.283 0.000
D04.7 Skin of lower limb, including hip
0.716 0.284 0.000
C83 Diffuse non-Hodgkin's lymphoma
0.716 0.284 0.000
T87 Complications peculiar to reattachment and amputation
0.716 0.284 0.000
Y70-Y82 Medical devices associated with adverse incidents in diagnostic and therapeutic use
0.716 0.284 0.000
Y35-Y36 Legal intervention and operations of war
0.716 0.284 0.000
Y10-Y34 Event of undetermined intent
0.716 0.284 0.000
Y00-Y09 Assault
0.716 0.284 0.000
X85-X99 Assault
0.716 0.284 0.000
X58-X59 Accidental exposure to other and unspecified factors
0.716 0.284 0.000
X30-X39 Exposure to forces of nature
0.716 0.284 0.000
X10-X19 Contact with heat and hot substances
0.716 0.284 0.000
X00-X09 Exposure to smoke, fire and flames
0.716 0.284 0.000
W85-W99 Exposure to electric current, radiation and extreme ambient air temperature and pressure
0.716 0.284 0.000
W75-W84 Other accidental threats to breathing
0.716 0.284 0.000
W65-W74 Accidental drowning and submersion
0.716 0.284 0.000
W50-W64 Exposure to animate mechanical forces
0.716 0.284 0.000
V98-V99 Other and unspecified transport accidents
0.716 0.284 0.000
V95-V97 Air and space transport accidents
0.716 0.284 0.000
V90-V94 Water transport accidents
0.716 0.284 0.000
V80-V89 Other land transport accidents
0.716 0.284 0.000
V70-V79 Bus occupant injured in transport accident
0.716 0.284 0.000
V60-V69 Occupant of heavy transport vehicle injured in transport accident
0.716 0.284 0.000
V50-V59 Occupant of pick-up truck or van injured in transport accident
0.716 0.284 0.000
V30-V39 Occupant of three-wheeled motor vehicle injured in transport accident
0.716 0.284 0.000
V01-V09 Pedestrian injured in transport accident
0.716 0.284 0.000
O85-O92 Complications predominantly related to the puerperium
0.716 0.284 0.000
J13 Pneumonia due to Streptococcus pneumoniae
0.716 0.284 0.000
C85 Other and unspecified types of non-Hodgkin's lymphoma
0.715 0.285 0.000
T79-T79 Certain early complications of trauma
0.715 0.285 0.000
Z50.4 Psychotherapy, not elsewhere classified
0.715 0.285 0.000
O45 Premature separation of placenta [abruptio placentae]
0.714 0.285 0.000
O44 Placenta praevia
0.714 0.285 0.000
O31 Complications specific to multiple gestation
0.714 0.285 0.000
O30 Multiple gestation
0.714 0.286 0.000
C45-C49 Malignant neoplasms of mesothelial and soft tissue
0.713 0.287 0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere
0.713 0.287 0.000
M33 Dermatopolymyositis
0.713 0.287 0.000
M32 Systemic lupus erythematosus
0.713 0.287 0.000
M30 Polyarteritis nodosa and related conditions
0.713 0.287 0.000
T83.8 Other complications of genito-urinary prosthetic devices, implants and grafts
0.713 0.287 0.000
B99-B99 Other infectious diseases
0.712 0.287 0.000
B85-B89 Pediculosis, acariasis and other infestations
0.712 0.287 0.000
B50-B64 Protozoal diseases
0.712 0.287 0.000
A92-A99 Arthropod-borne viral fevers and viral haemorrhagic fevers
0.712 0.287 0.000
A75-A79 Rickettsioses
0.712 0.287 0.000
A70-A74 Other diseases caused by chlamydiae
0.712 0.287 0.000
A65-A69 Other spirochaetal diseases
0.712 0.287 0.000
A20-A28 Certain zoonotic bacterial diseases
0.712 0.287 0.000
A15-A19 Tuberculosis
0.712 0.287 0.000
Q00-Q07 Congenital malformations of the nervous system
0.712 0.288 0.000
X20-X29 Contact with venomous animals and plants
0.711 0.288 0.000
Z52 Donors of organs and tissues
0.711 0.289 0.000
Z04 Examination and observation for other reasons
0.711 0.289 0.000
J81 Pulmonary oedema
0.711 0.289 0.000
O47 False labour
0.710 0.289 0.000
M34 Systemic sclerosis
0.709 0.291 0.000
W18 Other fall on same level
0.708 0.292 0.000
C64-C68 Malignant neoplasms of urinary tract
0.708 0.292 0.000
C97-C97 Malignant neoplasms of independent (primary) multiple sites
0.708 0.292 0.000
M66 Spontaneous rupture of synovium and tendon
0.708 0.292 0.000
J11 Influenza, virus not identified
0.707 0.292 0.000
C60-C63 Malignant neoplasms of male genital organs
0.707 0.293 0.000
Q61 Cystic kidney disease
0.707 0.293 0.000
S10-S19 Injuries to the neck
0.706 0.294 0.000
S60-S69 Injuries to the wrist and hand
0.705 0.295 0.000
S00-S09 Injuries to the head
0.704 0.296 0.000
M25.2 Flail joint
0.704 0.296 0.000
M25.1 Fistula of joint
0.704 0.296 0.000
M25.0 Haemarthrosis
0.704 0.296 0.000
T88.5 Other complications of anaesthesia
0.703 0.297 0.000
M25.57 Pain in joint (Ankle and foot)
0.703 0.297 0.000
D04.6 Skin of upper limb, including shoulder
0.703 0.297 0.000
O46.8 Other antepartum haemorrhage
0.703 0.297 0.000
O46.0 Antepartum haemorrhage with coagulation defect
0.703 0.297 0.000
S40-S49 Injuries to the shoulder and upper arm
0.701 0.299 0.000
T84.3 Mechanical complication of other bone devices, implants and grafts
0.701 0.299 0.000
Z99 Dependence on enabling machines and devices, not elsewhere classified
0.701 0.299 0.000
A07 Other protozoal intestinal diseases
0.700 0.299 0.000
A06 Amoebiasis
0.700 0.299 0.000
A05 Other bacterial foodborne intoxications
0.700 0.299 0.000
A03 Shigellosis
0.700 0.299 0.000
A01 Typhoid and paratyphoid fevers
0.700 0.299 0.000
A00 Cholera
0.700 0.299 0.000
T81.6 Acute reaction to foreign substance accidentally left during a procedure
0.700 0.300 0.000
T81.1 Shock during or resulting from a procedure, not elsewhere classified
0.700 0.300 0.000
Y43.1 Antineoplastic antimetabolites
0.700 0.300 0.000
Y45 Analgesics, antipyretics and anti-inflammatory drugs
0.699 0.301 0.000
Y40.8 Other systemic antibiotics
0.699 0.301 0.000
O26.9 Pregnancy-related condition, unspecified
0.698 0.302 0.000
Z88.9 Personal history of allergy to unspecified drugs, medicaments and biological substances
0.697 0.303 0.000
Z85.9 Personal history of malignant neoplasm, unspecified
0.697 0.303 0.000
O34 Maternal care for known or suspected abnormality of pelvic organs
0.696 0.304 0.000
M24.8 Other specific joint derangements, not elsewhere classified
0.696 0.304 0.000
T95 Sequelae of burns, corrosions and frostbite
0.695 0.304 0.000
T94 Sequelae of injuries involving multiple and unspecified body regions
0.695 0.304 0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source
0.695 0.304 0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances
0.695 0.304 0.000
T84.6 Infection and inflammatory reaction due to internal fixation device [any site]
0.695 0.305 0.000
O41.0 Oligohydramnios
0.695 0.305 0.000
M24.2 Disorder of ligament
0.694 0.306 0.000
O00-O08 Pregnancy with abortive outcome
0.694 0.306 0.000
T84.7 Infection and inflammatory reaction due to other internal orthopaedic prosthetic devices, implants and grafts
0.693 0.307 0.000
C26.0 Intestinal tract, part unspecified
0.693 0.307 0.000
M25.9 Joint disorder, unspecified
0.692 0.308 0.000
M13.9 Arthritis, unspecified
0.692 0.308 0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions
0.692 0.308 0.000
J38.7 Other diseases of larynx
0.692 0.308 0.000
M35 Other systemic involvement of connective tissue
0.692 0.308 0.000
J18 Pneumonia, organism unspecified
0.691 0.309 0.000
M25.45 Effusion of joint (Pelvic region and thigh)
0.691 0.309 0.000
Z44 Fitting and adjustment of external prosthetic device
0.690 0.310 0.000
M93 Other osteochondropathies
0.690 0.310 0.000
M14 Arthropathies in other diseases classified elsewhere
0.690 0.310 0.000
M12 Other specific arthropathies
0.690 0.310 0.000
M09 Juvenile arthritis in diseases classified elsewhere
0.690 0.310 0.000
M08 Juvenile arthritis
0.690 0.310 0.000
O80-O84 Delivery
0.690 0.310 0.000
Y59 Other and unspecified vaccines and biological substances
0.688 0.312 0.000
Y58 Bacterial vaccines
0.688 0.312 0.000
Y56 Topical agents primarily affecting skin and mucous membrane and ophthalmological, otorhinolaryngological and dental drugs
0.688 0.312 0.000
Y55 Agents primarily acting on smooth and skeletal muscles and the respiratory system
0.688 0.312 0.000
Y54 Agents primarily affecting water-balance and mineral and uric acid metabolism
0.688 0.312 0.000
Y53 Agents primarily affecting the gastro-intestinal system
0.688 0.312 0.000
Y50 Central nervous system stimulants, not elsewhere classified
0.688 0.312 0.000
Y49 Psychotropic drugs, not elsewhere classified
0.688 0.312 0.000
Y47 Sedatives, hypnotics and antianxiety drugs
0.688 0.312 0.000
Y46 Antiepileptics and anti-Parkinsonism drugs
0.688 0.312 0.000
J34.8 Other specified disorders of nose and nasal sinuses
0.688 0.312 0.000
M06.3 Rheumatoid nodule
0.688 0.312 0.000
Y43.4 Immunosuppressive agents
0.687 0.313 0.000
V18 Pedal cyclist injured in noncollision transport accident
0.687 0.313 0.000
O21 Excessive vomiting in pregnancy
0.687 0.313 0.000
Z50.6 Orthoptic training
0.686 0.314 0.000
Z50.3 Drug rehabilitation
0.686 0.314 0.000
T66-T78 Other and unspecified effects of external causes
0.686 0.314 0.000
S83.2 Tear of meniscus, current
0.685 0.315 0.000
W10 Fall on and from stairs and steps
0.684 0.316 0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)
0.684 0.316 0.000
C44.2 Skin of ear and external auricular canal
0.683 0.317 0.000
M31.5 Giant cell arteritis with polymyalgia rheumatica
0.682 0.318 0.000
A09 Diarrhoea and gastro-enteritis of presumed infectious origin
0.681 0.319 0.000
Y83.9 Surgical procedure, unspecified
0.681 0.319 0.000
B15-B19 Viral hepatitis
0.680 0.320 0.000
Z43.1 Attention to gastrostomy
0.680 0.320 0.000
Z97.4 Presence of external hearing-aid
0.680 0.320 0.000
Z85.8 Personal history of malignant neoplasms of other organs and systems
0.680 0.320 0.000
Z83 Family history of other specific disorders
0.680 0.320 0.000
Z54 Convalescence
0.679 0.321 0.000
Z10 Routine general health check-up of defined subpopulation
0.679 0.321 0.000
M21.0 Valgus deformity, not elsewhere classified
0.678 0.322 0.000
D02 Carcinoma in situ of middle ear and respiratory system
0.678 0.322 0.000
D01 Carcinoma in situ of other and unspecified digestive organs
0.678 0.322 0.000
D00 Carcinoma in situ of oral cavity, oesophagus and stomach
0.678 0.322 0.000
A04.9 Bacterial intestinal infection, unspecified
0.678 0.322 0.000
A04.6 Enteritis due to Yersinia enterocolitica
0.678 0.322 0.000
A04.4 Other intestinal Escherichia coli infections
0.678 0.322 0.000
A04.3 Enterohaemorrhagic Escherichia coli infection
0.678 0.322 0.000
A04.2 Enteroinvasive Escherichia coli infection
0.678 0.322 0.000
A04.1 Enterotoxigenic Escherichia coli infection
0.678 0.322 0.000
A04.0 Enteropathogenic Escherichia coli infection
0.678 0.322 0.000
Y84.0 Cardiac catheterisation
0.677 0.323 0.000
T83.1 Mechanical complication of other urinary devices and implants
0.677 0.323 0.000
J15.1 Pneumonia due to Pseudomonas
0.676 0.324 0.000
Q80-Q89 Other congenital malformations
0.675 0.324 0.000
Z29 Need for other prophylactic measures
0.675 0.325 0.000
Z84 Family history of other conditions
0.675 0.325 0.000
C23 Malignant neoplasm of gallbladder
0.674 0.326 0.000
Z08.1 Follow-up examination after radiotherapy for malignant neoplasm
0.674 0.326 0.000
Chapter XXII Codes for special purposes
0.673 0.327 0.000
Y84.7 Blood-sampling
0.672 0.328 0.000
Y84.5 Insertion of gastric or duodenal sound
0.672 0.328 0.000
Y84.3 Shock therapy
0.672 0.328 0.000
A50-A64 Infections with a predominantly sexual mode of transmission
0.672 0.328 0.000
Y84.1 Kidney dialysis
0.672 0.328 0.000
M11 Other crystal arthropathies
0.671 0.329 0.000
T88.6 Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
0.671 0.329 0.000
Y57 Other and unspecified drugs and medicaments
0.671 0.329 0.000
S20-S29 Injuries to the thorax
0.669 0.331 0.000
Z40.8 Other prophylactic surgery
0.669 0.331 0.000
M06.0 Seronegative rheumatoid arthritis
0.669 0.331 0.000
W06 Fall involving bed
0.668 0.332 0.000
S90-S99 Injuries to the ankle and foot
0.668 0.332 0.000
M22.1 Recurrent subluxation of patella
0.668 0.332 0.000
M22.9 Disorder of patella, unspecified
0.668 0.332 0.000
M22.3 Other derangements of patella
0.668 0.332 0.000
M22.0 Recurrent dislocation of patella
0.668 0.332 0.000
C43.4 Malignant melanoma of scalp and neck
0.667 0.333 0.000
M25.31 Other instability of joint (Shoulder region)
0.666 0.333 0.000
C43.9 Malignant melanoma of skin, unspecified
0.665 0.334 0.000
D03.3 Melanoma in situ of other and unspecified parts of face
0.665 0.334 0.000
O14 Gestational [pregnancy-induced] hypertension with significant proteinuria
0.665 0.335 0.000
Y52 Agents primarily affecting the cardiovascular system
0.665 0.335 0.000
M68 Disorders of synovium and tendon in diseases classified elsewhere
0.665 0.335 0.000
Q20-Q28 Congenital malformations of the circulatory system
0.664 0.335 0.000
A41.9 Septicaemia, unspecified
0.664 0.336 0.000
T98.1 Sequelae of other and unspecified effects of external causes
0.664 0.336 0.000
J17 Pneumonia in diseases classified elsewhere
0.664 0.336 0.000
J16 Pneumonia due to other infectious organisms, not elsewhere classified
0.664 0.336 0.000
J12 Viral pneumonia, not elsewhere classified
0.664 0.336 0.000
J09 Influenza due to certain identified influenza virus
0.664 0.336 0.000
M06.8 Other specified rheumatoid arthritis
0.663 0.336 0.000
M06.4 Inflammatory polyarthropathy
0.663 0.336 0.000
M06.2 Rheumatoid bursitis
0.663 0.336 0.000
M06.1 Adult-onset Still's disease
0.663 0.336 0.000
Z42.3 Follow-up care involving plastic surgery of upper extremity
0.664 0.336 0.000
C20 Malignant neoplasm of rectum
0.663 0.337 0.000
Z85.7 Personal history of other malignant neoplasms of lymphoid, haematopoietic and related tissues
0.662 0.338 0.000
M25.54 Pain in joint (Hand)
0.662 0.338 0.000
S32 Fracture of lumbar spine and pelvis
0.662 0.338 0.000
T81.5 Foreign body accidentally left in body cavity or operation wound following a procedure
0.662 0.338 0.000
B07 Viral warts
0.661 0.339 0.000
O35.1 Maternal care for (suspected) chromosomal abnormality in foetus
0.660 0.339 0.000
Z93.9 Artificial opening status, unspecified
0.660 0.340 0.000
Z93.8 Other artificial opening status
0.660 0.340 0.000
J10 Influenza due to identified influenza virus
0.660 0.340 0.000
Z89 Acquired absence of limb
0.659 0.341 0.000
M21.3 Wrist or foot drop (acquired)
0.658 0.341 0.000
C81 Hodgkin's disease
0.658 0.341 0.000
M94 Other disorders of cartilage
0.658 0.342 0.000
M67.1 Other contracture of tendon (sheath)
0.658 0.342 0.000
O94-O99 Other obstetric conditions, not elsewhere classified
0.658 0.342 0.000
B34.9 Viral infection, unspecified
0.658 0.342 0.000
O36.7 Maternal care for viable foetus in abdominal pregnancy
0.657 0.342 0.000
O36.4 Maternal care for intra-uterine death
0.657 0.342 0.000
O36.3 Maternal care for signs of foetal hypoxia
0.657 0.342 0.000
O36.2 Maternal care for hydrops foetalis
0.657 0.342 0.000
O36.1 Maternal care for other isoimmunisation
0.657 0.342 0.000
M22.2 Patellofemoral disorders
0.657 0.343 0.000
T88.4 Failed or difficult intubation
0.657 0.343 0.000
T15-T19 Effects of foreign body entering through natural orifice
0.657 0.343 0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)
0.657 0.343 0.000
Z08.9 Follow-up examination after unspecified treatment for malignant neoplasm
0.656 0.344 0.000
C21.0 Anus, unspecified
0.656 0.344 0.000
M05.9 Seropositive rheumatoid arthritis, unspecified
0.655 0.345 0.000
Q38-Q45 Other congenital malformations of the digestive system
0.654 0.346 0.000
Z94.4 Liver transplant status
0.654 0.346 0.000
J15.0 Pneumonia due to Klebsiella pneumoniae
0.654 0.346 0.000
A41.8 Other specified septicaemia
0.653 0.346 0.000
T83.9 Unspecified complication of genito-urinary prosthetic device, implant and graft
0.653 0.347 0.000
T83.6 Infection and inflammatory reaction due to prosthetic device, implant and graft in genital tract
0.653 0.347 0.000
T83.2 Mechanical complication of graft of urinary organ
0.653 0.347 0.000
Z46 Fitting and adjustment of other devices
0.652 0.348 0.000
J93.1 Other spontaneous pneumothorax
0.652 0.348 0.000
D03.4 Melanoma in situ of scalp and neck
0.651 0.349 0.000
A49 Bacterial infection of unspecified site
0.651 0.349 0.000
X60-X84 Intentional self-harm
0.651 0.349 0.000
Q65-Q79 Congenital malformations and deformations of the musculoskeletal system
0.650 0.350 0.000
O20 Haemorrhage in early pregnancy
0.650 0.350 0.000
Z01.9 Special examination, unspecified
0.649 0.350 0.000
Z01.7 Laboratory examination
0.649 0.350 0.000
Z01.5 Diagnostic skin and sensitisation tests
0.649 0.350 0.000
Z01.3 Examination of blood pressure
0.649 0.350 0.000
Z01.2 Dental examination
0.649 0.350 0.000
Z01.1 Examination of ears and hearing
0.649 0.350 0.000
Z01.0 Examination of eyes and vision
0.649 0.350 0.000
Z94.8 Other transplanted organ and tissue status
0.649 0.351 0.000
D04.5 Skin of trunk
0.649 0.351 0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

 

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

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