TreeWAS – Variant ID: rs2335077

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
Chapter XIII Diseases of the musculoskeletal system and connective tissue	1.000	0.000	0.000
M15-M19 Arthrosis	0.999	0.001	0.000
M80-M85 Disorders of bone density and structure	0.999	0.001	0.000
M40-M43 Deforming dorsopathies	0.995	0.005	0.000
M43 Other deforming dorsopathies	0.994	0.006	0.000
M85 Other disorders of bone density and structure	0.994	0.006	0.000
M43.1 Spondylolisthesis	0.994	0.006	0.000
M05-M14 Inflammatory polyarthropathies	0.992	0.008	0.000
M19 Other arthrosis	0.990	0.010	0.000
M19.0 Primary arthrosis of other joints	0.990	0.010	0.000
M85.8 Other specified disorders of bone density and structure	0.988	0.012	0.000
M43.16 Spondylolisthesis (Lumbar region)	0.984	0.016	0.000
M85.89 Other specified disorders of bone density and structure (Site unspecified)	0.983	0.017	0.000
M19.07 Primary arthrosis of other joints (Ankle and foot)	0.979	0.021	0.000
M06 Other rheumatoid arthritis	0.977	0.023	0.000
M05 Seropositive rheumatoid arthritis	0.975	0.025	0.000
M06.9 Rheumatoid arthritis, unspecified	0.965	0.035	0.000
M05.9 Seropositive rheumatoid arthritis, unspecified	0.965	0.035	0.000
M43.17 Spondylolisthesis (Lumbosacral region)	0.964	0.036	0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.960	0.040	0.000
M20-M25 Other joint disorders	0.952	0.048	0.000
M21 Other acquired deformities of limbs	0.944	0.056	0.000
M45-M49 Spondylopathies	0.939	0.061	0.000
M05.90 Seropositive rheumatoid arthritis, unspecified (Multiple sites)	0.937	0.063	0.000
M15 Polyarthrosis	0.935	0.065	0.000
M86-M90 Other osteopathies	0.934	0.066	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.931	0.069	0.000
M16 Coxarthrosis [arthrosis of hip]	0.931	0.069	0.000
M19.09 Primary arthrosis of other joints (Site unspecified)	0.923	0.077	0.000
M25 Other joint disorders, not elsewhere classified	0.918	0.082	0.000
M80 Osteoporosis with pathological fracture	0.918	0.082	0.000
M84 Disorders of continuity of bone	0.912	0.088	0.000
M60-M63 Disorders of muscles	0.908	0.092	0.000
M19.03 Primary arthrosis of other joints (Forearm)	0.900	0.100	0.000
M21.3 Wrist or foot drop (acquired)	0.892	0.108	0.000
M16.7 Other secondary coxarthrosis	0.891	0.109	0.000
M86 Osteomyelitis	0.890	0.110	0.000
M25.6 Stiffness of joint, not elsewhere classified	0.889	0.111	0.000
M50-M54 Other dorsopathies	0.880	0.120	0.000
M17 Gonarthrosis [arthrosis of knee]	0.880	0.120	0.000
M05.99 Seropositive rheumatoid arthritis, unspecified (Site unspecified)	0.877	0.123	0.000
M21.2 Flexion deformity	0.875	0.125	0.000
M25.7 Osteophyte	0.873	0.127	0.000
M16.3 Other dysplastic coxarthrosis	0.872	0.128	0.000
M46 Other inflammatory spondylopathies	0.871	0.129	0.000
M16.5 Other posttraumatic coxarthrosis	0.862	0.138	0.000
E10 Insulin-dependent diabetes mellitus	0.861	0.139	0.000
M21.37 Wrist or foot drop (acquired) (Ankle and foot)	0.854	0.146	0.000
E10.4 With neurological complications	0.851	0.149	0.000
E10.5 With peripheral circulatory complications	0.849	0.151	0.000
M19.04 Primary arthrosis of other joints (Hand)	0.835	0.165	0.000
M50 Cervical disk disorders	0.834	0.166	0.000
M05.95 Seropositive rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.831	0.169	0.000
M48 Other spondylopathies	0.828	0.172	0.000
M15.2 Bouchard's nodes (with arthropathy)	0.819	0.181	0.000
M25.71 Osteophyte (Shoulder region)	0.813	0.187	0.000
M33 Dermatopolymyositis	0.810	0.190	0.000
M53 Other dorsopathies, not elsewhere classified	0.808	0.192	0.000
M06.4 Inflammatory polyarthropathy	0.808	0.192	0.000
M85.86 Other specified disorders of bone density and structure (Lower leg)	0.807	0.193	0.000
M19.08 Primary arthrosis of other joints (Other)	0.803	0.197	0.000
M50.3 Other cervical disk degeneration	0.801	0.199	0.000
M43.10 Spondylolisthesis (Multiple sites in spine)	0.801	0.199	0.000
M25.8 Other specified joint disorders	0.800	0.200	0.000
M21.27 Flexion deformity (Ankle and foot)	0.799	0.201	0.000
M60 Myositis	0.793	0.207	0.000
M43.0 Spondylolysis	0.793	0.207	0.000
M17.0 Primary gonarthrosis, bilateral	0.792	0.208	0.000
M46.9 Inflammatory spondylopathy, unspecified	0.791	0.209	0.000
M87 Osteonecrosis	0.787	0.213	0.000
M85.9 Disorder of bone density and structure, unspecified	0.786	0.214	0.000
E10.9 Without complications	0.785	0.215	0.000
M85.85 Other specified disorders of bone density and structure (Pelvic region and thigh)	0.784	0.216	0.000
M95-M99 Other disorders of the musculoskeletal system and connective tissue	0.782	0.218	0.000
M25.0 Haemarthrosis	0.778	0.222	0.000
M80.1 Postoophorectomy osteoporosis with pathological fracture	0.777	0.223	0.000
M15.0 Primary generalised (osteo)arthrosis	0.776	0.224	0.000
M86.9 Osteomyelitis, unspecified	0.772	0.228	0.000
M25.68 Stiffness of joint, not elsewhere classified (Other)	0.772	0.228	0.000
M82 Osteoporosis in diseases classified elsewhere	0.771	0.228	0.000
M21.26 Flexion deformity (Lower leg)	0.770	0.230	0.000
M15.4 Erosive (osteo)arthrosis	0.770	0.230	0.000
M21.4 Flat foot [pes planus] (acquired)	0.770	0.230	0.000
M25.67 Stiffness of joint, not elsewhere classified (Ankle and foot)	0.768	0.232	0.000
M62 Other disorders of muscle	0.761	0.239	0.000
E10.3 With ophthalmic complications	0.760	0.240	0.000
M06.92 Rheumatoid arthritis, unspecified (Upper arm)	0.758	0.242	0.000
M86.6 Other chronic osteomyelitis	0.756	0.244	0.000
M90 Osteopathies in diseases classified elsewhere	0.752	0.248	0.000
M84.0 Malunion of fracture	0.752	0.248	0.000
M83 Adult osteomalacia	0.751	0.249	0.000
M84.8 Other disorders of continuity of bone	0.750	0.250	0.000
E10.2 With renal complications	0.748	0.252	0.000
M85.0 Fibrous dysplasia (monostotic)	0.747	0.253	0.000
M25.62 Stiffness of joint, not elsewhere classified (Upper arm)	0.746	0.254	0.000
M43.9 Deforming dorsopathy, unspecified	0.741	0.259	0.000
E10.6 With other specified complications	0.738	0.262	0.000
M36 Systemic disorders of connective tissue in diseases classified elsewhere	0.737	0.263	0.000
M80.9 Unspecified osteoporosis with pathological fracture	0.737	0.263	0.000
M46.99 Inflammatory spondylopathy, unspecified (Site unspecified)	0.737	0.263	0.000
M86.4 Chronic osteomyelitis with draining sinus	0.736	0.263	0.000
M46.4 Discitis, unspecified	0.734	0.266	0.000
M48.5 Collapsed vertebra, not elsewhere classified	0.733	0.267	0.000
M43.12 Spondylolisthesis (Cervical region)	0.733	0.267	0.000
M25.63 Stiffness of joint, not elsewhere classified (Forearm)	0.732	0.268	0.000
M17.4 Other secondary gonarthrosis, bilateral	0.732	0.268	0.000
M25.85 Other specified joint disorders (Pelvic region and thigh)	0.731	0.268	0.000
E10.0 With coma	0.731	0.269	0.000
M24 Other specific joint derangements	0.730	0.270	0.000
M21.9 Acquired deformity of limb, unspecified	0.729	0.271	0.000
E10.8 With unspecified complications	0.727	0.273	0.000
M85.2 Hyperostosis of skull	0.725	0.275	0.000
M19.00 Primary arthrosis of other joints (Multiple sites)	0.723	0.276	0.000
M84.3 Stress fracture, not elsewhere classified	0.722	0.278	0.000
M25.78 Osteophyte (Other)	0.721	0.279	0.000
M08 Juvenile arthritis	0.720	0.280	0.000
M20 Acquired deformities of fingers and toes	0.720	0.280	0.000
M85.88 Other specified disorders of bone density and structure (Other)	0.720	0.280	0.000
M06.8 Other specified rheumatoid arthritis	0.718	0.281	0.000
M21.5 Acquired clawhand, clubhand, clawfoot and clubfoot	0.717	0.283	0.000
M80.0 Postmenopausal osteoporosis with pathological fracture	0.716	0.284	0.000
M43.6 Torticollis	0.715	0.285	0.000
M86.97 Osteomyelitis, unspecified (Ankle and foot)	0.714	0.286	0.000
M42 Spinal osteochondrosis	0.714	0.286	0.000
M43.8 Other specified deforming dorsopathies	0.713	0.287	0.000
M43.5 Other recurrent vertebral subluxation	0.713	0.287	0.000
M43.4 Other recurrent atlantoaxial subluxation	0.713	0.287	0.000
M43.3 Recurrent atlantoaxial subluxation with myelopathy	0.713	0.287	0.000
M06.95 Rheumatoid arthritis, unspecified (Pelvic region and thigh)	0.713	0.287	0.000
M85.5 Aneurysmal bone cyst	0.713	0.287	0.000
M85.4 Solitary bone cyst	0.713	0.287	0.000
M85.3 Osteitis condensans	0.713	0.287	0.000
M85.1 Skeletal fluorosis	0.713	0.287	0.000
M80.5 Idiopathic osteoporosis with pathological fracture	0.713	0.287	0.000
M43.18 Spondylolisthesis (Sacral and sacrococcygeal region)	0.712	0.288	0.000
M43.15 Spondylolisthesis (Thoracolumbar region)	0.712	0.288	0.000
M43.14 Spondylolisthesis (Thoracic region)	0.712	0.288	0.000
M43.13 Spondylolisthesis (Cervicothoracic region)	0.712	0.288	0.000
M43.11 Spondylolisthesis (Occipito-atlanto-axial region)	0.712	0.288	0.000
M15.3 Secondary multiple arthrosis	0.712	0.288	0.000
M19.2 Other secondary arthrosis	0.712	0.288	0.000
M32 Systemic lupus erythematosus	0.712	0.288	0.000
M09 Juvenile arthritis in diseases classified elsewhere	0.711	0.289	0.000
M19.05 Primary arthrosis of other joints (Pelvic region and thigh)	0.710	0.290	0.000
M06.3 Rheumatoid nodule	0.709	0.290	0.000
M47 Spondylosis	0.710	0.290	0.000
M20.1 Hallux valgus (acquired)	0.709	0.291	0.000
M85.84 Other specified disorders of bone density and structure (Hand)	0.708	0.291	0.000
M85.82 Other specified disorders of bone density and structure (Upper arm)	0.708	0.291	0.000
M85.81 Other specified disorders of bone density and structure (Shoulder region)	0.708	0.291	0.000
M53.8 Other specified dorsopathies	0.708	0.292	0.000
M17.2 Posttraumatic gonarthrosis, bilateral	0.708	0.292	0.000
M48.8 Other specified spondylopathies	0.708	0.292	0.000
M50.2 Other cervical disk displacement	0.706	0.294	0.000
M60.9 Myositis, unspecified	0.705	0.294	0.000
M19.8 Other specified arthrosis	0.705	0.295	0.000
M33.2 Polymyositis	0.705	0.295	0.000
M05.97 Seropositive rheumatoid arthritis, unspecified (Ankle and foot)	0.704	0.296	0.000
M15.1 Heberden's nodes (with arthropathy)	0.703	0.297	0.000
M05.91 Seropositive rheumatoid arthritis, unspecified (Shoulder region)	0.701	0.299	0.000
M06.2 Rheumatoid bursitis	0.701	0.299	0.000
M06.1 Adult-onset Still's disease	0.701	0.299	0.000
M21.22 Flexion deformity (Upper arm)	0.700	0.300	0.000
M05.3 Rheumatoid arthritis with involvement of other organs and systems	0.699	0.301	0.000
M05.2 Rheumatoid vasculitis	0.699	0.301	0.000
M05.1 Rheumatoid lung disease	0.699	0.301	0.000
M05.0 Felty's syndrome	0.699	0.301	0.000
M85.6 Other cyst of bone	0.698	0.302	0.000
M46.90 Inflammatory spondylopathy, unspecified (Multiple sites in spine)	0.696	0.304	0.000
M86.1 Other acute osteomyelitis	0.694	0.306	0.000
M21.0 Valgus deformity, not elsewhere classified	0.694	0.306	0.000
M84.2 Delayed union of fracture	0.692	0.308	0.000
M05.98 Seropositive rheumatoid arthritis, unspecified (Other)	0.692	0.308	0.000
M05.93 Seropositive rheumatoid arthritis, unspecified (Forearm)	0.692	0.308	0.000
M25.72 Osteophyte (Upper arm)	0.688	0.312	0.000
M21.6 Other acquired deformities of ankle and foot	0.687	0.313	0.000
M25.73 Osteophyte (Forearm)	0.686	0.314	0.000
M87.2 Osteonecrosis due to previous trauma	0.686	0.314	0.000
M05.92 Seropositive rheumatoid arthritis, unspecified (Upper arm)	0.684	0.316	0.000
M25.79 Osteophyte (Site unspecified)	0.683	0.316	0.000
M85.83 Other specified disorders of bone density and structure (Forearm)	0.679	0.320	0.000
M25.06 Haemarthrosis (Lower leg)	0.677	0.322	0.000
M80.10 Postoophorectomy osteoporosis with pathological fracture (Multiple sites)	0.677	0.323	0.000
M85.87 Other specified disorders of bone density and structure (Ankle and foot)	0.676	0.324	0.000
M25.64 Stiffness of joint, not elsewhere classified (Hand)	0.675	0.325	0.000
M96 Postprocedural musculoskeletal disorders, not elsewhere classified	0.675	0.325	0.000
M86.67 Other chronic osteomyelitis (Ankle and foot)	0.673	0.327	0.000
M43.2 Other fusion of spine	0.670	0.329	0.000
M11 Other crystal arthropathies	0.670	0.330	0.000
M21.8 Other specified acquired deformities of limbs	0.669	0.331	0.000
M84.1 Nonunion of fracture [pseudarthrosis]	0.669	0.331	0.000
M21.1 Varus deformity, not elsewhere classified	0.668	0.332	0.000
M16.4 Posttraumatic coxarthrosis, bilateral	0.667	0.332	0.000
M80.8 Other osteoporosis with pathological fracture	0.667	0.333	0.000
M07 Psoriatic and enteropathic arthropathies	0.665	0.335	0.000
M25.88 Other specified joint disorders (Other)	0.664	0.336	0.000
M46.1 Sacro-iliitis, not elsewhere classified	0.664	0.336	0.000
M21.7 Unequal limb length (acquired)	0.664	0.336	0.000
M20.5 Other deformities of toe(s) (acquired)	0.664	0.336	0.000
M62.5 Muscle wasting and atrophy, not elsewhere classified	0.663	0.337	0.000
M15.00 Primary generalized (osteo)arthrosis, Multiple sites	0.662	0.338	0.000
M43.02 Spondylolysis (Cervical region)	0.660	0.339	0.000
M25.83 Other specified joint disorders (Forearm)	0.660	0.340	0.000
M19.01 Primary arthrosis of other joints (Shoulder region)	0.659	0.340	0.000
M06.49 Inflammatory polyarthropathy (Site unspecified)	0.659	0.341	0.000
M25.2 Flail joint	0.658	0.341	0.000
M25.1 Fistula of joint	0.658	0.341	0.000
M80.4 Drug-induced osteoporosis with pathological fracture	0.658	0.342	0.000
M80.3 Postsurgical malabsorption osteoporosis with pathological fracture	0.658	0.342	0.000
M80.2 Osteoporosis of disuse with pathological fracture	0.658	0.342	0.000
M06.93 Rheumatoid arthritis, unspecified (Forearm)	0.657	0.342	0.000
M05.8 Other seropositive rheumatoid arthritis	0.655	0.345	0.000
M84.9 Disorder of continuity of bone, unspecified	0.654	0.346	0.000
M43.19 Spondylolisthesis (Site unspecified)	0.653	0.346	0.000
M53.3 Sacrococcygeal disorders, not elsewhere classified	0.652	0.347	0.000
M25.75 Osteophyte (Pelvic region and thigh)	0.652	0.348	0.000
M84.03 Malunion of fracture (Forearm)	0.651	0.348	0.000
M63 Disorders of muscle in diseases classified elsewhere	0.651	0.349	0.000
M61 Calcification and ossification of muscle	0.651	0.349	0.000
M12 Other specific arthropathies	0.651	0.349	0.000
M50.9 Cervical disk disorder, unspecified	0.651	0.349	0.000
M47.1 Other spondylosis with myelopathy	0.650	0.350	0.000
M25.60 Stiffness of joint, not elsewhere classified (Multiple sites)	0.649	0.351	0.000
M25.76 Osteophyte (Lower leg)	0.649	0.351	0.000
M84.04 Malunion of fracture (Hand)	0.646	0.354	0.000
M17.3 Other posttraumatic gonarthrosis	0.646	0.354	0.000
M21.47 Flat foot [pes planus] (acquired)-Ankle/foot	0.645	0.355	0.000
M25.61 Stiffness of joint, not elsewhere classified (Shoulder region)	0.645	0.355	0.000
M14 Arthropathies in other diseases classified elsewhere	0.642	0.358	0.000
M80.99 Unspecified osteoporosis with pathological fracture (Site unspecified)	0.640	0.360	0.000
M21.39 Wrist or foot drop (acquired)-Site unspec	0.639	0.361	0.000
M21.38 Wrist or foot drop (acquired)-Other	0.639	0.361	0.000
M21.36 Wrist or foot drop (acquired)-Lower leg	0.639	0.361	0.000
M21.35 Wrist or foot drop (acquired)-Pelvic/thigh	0.639	0.361	0.000
M21.34 Wrist or foot drop (acquired) (Hand)	0.639	0.361	0.000
M21.33 Wrist or foot drop (acquired) (Forearm)	0.639	0.361	0.000
M21.32 Wrist or foot drop (acquired)-Upper arm	0.639	0.361	0.000
M21.31 Wrist or foot drop (acquired)-Shldr region	0.639	0.361	0.000
M21.30 Wrist or foot drop (acquired) (Multiple sites)	0.639	0.361	0.000
M84.4 Pathological fracture, not elsewhere classified	0.639	0.361	0.000
M16.2 Coxarthrosis resulting from dysplasia, bilateral	0.639	0.361	0.000
M24.4 Recurrent dislocation and subluxation of joint	0.639	0.361	0.000
M86.5 Other chronic haematogenous osteomyelitis	0.638	0.362	0.000
M86.3 Chronic multifocal osteomyelitis	0.638	0.362	0.000
M86.2 Subacute osteomyelitis	0.638	0.362	0.000
M86.0 Acute haematogenous osteomyelitis	0.638	0.362	0.000
M25.69 Stiffness of joint, not elsewhere classified (Site unspecified)	0.637	0.363	0.000
M25.65 Stiffness of joint, not elsewhere classified (Pelvic region and thigh)	0.636	0.364	0.000
E10.7 With multiple complications	0.635	0.365	0.000
M53.2 Spinal instabilities	0.634	0.366	0.000
M15.9 Polyarthrosis, unspecified	0.633	0.367	0.000
M50.8 Other cervical disk disorders	0.631	0.369	0.000
M96.0 Pseudarthrosis after fusion or arthrodesis	0.629	0.371	0.000
M84.16 Nonunion of fracture [pseudarthrosis] (Lower leg)	0.629	0.371	0.000
M85.95 Disorder of bone density and structure, unspecified (Pelvic region and thigh)	0.628	0.372	0.000
M48.56 Collapsed vertebra, not elsewhere classified (Lumbar region)	0.628	0.372	0.000
M21.29 Flexion deformity (Site unspecified)	0.627	0.373	0.000
M21.28 Flexion deformity (Other)	0.627	0.373	0.000
M21.23 Flexion deformity (Forearm)	0.627	0.373	0.000
M21.21 Flexion deformity (Shoulder region)	0.627	0.373	0.000
M21.20 Flexion deformity (Multiple sites)	0.627	0.373	0.000
M86.47 Chronic osteomyelitis with draining sinus (Ankle and foot)	0.627	0.373	0.000
M25.70 Osteophyte (Multiple sites)	0.626	0.374	0.000
M46.8 Other specified inflammatory spondylopathies	0.625	0.375	0.000
M46.5 Other infective spondylopathies	0.625	0.375	0.000
M46.0 Spinal enthesopathy	0.625	0.375	0.000
M53.82 Other specified dorsopathies (Cervical region)	0.623	0.377	0.000
M87.20 Osteonecrosis due to previous trauma (Multiple sites)	0.622	0.378	0.000
M86.8 Other osteomyelitis	0.620	0.380	0.000
M06.40 Inflammatory polyarthropathy (Multiple sites)	0.620	0.380	0.000
M60.2 Foreign body granuloma of soft tissue, not elsewhere classified	0.616	0.384	0.000
M24.8 Other specific joint derangements, not elsewhere classified	0.615	0.385	0.000
M00-M03 Infectious arthropathies	0.615	0.385	0.000
M87.8 Other osteonecrosis	0.615	0.385	0.000
M25.82 Other specified joint disorders (Upper arm)	0.608	0.392	0.000
M82.1 Osteoporosis in endocrine disorders	0.608	0.392	0.000
M05.94 Seropositive rheumatoid arthritis, unspecified (Hand)	0.607	0.393	0.000
M62.1 Other rupture of muscle (nontraumatic)	0.605	0.395	0.000
M48.50 Collapsed vertebra, not elsewhere classified (Multiple sites in spine)	0.604	0.396	0.000
M47.2 Other spondylosis with radiculopathy	0.603	0.397	0.000
M15.8 Other polyarthrosis	0.603	0.397	0.000
M88 Paget's disease of bone [osteitis deformans]	0.603	0.397	0.000
M80.95 Unspecified osteoporosis with pathological fracture (Pelvic region and thigh)	0.603	0.397	0.000
M47.12 Other spondylosis with myelopathy (Cervical region)	0.602	0.398	0.000
M46.2 Osteomyelitis of vertebra	0.601	0.399	0.000
M05.96 Seropositive rheumatoid arthritis, unspecified (Lower leg)	0.601	0.399	0.000
M46.46 Discitis, unspecified (Lumbar region)	0.601	0.399	0.000
M25.74 Osteophyte (Hand)	0.599	0.401	0.000
M17.1 Other primary gonarthrosis	0.598	0.402	0.000
M85.80 Other specified disorders of bone density and structure (Multiple sites)	0.598	0.402	0.000
M40 Kyphosis and lordosis	0.597	0.403	0.001
M84.87 Other disorders of continuity of bone (Ankle and foot)	0.596	0.404	0.000
M50.0 Cervical disk disorder with myelopathy	0.594	0.406	0.000
M48.4 Fatigue fracture of vertebra	0.594	0.406	0.000
M48.3 Traumatic spondylopathy	0.594	0.406	0.000
M48.2 Kissing spine	0.594	0.406	0.000
M48.1 Ankylosing hyperostosis [Forestier]	0.594	0.406	0.000
M84.18 Nonunion of fracture [pseudarthrosis] (Other)	0.594	0.406	0.000
M90.7 Fracture of bone in neoplastic disease	0.592	0.408	0.000
M83.1 Senile osteomalacia	0.592	0.408	0.000
M62.2 Ischaemic infarction of muscle	0.591	0.409	0.000
M84.83 Other disorders of continuity of bone (Forearm)	0.590	0.410	0.000
M48.55 Collapsed vertebra, not elsewhere classified (Thoracolumbar region)	0.589	0.411	0.000
M33.1 Other dermatomyositis	0.589	0.411	0.000
M85.68 Other cyst of bone (Other)	0.588	0.412	0.000
M48.87 Other specified spondylopathies (Lumbosacral region)	0.588	0.412	0.000
M46.98 Inflammatory spondylopathy, unspecified (Sacral and sacrococcygeal region)	0.587	0.413	0.000
M49 Spondylopathies in diseases classified elsewhere	0.586	0.414	0.000
M84.37 Stress fracture, not elsewhere classified (Ankle and foot)	0.585	0.415	0.000
M19.02 Primary arthrosis of other joints (Upper arm)	0.584	0.416	0.000
M99 Biomechanical lesions, not elsewhere classified	0.584	0.416	0.000
M36.8 Systemic disorders of connective tissue in other diseases classified elsewhere	0.583	0.417	0.000
M45 Ankylosing spondylitis	0.583	0.417	0.000
M86.94 Osteomyelitis, unspecified (Hand)	0.581	0.419	0.000
M33.9 Dermatopolymyositis, unspecified	0.581	0.419	0.000
M33.0 Juvenile dermatomyositis	0.581	0.419	0.000
M60.96 Myositis, unspecified (Lower leg)	0.581	0.419	0.000
M43.09 Spondylolysis (Site unspecified)	0.580	0.420	0.000
M46.3 Infection of intervertebral disk (pyogenic)	0.579	0.421	0.000
M53.1 Cervicobrachial syndrome	0.579	0.421	0.000
M53.0 Cervicocranial syndrome	0.579	0.421	0.000
M06.48 Inflammatory polyarthropathy (Other)	0.579	0.421	0.000
M06.47 Inflammatory polyarthropathy (Ankle and foot)	0.579	0.421	0.000
M06.46 Inflammatory polyarthropathy (Lower leg)	0.579	0.421	0.000
M06.45 Inflammatory polyarthropathy (Pelvic region and thigh)	0.579	0.421	0.000
M06.44 Inflammatory polyarthropathy (Hand)	0.579	0.421	0.000
M06.43 Inflammatory polyarthropathy (Forearm)	0.579	0.421	0.000
M06.42 Inflammatory polyarthropathy (Upper arm)	0.579	0.421	0.000
M06.41 Inflammatory polyarthropathy (Shoulder region)	0.579	0.421	0.000
M53.9 Dorsopathy, unspecified	0.578	0.422	0.000
M43.07 Spondylolysis (Lumbosacral region)	0.578	0.422	0.000
M06.0 Seronegative rheumatoid arthritis	0.577	0.423	0.000
M60.99 Myositis, unspecified (Site unspecified)	0.576	0.424	0.000
M85.99 Disorder of bone density and structure, unspecified (Site unspecified)	0.576	0.424	0.000
M06.37 Rheumatoid nodule (Ankle and foot)	0.576	0.424	0.000
M34 Systemic sclerosis	0.575	0.425	0.000
M84.06 Malunion of fracture (Lower leg)	0.575	0.425	0.000
M46.40 Discitis, unspecified (Multiple sites in spine)	0.574	0.426	0.000
M25.89 Other specified joint disorders (Site unspecified)	0.573	0.426	0.000
M25.80 Other specified joint disorders (Multiple sites)	0.573	0.426	0.000
M60.90 Myositis, unspecified (Multiple sites)	0.572	0.428	0.000
M19.06 Primary arthrosis of other joints-Lower leg	0.571	0.428	0.000
M80.00 Postmenopausal osteoporosis with pathological fracture (Multiple sites)	0.571	0.429	0.000
M85.00 Fibrous dysplasia (monostotic) (Multiple sites)	0.569	0.431	0.000
M21.07 Valgus deformity, not elsewhere classified (Ankle and foot)	0.569	0.431	0.000
M60.8 Other myositis	0.569	0.431	0.000
M60.1 Interstitial myositis	0.569	0.431	0.000
M43.08 Spondylolysis (Sacral and sacrococcygeal region)	0.568	0.431	0.000
M43.05 Spondylolysis (Thoracolumbar region)	0.568	0.431	0.000
M43.04 Spondylolysis (Thoracic region)	0.568	0.431	0.000
M43.03 Spondylolysis (Cervicothoracic region)	0.568	0.431	0.000
M43.01 Spondylolysis (Occipito-atlanto-axial region)	0.568	0.431	0.000
M43.00 Spondylolysis (Multiple sites in spine)	0.568	0.431	0.000
M90.8 Osteopathy in other diseases classified elsewhere	0.568	0.432	0.000
M84.08 Malunion of fracture (Other)	0.568	0.432	0.000
M46.95 Inflammatory spondylopathy, unspecified (Thoracolumbar region)	0.567	0.433	0.000
M46.94 Inflammatory spondylopathy, unspecified (Thoracic region)	0.567	0.433	0.000
M46.93 Inflammatory spondylopathy, unspecified (Cervicothoracic region)	0.567	0.433	0.000
M46.91 Inflammatory spondylopathy, unspecified (Occipito-atlanto-axial region)	0.567	0.433	0.000
M16.6 Other secondary coxarthrosis, bilateral	0.567	0.433	0.000
M24.2 Disorder of ligament	0.567	0.433	0.000
M53.38 Sacrococcygeal disorders, not elsewhere classified-Sacral/s	0.566	0.434	0.000
M21.97 Acquired deformity of limb, unspecified (Ankle and foot)	0.566	0.434	0.000
M62.9 Disorder of muscle, unspecified	0.566	0.434	0.000
M48.9 Spondylopathy, unspecified	0.565	0.435	0.000
M87.3 Other secondary osteonecrosis	0.564	0.435	0.000
M87.1 Osteonecrosis due to drugs	0.564	0.435	0.000
M87.0 Idiopathic aseptic necrosis of bone	0.564	0.435	0.000
M32.8 Other forms of systemic lupus erythematosus	0.564	0.436	0.000
M48.86 Other specified spondylopathies (Lumbar region)	0.564	0.436	0.000
M85.98 Disorder of bone density and structure, unspecified (Other)	0.564	0.436	0.000
M85.97 Disorder of bone density and structure, unspecified (Ankle and foot)	0.564	0.436	0.000
M85.96 Disorder of bone density and structure, unspecified (Lower leg)	0.564	0.436	0.000
M85.94 Disorder of bone density and structure, unspecified (Hand)	0.564	0.436	0.000
M85.93 Disorder of bone density and structure, unspecified (Forearm)	0.564	0.436	0.000
M85.92 Disorder of bone density and structure, unspecified (Upper arm)	0.564	0.436	0.000
M85.91 Disorder of bone density and structure, unspecified (Shoulder region)	0.564	0.436	0.000
M85.90 Disorder of bone density and structure, unspecified (Multiple sites)	0.564	0.436	0.000
M86.65 Other chronic osteomyelitis (Pelvic region and thigh)	0.561	0.439	0.000
M43.99 Deforming dorsopathy, unspecified (Site unspecified)	0.560	0.440	0.000
M25.09 Haemarthrosis (Site unspecified)	0.558	0.442	0.000
M25.08 Haemarthrosis (Other)	0.558	0.442	0.000
M25.07 Haemarthrosis (Ankle and foot)	0.558	0.442	0.000
M25.05 Haemarthrosis (Pelvic region and thigh)	0.558	0.442	0.000
M25.04 Haemarthrosis (Hand)	0.558	0.442	0.000
M25.03 Haemarthrosis (Forearm)	0.558	0.442	0.000
M25.02 Haemarthrosis (Upper arm)	0.558	0.442	0.000
M25.01 Haemarthrosis (Shoulder region)	0.558	0.442	0.000
M25.00 Haemarthrosis (Multiple sites)	0.558	0.442	0.000
M80.19 Postoophorectomy osteoporosis with pathological fracture (Site unspecified)	0.557	0.443	0.000
M80.18 Postoophorectomy osteoporosis with pathological fracture (Other)	0.557	0.443	0.000
M80.17 Postoophorectomy osteoporosis with pathological fracture (Ankle and foot)	0.557	0.443	0.000
M80.16 Postoophorectomy osteoporosis with pathological fracture (Lower leg)	0.557	0.443	0.000
M80.15 Postoophorectomy osteoporosis with pathological fracture (Pelvic region and thigh)	0.557	0.443	0.000
M80.14 Postoophorectomy osteoporosis with pathological fracture (Hand)	0.557	0.443	0.000
M80.13 Postoophorectomy osteoporosis with pathological fracture (Forearm)	0.557	0.443	0.000
M80.12 Postoophorectomy osteoporosis with pathological fracture (Upper arm)	0.557	0.443	0.000
M80.11 Postoophorectomy osteoporosis with pathological fracture (Shoulder region)	0.557	0.443	0.000
M84.14 Nonunion of fracture [pseudarthrosis] (Hand)	0.556	0.444	0.000
M86.17 Other acute osteomyelitis (Ankle and foot)	0.554	0.446	0.000
M86.93 Osteomyelitis, unspecified (Forearm)	0.554	0.446	0.000
M86.92 Osteomyelitis, unspecified (Upper arm)	0.554	0.446	0.000
M86.91 Osteomyelitis, unspecified (Shoulder region)	0.554	0.446	0.000
M86.90 Osteomyelitis, unspecified (Multiple sites)	0.554	0.446	0.000
M21.57 Acquired clawhand, clubhand, clawfoot and clubfoot (Ankle and foot)	0.554	0.446	0.000
M82.8 Osteoporosis in other diseases classified elsewhere	0.553	0.447	0.000
M82.0 Osteoporosis in multiple myelomatosis	0.553	0.447	0.000
M82.3 Osteoporosis in diseases classified elsewhere, Forearm	0.553	0.447	0.000
M21.49 Flat foot [pes planus] (acquired)-Site unspec	0.552	0.448	0.000
M21.48 Flat foot [pes planus] (acquired)-Other	0.552	0.448	0.000
M21.46 Flat foot [pes planus] (acquired)-Lower leg	0.552	0.448	0.000
M21.45 Flat foot [pes planus] (acquired)-Pelvic/thigh	0.552	0.448	0.000
M21.44 Flat foot [pes planus] (acquired)-Hand	0.552	0.448	0.000
M21.43 Flat foot [pes planus] (acquired)-Forearm	0.552	0.448	0.000
M21.42 Flat foot [pes planus] (acquired)-Upper arm	0.552	0.448	0.000
M21.41 Flat foot [pes planus] (acquired)-Shldr region	0.552	0.448	0.000
M21.40 Flat foot [pes planus] (acquired)-Mult sites	0.552	0.448	0.000
M25.9 Joint disorder, unspecified	0.552	0.448	0.000
M25.86 Other specified joint disorders (Lower leg)	0.551	0.449	0.000
M90.1 Periostitis in other infectious diseases classified elsewhere	0.550	0.449	0.000
M21.25 Flexion deformity (Pelvic region and thigh)	0.549	0.451	0.000
M21.76 Unequal limb length (acquired) (Lower leg)	0.545	0.454	0.000
M62.4 Contracture of muscle	0.545	0.455	0.000
M62.3 Immobility syndrome (paraplegic)	0.545	0.455	0.000
M86.96 Osteomyelitis, unspecified (Lower leg)	0.545	0.455	0.000
M48.59 Collapsed vertebra, not elsewhere classified (Site unspecified)	0.545	0.455	0.000
M17.9 Gonarthrosis, unspecified	0.544	0.456	0.000
M46.97 Inflammatory spondylopathy, unspecified (Lumbosacral region)	0.544	0.456	0.000
M80.50 Idiopathic osteoporosis with pathological fracture (Multiple sites)	0.544	0.456	0.000
M46.49 Discitis, unspecified (Site unspecified)	0.544	0.456	0.000
M86.69 Other chronic osteomyelitis (Site unspecified)	0.542	0.458	0.000
M86.68 Other chronic osteomyelitis (Other)	0.542	0.458	0.000
M86.64 Other chronic osteomyelitis (Hand)	0.542	0.458	0.000
M86.63 Other chronic osteomyelitis (Forearm)	0.542	0.458	0.000
M86.62 Other chronic osteomyelitis (Upper arm)	0.542	0.458	0.000
M86.61 Other chronic osteomyelitis (Shoulder region)	0.542	0.458	0.000
M86.60 Other chronic osteomyelitis (Multiple sites)	0.542	0.458	0.000
M24.6 Ankylosis of joint	0.541	0.459	0.000
M19.1 Posttraumatic arthrosis of other joints	0.541	0.459	0.000
M21.16 Varus deformity, not elsewhere classified (Lower leg)	0.540	0.460	0.000
M90.6 Osteitis deformans in neoplastic disease	0.539	0.461	0.000
M90.5 Osteonecrosis in other diseases classified elsewhere	0.539	0.461	0.000
M90.4 Osteonecrosis due to heamoglobinopathy	0.539	0.461	0.000
M90.3 Osteonecrosis in caisson disease	0.539	0.461	0.000
M90.2 Osteopathy in other infectious diseases classified elsewhere	0.539	0.461	0.000
M90.0 Tuberculosis of bone	0.539	0.461	0.000
M84.09 Malunion of fracture (Site unspecified)	0.539	0.461	0.000
M84.00 Malunion of fracture (Multiple sites)	0.539	0.461	0.000
M83.9 Adult osteomalacia, unspecified	0.539	0.461	0.000
M83.5 Other drug-induced osteomalacia in adults	0.539	0.461	0.000
M83.4 Aluminum bone disease	0.539	0.461	0.000
M83.3 Adult osteomalacia due to malnutrition	0.539	0.461	0.000
M83.2 Adult osteomalacia due to malabsorption	0.539	0.461	0.000
M83.0 Puerperal osteomalacia	0.539	0.461	0.000
M53.86 Other specified dorsopathies (Lumbar region)	0.539	0.461	0.000
M25.66 Stiffness of joint, not elsewhere classified (Lower leg)	0.539	0.461	0.000
M84.89 Other disorders of continuity of bone (Site unspecified)	0.538	0.462	0.000
M84.88 Other disorders of continuity of bone (Other)	0.538	0.462	0.000
M84.86 Other disorders of continuity of bone (Lower leg)	0.538	0.462	0.000
M84.85 Other disorders of continuity of bone (Pelvic region and thigh)	0.538	0.462	0.000
M84.84 Other disorders of continuity of bone (Hand)	0.538	0.462	0.000
M84.82 Other disorders of continuity of bone (Upper arm)	0.538	0.462	0.000
M84.81 Other disorders of continuity of bone (Shoulder region)	0.538	0.462	0.000
M84.80 Other disorders of continuity of bone (Multiple sites)	0.538	0.462	0.000
M19.89 Other specified arthrosis (Site unspecified)	0.537	0.463	0.000
M80.52 Idiopathic osteoporosis with pathological fracture (Upper arm)	0.537	0.463	0.000
M24.47 Recurrent dislocation and subluxation of joint (Ankle and foot)	0.536	0.464	0.000
M62.0 Diastasis of muscle	0.536	0.464	0.000
M47.27 Other spondylosis with radiculopathy (Lumbosacral region)	0.536	0.464	0.000
M85.09 Fibrous dysplasia (monostotic) (Site unspecified)	0.535	0.465	0.000
M85.08 Fibrous dysplasia (monostotic) (Other)	0.535	0.465	0.000
M85.07 Fibrous dysplasia (monostotic) (Ankle and foot)	0.535	0.465	0.000
M85.06 Fibrous dysplasia (monostotic) (Lower leg)	0.535	0.465	0.000
M85.05 Fibrous dysplasia (monostotic) (Pelvic region and thigh)	0.535	0.465	0.000
M85.04 Fibrous dysplasia (monostotic) (Hand)	0.535	0.465	0.000
M85.03 Fibrous dysplasia (monostotic) (Forearm)	0.535	0.465	0.000
M85.02 Fibrous dysplasia (monostotic) (Upper arm)	0.535	0.465	0.000
M85.01 Fibrous dysplasia (monostotic) (Shoulder region)	0.535	0.465	0.000
M25.3 Other instability of joint	0.535	0.465	0.001
M84.21 Delayed union of fracture (Shoulder region)	0.535	0.465	0.000
M46.44 Discitis, unspecified (Thoracic region)	0.535	0.465	0.000
M30 Polyarteritis nodosa and related conditions	0.534	0.466	0.000
M24.45 Recurrent dislocation and subluxation of joint (Pelvic region and thigh)	0.534	0.466	0.000
M21.94 Acquired deformity of limb, unspecified (Hand)	0.533	0.466	0.000
M06.89 Other specified rheumatoid arthritis (Site unspecified)	0.533	0.467	0.000
M86.99 Osteomyelitis, unspecified (Site unspecified)	0.533	0.467	0.000
M85.66 Other cyst of bone (Lower leg)	0.533	0.467	0.000
M85.20 Hyperostosis of skull-Mult sites	0.533	0.467	0.000
M47.14 Other spondylosis with myelopathy (Thoracic region)	0.532	0.468	0.000
M43.98 Deforming dorsopathy, unspecified (Sacral and sacrococcygeal region)	0.531	0.468	0.000
M43.97 Deforming dorsopathy, unspecified (Lumbosacral region)	0.531	0.468	0.000
M43.96 Deforming dorsopathy, unspecified (Lumbar region)	0.531	0.468	0.000
M43.95 Deforming dorsopathy, unspecified (Thoracolumbar region)	0.531	0.468	0.000
M43.94 Deforming dorsopathy, unspecified (Thoracic region)	0.531	0.468	0.000
M43.93 Deforming dorsopathy, unspecified (Cervicothoracic region)	0.531	0.468	0.000
M43.92 Deforming dorsopathy, unspecified (Cervical region)	0.531	0.468	0.000
M43.91 Deforming dorsopathy, unspecified (Occipito-atlanto-axial region)	0.531	0.468	0.000
M43.90 Deforming dorsopathy, unspecified (Multiple sites in spine)	0.531	0.468	0.000
M62.50 Muscle wasting and atrophy, not elsewhere classified (Multiple sites)	0.530	0.470	0.000
M47.22 Other spondylosis with radiculopathy (Cervical region)	0.529	0.471	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations