TreeWAS – Variant ID: rs11159086

Hospitalization Episode Statistics (HES)

Self-Reported Statistics (SRS)

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Results table

Term	Risk posterior probability	No effect posterior probability	Protective posterior probability
H72.9 Perforation of tympanic membrane, unspecified	0.981	0.019	0.000
H72 Perforation of tympanic membrane	0.980	0.020	0.000
H65-H75 Diseases of middle ear and mastoid	0.975	0.025	0.000
H72.0 Central perforation of tympanic membrane	0.954	0.046	0.000
H73 Other disorders of tympanic membrane	0.936	0.064	0.000
H71 Cholesteatoma of middle ear	0.936	0.064	0.000
H73.8 Other specified disorders of tympanic membrane	0.908	0.092	0.000
H65 Nonsuppurative otitis media	0.860	0.140	0.000
H66 Suppurative and unspecified otitis media	0.837	0.163	0.000
H70 Mastoiditis and related conditions	0.785	0.215	0.000
H65.2 Chronic serous otitis media	0.751	0.248	0.000
H65.0 Acute serous otitis media	0.733	0.267	0.000
H74 Other disorders of middle ear and mastoid	0.725	0.275	0.000
S00-S09 Injuries to the head	0.725	0.275	0.000
S01 Open wound of head	0.722	0.278	0.000
S01.9 Open wound of head, part unspecified	0.718	0.282	0.000
H66.3 Other chronic suppurative otitis media	0.716	0.283	0.000
H75 Other disorders of middle ear and mastoid in diseases classified elsewhere	0.699	0.301	0.000
H68 Eustachian salpingitis and obstruction	0.699	0.301	0.000
H67 Otitis media in diseases classified elsewhere	0.699	0.301	0.000
S06 Intracranial injury	0.698	0.302	0.000
H65.4 Other chronic nonsuppurative otitis media	0.697	0.303	0.000
H66.0 Acute suppurative otitis media	0.689	0.311	0.000
H73.9 Disorder of tympanic membrane, unspecified	0.671	0.329	0.000
H73.1 Chronic myringitis	0.671	0.329	0.000
H73.0 Acute myringitis	0.671	0.329	0.000
S06.5 Traumatic subdural haemorrhage	0.670	0.330	0.000
S05 Injury of eye and orbit	0.663	0.337	0.000
Chapter XIX Injury, poisoning and certain other consequences of external causes	0.656	0.344	0.000
S01.4 Open wound of cheek and temporomandibular area	0.652	0.348	0.000
S06.50 Traumatic subdural haemorrhage (without open intracranial wound)	0.650	0.350	0.000
H72.2 Other marginal perforations of tympanic membrane	0.649	0.351	0.000
S01.7 Multiple open wounds of head	0.640	0.360	0.000
H72.1 Attic perforation of tympanic membrane	0.639	0.361	0.000
H74.9 Disorder of middle ear and mastoid, unspecified	0.634	0.366	0.000
S90-S99 Injuries to the ankle and foot	0.632	0.368	0.000
H70.8 Other mastoiditis and related conditions	0.629	0.371	0.000
S00 Superficial injury of head	0.624	0.376	0.000
H66.4 Suppurative otitis media, unspecified	0.618	0.382	0.000
H65.1 Other acute nonsuppurative otitis media	0.616	0.383	0.000
T36-T50 Poisoning by drugs, medicaments and biological substances	0.613	0.387	0.000
S01.0 Open wound of scalp	0.611	0.389	0.000
S40-S49 Injuries to the shoulder and upper arm	0.609	0.391	0.000
H66.2 Chronic atticoantral suppurative otitis media	0.600	0.400	0.000
S05.8 Other injuries of eye and orbit	0.593	0.406	0.000
H70.1 Chronic mastoiditis	0.593	0.407	0.000
S01.3 Open wound of ear	0.587	0.413	0.000
S90 Superficial injury of ankle and foot	0.585	0.415	0.000
H72.8 Other perforations of tympanic membrane	0.584	0.416	0.000
H74.2 Discontinuity and dislocation of ear ossicles	0.583	0.417	0.000
H65.9 Nonsuppurative otitis media, unspecified	0.580	0.420	0.000
H66.1 Chronic tubotympanic suppurative otitis media	0.577	0.423	0.000
S50-S59 Injuries to the elbow and forearm	0.568	0.432	0.000
S91 Open wound of ankle and foot	0.567	0.433	0.000
H70.2 Petrositis	0.563	0.437	0.000
H70.0 Acute mastoiditis	0.563	0.437	0.000
S30-S39 Injuries to the abdomen, lower back, lumbar spine and pelvis	0.561	0.439	0.000
H70.9 Mastoiditis, unspecified	0.560	0.440	0.000
S70-S79 Injuries to the hip and thigh	0.559	0.441	0.000
S06.8 Other intracranial injuries	0.558	0.442	0.000
T46 Poisoning by agents primarily affecting the cardiovascular system	0.557	0.443	0.000
T43 Poisoning by psychotropic drugs, not elsewhere classified	0.554	0.446	0.000
S42 Fracture of shoulder and upper arm	0.550	0.450	0.000
S46 Injury of muscle and tendon at shoulder and upper arm level	0.550	0.450	0.000
S05.9 Injury of eye and orbit, part unspecified	0.545	0.455	0.000
S06.4 Epidural haemorrhage	0.542	0.457	0.000
H74.8 Other specified disorders of middle ear and mastoid	0.531	0.468	0.000
S05.6 Penetrating wound of eyeball without foreign body	0.531	0.469	0.000
T47 Poisoning by agents primarily affecting gastro-intestinal system	0.531	0.469	0.000
H66.9 Otitis media, unspecified	0.530	0.470	0.000
S06.6 Traumatic subarachnoid haemorrhage	0.526	0.474	0.000
S00.8 Superficial injury of other parts of head	0.525	0.475	0.000
S09 Other and unspecified injuries of head	0.521	0.479	0.000
S02 Fracture of skull and facial bones	0.520	0.480	0.000
S08 Traumatic amputation of part of head	0.520	0.480	0.000
S07 Crushing injury of head	0.520	0.480	0.000
S04 Injury of cranial nerves	0.520	0.480	0.000
S06.2 Diffuse brain injury	0.518	0.482	0.000
S56 Injury of muscle and tendon at forearm level	0.518	0.482	0.000
S05.3 Ocular laceration without prolapse or loss of intraocular tissue	0.515	0.485	0.000
S90.8 Other superficial injuries of ankle and foot	0.515	0.485	0.000
S96 Injury of muscle and tendon at ankle and foot level	0.515	0.485	0.000
T39 Poisoning by nonopioid analgesics, antipyretics and antirheumatics	0.511	0.489	0.000
S31 Open wound of abdomen, lower back and pelvis	0.510	0.490	0.000
S06.3 Focal brain injury	0.509	0.491	0.000
S99 Other and unspecified injuries of ankle and foot	0.502	0.498	0.000
H67.8 Otitis media in other diseases classified elsewhere	0.501	0.499	0.000
H67.1 Otitis media in viral diseases classified elsewhere	0.501	0.499	0.000
H67.0 Otitis media in bacterial diseases classified elsewhere	0.501	0.499	0.000
H68.1 Obstruction of Eustachian tube	0.501	0.499	0.000
H68.0 Eustachian salpingitis	0.501	0.499	0.000
H75.8 Other specified disorders of middle ear and mastoid in diseases classified elsewhere	0.501	0.499	0.000
H75.0 Mastoiditis in infectious and parasitic diseases classified elsewhere	0.501	0.499	0.000
S00.5 Superficial injury of lip and oral cavity	0.501	0.499	0.000
S42.2 Fracture of upper end of humerus	0.501	0.499	0.000
S06.7 Intracranial injury with prolonged coma	0.500	0.500	0.000
S06.1 Traumatic cerebral oedema	0.500	0.500	0.000
S42.4 Fracture of lower end of humerus	0.500	0.500	0.000
S91.3 Open wound of other parts of foot	0.499	0.501	0.000
T08-T14 Injuries to unspecified part of trunk, limb or body region	0.497	0.503	0.000
S01.5 Open wound of lip and oral cavity	0.488	0.512	0.000
H74.3 Other acquired abnormalities of ear ossicles	0.485	0.515	0.000
T39.0 Salicylates	0.485	0.515	0.000
S00.7 Multiple superficial injuries of head	0.483	0.516	0.000
S00.4 Superficial injury of ear	0.483	0.517	0.000
S03 Dislocation, sprain and strain of joints and ligaments of head	0.483	0.517	0.000
S06.51 Traumatic subdural haemorrhage (with open intracranial wound)	0.480	0.520	0.000
T46.4 Angiotensin-converting-enzyme inhibitors	0.479	0.521	0.000
S00.2 Other superficial injuries of eyelid and periocular area	0.478	0.522	0.000
S31.8 Open wound of other and unspecified parts of abdomen	0.478	0.522	0.000
H74.1 Adhesive middle ear disease	0.475	0.525	0.000
S05.7 Avulsion of eye	0.475	0.525	0.000
S05.5 Penetrating wound of eyeball with foreign body	0.475	0.525	0.000
S05.4 Penetrating wound of orbit with or without foreign body	0.475	0.525	0.000
S05.2 Ocular laceration and rupture with prolapse or loss of intraocular tissue	0.475	0.525	0.000
T90-T98 Sequelae of injuries, of poisoning and of other consequences of external causes	0.474	0.526	0.000
S70 Superficial injury of hip and thigh	0.472	0.528	0.000
T47.1 Other antacids and anti-gastric-secretion drugs	0.472	0.528	0.000
T33-T35 Frostbite	0.470	0.530	0.000
T26-T28 Burns and corrosions confined to eye and internal organs	0.470	0.530	0.000
S46.0 Injury of tendon of the rotator cuff of shoulder	0.469	0.531	0.000
T43.5 Other and unspecified antipsychotics and neuroleptics	0.468	0.532	0.000
S42.40 Fracture of lower end of humerus (closed)	0.468	0.532	0.000
S90.9 Superficial injury of ankle and foot, unspecified	0.467	0.533	0.000
S05.1 Contusion of eyeball and orbital tissues	0.466	0.534	0.000
S42.20 Fracture of upper end of humerus (closed)	0.466	0.534	0.000
T00-T07 Injuries involving multiple body regions	0.464	0.535	0.000
S06.9 Intracranial injury, unspecified	0.464	0.536	0.000
T42 Poisoning by antiepileptic, sedative-hypnotic and anti-Parkinsonism drugs	0.462	0.538	0.000
H69 Other disorders of Eustachian tube	0.461	0.539	0.001
S50 Superficial injury of forearm	0.459	0.541	0.000
T44 Poisoning by drugs primarily affecting the autonomic nervous system	0.458	0.542	0.000
H74.0 Tympanosclerosis	0.458	0.542	0.000
S10-S19 Injuries to the neck	0.457	0.543	0.000
S79 Other and unspecified injuries of hip and thigh	0.457	0.543	0.000
S06.80 Other intracranial injuries (without open intracranial wound)	0.457	0.543	0.000
S90.1 Contusion of toe(s) without damage to nail	0.457	0.543	0.000
S98 Traumatic amputation of ankle and foot	0.453	0.546	0.000
S97 Crushing injury of ankle and foot	0.453	0.546	0.000
S95 Injury of blood vessels at ankle and foot level	0.453	0.546	0.000
S94 Injury of nerves at ankle and foot level	0.453	0.546	0.000
S80-S89 Injuries to the knee and lower leg	0.453	0.547	0.000
S00.1 Contusion of eyelid and periocular area	0.451	0.548	0.000
S02.2 Fracture of nasal bones	0.451	0.549	0.000
S56.7 Injury of multiple muscles and tendons at forearm level	0.450	0.550	0.000
S91.1 Open wound of toe(s) without damage to nail	0.448	0.552	0.000
T46.1 Calcium-channel blockers	0.447	0.553	0.000
S90.3 Contusion of other and unspecified parts of foot	0.443	0.556	0.000
T43.2 Other and unspecified antidepressants	0.441	0.559	0.000
S60-S69 Injuries to the wrist and hand	0.441	0.559	0.000
T37 Poisoning by other systemic anti-infectives and antiparasitics	0.441	0.559	0.000
T49 Poisoning by topical agents primarily affecting skin and mucous membrane and by ophthalmological, otorhinolarygological and dental drugs	0.440	0.560	0.000
T48 Poisoning by agents primarily acting on smooth and skeletal muscles and the respiratory system	0.440	0.560	0.000
T41 Poisoning by anaesthetics and therapeutic gases	0.440	0.560	0.000
S93 Dislocation, sprain and strain of joints and ligaments at ankle and foot level	0.440	0.560	0.000
S46.8 Injury of other muscles and tendons at shoulder and upper arm level	0.440	0.560	0.000
S62 Fracture at wrist and hand level	0.439	0.561	0.000
S48 Traumatic amputation of shoulder and upper arm	0.437	0.563	0.000
S45 Injury of blood vessels at shoulder and upper arm level	0.437	0.563	0.000
S44 Injury of nerves at shoulder and upper arm level	0.437	0.563	0.000
S47 Crushing injury of shoulder and upper arm	0.437	0.563	0.000
S56.8 Injury of other and unspecified muscles and tendons at forearm level	0.436	0.564	0.000
S40 Superficial injury of shoulder and upper arm	0.435	0.565	0.000
T43.6 Psychostimulants with abuse potential	0.433	0.567	0.000
S00.9 Superficial injury of head, part unspecified	0.433	0.567	0.000
S02.5 Fracture of tooth	0.433	0.567	0.000
S41 Open wound of shoulder and upper arm	0.432	0.567	0.000
S06.40 Epidural haemorrhage (without open intracranial wound)	0.431	0.569	0.000
S96.1 Injury of muscle and tendon of long extensor muscle of toe at ankle and foot level	0.430	0.570	0.000
T29-T32 Burns and corrosions of multiple and unspecified body regions	0.428	0.572	0.000
S46.2 Injury of muscle and tendon of other parts of biceps	0.427	0.573	0.000
S06.0 Concussion	0.426	0.574	0.000
T43.4 Butyrophenone and thioxanthene neuroleptics	0.426	0.574	0.000
T46.6 Antihyperlipidaemic and antiarteriosclerotic drugs	0.425	0.575	0.000
T93 Sequelae of injuries of lower limb	0.424	0.576	0.000
S62.3 Fracture of other metacarpal bone	0.424	0.576	0.000
S70.1 Contusion of thigh	0.423	0.577	0.000
S73 Dislocation, sprain and strain of joint and ligaments of hip	0.422	0.578	0.000
S62.2 Fracture of first metacarpal bone	0.422	0.578	0.000
S90.7 Multiple superficial injuries of ankle and foot	0.419	0.581	0.000
S90.2 Contusion of toe(s) with damage to nail	0.419	0.581	0.000
S53 Dislocation, sprain and strain of joints and ligaments of elbow	0.417	0.583	0.000
S91.0 Open wound of ankle	0.416	0.584	0.000
S37 Injury of urinary and pelvic organs	0.416	0.584	0.000
T43.3 Phenothiazine antipsychotics and neuroleptics	0.413	0.586	0.000
T46.5 Other antihypertensive drugs, not elsewhere classified	0.412	0.587	0.000
S90.0 Contusion of ankle	0.411	0.589	0.000
S62.20 Fracture of first metacarpal bone (closed)	0.411	0.589	0.000
S39 Other and unspecified injuries of abdomen, lower back and pelvis	0.411	0.589	0.000
S71 Open wound of hip and thigh	0.411	0.589	0.000
S81 Open wound of lower leg	0.410	0.590	0.000
S58 Traumatic amputation of forearm	0.407	0.593	0.000
S57 Crushing injury of forearm	0.407	0.593	0.000
S55 Injury of blood vessels at forearm level	0.407	0.593	0.000
S62.30 Fracture of other metacarpal bone (closed)	0.407	0.593	0.000
S91.7 Multiple open wounds of ankle and foot	0.406	0.593	0.000
S91.2 Open wound of toe(s) with damage to nail	0.406	0.593	0.000
T46.3 Coronary vasodilators, not elsewhere classified	0.406	0.594	0.000
T20-T25 Burns and corrosions of external body surface, specified by site	0.406	0.594	0.000
S00.3 Superficial injury of nose	0.404	0.595	0.000
T51-T65 Toxic effects of substances chiefly nonmedicinal as to source	0.404	0.596	0.000
S06.60 Traumatic subarachnoid haemorrhage (without open intracranial wound)	0.404	0.596	0.000
S12 Fracture of neck	0.403	0.597	0.000
S38 Crushing injury and traumatic amputation of part of abdomen, lower back and pelvis	0.402	0.598	0.000
S35 Injury of blood vessels at abdomen, lower back and pelvis level	0.402	0.598	0.000
S34 Injury of nerves and lumbar spinal cord at abdomen, lower back and pelvis level	0.402	0.598	0.000
S33 Dislocation, sprain and strain of joints and ligaments of lumbar spine and pelvis	0.402	0.598	0.000
S56.3 Injury of extensor or abductor muscles and tendons of thumb at forearm level	0.402	0.598	0.000
S46.1 Injury of muscle and tendon of long head of biceps	0.402	0.598	0.000
S30 Superficial injury of abdomen, lower back and pelvis	0.401	0.599	0.000
M06.9 Rheumatoid arthritis, unspecified	0.401	0.599	0.000
S78 Traumatic amputation of hip and thigh	0.401	0.599	0.000
S77 Crushing injury of hip and thigh	0.401	0.599	0.000
S75 Injury of blood vessels at hip and thigh level	0.401	0.599	0.000
S74 Injury of nerves at hip and thigh level	0.401	0.599	0.000
S06.81 Other intracranial injuries (with open intracranial wound)	0.400	0.600	0.000
T46.9 Other and unspecified agents primarily affecting the cardiovascular system	0.400	0.600	0.000
T46.8 Antivaricose drugs, including sclerosing agents	0.400	0.600	0.000
T46.7 Peripheral vasodilators	0.400	0.600	0.000
T46.2 Other antidysrhythmic drugs, not elsewhere classified	0.400	0.600	0.000
T46.0 Cardiac-stimulant glycosides and drugs of similar action	0.400	0.600	0.000
M06 Other rheumatoid arthritis	0.399	0.601	0.000
S49 Other and unspecified injuries of shoulder and upper arm	0.398	0.601	0.000
H65.3 Chronic mucoid otitis media	0.398	0.602	0.000
T43.9 Psychotropic drug, unspecified	0.397	0.602	0.000
T43.8 Other psychotropic drugs, not elsewhere classified	0.397	0.602	0.000
T43.1 Monoamine-oxidase-inhibitor antidepressants	0.397	0.602	0.000
M06.90 Rheumatoid arthritis, unspecified (Multiple sites)	0.397	0.603	0.000
T38 Poisoning by hormones and their synthetic substitutes and antagonists, not elsewhere classified	0.397	0.603	0.000
H74.4 Polyp of middle ear	0.395	0.605	0.000
S42.8 Fracture of other parts of shoulder and upper arm	0.394	0.606	0.000
S46.9 Injury of unspecified muscle and tendon at shoulder and upper arm level	0.394	0.606	0.000
S46.7 Injury of multiple muscles and tendons at shoulder and upper arm level	0.394	0.606	0.000
S46.3 Injury of muscle and tendon of triceps	0.394	0.606	0.000
T36 Poisoning by systemic antibiotics	0.394	0.606	0.000
S62.6 Fracture of other finger	0.394	0.606	0.000
S02.20 Fracture of nasal bones (closed)	0.394	0.606	0.000
S99.8 Other specified injuries of ankle and foot	0.392	0.608	0.000
S36 Injury of intra-abdominal organs	0.392	0.608	0.000
S54 Injury of nerves at forearm level	0.391	0.609	0.000
M06.0 Seronegative rheumatoid arthritis	0.390	0.610	0.000
S06.20 Diffuse brain injury (without open intracranial wound)	0.390	0.610	0.000
T50 Poisoning by diuretics and other and unspecified drugs, medicaments and biological substances	0.389	0.611	0.000
S06.41 Epidural haemorrhage (with open intracranial wound)	0.389	0.611	0.000
S42.9 Fracture of shoulder girdle, part unspecified	0.388	0.612	0.000
S56.1 Injury of flexor muscle and tendon of other finger(s) at forearm level	0.388	0.612	0.000
S56.5 Injury of other extensor muscle and tendon at forearm level	0.388	0.612	0.000
S79.9 Unspecified injury of hip and thigh	0.387	0.612	0.000
S42.3 Fracture of shaft of humerus	0.387	0.613	0.000
S59 Other and unspecified injuries of forearm	0.386	0.614	0.000
T13 Other injuries of lower limb, level unspecified	0.384	0.616	0.000
S43 Dislocation, sprain and strain of joints and ligaments of shoulder girdle	0.384	0.616	0.000
S02.9 Fracture of skull and facial bones, part unspecified	0.383	0.617	0.000
S09.9 Unspecified injury of head	0.382	0.618	0.000
S99.9 Unspecified injury of ankle and foot	0.381	0.618	0.000
T47.9 Agent primarily affecting the gastro-intestinal system, unspecified	0.381	0.619	0.000
T47.8 Other agents primarily affecting the gastro-intestinal system	0.381	0.619	0.000
T47.7 Emetics	0.381	0.619	0.000
T47.6 Antidiarrhoeal drugs	0.381	0.619	0.000
T47.5 Digestants	0.381	0.619	0.000
T47.4 Other laxatives	0.381	0.619	0.000
T47.3 Saline and osmotic laxatives	0.381	0.619	0.000
T47.2 Stimulant laxatives	0.381	0.619	0.000
T47.0 Histamine H(2)-receptor antagonists	0.381	0.619	0.000
S81.9 Open wound of lower leg, part unspecified	0.380	0.620	0.000
S09.8 Other specified injuries of head	0.379	0.621	0.000
S06.61 Traumatic subarachnoid haemorrhage (with open intracranial wound)	0.377	0.622	0.000
T79-T79 Certain early complications of trauma	0.377	0.623	0.000
T44.9 Other and unspecified drugs primarily affecting the nervous system	0.377	0.623	0.000
S76 Injury of muscle and tendon at hip and thigh level	0.376	0.623	0.000
T93.3 Sequelae of dislocation, sprain and strain of lower limb	0.376	0.624	0.000
M06.99 Rheumatoid arthritis, unspecified (Site unspecified)	0.376	0.624	0.000
S02.1 Fracture of base of skull	0.375	0.625	0.000
S09.7 Multiple injuries of head	0.374	0.626	0.000
S09.2 Traumatic rupture of ear drum	0.374	0.626	0.000
S09.1 Injury of muscle and tendon of head	0.374	0.626	0.000
S06.30 Focal brain injury (without open intracranial wound)	0.373	0.627	0.000
S04.9 Injury of unspecified cranial nerve	0.373	0.627	0.000
S04.8 Injury of other cranial nerves	0.373	0.627	0.000
S04.7 Injury of accessory nerve	0.373	0.627	0.000
S04.6 Injury of acoustic nerve	0.373	0.627	0.000
S04.5 Injury of facial nerve	0.373	0.627	0.000
S04.4 Injury of abducent nerve	0.373	0.627	0.000
S04.3 Injury of trigeminal nerve	0.373	0.627	0.000
S04.2 Injury of trochlear nerve	0.373	0.627	0.000
S04.1 Injury of oculomotor nerve	0.373	0.627	0.000
S04.0 Injury of optic nerve and pathways	0.373	0.627	0.000
S07.9 Crushing injury of head, part unspecified	0.373	0.627	0.000
S07.8 Crushing injury of other parts of head	0.373	0.627	0.000
S07.1 Crushing injury of skull	0.373	0.627	0.000
S07.0 Crushing injury of face	0.373	0.627	0.000
S08.9 Traumatic amputation of unspecified part of head	0.373	0.627	0.000
S08.8 Traumatic amputation of other parts of head	0.373	0.627	0.000
S08.1 Traumatic amputation of ear	0.373	0.627	0.000
S08.0 Avulsion of scalp	0.373	0.627	0.000
S06.21 Diffuse brain injury (with open intracranial wound)	0.372	0.628	0.000
M06.00 Seronegative rheumatoid arthritis (Multiple sites)	0.372	0.628	0.000
S56.2 Injury of other flexor muscle and tendon at forearm level	0.371	0.629	0.000
S56.0 Injury of flexor muscle and tendon of thumb at forearm level	0.371	0.629	0.000
S02.50 Fracture of tooth (closed)	0.371	0.629	0.000
S51 Open wound of forearm	0.370	0.630	0.000
S96.9 Injury of unspecified muscle and tendon at ankle and foot level	0.369	0.631	0.000
S96.8 Injury of other muscles and tendons at ankle and foot level	0.369	0.631	0.000
S96.7 Injury of multiple muscles and tendons at ankle and foot level	0.369	0.631	0.000
S96.2 Injury of intrinsic muscle and tendon at ankle and foot level	0.369	0.631	0.000
S96.0 Injury of muscle and tendon of long flexor muscle of toe at ankle and foot level	0.369	0.631	0.000
S02.6 Fracture of mandible	0.368	0.631	0.000
T39.4 Antirheumatics, not elsewhere classified	0.367	0.633	0.000
T39.2 Pyrazolone derivatives	0.367	0.633	0.000
S42.7 Multiple fractures of clavicle, scapula and humerus	0.366	0.634	0.000
S31.7 Multiple open wounds of abdomen, lower back and pelvis	0.366	0.634	0.000
S31.5 Open wound of other and unspecified external genital organs	0.366	0.634	0.000
S31.3 Open wound of scrotum and testes	0.366	0.634	0.000
S31.2 Open wound of penis	0.366	0.634	0.000
S31.0 Open wound of lower back and pelvis	0.366	0.634	0.000
T43.0 Tricyclic and tetracyclic antidepressants	0.365	0.635	0.000
S06.31 Focal brain injury (with open intracranial wound)	0.365	0.635	0.000
T39.8 Other nonopioid analgesics and antipyretics, not elsewhere classified	0.365	0.635	0.000
S02.7 Multiple fractures involving skull and facial bones	0.364	0.636	0.000
S31.1 Open wound of abdominal wall	0.364	0.636	0.000
M06.91 Rheumatoid arthritis, unspecified (Shoulder region)	0.364	0.636	0.000
T93.8 Sequelae of other specified injuries of lower limb	0.363	0.637	0.000
S40.0 Contusion of shoulder and upper arm	0.363	0.637	0.000
T11 Other injuries of upper limb, level unspecified	0.363	0.637	0.000
T42.7 Antiepileptic and sedative-hypnotic drugs, unspecified	0.362	0.638	0.000
S52 Fracture of forearm	0.361	0.639	0.000
T14 Injury of unspecified body region	0.361	0.639	0.000
S09.0 Injury of blood vessels of head, not elsewhere classified	0.361	0.639	0.000
S99.7 Multiple injuries of ankle and foot	0.360	0.640	0.000
S42.21 Fracture of upper end of humerus (open)	0.359	0.641	0.000
T42.0 Hydantoin derivatives	0.359	0.641	0.000
S06.11 Traumatic cerebral oedema (with open intracranial wound)	0.359	0.641	0.000
S06.10 Traumatic cerebral oedema (without open intracranial wound)	0.359	0.641	0.000
S06.71 Intracranial injury with prolonged coma (with open intracranial wound)	0.359	0.641	0.000
S06.70 Intracranial injury with prolonged coma (without open intracranial wound)	0.359	0.641	0.000
S70.8 Other superficial injuries of hip and thigh	0.358	0.642	0.000
T12.X1 Fracture of lower limb, level unspecified (open)	0.357	0.643	0.000
T12.X0 Fracture of lower limb, level unspecified (closed)	0.357	0.643	0.000
T12 Fracture of lower limb, level unspecified	0.357	0.643	0.000
T10.X1 Fracture of upper limb, level unspecified (open)	0.357	0.643	0.000
T10.X0 Fracture of upper limb, level unspecified (closed)	0.357	0.643	0.000
T10 Fracture of upper limb, level unspecified	0.357	0.643	0.000
T08.X1 Fracture of spine, level unspecified (open)	0.357	0.643	0.000
T08.X0 Fracture of spine, level unspecified (closed)	0.357	0.643	0.000
T08 Fracture of spine, level unspecified	0.357	0.643	0.000
S50.9 Superficial injury of forearm, unspecified	0.355	0.645	0.000
S50.8 Other superficial injuries of forearm	0.354	0.646	0.000
S00.0 Superficial injury of scalp	0.354	0.646	0.000
S65 Injury of blood vessels at wrist and hand level	0.353	0.647	0.000
S31.4 Open wound of vagina and vulva	0.353	0.647	0.000
S50.0 Contusion of elbow	0.353	0.647	0.000
S01.1 Open wound of eyelid and periocular area	0.352	0.648	0.000
S93.1 Dislocation of toe(s)	0.351	0.648	0.000
S62.31 Fracture of other metacarpal bone (open)	0.350	0.650	0.000
S72 Fracture of femur	0.349	0.651	0.000
S62.60 Fracture of other finger (closed)	0.349	0.651	0.000
T90 Sequelae of injuries of head	0.348	0.652	0.000
S03.5 Sprain and strain of joints and ligaments of other and unspecified parts of head	0.346	0.653	0.000
S03.4 Sprain and strain of jaw	0.346	0.653	0.000
S03.3 Dislocation of other and unspecified parts of head	0.346	0.653	0.000
S03.1 Dislocation of septal cartilage of nose	0.346	0.653	0.000
S03.0 Dislocation of jaw	0.346	0.653	0.000
S02.0 Fracture of vault of skull	0.346	0.654	0.000
S42.41 Fracture of lower end of humerus (open)	0.346	0.654	0.000
S12.1 Fracture of second cervical vertebra	0.345	0.655	0.000
T09 Other injuries of spine and trunk, level unspecified	0.345	0.655	0.000
S83 Dislocation, sprain and strain of joints and ligaments of knee	0.344	0.656	0.000
T95 Sequelae of burns, corrosions and frostbite	0.344	0.656	0.000
T66-T78 Other and unspecified effects of external causes	0.342	0.657	0.001
S52.0 Fracture of upper end of ulna	0.342	0.658	0.000
S02.21 Fracture of nasal bones (open)	0.341	0.659	0.000
T97 Sequelae of toxic effects of substances chiefly nonmedicinal as to source	0.340	0.660	0.000
T96 Sequelae of poisoning by drugs, medicaments and biological substances	0.340	0.660	0.000
T02 Fractures involving multiple body regions	0.339	0.661	0.000
S70.7 Multiple superficial injuries of hip and thigh	0.339	0.661	0.000
T28 Burn and corrosion of other internal organs	0.337	0.662	0.000
T27 Burn and corrosion of respiratory tract	0.337	0.662	0.000
T26 Burn and corrosion confined to eye and adnexa	0.337	0.662	0.000
T35 Frostbite involving multiple body regions and unspecified frostbite	0.337	0.662	0.000
T34 Frostbite with tissue necrosis	0.337	0.662	0.000
T33 Superficial frostbite	0.337	0.662	0.000
M06.09 Seronegative rheumatoid arthritis (Site unspecified)	0.337	0.663	0.000
S30.0 Contusion of lower back and pelvis	0.336	0.664	0.000
S67 Crushing injury of wrist and hand	0.336	0.664	0.000
T23 Burn and corrosion of wrist and hand	0.336	0.664	0.000
S39.9 Unspecified injury of abdomen, lower back and pelvis	0.335	0.665	0.000
T00 Superficial injuries involving multiple body regions	0.335	0.665	0.000
T39.3 Other nonsteroidal anti-inflammatory drugs [NSAID]	0.335	0.665	0.000
T06 Other injuries involving multiple body regions, not elsewhere classified	0.333	0.667	0.000
T05 Traumatic amputations involving multiple body regions	0.333	0.667	0.000
T04 Crushing injuries involving multiple body regions	0.333	0.667	0.000
T03 Dislocations, sprains and strains involving multiple body regions	0.333	0.667	0.000
T07 Unspecified multiple injuries	0.333	0.667	0.000
T39.9 Nonopioid analgesic, antipyretic and antirheumatic, unspecified	0.333	0.667	0.000
S06.91 Intracranial injury, unspecified (with open intracranial wound)	0.333	0.667	0.000
S02.3 Fracture of orbital floor	0.333	0.667	0.000
S05.0 Injury of conjunctiva and corneal abrasion without mention of foreign body	0.332	0.668	0.000
T42.8 Anti-Parkinsonism drugs and other central muscle-tone depressants	0.332	0.668	0.000
T42.5 Mixed antiepileptics, not elsewhere classified	0.332	0.668	0.000
T42.3 Barbiturates	0.332	0.668	0.000
T42.2 Succinimides and oxazolidinediones	0.332	0.668	0.000
S52.00 Fracture of upper end of ulna (closed)	0.331	0.669	0.000
H69.0 Patulous Eustachian tube	0.330	0.669	0.001
S32 Fracture of lumbar spine and pelvis	0.331	0.669	0.000
M06.3 Rheumatoid nodule	0.330	0.670	0.000
S50.7 Multiple superficial injuries of forearm	0.329	0.671	0.000
T44.8 Centrally acting and afrenergic-neuron-blocking agents, not elsewhere classified	0.328	0.671	0.000
T44.6 Alpha-Adrenoreceeptor antagonists, not elsewhere classified	0.328	0.671	0.000
T44.5 Predominantly Beta-adrenoreceptor agonists, not elsewhere classified	0.328	0.671	0.000
T44.4 Predominantly Alpha-adrenoreceptor agonists, not elsewhere classified	0.328	0.671	0.000
T44.2 Ganglionic blocking drugs, not elsewhere classified	0.328	0.671	0.000
T44.1 Other parasympathomimetics [cholinergics]	0.328	0.671	0.000
T44.0 Anticholinesterase agents	0.328	0.671	0.000
T94 Sequelae of injuries involving multiple and unspecified body regions	0.328	0.671	0.000
S17 Crushing injury of neck	0.328	0.672	0.000
S15 Injury of blood vessels at neck level	0.328	0.672	0.000
S18 Traumatic amputation at neck level	0.328	0.672	0.000
S16 Injury of muscle and tendon at neck level	0.328	0.672	0.000
M06.4 Inflammatory polyarthropathy	0.328	0.672	0.000
S20-S29 Injuries to the thorax	0.328	0.672	0.000
S79.7 Multiple injuries of hip and thigh	0.328	0.672	0.000
S42.0 Fracture of clavicle	0.327	0.673	0.000
T42.6 Other antiepileptic and sedative-hypnotic drugs	0.326	0.674	0.000
S10 Superficial injury of neck	0.326	0.674	0.000
S94.9 Injury of unspecified nerve at ankle and foot level	0.325	0.675	0.000
S94.8 Injury of other nerves at ankle and foot level	0.325	0.675	0.000
S94.7 Injury of multiple nerves at ankle and foot level	0.325	0.675	0.000
S94.3 Injury of cutaneous sensory nerve at ankle and foot level	0.325	0.675	0.000
S94.2 Injury of deep peroneal nerve at ankle and foot level	0.325	0.675	0.000
S94.1 Injury of medial plantar nerve	0.325	0.675	0.000
S94.0 Injury of lateral plantar nerve	0.325	0.675	0.000
S95.9 Injury of unspecified blood vessel at ankle and foot level	0.325	0.675	0.000
S95.8 Injury of other blood vessels at ankle and foot level	0.325	0.675	0.000
S95.7 Injury of multiple blood vessels at ankle and foot level	0.325	0.675	0.000
S95.2 Injury of dorsal vein of foot	0.325	0.675	0.000
S95.1 Injury of plantar artery of foot	0.325	0.675	0.000
S95.0 Injury of dorsal artery of foot	0.325	0.675	0.000
S97.8 Crushing injury of other parts of ankle and foot	0.325	0.675	0.000
S97.1 Crushing injury of toe(s)	0.325	0.675	0.000
S97.0 Crushing injury of ankle	0.325	0.675	0.000
S98.4 Traumatic amputation of foot, level unspecified	0.325	0.675	0.000
S98.3 Traumatic amputation of other parts of foot	0.325	0.675	0.000
S98.2 Traumatic amputation of two or more toes	0.325	0.675	0.000
S98.1 Traumatic amputation of one toe	0.325	0.675	0.000
S98.0 Traumatic amputation of foot at ankle level	0.325	0.675	0.000
S51.9 Open wound of forearm, part unspecified	0.325	0.675	0.000
S88 Traumatic amputation of lower leg	0.325	0.675	0.000
S87 Crushing injury of lower leg	0.325	0.675	0.000
S85 Injury of blood vessels at lower leg level	0.325	0.675	0.000
S84 Injury of nerves at lower leg level	0.325	0.675	0.000
S73.0 Dislocation of hip	0.324	0.676	0.000
T54 Toxic effect of corrosive substances	0.322	0.678	0.000
S79.8 Other specified injuries of hip and thigh	0.322	0.678	0.000
T42.1 Iminostilbenes	0.320	0.680	0.000
S42.1 Fracture of scapula	0.320	0.680	0.000
T01 Open wounds involving multiple body regions	0.318	0.681	0.000
S80 Superficial injury of lower leg	0.319	0.681	0.000
S86 Injury of muscle and tendon at lower leg level	0.317	0.682	0.000
T37.8 Other specified systemic anti-infectives and antiparasitics	0.317	0.683	0.000
T93.0 Sequelae of open wound of lower limb	0.316	0.684	0.000
T37.9 Systemic anti-infective and antiparasitic, unspecified	0.316	0.684	0.000
T37.5 Antiviral drugs	0.316	0.684	0.000
T37.4 Anthelminthics	0.316	0.684	0.000
T37.3 Other antiprotozoal drugs	0.316	0.684	0.000
T37.2 Antimalarials and drugs acting on other blood protozoa	0.316	0.684	0.000
T37.1 Antimycobacterial drugs	0.316	0.684	0.000
T37.0 Sulphonamides	0.316	0.684	0.000
T41.5 Therapeutic gases	0.315	0.684	0.000
T41.4 Anaesthetic, unspecified	0.315	0.684	0.000
T41.3 Local anaesthetics	0.315	0.684	0.000
T41.2 Other and unspecified general anaesthetics	0.315	0.684	0.000
T41.1 Intravenous anaesthetics	0.315	0.684	0.000
T41.0 Inhaled anaesthetics	0.315	0.684	0.000
T48.7 Other and unspecified agents primarily acting on the respiratory system	0.315	0.684	0.000
T48.6 Antiasthmatics, not elsewhere classified	0.315	0.684	0.000
T48.5 Anti-common-cold drugs	0.315	0.684	0.000
T48.4 Expectorants	0.315	0.684	0.000
T48.3 Antitussives	0.315	0.684	0.000
T48.2 Other and unspecified agents primarily acting on muscles	0.315	0.684	0.000
T48.1 Skeletal muscle relaxants [neuromuscular blocking agents]	0.315	0.684	0.000
T48.0 Oxytocic drugs	0.315	0.684	0.000
T49.9 Topical agent, unspecified	0.315	0.684	0.000
T49.8 Other topical agents	0.315	0.684	0.000
T49.7 Dental drugs, topically applied	0.315	0.684	0.000
T49.6 Otorhinolaryngological drugs and preparations	0.315	0.684	0.000
T49.5 Ophthalmological drugs and preparations	0.315	0.684	0.000
T49.4 Keratolytics, keratoplastics and other hair treatment drugs and preparations	0.315	0.684	0.000
T49.3 Emollients, demulcents and protectants	0.315	0.684	0.000
T49.2 Local astringents and local detergents	0.315	0.684	0.000
T49.1 Antipruritics	0.315	0.684	0.000
T49.0 Local antifungal, anti-infective and anti-inflammatory drugs, not elsewhere classified	0.315	0.684	0.000
S93.4 Sprain and strain of ankle	0.315	0.684	0.000
S93.6 Sprain and strain of other and unspecified parts of foot	0.315	0.684	0.000
S93.5 Sprain and strain of toe(s)	0.315	0.684	0.000
S93.3 Dislocation of other and unspecified parts of foot	0.315	0.684	0.000
S93.2 Rupture of ligaments at ankle and foot level	0.315	0.684	0.000
S62.1 Fracture of other carpal bone(s)	0.315	0.685	0.000
T93.5 Sequelae of injury of muscle and tendon of lower limb	0.315	0.685	0.000
S62.61 Fracture of other finger (open)	0.315	0.685	0.000
S14 Injury of nerves and spinal cord at neck level	0.313	0.687	0.000

This table lists the top 500 terms ordered by p(effect).

The full results table can be downloaded from this page.

The TreeWAS Database is the result of research conducted at the Oxford Big Data Institute at the University of Oxford.

This research has been conducted using the UK Biobank Resource (application number 10625). This work uses data provided by patients and collected by the NHS as part of their care and support.

This research has been conducted with the support of the Wellcome Trust (100956/Z/13/Z and 090532/Z/09/Z and 100308/Z/12/Z), the Danish National Research Foundation, Takeda, the Medical Research Council (MC_UU_12010/3), the Oak Foundation (OCAY-15-520), the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), the Wellcome Trust/Royal Society (204290/Z/16/Z) and the Li Ka Shing Foundation.

Variant-specific associations