TreeWAS – Variant ID: rs9270965

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

Hierarchical visualisation How to interpret this figure?

Click here to show this figure without filtering.

Click on a node to zoom (except terminal nodes).

Download this figure in format

Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
E03.9 Hypothyroidism, unspecified	1.000	0.000	0.000
E10.9 Without complications	1.000	0.000	0.000
E10.3 With ophthalmic complications	1.000	0.000	0.000
E10.1 With ketoacidosis	1.000	0.000	0.000
E16.2 Hypoglycaemia, unspecified	1.000	0.000	0.000
K51.9 Ulcerative colitis, unspecified	0.000	0.000	1.000
K90.0 Coeliac disease	1.000	0.000	0.000
E10 Insulin-dependent diabetes mellitus	1.000	0.000	0.000
G35 Multiple sclerosis	0.000	0.000	1.000
E10-E14 Diabetes mellitus	1.000	0.000	0.000
E00-E07 Disorders of thyroid gland	1.000	0.000	0.000
Chapter IV Endocrine, nutritional and metabolic diseases	1.000	0.000	0.000
J45.9 Asthma, unspecified	1.000	0.000	0.000
E03 Other hypothyroidism	1.000	0.000	0.000
E14 Unspecified diabetes mellitus	1.000	0.000	0.000
E16 Other disorders of pancreatic internal secretion	1.000	0.000	0.000
E11 Non-insulin-dependent diabetes mellitus	1.000	0.000	0.000
E15-E16 Other disorders of glucose regulation and pancreatic internal secretion	1.000	0.000	0.000
K51 Ulcerative colitis	0.000	0.000	1.000
E05 Thyrotoxicosis [hyperthyroidism]	1.000	0.000	0.000
E83.1 Disorders of iron metabolism	0.000	0.001	0.999
E05.9 Thyrotoxicosis, unspecified	0.996	0.004	0.000
E14.3 With ophthalmic complications	0.995	0.005	0.000
E14.9 Without complications	0.995	0.005	0.000
E10.4 With neurological complications	0.991	0.009	0.000
E11.1 With ketoacidosis	0.988	0.012	0.000
K51.4 Pseudopolyposis of colon	0.000	0.017	0.983
E05.0 Thyrotoxicosis with diffuse goitre	0.983	0.017	0.000
K51.3 Ulcerative (chronic) rectosigmoiditis	0.000	0.018	0.982
E11.3 With ophthalmic complications	0.982	0.018	0.000
K51.8 Other ulcerative colitis	0.000	0.024	0.976
G35-G37 Demyelinating diseases of the central nervous system	0.001	0.029	0.970
G37 Other demyelinating diseases of central nervous system	0.000	0.036	0.964
E11.9 Without complications	0.960	0.040	0.000
G37.9 Demyelinating disease of central nervous system, unspecified	0.000	0.043	0.957
E20-E35 Disorders of other endocrine glands	0.956	0.044	0.000
Z93.2 Ileostomy status	0.000	0.046	0.954
H36.0 Diabetic retinopathy	0.953	0.047	0.000
E06 Thyroiditis	0.951	0.049	0.000
E21 Hyperparathyroidism and other disorders of parathyroid gland	0.944	0.056	0.000
E10.5 With peripheral circulatory complications	0.942	0.058	0.000
E11.2 With renal complications	0.930	0.070	0.000
E10.0 With coma	0.929	0.071	0.000
E24 Cushing's syndrome	0.923	0.077	0.000
E10.8 With unspecified complications	0.915	0.085	0.000
E03.8 Other specified hypothyroidism	0.910	0.090	0.000
E14.1 With ketoacidosis	0.887	0.113	0.000
E16.0 Drug-induced hypoglycaemia without coma	0.882	0.118	0.000
E21.0 Primary hyperparathyroidism	0.880	0.120	0.000
E14.8 With unspecified complications	0.878	0.122	0.000
E16.1 Other hypoglycaemia	0.870	0.130	0.000
K51.2 Ulcerative (chronic) proctitis	0.000	0.136	0.864
E21.3 Hyperparathyroidism, unspecified	0.862	0.138	0.000
E10.2 With renal complications	0.857	0.143	0.000
E06.3 Autoimmune thyroiditis	0.856	0.144	0.000
E03.2 Hypothyroidism due to medicaments and other exogenous substances	0.854	0.146	0.000
K51.5 Mucosal proctocolitis	0.000	0.148	0.852
E13 Other specified diabetes mellitus	0.849	0.151	0.000
E24.2 Drug-induced Cushing's syndrome	0.838	0.162	0.000
E11.6 With other specified complications	0.815	0.185	0.000
E06.5 Other chronic thyroiditis	0.814	0.186	0.000
E24.9 Cushing's syndrome, unspecified	0.812	0.188	0.000
E10.6 With other specified complications	0.805	0.195	0.000
E24.0 Pituitary-dependent Cushing's disease	0.799	0.201	0.000
E05.2 Thyrotoxicosis with toxic multinodular goitre	0.788	0.212	0.000
E21.1 Secondary hyperparathyroidism, not elsewhere classified	0.788	0.212	0.000
E11.7 With multiple complications	0.782	0.217	0.000
E40-E46 Malnutrition	0.777	0.223	0.000
E07 Other disorders of thyroid	0.775	0.225	0.000
G37.8 Other specified demyelinating diseases of central nervous system	0.000	0.228	0.772
E10.7 With multiple complications	0.771	0.229	0.000
E14.4 With neurological complications	0.760	0.240	0.000
E21.5 Disorder of parathyroid gland, unspecified	0.758	0.242	0.000
E13.9 Without complications	0.745	0.255	0.000
E06.9 Thyroiditis, unspecified	0.727	0.273	0.000
E14.5 With peripheral circulatory complications	0.726	0.274	0.000
E32 Diseases of thymus	0.721	0.278	0.000
E14.2 Withrenal complications	0.721	0.279	0.000
E14.6 With other specified complications	0.720	0.280	0.000
G37.3 Acute transverse myelitis in demyelinating disease of central nervous system	0.000	0.282	0.718
E01 Iodine-deficiency-related thyroid disorders and allied conditions	0.717	0.283	0.000
E00 Congenital iodine-deficiency syndrome	0.717	0.283	0.000
E12 Malnutrition-related diabetes mellitus	0.717	0.283	0.000
E03.5 Myxoedema coma	0.717	0.283	0.000
E03.4 Atrophy of thyroid (acquired)	0.717	0.283	0.000
E03.3 Postinfectious hypothyroidism	0.717	0.283	0.000
E14.7 With multiple complications	0.717	0.283	0.000
E16.9 Disorder of pancreatic internal secretion, unspecified	0.717	0.283	0.000
E16.8 Other specified disorders of pancreatic internal secretion	0.717	0.283	0.000
E16.4 Abnormal secretion of gastrin	0.717	0.283	0.000
E16.3 Increased secretion of glucagon	0.717	0.283	0.000
E15 Nondiabetic hypoglycaemic coma	0.717	0.283	0.000
E06.1 Subacute thyroiditis	0.717	0.283	0.000
E05.5 Thyroid crisis or storm	0.717	0.283	0.000
E05.4 Thyrotoxicosis factitia	0.717	0.283	0.000
E05.3 Thyrotoxicosis from ectopic thyroid tissue	0.717	0.283	0.000
E03.0 Congenital hypothyroidism with diffuse goitre	0.714	0.286	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.290	0.710
M06.9 Rheumatoid arthritis, unspecified	0.000	0.290	0.710
M06 Other rheumatoid arthritis	0.000	0.296	0.704
E11.5 With peripheral circulatory complications	0.703	0.297	0.000
E14.0 With coma	0.702	0.298	0.000
G36 Other acute disseminated demyelination	0.001	0.301	0.698
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.302	0.698
M06.0 Seronegative rheumatoid arthritis	0.000	0.303	0.697
E02 Subclinical iodine-deficiency hypothyroidism	0.692	0.308	0.000
G37.5 Concentric sclerosis [Balo]	0.000	0.309	0.691
G37.4 Subacute necrotising myelitis	0.000	0.309	0.691
G37.2 Central pontine myelinolysis	0.000	0.309	0.691
G37.1 Central demyelination of corpus callosum	0.000	0.309	0.691
G37.0 Diffuse sclerosis	0.000	0.309	0.691
E35 Disorders of endocrine glands in diseases classified elsewhere	0.685	0.315	0.000
E30 Disorders of puberty, not elsewhere classified	0.685	0.315	0.000
E21.4 Other specified disorders of parathyroid gland	0.683	0.317	0.000
E06.4 Drug-induced thyroiditis	0.682	0.318	0.000
E06.2 Chronic thyroiditis with transient thyrotoxicosis	0.682	0.318	0.000
E06.0 Acute thyroiditis	0.682	0.318	0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.000	0.324	0.676
E31 Polyglandular dysfunction	0.675	0.325	0.000
K90 Intestinal malabsorption	0.674	0.326	0.000
E28 Ovarian dysfunction	0.669	0.331	0.000
E21.2 Other hyperparathyroidism	0.664	0.335	0.000
E24.4 Alcohol-induced pseudo-Cushing's syndrome	0.662	0.338	0.000
E24.3 Ectopic ACTH syndrome	0.662	0.338	0.000
E24.1 Nelson's syndrome	0.662	0.338	0.000
E05.1 Thyrotoxicosis with toxic single thyroid nodule	0.658	0.341	0.000
E29 Testicular dysfunction	0.645	0.355	0.000
E11.8 With unspecified complications	0.636	0.364	0.000
E03.1 Congenital hypothyroidism without goitre	0.632	0.367	0.000
H36 Retinal disorders in diseases classified elsewhere	0.622	0.378	0.000
E46 Unspecified protein-energy malnutrition	0.617	0.383	0.000
E25 Adrenogenital disorders	0.616	0.384	0.000
K90.9 Intestinal malabsorption, unspecified	0.610	0.390	0.000
E13.8 With unspecified complications	0.609	0.391	0.000
E13.7 With multiple complications	0.609	0.391	0.000
E13.6 With other specified complications	0.609	0.391	0.000
E13.5 With peripheral circulatory complications	0.609	0.391	0.000
E13.4 With neurological complications	0.609	0.391	0.000
E13.2 With renal complications	0.609	0.391	0.000
E13.1 With ketoacidosis	0.609	0.391	0.000
E13.0 With coma	0.609	0.391	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.000	0.394	0.606
M06.3 Rheumatoid nodule	0.000	0.395	0.605
E05.8 Other thyrotoxicosis	0.605	0.395	0.000
E34 Other endocrine disorders	0.604	0.395	0.000
E07.8 Other specified disorders of thyroid	0.603	0.397	0.000
K51.1 Ulcerative (chronic) ileocolitis	0.000	0.398	0.602
M05 Seropositive rheumatoid arthritis	0.000	0.399	0.601
E13.3 With ophthalmic complications	0.599	0.401	0.000
M05-M14 Inflammatory polyarthropathies	0.000	0.401	0.599
J45 Asthma	0.597	0.403	0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.000	0.403	0.597
M06.07 Seronegative rheumatoid arthritis (Ankle and foot)	0.000	0.412	0.588
M06.96 Rheumatoid arthritis, unspecified (Lower leg)	0.000	0.419	0.581
M06.06 Seronegative rheumatoid arthritis (Lower leg)	0.000	0.423	0.577
E20 Hypoparathyroidism	0.577	0.423	0.000
E07.9 Disorder of thyroid, unspecified	0.570	0.430	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.000	0.433	0.567
E24.8 Other Cushing's syndrome	0.566	0.434	0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.000	0.436	0.564
E11.0 With coma	0.560	0.440	0.000
E44 Protein-energy malnutrition of moderate and mild degree	0.557	0.443	0.000
E45 Retarded development following protein-energy malnutrition	0.557	0.443	0.000
E43 Unspecified severe protein-energy malnutrition	0.557	0.443	0.000
E42 Marasmic kwashiorkor	0.557	0.443	0.000
E41 Nutritional marasmus	0.557	0.443	0.000
E40 Kwashiorkor	0.557	0.443	0.000
E07.1 Dyshormogenetic goitre	0.556	0.444	0.000
E07.0 Hypersecretion of calcitonin	0.556	0.444	0.000
E26 Hyperaldosteronism	0.554	0.445	0.000
E32.8 Other diseases of thymus	0.554	0.446	0.000
E27 Other disorders of adrenal gland	0.553	0.447	0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.000	0.452	0.548
K51.0 Ulcerative (chronic) enterocolitis	0.000	0.459	0.541
M06.05 Seronegative rheumatoid arthritis (Pelvic region and thigh)	0.000	0.474	0.526
M06.34 Rheumatoid nodule (Hand)	0.000	0.476	0.524
E28.2 Polycystic ovarian syndrome	0.519	0.481	0.000
E32.9 Disease of thymus, unspecified	0.517	0.483	0.000
E32.1 Abscess of thymus	0.517	0.483	0.000
E32.0 Persistent hyperplasia of thymus	0.517	0.483	0.000
E83 Disorders of mineral metabolism	0.000	0.486	0.514
E00.9 Congenital iodine-deficiency syndrome, unspecified	0.514	0.486	0.000
E00.2 Congenital iodine-deficiency syndrome, mixed type	0.514	0.486	0.000
E00.1 Congenital iodine-deficiency syndrome, myxoedematous type	0.514	0.486	0.000
E00.0 Congenital iodine-deficiency syndrome, neurological type	0.514	0.486	0.000
E01.8 Other iodine-deficiency-related thyroid disorders and allied conditions	0.514	0.486	0.000
E01.2 Iodine-deficiency-related (endemic) goitre, unspecified	0.514	0.486	0.000
E01.1 Iodine-deficiency-related multinodular (endemic) goitre	0.514	0.486	0.000
E01.0 Iodine-deficiency-related diffuse (endemic) goitre	0.514	0.486	0.000
E12.9 Without complications	0.514	0.486	0.000
E12.8 With unspecified complications	0.514	0.486	0.000
E12.7 With multiple complications	0.514	0.486	0.000
E12.6 With other specified complications	0.514	0.486	0.000
E12.5 With peripheral circulatory complications	0.514	0.486	0.000
E12.4 With neurological complications	0.514	0.486	0.000
E12.3 With ophthalmic complications	0.514	0.486	0.000
E12.2 With renal complications	0.514	0.486	0.000
E12.1 With ketoacidosis	0.514	0.486	0.000
E12.0 With coma	0.514	0.486	0.000
M06.2 Rheumatoid bursitis	0.000	0.495	0.505
M06.1 Adult-onset Still's disease	0.000	0.495	0.505
G36.0 Neuromyelitis optica [Devic]	0.001	0.496	0.503
G36.9 Acute disseminated demyelination, unspecified	0.001	0.499	0.501
G36.8 Other specified acute disseminated demyelination	0.001	0.499	0.501
G36.1 Acute and subacute haemorrhagic leukoencephalitis [Hurst]	0.001	0.499	0.501
M06.08 Seronegative rheumatoid arthritis (Other)	0.000	0.500	0.500
M06.03 Seronegative rheumatoid arthritis (Forearm)	0.000	0.500	0.500
M06.01 Seronegative rheumatoid arthritis (Shoulder region)	0.000	0.502	0.498
M06.04 Seronegative rheumatoid arthritis (Hand)	0.000	0.507	0.493
E30.9 Disorder of puberty, unspecified	0.491	0.509	0.000
E30.8 Other disorders of puberty	0.491	0.509	0.000
E30.1 Precocious puberty	0.491	0.509	0.000
E30.0 Delayed puberty	0.491	0.509	0.000
E35.8 Disorders of other endocrine glands in diseases classified elsewhere	0.491	0.509	0.000
E35.1 Disorders of adrenal glands in diseases classified elsewhere	0.491	0.509	0.000
E35.0 Disorders of thyroid gland in diseases classified elsewhere	0.491	0.509	0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.000	0.509	0.491
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.510	0.489
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.510	0.489
E34.8 Other specified endocrine disorders	0.487	0.513	0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.000	0.514	0.486
E31.9 Polyglandular dysfunction, unspecified	0.484	0.516	0.000
E31.8 Other polyglandular dysfunction	0.484	0.516	0.000
E31.1 Polyglandular hyperfunction	0.484	0.516	0.000
K90.3 Pancreatic steatorrhoea	0.483	0.517	0.000
K90.2 Blind loop syndrome, not elsewhere classified	0.483	0.517	0.000
K90.1 Tropical sprue	0.483	0.517	0.000
E28.9 Ovarian dysfunction, unspecified	0.479	0.520	0.000
E28.8 Other ovarian dysfunction	0.479	0.520	0.000
E28.1 Androgen excess	0.479	0.520	0.000
E28.0 Oestrogen excess	0.479	0.520	0.000
E34.3 Short stature, not elsewhere classified	0.477	0.523	0.000
E31.0 Autoimmune polyglandular failure	0.473	0.527	0.000
M06.8 Other specified rheumatoid arthritis	0.000	0.535	0.465
E27.3 Drug-induced adrenocortical insufficiency	0.464	0.536	0.000
E83.3 Disorders of phosphorus metabolism	0.000	0.537	0.463
K90.8 Other intestinal malabsorption	0.463	0.537	0.000
E29.8 Other testicular dysfunction	0.462	0.538	0.000
E29.0 Testicular hyperfunction	0.462	0.538	0.000
L40.9 Psoriasis, unspecified	0.461	0.539	0.000
E29.1 Testicular hypofunction	0.461	0.539	0.000
M12 Other specific arthropathies	0.000	0.544	0.456
M06.02 Seronegative rheumatoid arthritis (Upper arm)	0.000	0.546	0.454
M06.30 Rheumatoid nodule (Multiple sites)	0.000	0.546	0.454
M06.32 Rheumatoid nodule (Upper arm)	0.000	0.549	0.451
L40 Psoriasis	0.451	0.549	0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.000	0.552	0.448
H36.8 Other retinal disorders in diseases classified elsewhere	0.446	0.554	0.000
E20.1 Pseudohypoparathyroidism	0.442	0.557	0.000
E65-E68 Obesity and other hyperalimentation	0.442	0.558	0.000
E25.9 Adrenogenital disorder, unspecified	0.442	0.558	0.000
E25.8 Other adrenogenital disorders	0.442	0.558	0.000
M05.1 Rheumatoid lung disease	0.000	0.561	0.439
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.000	0.562	0.438
M06.36 Rheumatoid nodule (Lower leg)	0.000	0.563	0.437
J45.1 Nonallergic asthma	0.435	0.565	0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.000	0.565	0.435
M06.39 Rheumatoid nodule (Site unspecified)	0.000	0.566	0.434
M06.38 Rheumatoid nodule (Other)	0.000	0.566	0.434
M06.35 Rheumatoid nodule (Pelvic region and thigh)	0.000	0.566	0.434
M06.33 Rheumatoid nodule (Forearm)	0.000	0.566	0.434
M06.31 Rheumatoid nodule (Shoulder region)	0.000	0.566	0.434
E34.5 Androgen resistance syndrome	0.433	0.566	0.000
E34.4 Constitutional tall stature	0.433	0.566	0.000
E34.2 Ectopic hormone secretion, not elsewhere classified	0.433	0.566	0.000
E34.1 Other hypersecretion of intestinal hormones	0.433	0.566	0.000
D64.9 Anaemia, unspecified	0.432	0.568	0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.000	0.569	0.431
M09 Juvenile arthritis in diseases classified elsewhere	0.000	0.571	0.429
M05.2 Rheumatoid vasculitis	0.000	0.572	0.428
M05.0 Felty's syndrome	0.000	0.572	0.428
L90.0 Lichen sclerosus et atrophicus	0.428	0.572	0.000
J45.0 Predominantly allergic asthma	0.427	0.573	0.000
M10 Gout	0.000	0.574	0.426
E29.9 Testicular dysfunction, unspecified	0.423	0.577	0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.000	0.577	0.422
E22 Hyperfunction of pituitary gland	0.421	0.579	0.000
L40.0 Psoriasis vulgaris	0.421	0.579	0.000
M06.97 Rheumatoid arthritis, unspecified (Ankle and foot)	0.000	0.580	0.420
E83.9 Disorder of mineral metabolism, unspecified	0.000	0.582	0.418
M06.98 Rheumatoid arthritis, unspecified (Other)	0.000	0.583	0.417
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.000	0.584	0.416
M06.37 Rheumatoid nodule (Ankle and foot)	0.000	0.585	0.414
E20.0 Idiopathic hypoparathyroidism	0.414	0.586	0.000
M05.8 Other seropositive rheumatoid arthritis	0.000	0.588	0.412
E27.1 Primary adrenocortical insufficiency	0.412	0.588	0.000
J45.8 Mixed asthma	0.411	0.588	0.000
E27.9 Disorder of adrenal gland, unspecified	0.411	0.588	0.000
E28.3 Primary ovarian failure	0.408	0.591	0.000
E44.1 Mild protein-energy malnutrition	0.399	0.600	0.000
E44.0 Moderate protein-energy malnutrition	0.399	0.600	0.000
E26.8 Other hyperaldosteronism	0.397	0.602	0.000
E26.1 Secondary hyperaldosteronism	0.397	0.602	0.000
M08 Juvenile arthritis	0.000	0.603	0.397
E27.5 Adrenomedullary hyperfunction	0.397	0.603	0.000
E27.0 Other adrenocortical overactivity	0.397	0.603	0.000
E23 Hypofunction and other disorders of pituitary gland	0.395	0.605	0.000
E20.8 Other hypoparathyroidism	0.393	0.607	0.000
M14 Arthropathies in other diseases classified elsewhere	0.000	0.611	0.389
M10.0 Idiopathic gout	0.000	0.613	0.387
E27.8 Other specified disorders of adrenal gland	0.387	0.613	0.000
H30-H36 Disorders of choroid and retina	0.385	0.615	0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.000	0.626	0.373
E25.0 Congenital adrenogenital disorders associated with enzyme deficiency	0.373	0.627	0.000
D64 Other anaemias	0.371	0.628	0.000
E34.0 Carcinoid syndrome	0.370	0.630	0.000
L40-L45 Papulosquamous disorders	0.370	0.630	0.000
E83.8 Other disorders of mineral metabolism	0.000	0.631	0.369
E83.2 Disorders of zinc metabolism	0.000	0.631	0.369
E83.0 Disorders of copper metabolism	0.000	0.631	0.369
L40.8 Other psoriasis	0.365	0.635	0.000
L40.1 Generalised pustular psoriasis	0.364	0.636	0.000
K90.4 Malabsorption due to intolerance, not elsewhere classified	0.362	0.638	0.000
M06.19 Adult-onset Still's disease (Site unspecified)	0.000	0.638	0.362
M06.18 Adult-onset Still's disease (Other)	0.000	0.638	0.362
M06.17 Adult-onset Still's disease (Ankle and foot)	0.000	0.638	0.362
M06.16 Adult-onset Still's disease (Lower leg)	0.000	0.638	0.362
M06.15 Adult-onset Still's disease (Pelvic region and thigh)	0.000	0.638	0.362
M06.14 Adult-onset Still's disease (Hand)	0.000	0.638	0.362
M06.13 Adult-onset Still's disease (Forearm)	0.000	0.638	0.362
M06.12 Adult-onset Still's disease (Upper arm)	0.000	0.638	0.362
M06.11 Adult-onset Still's disease (Shoulder region)	0.000	0.638	0.362
M06.10 Adult-onset Still's disease (Multiple sites)	0.000	0.638	0.362
M06.29 Rheumatoid bursitis (Site unspecified)	0.000	0.638	0.362
M06.28 Rheumatoid bursitis (Other)	0.000	0.638	0.362
M06.27 Rheumatoid bursitis (Ankle and foot)	0.000	0.638	0.362
M06.26 Rheumatoid bursitis (Lower leg)	0.000	0.638	0.362
M06.25 Rheumatoid bursitis (Pelvic region and thigh)	0.000	0.638	0.362
M06.24 Rheumatoid bursitis (Hand)	0.000	0.638	0.362
M06.23 Rheumatoid bursitis (Forearm)	0.000	0.638	0.362
M06.22 Rheumatoid bursitis (Upper arm)	0.000	0.638	0.362
M06.21 Rheumatoid bursitis (Shoulder region)	0.000	0.638	0.362
M06.20 Rheumatoid bursitis (Multiple sites)	0.000	0.638	0.362
L40.3 Pustulosis palmaris et plantaris	0.357	0.643	0.000
D60-D64 Aplastic and other anaemias	0.352	0.648	0.000
H43.8 Other disorders of vitreous body	0.352	0.648	0.000
E11.4 With neurological complications	0.350	0.650	0.000
M12.2 Villonodular synovitis (pigmented)	0.000	0.650	0.349
H43 Disorders of vitreous body	0.349	0.651	0.000
E26.0 Primary hyperaldosteronism	0.346	0.653	0.000
Chapter III Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	0.346	0.654	0.000
H34 Retinal vascular occlusions	0.345	0.655	0.000
# Top node	0.343	0.657	0.000
Chapter XII Diseases of the skin and subcutaneous tissue	0.341	0.659	0.000
Chapter XVII Congenital malformations, deformations and chromosomal abnormalities	0.340	0.660	0.000
L90 Atrophic disorders of skin	0.338	0.662	0.000
E26.9 Hyperaldosteronism, unspecified	0.337	0.662	0.000
M12.8 Other specific arthropathies, not elsewhere classified	0.000	0.663	0.336
M07 Psoriatic and enteropathic arthropathies	0.000	0.664	0.336
H43.3 Other vitreous opacities	0.335	0.665	0.000
M06.88 Other specified rheumatoid arthritis (Other)	0.000	0.666	0.334
M06.87 Other specified rheumatoid arthritis (Ankle and foot)	0.000	0.666	0.334
M06.86 Other specified rheumatoid arthritis (Lower leg)	0.000	0.666	0.334
M06.85 Other specified rheumatoid arthritis (Pelvic region and thigh)	0.000	0.666	0.334
M06.84 Other specified rheumatoid arthritis (Hand)	0.000	0.666	0.334
M06.83 Other specified rheumatoid arthritis (Forearm)	0.000	0.666	0.334
M06.82 Other specified rheumatoid arthritis (Upper arm)	0.000	0.666	0.334
M06.81 Other specified rheumatoid arthritis (Shoulder region)	0.000	0.666	0.334
H43-H45 Disorders of vitreous body and globe	0.333	0.667	0.000
L40.4 Guttate psoriasis	0.332	0.668	0.000
Q60-Q64 Congenital malformations of the urinary system	0.332	0.668	0.000
M11 Other crystal arthropathies	0.000	0.669	0.331
Chapter VII Diseases of the eye and adnexa	0.331	0.669	0.000
M10.07 Idiopathic gout (Ankle and foot)	0.000	0.670	0.330
D50.9 Iron deficiency anaemia, unspecified	0.330	0.670	0.000
M12.4 Intermittent hydrarthrosis	0.000	0.673	0.327
M12.1 Kaschin-Beck disease	0.000	0.673	0.327
M12.0 Chronic postrheumatic arthropathy [Jaccoud]	0.000	0.673	0.327
M12.3 Palindromic rheumatism	0.000	0.674	0.326
M10.09 Idiopathic gout (Site unspecified)	0.000	0.674	0.326
J40-J47 Chronic lower respiratory diseases	0.325	0.675	0.000
H34.8 Other retinal vascular occlusions	0.324	0.676	0.000
M05.19 Rheumatoid lung disease (Site unspecified)	0.000	0.676	0.324
L40.2 Acrodermatitis continua	0.323	0.677	0.000
M12.5 Traumatic arthropathy	0.000	0.677	0.323
E83.4 Disorders of magnesium metabolism	0.000	0.678	0.322
D50-D53 Nutritional anaemias	0.321	0.679	0.000
M06.80 Other specified rheumatoid arthritis (Multiple sites)	0.000	0.680	0.320
Q61 Cystic kidney disease	0.318	0.682	0.000
D50 Iron deficiency anaemia	0.318	0.682	0.000
E67 Other hyperalimentation	0.317	0.683	0.000
E68 Sequelae of hyperalimentation	0.317	0.683	0.000
M05.20 Rheumatoid vasculitis (Multiple sites)	0.000	0.684	0.315
J43 Emphysema	0.315	0.685	0.000
M05.18 Rheumatoid lung disease (Other)	0.000	0.685	0.315
M05.17 Rheumatoid lung disease (Ankle and foot)	0.000	0.685	0.315
M05.16 Rheumatoid lung disease (Lower leg)	0.000	0.685	0.315
M05.15 Rheumatoid lung disease (Pelvic region and thigh)	0.000	0.685	0.315
M05.14 Rheumatoid lung disease (Hand)	0.000	0.685	0.315
M05.13 Rheumatoid lung disease (Forearm)	0.000	0.685	0.315
M05.12 Rheumatoid lung disease (Upper arm)	0.000	0.685	0.315
M05.11 Rheumatoid lung disease (Shoulder region)	0.000	0.685	0.315
M05.10 Rheumatoid lung disease (Multiple sites)	0.000	0.685	0.315
M06.94 Rheumatoid arthritis, unspecified (Hand)	0.000	0.685	0.314
L80-L99 Other disorders of the skin and subcutaneous tissue	0.314	0.686	0.000
M14.8 Arthropathies in other specified diseases classified elsewhere	0.000	0.687	0.313
M06.4 Inflammatory polyarthropathy	0.000	0.687	0.313
J43.9 Emphysema, unspecified	0.313	0.687	0.000
M06.89 Other specified rheumatoid arthritis (Site unspecified)	0.000	0.690	0.310
M05.39 Rheumatoid arthritis with involvement of other organs and systems (Site unspecified)	0.000	0.691	0.309
M05.38 Rheumatoid arthritis with involvement of other organs and systems (Other)	0.000	0.691	0.309
M05.37 Rheumatoid arthritis with involvement of other organs and systems (Ankle and foot)	0.000	0.691	0.309
M05.36 Rheumatoid arthritis with involvement of other organs and systems (Lower leg)	0.000	0.691	0.309
M05.35 Rheumatoid arthritis with involvement of other organs and systems (Pelvic region and thigh)	0.000	0.691	0.309
M05.34 Rheumatoid arthritis with involvement of other organs and systems (Hand)	0.000	0.691	0.309
M05.33 Rheumatoid arthritis with involvement of other organs and systems (Forearm)	0.000	0.691	0.309
M05.32 Rheumatoid arthritis with involvement of other organs and systems (Upper arm)	0.000	0.691	0.309
M05.31 Rheumatoid arthritis with involvement of other organs and systems (Shoulder region)	0.000	0.691	0.309
M05.30 Rheumatoid arthritis with involvement of other organs and systems (Multiple sites)	0.000	0.691	0.309
Q38-Q45 Other congenital malformations of the digestive system	0.309	0.691	0.000
M10.3 Gout due to impairment of renal function	0.000	0.692	0.308
M09.8 Juvenile arthritis in other diseases classified elsewhere	0.000	0.692	0.308
M09.2 Juvenile arthritis in ulcerative colitis	0.000	0.692	0.308
M09.1 Juvenile arthritis in Crohn's disease [regional enteritis]	0.000	0.692	0.308
M09.0 Juvenile arthritis in psoriasis	0.000	0.692	0.308
M05.28 Rheumatoid vasculitis (Other)	0.000	0.693	0.307
M05.27 Rheumatoid vasculitis (Ankle and foot)	0.000	0.693	0.307
M05.26 Rheumatoid vasculitis (Lower leg)	0.000	0.693	0.307
M05.25 Rheumatoid vasculitis (Pelvic region and thigh)	0.000	0.693	0.307
M05.24 Rheumatoid vasculitis (Hand)	0.000	0.693	0.307
M05.23 Rheumatoid vasculitis (Forearm)	0.000	0.693	0.307
M05.22 Rheumatoid vasculitis (Upper arm)	0.000	0.693	0.307
M05.21 Rheumatoid vasculitis (Shoulder region)	0.000	0.693	0.307
M05.08 Felty's syndrome (Other)	0.000	0.693	0.307
M05.07 Felty's syndrome (Ankle and foot)	0.000	0.693	0.307
M05.06 Felty's syndrome (Lower leg)	0.000	0.693	0.307
M05.05 Felty's syndrome (Pelvic region and thigh)	0.000	0.693	0.307
M05.04 Felty's syndrome (Hand)	0.000	0.693	0.307
M05.03 Felty's syndrome (Forearm)	0.000	0.693	0.307
M05.02 Felty's syndrome (Upper arm)	0.000	0.693	0.307
M05.01 Felty's syndrome (Shoulder region)	0.000	0.693	0.307
M05.00 Felty's syndrome (Multiple sites)	0.000	0.693	0.307
E27.2 Addisonian crisis	0.306	0.694	0.000
Q80-Q89 Other congenital malformations	0.306	0.694	0.000
M10.4 Other secondary gout	0.000	0.694	0.305
M10.2 Drug-induced gout	0.000	0.694	0.305
M10.1 Lead-induced gout	0.000	0.694	0.305
M05.09 Felty's syndrome (Site unspecified)	0.000	0.696	0.304
M10.06 Idiopathic gout (Lower leg)	0.000	0.697	0.303
L97 Ulcer of lower limb, not elsewhere classified	0.303	0.697	0.000
E22.8 Other hyperfunction of pituitary gland	0.302	0.698	0.000
Q61.2 Polycystic kidney, adult type	0.300	0.700	0.000
L10-L14 Bullous disorders	0.299	0.701	0.000
M05.89 Other seropositive rheumatoid arthritis (Site unspecified)	0.000	0.703	0.297
E23.6 Other disorders of pituitary gland	0.297	0.703	0.000
L92 Granulomatous disorders of skin and subcutaneous tissue	0.296	0.704	0.000
M05.88 Other seropositive rheumatoid arthritis (Other)	0.000	0.704	0.295
M05.87 Other seropositive rheumatoid arthritis (Ankle and foot)	0.000	0.704	0.295
M05.86 Other seropositive rheumatoid arthritis (Lower leg)	0.000	0.704	0.295
M05.85 Other seropositive rheumatoid arthritis (Pelvic region and thigh)	0.000	0.704	0.295
M05.84 Other seropositive rheumatoid arthritis (Hand)	0.000	0.704	0.295
M05.83 Other seropositive rheumatoid arthritis (Forearm)	0.000	0.704	0.295
M05.82 Other seropositive rheumatoid arthritis (Upper arm)	0.000	0.704	0.295
M05.81 Other seropositive rheumatoid arthritis (Shoulder region)	0.000	0.704	0.295
M05.29 Rheumatoid vasculitis (Site unspecified)	0.000	0.704	0.295
E50-E64 Other nutritional deficiencies	0.295	0.704	0.000
Q60 Renal agenesis and other reduction defects of kidney	0.294	0.706	0.000
E23.3 Hypothalamic dysfunction, not elsewhere classified	0.291	0.708	0.000
E04 Other non-toxic goitre	0.291	0.709	0.000
Q00-Q07 Congenital malformations of the nervous system	0.290	0.710	0.000
K90-K93 Other diseases of the digestive system	0.289	0.710	0.000
L44 Other papulosquamous disorders	0.289	0.710	0.000
Q61.3 Polycystic kidney, unspecified	0.289	0.711	0.000
D80-D89 Certain disorders involving the immune mechanism	0.288	0.712	0.000
Chapter X Diseases of the respiratory system	0.288	0.712	0.000
E22.1 Hyperprolactinaemia	0.288	0.712	0.000
E20.9 Hypoparathyroidism, unspecified	0.285	0.715	0.001
L80 Vitiligo	0.285	0.715	0.000
M08.8 Other juvenile arthritis	0.000	0.715	0.285
M08.4 Pauciarticular juvenile arthritis	0.000	0.715	0.285
M08.3 Juvenile polyarthritis (seronegative)	0.000	0.715	0.285
M08.2 Juvenile arthritis with systemic onset	0.000	0.715	0.285
M08.1 Juvenile ankylosing spondylitis	0.000	0.715	0.285
Q38 Other congenital malformations of tongue, mouth and pharynx	0.284	0.716	0.000
L92.0 Granuloma annulare	0.284	0.716	0.000
E23.1 Drug-induced hypopituitarism	0.283	0.716	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.001	0.718	0.281
Q90-Q99 Chromosomal abnormalities, not elsewhere classified	0.281	0.719	0.000
D63 Anaemia in chronic diseases classified elsewhere	0.280	0.720	0.000
M10.02 Idiopathic gout (Upper arm)	0.000	0.720	0.280
Q44 Congenital malformations of gallbladder, bile ducts and liver	0.280	0.720	0.000
M12.24 Villonodular synovitis (pigmented) (Hand)	0.000	0.721	0.279
M14.4 Arthropathy in amyloidosis	0.000	0.721	0.279
M14.3 Lipoid dermatoarthritis	0.000	0.721	0.279
M14.1 Crystal arthropathy in other metabolic disorders	0.000	0.721	0.279
M14.0 Gouty arthropathy due to enzyme defects and other inherited disorders	0.000	0.721	0.279
M10.08 Idiopathic gout (Other)	0.000	0.722	0.277
M10.05 Idiopathic gout (Pelvic region and thigh)	0.000	0.722	0.277
M10.03 Idiopathic gout (Forearm)	0.000	0.722	0.277
M10.01 Idiopathic gout (Shoulder region)	0.000	0.722	0.277
H43.2 Crystalline deposits in vitreous body	0.278	0.722	0.000
J85-J86 Suppurative and necrotic conditions of lower respiratory tract	0.277	0.723	0.000
H32 Chorioretinal disorders in diseases classified elsewhere	0.276	0.724	0.000
M05.80 Other seropositive rheumatoid arthritis (Multiple sites)	0.000	0.725	0.275
M10.00 Idiopathic gout (Multiple sites)	0.000	0.726	0.273
E65 Localised adiposity	0.273	0.727	0.000
D55-D59 Haemolytic anaemias	0.273	0.727	0.000
Q85 Phakomatoses, not elsewhere classified	0.273	0.727	0.000
M08.0 Juvenile rheumatoid arthritis	0.000	0.727	0.273
M14.6 Neuropathic arthropathy	0.000	0.728	0.272

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations